Cq-10

[mzzxx11]

are there any benefits for supplementing with CQ-10? if so, what's the recommended daily dosage? any recommended products?

TIA

[rhadam]

search function, use it. Lots of info to be had if you simply spend a few minutes looking.

[poison]

Research Overview

Human and animal studies were reviewed.

Coenzyme Q10 supplementation has been shown to:
1. Reduce systolic blood pressure
2. Reduce oxidative stress
3. Be an effective treatment for hypertension
4. Be effective in managing chronic heart failure
5. Be effective in managing angina
6. Improve symptoms of Parkinson’s disease
7. Increase mitochondrial functioning
8. Prevent migraines
9. Increase well-being in fibromyalgia sufferers
10. Reduce apoptosis (cell death) following eye surgery
11. Improve exercise tolerance
12. Be an effective antioxidant, combating side effects of HIV drugs
13. Be an effective treatment for nephrology
14. Regenerate plasma vitamin E levels
15. Suppress atherosclerosis
16. Prevent ischemic injury
17. Treat ischemic injury
18. Improve myocardial tolerance to aerobic stress
19. Reduce brain neuron damage from free radicals
20. Decrease atherogenesis
21. Prevent and treat hyperlipidemia
22. Prevent and treat coronary artery disease
23. Combat negative effects of beta-blockers
24. Stabilize erythrocyte, reticulocyte, and leukocyte counts after radiation
25. Prevent striatal lesions in Huntington’s disease
26. Slow weight loss in Huntington’s disease
27. Improve symptoms in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)
28. Improve endothelial function in Type II diabetes
29. Increase mitochondrial production
30. Improve energy production
31. Prevent lipid peroxidations

.....

[poison]

CoQ10: 43 Citations

1: Muller T, Buttner T, Gholipour AF, Kuhn W.
Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease.
Neurosci Lett. 2003 May 8;341(3):201-4.
PMID: 12697283 [PubMed - indexed for MEDLINE]

2: Elshershari H, Ozer S, Ozkutlu S, Ozme S.
Potential usefulness of coenzyme Q10 in the treatment of idiopathic dilated cardiomyopathy in children.
Int J Cardiol. 2003 Mar;88(1):101-2.
PMID: 12659993 [PubMed - indexed for MEDLINE]

3: Beal MF.
Bioenergetic approaches for neuroprotection in Parkinson's disease.
Ann Neurol. 2003;53 Suppl 3:S39-47; discussion S47-8. Review.
PMID: 12666097 [PubMed - indexed for MEDLINE]

4: Lu WL, Zhang Q, Lee HS, Zhou TY, Sun HD, Zhang DW, Zheng L, Lee M, Wong SM.
Total coenzyme Q10 concentrations in Asian men following multiple oral 50-mg doses administered as coenzyme Q10 sustained release tablets or regular tablets.
Biol Pharm Bull. 2003 Jan;26(1):52-5.
PMID: 12520172 [PubMed - indexed for MEDLINE]

5: Van Maldergem L, Trijbels F, DiMauro S, Sindelar PJ, Musumeci O, Janssen A, Delberghe X, Martin JJ, Gillerot Y.
Coenzyme Q-responsive Leigh's encephalopathy in two sisters.
Ann Neurol. 2002 Dec;52(6):750-4.
PMID: 12447928 [PubMed - indexed for MEDLINE]

6: Ramadan LA, Abd-Allah AR, Aly HA, Saad-el-Din AA.
Testicular toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q10 and L-carnitine in mice.
Pharmacol Res. 2002 Oct;46(4):363-70.
PMID: 12361700 [PubMed - indexed for MEDLINE]

7: Turunen M, Wehlin L, Sjoberg M, Lundahl J, Dallner G, Brismar K, Sindelar PJ.
beta2-Integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10.
Biochem Biophys Res Commun. 2002 Aug 16;296(2):255-60.
PMID: 12163010 [PubMed - indexed for MEDLINE]

8: Sarter B.
Coenzyme Q10 and cardiovascular disease: a review.
J Cardiovasc Nurs. 2002 Jul;16(4):9-20. Review.
PMID: 12597259 [PubMed - indexed for MEDLINE]

9: Koryagin AS, Krylova EV, Luk'yanova LD.
Effect of ubiquinone-10 on the blood system in rats exposed to radiation.
Bull Exp Biol Med. 2002 Jun;133(6):562-4.
PMID: 12447465 [PubMed - indexed for MEDLINE]

10: Lamson DW, Plaza SM.
Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment.
Altern Med Rev. 2002 Apr;7(2):94-111. Review.
PMID: 11991790 [PubMed - indexed for MEDLINE]

