7-methoxyflavone- Aromatase inhibitors have been used extensively by the
medical community as a means to reduce the amount of estrogen that is produced
in the body from testosterone. Research studies have reported benefits in men
using aromatase inhibitors, demonstrating lower estrogen levels and
simultaneously causing an increase in testosterone levels. Therefore, the use
of aromatase inhibitors have become common among bodybuilders and other
strength athletes who want to maintain highest testosterone levels for maximum
anabolic muscle-building effects, while reducing their estrogen levels.
Aromatase enzymes are part of the body***8217;s biochemistry system that are used in
the conversion of testosterone to estrogen. So, when aromatase enzyme activity
is inhibited , this prevents conversion of testosterone into estrogen thus
preventing the negative feedback loop in the HPTA(Hypothalamic-Pituitary-
Testicular-Axis).
During the researchers constant effort for discovering a naturally occurring
( 7-methoxyflavone has been found in extracts from Meliaceae and Rutaceae
plants) improved aromatase-inhibiting product, their attention was drawn to
this compound . While several of these substances exhibited high aromatase-
inhibiting activity, when it came to intestinal absorption and metabolic
stability in the body, it was determined that there was a clear grouping of the
majority of flavonoids that scored low(Chrysin anyone?) and only a few that
scored high. When subjected to independent research, it was determined that 7-
methoxiflavone had one of the highest aromatase-inhibiting scores, with high
intestinal absorption and metabolic stability in the body.
These characteristics are extremely important for developing the most
effective naturally occurring aromatase inhibitor. Even if a substance has high
aromatase-inhibiting activity, if it is poorly absorbed or unstable and
metabolized quickly in the body, it will be ineffective. Therefore 7-
methoxyflavone is the top choice due to its combination of characteristics
required for maximum aromatase-inhibiting activity inside the body.
Flavones are plant chemicals known to be competitive inhibitors of
cytochrome P450 aromatase with respect to the androgen substrate.
A welcome plus with the 7-methoxyflavone is that it's not only orally
available and resistant to metabolism but unlike most flavones it's very
selective, it inhibits aromatase but not 17beta-hydroxysteroid dehydrogenase
.
Optimal 17b-HSD activity is crucial for the endogenous testosterone synthesis
. The 7-meth here shines again.
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