Gaspari Glycofuse: hype or science?

[poison]

Agreed.





Agreed.





The writeup indicates that the product is not exclusive to endurance athletes, but rather is marketed as a general carb source for various exercise intensities & durations.

Bull****. Here's the totality of the writeup cut/pasted from a site currently selling Glycofuse:

GlycoFuse, Rapid Performance & Recovery SUPERCARB™

JUST THE FACTS

25G Pure Highly Branched Cyclic Dextrin Per Serving
Accelerates Performance And Glycogen Loading†
Rapid Gastric Clearance Using Osm Technology†
Loaded With Electrolytes
Sugar And Gluten Free
Performance endurance requires fuel, Carbs = fuel! Carbohydrates fuel the body's glycolytic and anaerobic ATP-PC energy systems for true athletic power performance. However, not all carbohydrates are created equal. For optimal performance there must be a balance between how much you take in and how fast it leaves your stomach (gastric clearance rate) to avoid potential cramping. Gaspari researchers utilize proprietary Osm Technology to finely tune Glycofuse in solution to ensure a low osmolality to achieve this balance which means a faster gastric clearance! We have chosen to deliver only pure HIGHLY BRANCHED CYCLIC DEXTRIN to athletes looking for a clinically studied carbohydrate for their high performance power, glycogen loading, and endurance needs with a proven track record. Do you want fuel for your workouts and rapid replenishment for the next training session? Do you want sustained energy and balanced glucose levels which won't inhibit fat burning? If you want all that, then you want Glycofuse.

I merely used ground oats as an example, as I am not an endurance athlete. Again, their marketing suggests that all will benefit from Glycofuse, and that nearly all the other carb products are bogus, and result in unstable glucose levels that impair fat burning capabilities.

Nope. From Gaspari's own site:

If you're a 'carbo-phobe' then you really aren't concerned with performance, recovery, or lean muscle. True Athletes understand the importance of carbohydrates and embrace them. Whether they are carb-loading before a competition, rolling on the mat, banging out a WOD, slamming a drink during a race, or refueling after a tough training session they know that in order to get to where they want to be they need the energy to get there.

Let's see: carb loading = pre-endurance event protocol; rolling on the mat = endurance event; WOD = endurance/power; race = endurance; refueling after a tough training session = ambiguously any workout. They are marketing it primarily toward endurance athletes. Which, as you say, you are not. So why delve into territory with which you are wholly unfamiliar, in an effort to make a non-point?

[NO HYPE]

Bull****.

Let's see: carb loading = pre-endurance event protocol; rolling on the mat = endurance event; WOD = endurance/power; race = endurance; refueling after a tough training session = ambiguously any workout. They are marketing it primarily toward endurance athletes.

Obviously endurance performance was mentioned, but the promo video definitely left the impression that this product was marketed not only for endurance exercise, but for resistance exercise as well. The writeup wasn't much different....

'When you are working out, what is the worst thing that can happen after you take a few sips of water or any other intraworkout drink?'

'refueling after a tough training session'

'Glycogen is what helps fuel your workouts and keep muscles volumized.'

'Gaspari Nutrition chose highly branched cluster dextrin for what will become the gold standard of recovery and performance drinks.'

'Do you want fuel for your workouts and rapid replenishment for the next training session?'

endurance athlete - Which, as you say, you are not. So why delve into territory with which you are wholly unfamiliar, in an effort to make a non-point?

rofl

Yeah, I'm not an endurance athlete.... so I have no clue about what I'm talking about, nor am I making any valid points. Please.

[NO HYPE]

Gaspari posted studies on page 4

Yeah, a mouse study and a kinetic evaluation.

Here's a more pertinent human performance study that you won't find in the Gaspari writeups, on cyclic dextrin that demonstrated a lack of efficacy when compared to that of glucose i.e. decreased CHO oxidation, as well as the side effect of nausea.

Appl Physiol Nutr Metab. 2011 Apr;36(2):298-306.
Rowlands DS, Clarke J.
Lower oxidation of a high molecular weight glucose polymer vs. glucose during cycling.

