Alpha Yohimbine vs. Yohimbine Supplementation

[MCWTRAINER]

Alpha Yohimbine vs. Yohimbine Supplementation

*note* There really wasn't much information to pull up on these topics so here is what I have found. I know Pu said we could use a write-up on this but right now this is the best we are going to get until more information becomes available. If anyone has or finds more information please post it..


Yohimbine HCl
Hydrochloride version of yohimbine, a sympatholytic alpha2 adrenergic receptor antagonist that allows NE to act on adipocytes by deactivating the alpha2 andrenoreceptors that would normally block its ability to mobilize FFAs out of the cell(s). It also increases blood flow to adipose tissue, and is mildly serotonergic, noradrenergic and dopaminergic.

What is it and where does it come from?

Yohimbe has been one of the most popular supplements for men and women for years. When ingested, the body converts it to yohimbine and assimilates it into the bloodstream. Yohimbe comes from the bark of a tree that grows primarily in West Africa. Yohimbine, an alkaloid, is the primary active ingredient of yohimbe.

Similar alkaloids also play a role. Bodybuilding.com's high alkaline herbal yohimbe is made from the finest sources in the world.

What does it do and what scientific studies give evidence to support this?

What an awesome supplement! Its popularity has been ignited not only by it's claimed effects as an aphrodisiac and hallucinogen, but also new research that shows it could be an herb with very effective antioxidant potential. Research shows it is a vasodilator, which means that it increases blood flow to the extremities and appendages.

Who needs it and are there any symptoms of deficiency?

Body builders or athletes who want that washboard stomach and/or a healthy heart should look into using Yohimbe. It's not an essential nutrient; therefore, one cannot be "deficient."

How much should be taken? Are there any side effects?

Any of the supplements below have a good amount of Yohimbe that will help you acheive the best results. Tyramine is a substance contained in foods such as cheese, liver, and red wine. These foods should not be consumed while taking yohimbe. Also, antidepressants such as Prozac should be taken in combination with yohimbe only under the close supervision of a physician.

Alpha-Yohimbine
A yohimbine-isomer that works with far more potent MAOI-inhibiting properties (normally, yohimbine isn't very strong in this regard). Because of this, it basically works as an amphetemine-potentiator, because it prevents the neuro-breakdown of the brain's 'big three'-- serotonin, noradrenaline, and dopamine. It also has similar alpha-2 antagonistic properties to yohimbine HCl, but is also less vasoconstrictive in areas, making it less likely to induce large increases in BP.

Alpha-yohimbine (Alpha-Y) is an analogue of yohimbine, but its potency at the subreceptors of alpha2 differ quite a bit--most notably at the alpha2b and alpha2c adrenergic subreceptors. It is 3 times more potent at alpha2b and 4 times more potent at alpha2c. It is equipotent at alpha2a. The differing ratios of activity is where it allows us to do good stuff with it that we could not do with yohimbine.

Alpha2a mediates most the classic effects of alpha2 receptor agonists and antagonists. There is plenty of info on this in regard to the equipotent yohimbine, so I will not get into it, except to say its superior potency at the other receptors lets us use less to hit them, so we can minimize the negatives here – namely, an increase in heart rate, blood pressure, anxiety, and norepinephrine (NE) hyperactivity, centrally.

The alpha2c receptor plays a minor role in the negative feedback signal on NE, but it plays a major role in certain brain areas where sympathetic innervation is low, and the dopamine system is prominent, which just happen to be the areas that are critical for reward, reinforcement, and metabolic control, such as the VTA and striatum. In these areas, dopamine--not NE--is the primary agonist at alpha 2 receptors, and alpha2c makes up the majority of these receptors. So, it will block dopamine’s negative feedback signal, thus increasing dopaminergic tone, which is lacking in the obese, and ****ed up by dieting and high NE levels.

If that were not handy enough, the only other place the alpha2c receptors are highly expressed is in the adrenal medulla, where it modulates negative feedback on epinephrine (E), much like alpha2a does on NE. In other word, alpha-y allows for a much greater increase in E levels, with its superior effect on thermogenesis, energy expenditure, and nutrient partitioning.

The alpha2b receptor is prominent in development (it is the only adrenergic deletion that impacts survival), but in adults, it only affects blood pressure. Namely, it increases the hell out of it, especially in regard to salt loading. In the obese, and with overfeeding, receptor levels are upregulated. Not coincidentally, it also increases Arginine vasopressin activity. And, if you have read my Ab-Solved write-up, and the leptin series on our site, you might note how strongly tied in obesity, blood pressure, and the renin-angiotensin/cortisol systems are. So, not only are we minimizing the increase in the alpha2b agonist NE, we are blocking the receptor more strongly than with yohimbine.

[BringnIt]

http://forum.bodybuilding.com/showpo...6&postcount=14

http://forum.bodybuilding.com/showpo...8&postcount=15

[MCWTRAINER]

http://forum.bodybuilding.com/showpo...6&postcount=14

http://forum.bodybuilding.com/showpo...8&postcount=15

Thanks man! I saw them too but forgot to copy the link.