So the new USP Labs product VERSA-1 recently released the compound ingredients below.
1 capsule:
Proprietary Blend 400 mg
N-[2-hydroxy-2(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide, Cytidine 5’-diphoscholine
As many people have already pointed out, the first compound listed is aegeline, which shows antihyperlipidemic, antihyperglycemic and antidyslipidemic properties in diabetic rat models. Also, it has been postulated to be a beta(3)-adrenergic receptor agonist as well. This is one of the ingredients in the new formulation of OEP, and certainly makes sense for inclusion in a weight loss formula and makes sense based on the results of leaning out that some users of VERSA-1 reported. However, it is the purported anabolic properties of OEP that I am more interested in. If you look at the third reference cited by USP Labs, they list Sharma et al., which is actually anacyclus pyrethrum. http://www.ncbi.nlm.nih.gov/pubmed/22473789
Following up on this, it seems more likely that this compound is responsible for the anabolic properties and lean mass gains reported by users in the test logs. Taken from the Sharma abstract:
Additionally, an earlier publication from 2010 from the same group (full study is available on pubmed here, http://www.ncbi.nlm.nih.gov/pubmed/20727332) demonstrated improved sexual behavior in male rats following an ethanol extract of anacyclus pyrethrum, but more interestingly, also demonstrated significant improvements in body weight and sexual organs (testes, prostate, seminal vesicles, and epididymides), similar to administration of testosterone. This led the authors to conclude that anacyclus had both anabolic and androgenic properties.Extract administration at all the doses produced significant increase in body weight, sperm count, motility, and viability along with serum testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations... Our results suggest that the ethanol solution extract of the roots of A. pyrethrum has androgenic potential...
Now, while I'm not keen on the idea of an enlarged prostate, this does make this compound seem very interesting. But the question is then, is N-[2-hydroxy-2(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide found in anacyclus pyrethrum?
THEHUGE had experimented with anacyclus awhile back (http://forum.bodybuilding.com/showth...4866411&page=1), and I know that this is the ingredient in PES' Anabeta, which also generated a lot of buzz in the beginning, although I haven't heard much about it lately.
So I was curious to see what others thoughts were on this subject and whether anyone knows if aegeline is also found in extracts of anacyclus pyrethrum.
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01-11-2013, 07:29 PM #1
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USP Labs VERSA-1: Aegeline/Anacylcus?
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01-11-2013, 08:18 PM #2
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01-12-2013, 09:08 AM #3
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Agreed. Fadogia is the most similar recent extract with similar properties that I can recall. But I don't remember seeing overall increases in bodyweight, just testes with fadogia. Also, this study showed similar increases to testosterone administration, and I don't believe the fadogia studies used an active comparator.
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01-13-2013, 07:26 AM #4
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01-13-2013, 04:19 PM #5
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01-13-2013, 04:46 PM #6
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01-15-2013, 12:12 AM #7
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01-15-2013, 07:32 AM #8
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Aegeline looks like a great selective b3 agonist because with b3 you can replace a para H-bond donor with an acceptor (methoxy group in this case) and preserve agonist activity without targeting b1 and b2. However, because of its predominance in hibernating animals, brown adipose tissue and b3 receptors are a largely inconsequential target in humans. Physiologically there are a lot of inconsistencies regarding tachyphylaxis and agonist affinities between b3 and b1/2, and it makes sense if you think about the respective physiological differences viz. b3 predominance in hibernating animals.
Driven Sports
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01-15-2013, 02:07 PM #9
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01-15-2013, 02:14 PM #10
USP Labs VERSA-1: Aegeline/Anacylcus?
This is my understanding of the reference USP cited: (3)Sharma V, Boonen J, Spiegeleer BD, et al.
- Aegeline is not the same as anacylcus. However the extract from both contains N-Alkylamide.
-The phytochemical studies carried out in A. pyrethrum suggested presence of alkylamide and polymeric carbohydrates. Both have been reported to possess potent androgenic activity; hence, the alkylamide content found in the investigated ethanol solution extract may be implicated for the observed effects for A.pyrethrum extract in treated rats.(Sharma V, Boonen J, Spiegeleer BD, et al).