We previously reported no difference in the oxidation rate of a high molecular weight glucose polymer (GP) vs. maltodextrin (8 kDa) during exercise; however, the ingestion rate (1.8 g·min(-1)) was above the glucose absorption-oxidation maxima (∼1.0 g·min(-1)), possibly masking either faster gastric emptying of the GP and delivery to the circulation observed at rest or physical properties of the GP that might slow intestinal absorption. Therefore, we asked whether GP oxidation could be differentially affected when ingested at a lower rate (0.8 g·min(-1)). Eight cyclists performed three 150-min rides at 50% peak power while ingesting solutions containing 8% GP (500-750 kDa, 21 mosm·kg(-1)), 8% glucose (469 mosm·kg(-1)), or water. The exogenous carbohydrate oxidation rate was determined using stable isotope methodology and indirect calorimetry. Glucose and GP were oxidized on average at 0.54 g·min(-1) (coefficient of variation (CV) 37%) and 0.41 g·min(-1) (CV 60%), respectively, which equated to a moderate (effect size) reduction of 24% (90% confidence limits: ±22%) with GP. The endogenous carbohydrate oxidation rate with glucose (1.04 g·min(-1); CV 68%) was not clearly different from GP (15%; 90% confidence limits: ±24%) and total carbohydrate oxidation rate was not affected. Plasma glucose concentration was 8.3% lower (±7.0%, moderate) and nausea 0.4 units higher (±0.4 units, moderate) with GP vs. glucose. To conclude, the oxidation rate of GP when ingested below the glucose absorption-oxidation maxima is slower than glucose. Further work could determine the physical properties of the carbohydrate and (or) physiological mechanism determining this response. Meanwhile, utility of the glucose polymer over glucose or maltodextrin in energy beverages appears limited.

[ferfe1234]

Yeah, a mouse study and a kinetic evaluation.

Here's a more pertinent human performance study that you won't find in the Gaspari writeups, on cyclic dextrin that demonstrated a lack of efficacy when compared to that of glucose i.e. decreased CHO oxidation, as well as the side effect of nausea.


Appl Physiol Nutr Metab. 2011 Apr;36(2):298-306.
Rowlands DS, Clarke J.
Lower oxidation of a high molecular weight glucose polymer vs. glucose during cycling.

We previously reported no difference in the oxidation rate of a high molecular weight glucose polymer (GP) vs. maltodextrin (8 kDa) during exercise; however, the ingestion rate (1.8 g·min(-1)) was above the glucose absorption-oxidation maxima (∼1.0 g·min(-1)), possibly masking either faster gastric emptying of the GP and delivery to the circulation observed at rest or physical properties of the GP that might slow intestinal absorption. Therefore, we asked whether GP oxidation could be differentially affected when ingested at a lower rate (0.8 g·min(-1)). Eight cyclists performed three 150-min rides at 50% peak power while ingesting solutions containing 8% GP (500-750 kDa, 21 mosm·kg(-1)), 8% glucose (469 mosm·kg(-1)), or water. The exogenous carbohydrate oxidation rate was determined using stable isotope methodology and indirect calorimetry. Glucose and GP were oxidized on average at 0.54 g·min(-1) (coefficient of variation (CV) 37%) and 0.41 g·min(-1) (CV 60%), respectively, which equated to a moderate (effect size) reduction of 24% (90% confidence limits: ±22%) with GP. The endogenous carbohydrate oxidation rate with glucose (1.04 g·min(-1); CV 68%) was not clearly different from GP (15%; 90% confidence limits: ±24%) and total carbohydrate oxidation rate was not affected. Plasma glucose concentration was 8.3% lower (±7.0%, moderate) and nausea 0.4 units higher (±0.4 units, moderate) with GP vs. glucose. To conclude, the oxidation rate of GP when ingested below the glucose absorption-oxidation maxima is slower than glucose. Further work could determine the physical properties of the carbohydrate and (or) physiological mechanism determining this response. Meanwhile, utility of the glucose polymer over glucose or maltodextrin in energy beverages appears limited.

Since plasma glucose concentrations are far more relevant than intestinal glucose concentrations after XX period of time, this is even mildly inferior to glucose (again, it won't matter because at this level, there are no tangible differences between simple carbohydrates). The bigger issue is that the hypothesized slower intestinal absorption of cyclic dextrin can induce nausea when conducting sympathogenic activity.

[NO HYPE]

Since plasma glucose concentrations are far more relevant than intestinal glucose concentrations after XX period of time, this is even mildly inferior to glucose (again, it won't matter because at this level, there are no tangible differences between simple carbohydrates). The bigger issue is that the hypothesized slower intestinal absorption of cyclic dextrin can induce nausea when conducting sympathogenic activity.

