Alpha-burn/Alpha-yohimbine -- stim-free?

[Mr.Cooper69]

I was given some alphaburn from a genomyx promo and I'm almost done with the 10 days and ready to post a review. However, I have 3 more days which are stim-free since I'm cycling off stims.

I was wondering, does Alpha-Yohimbine act as a CNS stimulant, and should it be avoided when trying to go stim-free?

Repssssss

[_Smitty_]

yes and no... it's (a-yohimbine) a sympathomimetic stimulant and acts indirectly (but not nearly such an impact on dopaminergic CNS stimulation as caffeine or 1,3).

plainly put, its fine to use if you're "stim free".

[Mr.Cooper69]

yes and no... it's (a-yohimbine) a sympathomimetic stimulant and acts indirectly (but not nearly such an impact on dopaminergic CNS stimulation as caffeine or 1,3).

plainly put, its fine to use if you're "stim free".

Gotcha, so I'm going to be picking up a bottle because this stuff freaking rocks. I'm gonna be stim-free for the next 2 months; will chronic use (i.e. more than 1 cap a day for 1-2 months) be more of an issue for allowing my adrenals to reset?

[_Smitty_]

Gotcha, so I'm going to be picking up a bottle because this stuff freaking rocks. I'm gonna be stim-free for the next 2 months; will chronic use (i.e. more than 1 cap a day for 1-2 months) be more of an issue for allowing my adrenals to reset?

honestly, anything that stimulates CNS response over an extended period will prohibit full adrenal reset... the only way you'll achieve that is buy taking nothing. but the effects are mild enough that you can certainly take this while taking a stim-break and the impact (on CNS and aggravating adrenal fatigue) is extremely minimal.

to ensure full reset, you can continue using alphaburn alongside a gram or two of tyrosine... after 2 months of that a cup of decaf will send you ragin'.

[Rodzilla]

yeah, mild and different receptors. I believe you'll still see some recovery from caffeine.

A-yohimbine is the only form I can take without having incredibly anxiety. It's also very, very hard to source find these days.

[DanND33]

this stuff freaking rocks.

I am DanND33 and I agree with this post.

[_Smitty_]

just as an aside, anyone concerned with adrenal fatigue may be pleased to hear that we're considering formulation/release of a reset-AD-type product... if things go smoothly, it may see a release during late-2011/early-2012.

[rhizome]

just as an aside, anyone concerned with adrenal fatigue may be pleased to hear that we're considering formulation/release of a reset-AD-type product... if things go smoothly, it may see a release during late-2011/early-2012.

Please no. Adrenal fatigue is just plain quackery. Respect will be lost. neuron will flame. I will swear. LULZ will be had.

[sdfan13]

Please no. Adrenal fatigue is just plain quackery. Respect will be lost. neuron will flame. I will swear. LULZ will be had.

Meaning that a supplement can't help with adrenal fatigue, or that the state of "adrenal fatigue" is harder to reach than people thing? I've always been curious.

[pa mma]

Meaning that a supplement can't help with adrenal fatigue, or that the state of "adrenal fatigue" is harder to reach than people thing? I've always been curious.

according to most medical proff-doesn't exist

[PinchTheBear]

Meaning that a supplement can't help with adrenal fatigue, or that the state of "adrenal fatigue" is harder to reach than people thing? I've always been curious.

http://www.hormone.org/Public/upload...atigue-Web.pdf
http://endocrine.niddk.nih.gov/pubs/addison/addison.htm.

[poison]

according to most medical proff-doesn't exist

What 'medical professional'? A nurse? A lab assistant? An MD? My UCLA dr told me working out is bad because it creates a lot of wear and tear on the body, and that I should switch to speed walking.

[neuron]

What 'medical professional'? A nurse? A lab assistant? An MD? My UCLA dr told me working out is bad because it creates a lot of wear and tear on the body, and that I should switch to speed walking.

"Adrenal fatigue" is a nonsensical entity marketed by psuedoscientists and quacks. It has no basis in reality, and if such a disorder existed, would present much differently (i.e. Addison's disease) than is commonly characterized. Furthermore, it would be easily diagnosed with a simple electrolyte panel (i.e. hyperkalemia), among other tests (ACTH).

[Elliptical Envy]

http://www.hormone.org/Public/upload...atigue-Web.pdf
http://endocrine.niddk.nih.gov/pubs/addison/addison.htm.

Well there goes the marketing for Reset A.D.

[bloodsimple1234]

according to most medical proff-doesn't exist

actually some top doctors in the country,who I happen to come in contact with on a weekly basis do believe there is validity to this.

when I say top,I mean very well known and respected.


I for one,am at least interested in the product.

I def respect others thoughts and opinions and love to debate and hear information.

[wakingmalice]

If people had any basic medical knowledge at all would logically dismiss the word "fatigue". Insufficiency, tolerance, etc. are real terms but fatigue doesn't even make sense.

http://books.google.com/books?id=WKL...0means&f=false


Easy read with great sources attached.