11: Beal MF.
Coenzyme Q10 as a possible treatment for neurodegenerative diseases.
Free Radic Res. 2002 Apr;36(4):455-60. Review.
PMID: 12069110 [PubMed - indexed for MEDLINE]

12: Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD.
Open label trial of coenzyme Q10 as a migraine preventive.
Cephalalgia. 2002 Mar;22(2):137-41.
PMID: 11972582 [PubMed - indexed for MEDLINE]

13: Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V.
Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus.
Diabetologia. 2002 Mar;45(3):420-6.
PMID: 11914748 [PubMed - indexed for MEDLINE]

14: Lister RE.
An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome.
J Int Med Res. 2002 Mar-Apr;30(2):195-9.
PMID: 12025528 [PubMed - indexed for MEDLINE]

15: Huang CC, Kuo HC, Chu CC, Kao LY.
Rapid visual recovery after coenzyme q10 treatment of leber hereditary optic neuropathy.
J Neuroophthalmol. 2002 Mar;22(1):66.
PMID: 11937918 [PubMed - indexed for MEDLINE]

16: Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF.
Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.
J Neurosci. 2002 Mar 1;22(5):1592-9.
PMID: 11880489 [PubMed - indexed for MEDLINE]

17: Brancato R, Fiore T, Papucci L, Schiavone N, Formigli L, Orlandini SZ, Gobbi PG, Carones F, Donnini M, Lapucci A, Capaccioli S.
Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits.
J Refract Surg. 2002 Mar-Apr;18(2):135-9.
PMID: 11934201 [PubMed - indexed for MEDLINE]

18: Schilling G, Coonfield ML, Ross CA, Borchelt DR.
Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model.
Neurosci Lett. 2001 Nov 27;315(3):149-53.
PMID: 11716985 [PubMed - indexed for MEDLINE]

19: Burke BE, Neuenschwander R, Olson RD.
Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension.
South Med J. 2001 Nov;94(11):1112-7.
PMID: 11780680 [PubMed - indexed for MEDLINE]

20: Di Giovanni S, Mirabella M, Spinazzola A, Crociani P, Silvestri G, Broccolini A, Tonali P, Di Mauro S, Servidei S.
Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency.
Neurology. 2001 Aug 14;57(3):515-8.
PMID: 11502923 [PubMed - indexed for MEDLINE]

21: Tran MT, Mitchell TM, Kennedy DT, Giles JT.
Role of coenzyme Q10 in chronic heart failure, angina, and hypertension.
Pharmacotherapy. 2001 Jul;21(7):797-806. Review.
PMID: 11444576 [PubMed - indexed for MEDLINE]

22: [No authors listed]
Extra co-enzyme Q10 for statin-users?
Treatmentupdate. 2001 Jun;13(2):4-7.
PMID: 11570288 [PubMed - indexed for MEDLINE]

23: Gazdikova K, Gvozdjakova A, Kucharska J, Spustova V, Braunova Z, Dzurik R.
[Effect of coenzyme Q10 in patients with kidney diseases]
Cas Lek Cesk. 2001 May 24;140(10):307-10. Slovak.
PMID: 11411060 [PubMed - indexed for MEDLINE]

24: Thomas SR, Leichtweis SB, Pettersson K, Croft KD, Mori TA, Brown AJ, Stocker R.
Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.
Arterioscler Thromb Vasc Biol. 2001 Apr;21(4):585-93.
PMID: 11304477 [PubMed - indexed for MEDLINE]

25: Rauchova H, Lenaz G.
[Coenzyme Q and its therapeutic use]
Ceska Slov Farm. 2001 Mar;50(2):78-82. Review. Czech.
PMID: 11288594 [PubMed - indexed for MEDLINE]

26: Piotrowski P, Wierzbicka K, Smialek M.
Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants.
Folia Neuropathol. 2001;39(3):147-54.
PMID: 11770125 [PubMed - indexed for MEDLINE]

27: Rauscher FM, Sanders RA, Watkins JB 3rd.
Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats.
J Biochem Mol Toxicol. 2001;15(1):41-6.
PMID: 11170314 [PubMed - indexed for MEDLINE]

28: Shinkai T, Nakashima M, Ohmori O, Terao T, Nakamura J, Hiramatsu N, Hashiguchi H, Tsuji S.
Coenzyme Q10 improves psychiatric symptoms in adult-onset mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: a case report.
Aust N Z J Psychiatry. 2000 Dec;34(6):1034-5.
PMID: 11127618 [PubMed - indexed for MEDLINE]

29: Choi C, Sunwoo IN, Kim HS, Kim DI.
Transient improvement of pyruvate metabolism after coenzyme Q therapy in Kearns-Sayre syndrome: MRS study.
Yonsei Med J. 2000 Oct;41(5):676-9.
PMID: 11079632 [PubMed - indexed for MEDLINE]