Do us all a favor.... post more often [and don't get banned].

[poison]

Obviously endurance performance was mentioned, but the promo video definitely left the impression that this product was marketed not only for endurance exercise, but for resistance exercise as well. The writeup wasn't much different....

'When you are working out, what is the worst thing that can happen after you take a few sips of water or any other intraworkout drink?'

'refueling after a tough training session'

'Glycogen is what helps fuel your workouts and keep muscles volumized.'

'Gaspari Nutrition chose highly branched cluster dextrin for what will become the gold standard of recovery and performance drinks.'

'Do you want fuel for your workouts and rapid replenishment for the next training session?'

'Working out and 'training' are not synonymous solely with weights, particularly when used in tandem with specifically named training disciplines (like 'rolling', 'racing', and WOT'ing ). The fact that you need to semanticize your argument to this extent leads me to believe your point is moot. Why not post evidence against the product, instead of playing petty word games?

I don't have a problem with you, I've enjoyed past threads of yours; but this one is unfounded, and unnecessary.

rofl

Yeah, I'm not an endurance athlete.... so I have no clue about what I'm talking about, nor am I making any valid points. Please.

When you mention oats vs glycofuse, and 'the only benefit is reduced chance of an upset tummy', and 'we got along without it before', well...experience does come into play, and as your statements in this thread show, on this subject you clearly lack.

Gaspari wasn't spamming the forum with glycofuse pimping, in fact there's only a handful of threads on it. But you called them out on the tone of their advertising, as if they are doing something unusual or lacking integrity, when in fact the writeup is pretty low key, as writeups go, and far from the worst offender when it comes to fluffing the claims. So the only conclusion to be drawn is you have a personal beef with Gaspari, as other statements you've made here make obvious.

The only thing you've done is increase awareness and sales of Glycofuse, and wasted bb.com server space.

[NO HYPE]

The only thing you've done is increase awareness and sales of Glycofuse

Glad I could help.

and wasted bb.com server space.

Do you understand post #123 and it's correlation with the thread title? --> Or did you know that already?

[poison]

Gastrointestinal disorders after ingesting a sports drink were investigated during bicycle exercise. The experiment consisted of a preliminary exercise, a 10 min rest, and 30 min of exercise. Seven healthy untrained volunteers ingested either water or a sports drink based on highly branched cyclic dextrin (HBCD), commercially available dextrin of DE16 or glucose immediately after the preliminary exercise. The mean gastric emptying time after ingestion of the HBCD-based sports drink was significantly faster than that of the glucose-based drink. Gastrointestinal disorders were monitored by a questionnaire. The mean degree of subjective flatulence and the mean number of belches were few with the HBCD-based drink during exercise. When volunteers drank the sports drink based on 10% HBCD during bicycle exercise, they experienced few gastrointestinal disorders and consequently could continue the exercise comfortably with little fatigue.

Takii H, Takii Nagao Y, Kometani T, Nishimura T, Nakae T, Kuriki T, Fushiki T.
Source
Biochemical Research Laboratory, Ezaki Glico Co., Ltd., Osaka, Japan. takii-hiroshi@glico.co.jp
Abstract
The rates of gastric emptying for highly branched cyclic dextrin (HBCD) and other carbohydrate (CHO) solutions were examined using ultrasonograph techniques. Ten healthy volunteers ingested water, physiological saline, or solutions containing various CHO, such as HBCD, glucose, maltose, sucrose, and commercially available dextrin. After a subject drank one of the solutions, the relaxed cross-sectional area of the pylorus antrum was measured at rest by real-time ultrasonography. The time required for gastric emptying was correlated with the relaxed cross-sectional area of the pylorus antrum. Among all of the solutions tested, physiological saline was transferred fastest from the stomach to the small intestine. For solutions of the same CHO, 5 % solution was transferred faster than 10 % solution. For CHO solutions other than HBCD, a low osmotic pressure was associated with rapid transfer from the stomach. The gastric emptying time (GET) of HBCD solution increased with an increase in its concentration. A shorter GET was observed for the CHO solutions at 59 to 160 mOsm regardless of their concentration. A sports drink based on 10 % HBCD adjusted to 150 mOsm by the addition of various minerals, vitamins, and organic acids was evacuated significantly (p < 0.05) faster than a 10 % HBCD solution or a sports drink based on 10 % commercially available dextrin (DE16), which has a higher osmotic pressure (269 mOsm). Our results suggest that a shorter GET could be achieved with CHO solutions with osmotic pressures of 59 - 160 mOsm. Therefore, a sports drink based on 10 % HBCD adjusted to 150 mOsm by the addition of minerals, vitamins, and organic acids could supply adequate quantities of CHO, fluid, and minerals simultaneously in a short time, without increasing GET.