-Using that study(3) as a reference for aegeline is a questionable. I would like for USP to explain the specific relationship of their product and the alkylamides in question in that publication. N-alkylamides can also occur in plants such as Ecinacea.
-Stacking: The ingredients label on OES listed it as aegeline and the chemical name N-[2-hydroxy-2(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide for versa-1. Since we don't know the specific amount in both of them, can they be stacked together?
-Other scientist would argue that the anabolism that aegeline induces is likely restricted to adipocytes since humans are extremely insensitive to beta(3)-AR agonism.
-In my opinion, I don't think there is enough evidence to discredit USP and also I don't think that the studies they presented strongly back their claim. Hence the beta testing was somewhat used as a non clinical human trial for this product.
-I am a fan of USP labs for their innovation. I really really hope that they are researching the safety of their product enough. Some in the supplement industry recycles the same old products and switched the name to their chemical name or something else because they think we are all dumb. More and more people are beginning to actually research their claims and their products. We need to call out all the cabbage as soon as we see them.
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01-15-2013, 03:45 PM #11
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01-15-2013, 04:20 PM #12
Interestingly enough, I was perusing the chemical databases for other para-methoxy-octopamine amide derivatives and ran into "Tembamide."
Apparently, PES Alphamine has used this compound for awhile without many people noticing. It's likely they derive their "pubmed research" from rodent studies which do not translate to humans, although they do not cite any sources. It's also likely that they did not realize that tembamide was a P-OMe-octopamine precursor.
arkat-usa. org/get-file/19523/
njeong-chem-korea .ac.kr/publication/image/pdf/47.Tetrahedron.pdf
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01-15-2013, 07:02 PM #13
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^ This is what I was trying to get at.
If they are just citing the anacylcus research to say there might be an anabolic/androgenic property with aegeline, just because another herb has displayed this, then that is a complete misuse and citation of the data.
But if they are trying to say, or hint at, that some of the same actives in their product may be found in anacyclus - and hence the anabolic/androgenic properties as outlined in the research - I would like to know that. If this is the case though, it would have to be aegeline, since there is no other ingredient listed aside from citicholine. Unless they left off an ingredient.Back in action.
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01-15-2013, 08:09 PM #14
USP Labs VERSA-1: Aegeline/Anacylcus?
I am sorry if I wasn't clear. I know N-alkylamide does not refer to any specific compound. I was able to get the full papers from pubmed. I was speculating on the reason USP lab cited that paper(3). The only relationship I can find between Aegeline and anacyclus is the fact that their extact contains some kind of alkylamide. That is the reason I also stated that Ecinacea extract also contain the same class of compounds.
USP Lab Reference.
(1)Antihyperglycemic and antidyslipidemic agent from Aegle marmelos.
(3) Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC*. (Questionable)
Segansational has a very good point about why that paper was cited as part of the research that back their claims. After reading both references (1) and (3) by USP labs, I can find no relationship between these two except that some kind of alkylamide was isolated. Even though I have my reservations, I was also careful not to jump into any conclusion or discredit any claim until USP lab can explain this.
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01-15-2013, 08:45 PM #15
[QUOTE=Magnetotropic;1010470363]Interestingly enough, I was perusing the chemical databases for other para-methoxy-octopamine amide derivatives and ran into "Tembamide."
Apparently, PES Alphamine has used this compound for awhile without many people noticing. It's likely they derive their "pubmed research" from rodent studies which do not translate to humans, although they do not cite any sources. It's also likely that they did not realize that tembamide was a P-OMe-octopamine precursor.
You are very correct PES has also used , N-(2-hydroxy-2-pmethoxyphenylethyl)benzamide for alphamine. I wonder why USP is trying to patent it when it has been used before for the same purpose. Or maybe they are trying to patent their propriety blend. I read PES alphamine product description, they did not elaborate on it either.