[wakingmalice]

actually some top doctors in the country,who I happen to come in contact with on a weekly basis do believe there is validity to this.

when I say top,I mean very well known and respected.


I for one,am at least interested in the product.

I def respect others thoughts and opinions and love to debate and hear information.

Doctors are wrong a lot. Just sayin. Look through the thread. their are 5-6 studies and pharmacology explanations on the non-existance of the disorder.

[Synapsin]

http://forum.bodybuilding.com/showpo...3&postcount=33

[bloodsimple1234]

Aren't you the guy that said PEA is in no way a stimulant?

Doctors are wrong a lot. Just sayin. Look through the thread. their are 5-6 studies and pharmacology explanations on the non-existance of the disorder.

where did I say " pea is in no way a stimulant? "

[_Smitty_]

Well there goes the marketing for Reset A.D.

as for ours, matt has a rhyme and reason for formulating what he's formulating... based on his reputation, i'm sure he wouldn't release something that had no scientific foundation.

[Elliptical Envy]

as for ours, matt has a rhyme and reason for formulating what he's formulating... based on his reputation, i'm sure he wouldn't release something that had no scientific foundation.

I had no idea y'all were working on such a product.

[wakingmalice]

where did I say " pea is in no way a stimulant? "

wrong guy. But I urge you to take notice of the second part of that post.

[Mr.Cooper69]

as for ours, matt has a rhyme and reason for formulating what he's formulating... based on his reputation, i'm sure he wouldn't release something that had no scientific foundation.

i agree, no scientific foundation and genomyx never belong in the same sentence.

[neuron]

i agree, no scientific foundation and genomyx never belong in the same sentence.

If they market a product towards this syndrome, then they will get raped, by me.

Post the ingredients when available.

[neuron]

As luck would have it, I just stumbled upon a product called "Revamp" by some unknown company.

The ingredients are borderline comical: Pregnenolone (huh?), pantothenic acid (uhh), and licorice, among other things.

The adrenal gland it is an organ made up of 2 histological sections (medulla and cortex), and the cortex can be broken down further into 3 different divisions (zona glomerula, zona fasciculata, and zona reticularis). The cortex produces steroid hormones (glucocorticoids, mineralcorticoids, and sex hormones), whereas the medulla produces NE and EP. Three different signaling pathways are responsible for eliciting the production/release of the adrenal contents: ANG II for mineralcorticoids, ACTH for glucocortioids and sex hormones, and neuronal signaling for EP/NE.

First of all, to adequately address "adrenal fatigue," which location in this gland is responsible for the insufficiency? As I have pointed out previously, a deficiency in mineralcorticoids would cause hyperkalemia, which would manifest as weakness and parenthesias. A zona glomerula insufficiency (which produces mineralcorticoids) would cause salt wasting (hyponatremia), and an increase in plasma renin, ANG, and ANG II. The latter would result in systemic vasoconstriction, and the decrease in plasma volume would cause an increase in both ACTH and cortisol (cortisol has weak glucocorticoid activity). The resultant hyperkalemia could cause heart conduction problems and death.


...I started to go through the deficiencies of the zona fasciculata and zona reticularis, but became too lazy. If need be, I will, however. The point is that "adrenal fatigue" is nonsense, and the supplements oriented towards alleviating "adrenal fatigue" are as dubious as the syndrome itself.

I may write more about this later, and go in depth into the ingredients of these products.

[greekmanman]

As luck would have it, I just stumbled upon a product called "Revamp" by some unknown company.

The ingredients are borderline comical: Pregnenolone (huh?), pantothenic acid (uhh), and licorice, among other things.

The adrenal gland it is an organ made up of 2 histological sections (medulla and cortex), and the cortex can be broken down further into 3 different divisions (zona glomerula, zona fasciculata, and zona reticularis). The cortex produces steroid hormones (glucocorticoids, mineralcorticoids, and sex hormones), whereas the medulla produces NE and EP. Three different signaling pathways are responsible for eliciting the production/release of the adrenal contents: ANG II for mineralcorticoids, ACTH for glucocortioids and sex hormones, and neuronal signaling for EP/NE.

First of all, to adequately address "adrenal fatigue," which location in this gland is responsible for the insufficiency? As I have pointed out previously, a deficiency in mineralcorticoids would cause hyperkalemia, which would manifest as weakness and parenthesias. A zona glomerula insufficiency (which produces mineralcorticoids) would cause salt wasting (hyponatremia), and an increase in plasma renin, ANG, and ANG II. The latter would result in systemic vasoconstriction, and the decrease in plasma volume would cause an increase in both ACTH and cortisol (cortisol has weak glucocorticoid activity). The resultant hyperkalemia could cause heart conduction problems and death.


...I started to go through the deficiencies of the zona fasciculata and zona reticularis, but became too lazy. If need be, I will, however. The point is that "adrenal fatigue" is nonsense, and the supplements oriented towards alleviating "adrenal fatigue" are as dubious as the syndrome itself.

I may write more about this later, and go in depth into the ingredients of these products.

Reps for yet another informative post and for being one of the most valuable members on these boards :P