Two pertinent studies, right? Reality: is it going to help improve Joe Blows lap times, or make Suzie a national champ? Not if they weren't already headed that way, no. But it apparently has some benefits, and there's no harm in trying it.

What now?

[ferfe1234]

Two pertinent studies, right? Reality: is it going to help improve Joe Blows lap times, or make Suzie a national champ? Not if they weren't already headed that way, no. But it apparently has some benefits, and there's no harm in trying it.

What now?

GET isn't the relevant endpoint. It's delivery of glucose to skeletal muscle and liver that is of greatest significance. And the closest marker we have to that is plasma concentrations, which are elevated more rapidly in glucose vs cyclic dextrin. The difference in absorption rates is too insignificant to matter. Unfortunately, given the cost of pure dextrose, the same cannot be said about price.

[poison]

GET isn't the relevant endpoint. It's delivery of glucose to skeletal muscle and liver that is of greatest significance.

Is it? To who? When you're 7 hours into a 15hr cardio event, you won't give a **** about delivery of glucose to muscle and liver (seeing as any carb source will do that), but you may be very interested in GET.

And the closest marker we have to that is plasma concentrations, which are elevated more rapidly in glucose vs cyclic dextrin. The difference in absorption rates is too insignificant to matter. Unfortunately, given the cost of pure dextrose, the same cannot be said about price.

Bold: possibly. The rest: unless you are the personal accountant of every Glycofuse user, who cares? Cost:benefit ratio is a personal decision, and definitely not deserving of THIS thread.

[NO HYPE]

Gaspari wasn't spamming the forum with glycofuse pimping, in fact there's only a handful of threads on it. But you called them out on the tone of their advertising

I called them out on the lack of scientific evidence in contrast to the hype.

So the only conclusion to be drawn is you have a personal beef with Gaspari, as other statements you've made here make obvious.

Like as if that's a problem? I wasn't the one who put the underdosed the nitrates in a proprietary blend, and blamed it on safety concerns & tablet size restrictions. I don't take kindly to companies that use such shady practices. Maybe Gaspari will move away from the past, but I'm not about to welcome them with open arms, nor should I. Nonetheless, if there was at least a decent body of evidence supporting the hype, I wouldn't have bothered with this thread.

[poison]

Here's the hype you speak of:

http://forum.bodybuilding.com/search...chid=213644493

Nine threads with Glycofuse in the title, and a total of 2 pages of results on the whole forum. For a Gaspari product?

404hypenotfound

[NO HYPE]

Cost:benefit ratio is a personal decision, and definitely not deserving of THIS thread.

rofl

Post *123 relates to a lack of efficacy combined with nausea when using cyclic dextrin over glucose. --> I thought this stuff was supposed to outperform all the other inferior carb sources and diminish the possibility of GI distress?

[poison]

rofl

Post *123 relates to a lack of efficacy combined with nausea when using cyclic dextrin over glucose. --> I thought this stuff was supposed to outperform all the other inferior carb sources and diminish the possibility of GI distress?

I though we had moved on to hype?

You posted that study, I posted the Japanese study. A quick ninja-jaunt shows more positive evidence than negative. But back to hype: your issue was the hype:evidence ratio. I just demonstrated a distinct lack of Glycofuse hype above; I also showed studies proving benefits. I'd say the hype:evidence ratio is pretty decent.

[ferfe1234]

Is it? To who? When you're 7 hours into a 15hr cardio event, you won't give a **** about delivery of glucose to muscle and liver (seeing as any carb source will do that), but you may be very interested in GET.

