quercetin with E/C stack?

[AvengeMe]

I cant find the thread but I remember someone mentioning that they take quercetin with the E/C stack to increase the duration of its effects. Any thoughts on this?

[AvengeMe]

bump

[thundaclap]

I don't know about EC + quercetin, but quercetin appears to have benefits on its own:


http://clinicaltrials.gov/ct2/show/N...etin%22&rank=6

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Biochem Biophys Res Commun. 2008 Sep 5;373(4):545-9. Epub 2008 Jun 27.
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.
Ahn J, Lee H, Kim S, Park J, Ha T.
Food Function Research Center, Korea Food Research Institute, 516, Baekhyun-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-746, Republic of Korea.
Abstract

Quercetin is the most abundant flavonoid and is assumed to have protective roles against the pathogenesis of multiple diseases associated with oxidative stress. In the present study, we investigated the molecular mechanisms by which quercetin affects adipogenesis and apoptosis in 3T3-L1 cells. The exposure of 3T3-L1 preadipocytes to quercetin resulted in attenuated adipogenesis and decreased expression of adipogenesis-related factors and enzymes. Moreover, quercetin exposure up-regulated the levels of phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylase (ACC). Treatment of 3T3-L1 adipocytes with quercetin resulted in the induction of apoptosis and a concomitant decrease in ERK and JNK phosphorylation. Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.

PMID: 18586010 [PubMed - indexed for MEDLINE]

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J Med Food. 2008 Dec;11(4):773-83.
Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes.
Park HJ, Yang JY, Ambati S, Della-Fera MA, Hausman DB, Rayalam S, Baile CA.
Department of Animal & Dairy Science, University of Georgia, Athens, Georgia 30602-2771, USA.
Abstract

The natural compounds genistein (G), quercetin (Q), and resveratrol (R) have been reported to each exhibit anti-adipogenic activities in adipocytes and antiproliferative and pro-apoptotic activities in several cell types. We studied the combined effects of G, Q, and R on adipogenesis and apoptosis in primary human adipocytes (HAs) and 3T3-L1 murine adipocyte (MAs). Combined treatment with 6.25 microM G, 12.5 microM Q, and 12.5 microM R during the 14-day differentiation period caused an enhanced inhibition of lipid accumulation in maturing HAs that was greater than the responses to individual compounds and to the calculated additive response. Glycerol 3-phosphate dehydrogenase activity, a marker of late adipocyte differentiation, was decreased markedly in HAs treated with the combination of G+Q+R. In addition, combined treatment with 50 microM G, 100 microM Q, and 100 microM R for 3 days decreased cell viability and induced apoptosis in early- and mid- phase maturing and lipid-filled mature HAs. In contrast, no compound alone induced apoptosis. Oil Red O stain and Hoechst 33342 stain were performed to confirm the effects on lipid accumulation and apoptosis, respectively. We also determined whether MAs responded to the combination treatment similarly to HAs. As in HAs, G+Q+R treatment decreased lipid accumulation in maturing MAs and increased apoptosis in pre- and lipid-filled mature MAs more than the responses to G, Q, and R when used separately. These results show that lower concentrations of combined treatments with several natural compounds may be useful for treatments for obesity through the suppression of adipogenesis and enhanced adipocyte apoptosis.

PMID: 19053873 [PubMed - indexed for MEDLINE]

[johnnyironboard]

grapefruit will extend the effects.