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01-15-2013, 09:16 PM #16
[QUOTE=Anabolicmode;1010604673] It's not the same ingredient.
Tembamide:
Aegeline
Although, interestingly enough, BOTH compounds can be found in both Aegle Marmelos, as well as another plant.
Also, in studies on the antispermatogenic effects of Aegle Marmelos, the effect increased as the concentration of the extract increased, which would not bode well for USPLabs saying it gets more anabolic the more you take.
Some reading:
In vitro effect of Aegle marmelos on human sperm
motility
Medicinal Values of Bael
(Aegle marmelos) (L.) Corr.: A Review
An asymmetric dihydroxylation route to
(R)-(–)-octopamine, (R)-(–)-tembamide and (R)-(–)-aegeline
Shahidine, a novel and highly labile oxazoline from Aegle marmelos: the parent
compound of aegeline and related amidesLast edited by De__eB; 01-16-2013 at 09:01 AM.
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01-16-2013, 06:07 AM #17
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01-16-2013, 06:10 AM #18
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01-16-2013, 06:26 AM #19
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01-16-2013, 08:14 AM #20
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01-28-2013, 09:40 AM #21
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Nice...was looking out this explanation ^^
~ GrowUpOrDieTryin'
"For physical training is of some value, but godliness has value for all things, holding promise for both the present life and the life to come.
This is a trustworthy saying that deserves full acceptance." 1 Timothy 4:8-10
"Or don't you know that your body is the temple of the Holy Spirit, who lives in you and was given to you by God? You do not belong to yourself, for God bought you with a high price. So you must honor God with your body." 1 Corinthians 6:19-20
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02-26-2013, 12:37 PM #22
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You know, I won free products from USPLabs. I have always liked their OxyElite Pro, which is the greatest Thermo I have ever experienced. I also like Jack3d original.
I won some Versa-1 from USPLabs, and I am half way through the bottle. I have to say, I am getting better workouts, exponentially better. Better focus, drive, energy, pump, vascularity, and stamina.
The truth is, this product is working. If you haven’t tried it, then I don’t know why you are bashing it. Grab a bottle and do a log. Even if it works only as a placebo, then oh well. I like it and I am getting ripped and prepping for Ranger School.
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02-26-2013, 01:54 PM #23
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12-01-2013, 09:17 AM #24
USPlabs LLC Announces a Recall of OxyElite Pro Dietary Supplements Due to Possible Health Risk
Contact:
Consumer:
USPlabs LLC
1-800-890-3067
FOR IMMEDIATE RELEASE —November 9, 2013 – USPlabs LLC, Dallas, TX is voluntarily conducting a national recall of all lots and sizes of the OxyElite Pro dietary supplement products listed below. These products contain Aegeline, a synthesized version of a natural extract from the Bael tree.
Epidemiological evidence shows that use of these products has been associated with serious adverse health consequences, namely serious liver damage or acute liver failure, concentrated in Hawaii. Investigations are ongoing into a potential causal relationship. The Company agrees with FDA that a national recall is appropriate as a precautionary measure. Product was distributed nationwide through retail stores, mail orders and direct delivery.
OxyElite Pro Super Thermo capsules
2 count capsules UPC #094922417275
10 count capsules UPC #094922417251
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21 count capsules UPC #094922426604
90 count capsules UPC #094922395573
90 count capsules "Pink label" UPC #094922447906
180 count capsules UPC #094922447852
OxyElite Pro Ultra-Intense Thermo capsules
3 count capsules UPC #094922447883
3 count capsules UPC #094922447876
90 count capsules UPC #094922395627
180 count capsules UPC #094922447869
OxyElite Pro Super Thermo Powder
Fruit Punch 0.15 oz UPC #094922417237
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Fruit Punch 5 oz. UPC #094922447487
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Grape Bubblegum 4.6 oz UPC #094922447500
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No other products produced by USPlabs are subject to recall. Consumers who have purchased the products should immediately discontinue use of the product and return it to where they purchased it for a refund. Contact your health care professional if you have experienced any adverse effects.
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