What the hell are you talking about? An endurance athlete won't give a **** about delivery of glucose to skeletal muscle and liver? Then why are you taking carbohydrates, to please your palate? GET is relevant in your [myopic] eyes because you think it will lead to more rapid energy distribution deep into an endurance event. Unfortunately, your [lack of] understanding of human physiology is rather apparent by thinking that clearance of plasma glucose (the final step in energy distribution for meeting metabolic demands) isn't "worth a ****," when the whole marketing behind improved GET is more rapid delivery to metabolically-strained tissues. If you increase GET while simultaneously causing a reduction in plasma glucose, you are taking one step forward and two steps back.

[poison]

Lol, another non-endurance athlete here. Your reading comprehension sucks, both of my post, and gasparis claims.

Don't misquote me. What I said was 'an endurance athlete won't care about the glucose delivery performance of a carb, BECAUSE ANY CARB WILL DO THAT'. Delivery rates will vary; in a long event, it won't particularly matter, and in a short one, it may.

Gasparis marketing clearly states in the first sentence of their marketing spiel:

When you are working out, what is the worst thing that can happen after you take a few sips of water or any other intraworkout drink? Cramps. Nothing can kill a workout faster than some rib thumping cramps. Because of this, intelligently formulated 'sports drinks should have a verified osmolarity which is a key indicator of how fast it can clear the stomach, thus potentially avoiding cramps.

In other words, what you don't realize, because you've never done it, is that in high intensity, long endurance events, GET is very important, so you don't puke your ****ing guts out. The studies I posted showed glycofuse should have faster gastric emptying than other products, and that is their claim. The carb you don't puke up is the carb with the best rate of absorption and muscular delivery rates.

[ferfe1234]

Lol, another non-endurance athlete here. Your reading comprehension sucks, both of my post, and gasparis claims.

Don't misquote me. What I said was 'an endurance athlete won't care about the glucose delivery performance of a carb, BECAUSE ANY CARB WILL DO THAT'. Delivery rates will vary; in a long event, it won't particularly matter, and in a short one, it may.

Gasparis marketing clearly states in the first sentence of their marketing spiel:



In other words, what you don't realize, because you've never done it, is that in high intensity, long endurance events, GET is very important, so you don't puke your ****ing guts out. The studies I posted showed glycofuse should have faster gastric emptying than other products, and that is their claim. The carb you don't puke up is the carb with the best rate of absorption and muscular delivery rates.

I guess a lack of reading comprehension is a pre-requisite for an endurance trainee since No Hype and I don't qualify, but you do. Stomach cramps are not the same as puking/nausea, the latter of which was found to be a bigger issue with cyclic dextrin than it was for glucose. It is stated quite clearly in the study No Hype referenced.

The first study you cited compared CD to water, not dextrose. The second study, while equally fallacious, did not use exercising individuals (GET changes quite drastically during sympathogenic activity).

I have no horse in this race and am merely acting as an objective party. Nausea was clearly demonstrated to be a bigger issue with CD than it was with glucose solution. At this point, I don't care if you agree or not.

[poison]

Stomach cramps are not the same as puking/nausea, the latter of which was found to be a bigger issue with cyclic dextrin than it was for glucose. It is stated quite clearly in the study No Hype referenced.

Oh really? Lol. Go do some long endurance work and get back to me on that.

As far as studies, what do you not understand?

The mean gastric emptying time after ingestion of the HBCD-based sports drink was significantly faster than that of the glucose-based drink.

When volunteers drank the sports drink based on 10% HBCD during bicycle exercise, they experienced few gastrointestinal disorders and consequently could continue the exercise comfortably with little fatigue.

I have no horse in this race and am merely acting as an objective party. Nausea was clearly demonstrated to be a bigger issue with CD than it was with glucose solution. At this point, I don't care if you agree or not.

And I do have a horse in this race? Ok. /sarcasm

[PuZo]

I'll get cramps but I dont get nauseous. Doesn't potassium help with cramps? They say to eat a banana but for the potassium and not the carbs to prevent cramping?

[ferfe1234]

Oh really? Lol. Go do some long endurance work and get back to me on that.

As far as studies, what do you not understand?







And I do have a horse in this race? Ok. /sarcasm

You think stomach cramps and nausea are the same thing? Looks like I'll have to turn in my nutrition degree because you obviously just made me look stupid!

Sorry, what do you not understand?

"Plasma glucose concentration was 8.3% lower (±7.0%, moderate) and nausea 0.4 units higher (±0.4 units, moderate) with GP vs. glucose."