30: Kaikkonen J, Nyyssonen K, Tomasi A, Iannone A, Tuomainen TP, Porkkala-Sarataho E, Salonen JT.
Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study.
Free Radic Res. 2000 Sep;33(3):329-40.
PMID: 10993487 [PubMed - indexed for MEDLINE]

31: Rotig A, Appelkvist EL, Geromel V, Chretien D, Kadhom N, Edery P, Lebideau M, Dallner G, Munnich A, Ernster L, Rustin P.
Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency.
Lancet. 2000 Jul 29;356(9227):391-5.
PMID: 10972372 [PubMed - indexed for MEDLINE]

32: Raitakari OT, McCredie RJ, Witting P, Griffiths KA, Letters J, Sullivan D, Stocker R, Celermajer DS.
Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults.
Free Radic Biol Med. 2000 Apr 1;28(7):1100-5.
PMID: 10832071 [PubMed - indexed for MEDLINE]

33: Liou CW, Huang CC, Lin TK, Tsai JL, Wei YH.
Correction of pancreatic beta-cell dysfunction with coenzyme Q(10) in a patient with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome and diabetes mellitus.
Eur Neurol. 2000;43(1):54-5.
PMID: 10601810 [PubMed - indexed for MEDLINE]

34: Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S.
Coenzyme Q10 in health and disease.
Eur J Clin Nutr. 1999 Oct;53(10):764-70. Review.
PMID: 10556981 [PubMed - indexed for MEDLINE]

35: Svensson M, Malm C, Tonkonogi M, Ekblom B, Sjodin B, Sahlin K.
Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.
Int J Sport Nutr. 1999 Jun;9(2):166-80.
PMID: 10362453 [PubMed - indexed for MEDLINE]

36: Abe K, Matsuo Y, Kadekawa J, Inoue S, Yanagihara T.
Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): evaluation by noninvasive tissue oximetry.
J Neurol Sci. 1999 Jan 1;162(1):65-8.
PMID: 10064171 [PubMed - indexed for MEDLINE]

37: Piotrowski P, Ostrowski RP, Pankowska T, Smialek M.
[The effect of coenzyme Q10 on lactate acidosis at the beginning of experimental cerebral ischemia in rats after the use of endothelin 1 (preliminary results)]
Neurol Neurochir Pol. 1998 Nov-Dec;32(6):1397-404. Polish.
PMID: 10358830 [PubMed - indexed for MEDLINE]

38: Rowland MA, Nagley P, Linnane AW, Rosenfeldt FL.
Coenzyme Q10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat.
Cardiovasc Res. 1998 Oct;40(1):165-73.
PMID: 9876329 [PubMed - indexed for MEDLINE]

39: Palomaki A, Malminiemi K, Solakivi T, Malminiemi O.
Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo.
J Lipid Res. 1998 Jul;39(7):1430-7.
PMID: 9684746 [PubMed - indexed for MEDLINE]

40: Singh RB, Niaz MA, Rastogi V, Rastogi SS.
Coenzyme Q in cardiovascular disease.
J Assoc Physicians India. 1998 Mar;46(3):299-306. Review.
PMID: 11273351 [PubMed - indexed for MEDLINE]

41: Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE.
Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake.
Folia Microbiol (Praha). 1998;43(5):505-6.
PMID: 9821311 [PubMed - indexed for MEDLINE]

42: Ostrowski RP, Piotrowski P, Pankowska T, Smialek M.
Evaluation of morphological changes after treatment with coenzyme Q10 (CoQ10) in endothelin-1 induced experimental ischemia in the rat.
Folia Neuropathol. 1998;36(3):185-8.
PMID: 9833395 [PubMed - indexed for MEDLINE]

43: Dlugosz A, Sawicka E.
The chemoprotective effect of coenzyme Q on lipids in the paint and lacquer industry workers.
Int J Occup Med Environ Health. 1998;11(2):153-63.
PMID: 9753894 [PubMed - indexed for MEDLINE]

Enjoy.

[mzzxx11]

I've looked at quite a few threads where cq-10 was mentioned, but this didnt answer my questions:

1. does it "work"? are there any noticable benefits?

2. what's the daily dosage needed for it to be be effective?

TIA

[bodybuilder03]

It all depends on what your using it for. If your using it to help lower blood pressure or lower cholesterol for example it has been shown to help in lowering it but in conjunction with exercise diet and usually with the aide of a physician as well. Most daily recommendations for adults is usually 30-200mg a day and soft gels are the best form as they absorb better. But depending on use and doctors orders it could be higher.

[mzzxx11]

thanks, but 30-200mg is almost a 10 times difference, that's a big range.

can people comment on what dosage they're actually using and why?

Im mainly looking at cq-10 as a preventive measure for the heart, and potentially as something beneficial to other systems in the body.

TIA