Actual quantified data in exercising individuals, versus your inane assumptions about the GET-nausea interrelationship. Better throw out our casein mixes since we will puke the moment they hit our pyloric sphincters!

[poison]

If you are experiencing exercise-induced stomach cramps, involving the ingestion of any food or liquids, the potential for throwing up is there. It's nothing like what most people would call 'feeling nauseous', it's simply the body taking care of business.

If you had a nutrition degree, maybe you could turn it in. yeah, I know who you are, and you aren't all that.

[ferfe1234]

If you are experiencing exercise-induced stomach cramps, involving the ingestion of any food or liquids, the potential for throwing up is there. It's nothing like what most people would call 'feeling nauseous', it's simply the body taking care of business.

If you had a nutrition degree, maybe you could turn it in. yeah, I know who you are, and you aren't all that.

I find that rather odd, since I don't have a damned clue who you are besides an "endurance athlete." If you'd like to see my credentials, you are welcome to PM me.

Nausea is intimately related with increased tone and nutritional overload in the duodenum. In fact, the unusually high GET of CD may be the reason that it created a stronger effect on nausea than glucose. But as we stated above, hairs are being split.

[poison]

Mmmhmm. Lots of split hairs in this thread, over a carb drink. Lulz!

[phosphos]

I'll get cramps but I dont get nauseous. Doesn't potassium help with cramps? They say to eat a banana but for the potassium and not the carbs to prevent cramping?

Cramping has very little to do with the pharmacokinetics of glucose. It is a neuronal issue brought upon by a deficiency in ions. Ion gated channels rely on the aforementioned 'ligand' (the term is inaccurate but using this from a layman's standpoint...) in order to contract.

[Nailbomb9]

Mmmhmm. Lots of split hairs in this thread, over a carb drink. Lulz!

Agreed, just eat your damn oatmeal and save that money for a nice protein or something...

[ScivationLead]

Agreed, just eat your damn oatmeal and save that money for a nice protein or something...

I'm having trouble finding a hydration pack that will allow oatmeal through the straw Hopefully I can get by with Glycofuse for my ultra marathon this weekend.

[Nailbomb9]

I'm having trouble finding a hydration pack that will allow oatmeal through the straw Hopefully I can get by with Glycofuse for my ultra marathon this weekend.

Wow, nice marketing scheme!! When and where will it end...???

[Nailbomb9]

Gatorade/Carbo Plus=MIX!!! Wha La!!!!!

Carbo Plus-CHEEEEEAP!!!!

[|ceman]

Obviously endurance performance was mentioned, but the promo video definitely left the impression that this product was marketed not only for endurance exercise, but for resistance exercise as well. The writeup wasn't much different....

'When you are working out, what is the worst thing that can happen after you take a few sips of water or any other intraworkout drink?'

'refueling after a tough training session'

'Glycogen is what helps fuel your workouts and keep muscles volumized.'

'Gaspari Nutrition chose highly branched cluster dextrin for what will become the gold standard of recovery and performance drinks.'

'Do you want fuel for your workouts and rapid replenishment for the next training session?'

None of those italicized sentences specifically reference weight training, resistance training or bodybuilding. "Working out", "Training", "workouts" are all general descriptors used for any kind of athletic endeavor. Recovery and replenishment are key elements for any athlete looking to quickly heal from the tolls of the workout and get ready to hit another workout soon. If your frame of reference is weight training, then you'll logically see those sentences as applying to you, but someone who trains for obstacle races, for example, will read the exact same sentences and take it to apply to their workout routines.

It's just so baffling how hyper critical you can be over the tiniest minutia.

I called them out on the lack of scientific evidence in contrast to the hype.

What "hype"? Just because we did some marketing and had some relevant studies to mention you consider that "hype"? Wow. Maybe we should have just said "Glycofuse - Some people think it tastes good"?

Or maybe you are just looking for a fight with Gaspari at every opportunity?

[imagedynamix]

It's hard to dispute its taste... So you should change "some people" to "a majority," but be sure to provide a reputable source for that.

And to be honest, before seeing one thread on someone receiving this in the mail from Gaspari, I didn't hear about it. I frequent the boards a lot, much to the dismay of my wife, and never once heard about Glycofuse... so that could mean that it wasn't hyped.

I dunno tho.