Let's take an example : Pre-workout Leucine Consumption Is Detrimental to Muscle Growth
First of all, lets just point out how fcking ridiculous this is. AA are basic components of protein. In other words, protein is like a chain of AA. It's like saying "eating protein pre-work out is detrimental to muscle growth".
The author play with the word quite well. "the consumption of leucine before training
seems to diminish muscular performance." Without references, of course. In other words, his claim has never been supported by scientific studies. Weak argument if you ask me.
Then, he goes on explaining why leucine could be detrimental to anabolic response when consumed pre-workout. His arguments to explain why leucine SEEMS to diminish muscular performance : it mitigates glycogen conversion, insulin-signaling desensitization and inhibitation of dopamine production. Let's see why his arguments are **** :
Glycogen conversion : His reference , "Branched-chain amino acids activate key enzymes in protein synthesis
after physical exercise".
Insulin : His reference, "Role of dietary proteins and amino acids in the
pathogenesis of insulin resistance" and "A branched-chain amino acid-related metabolic signature that
differentiates obese and lean humans and
contributes to insulin resistance"
Dopamine : His reference, "Oral branched-chain amino acid supplements that reduce brain serotonin during exercise
in rats also lower brain catecholamines"
So, his whole argumentation is based on unrelated studies. He goes on saying leucine prework out mitigates glycogen conversion, but he cites an article that studied post work out protein synthesis (completly unrelated to his argument). His insulin desentisation is also bull****. Pathogenic insulin resistance and obese people can not be compare to average lifters. It is completely unrelated, again. Then, his dopamine argument is based on an article done on rats. Once again, it means jack ****. EVEN if all his arguments were true, it doesnt mean leucine pre work out is detrimental to muscle growth. All the biomechanism he talked about might happen for real, but leucine pre work out can still has positive effect on muscle growth when consume pre work out. I mean, even if there is negative effects to pre work-out leucine, there might have much more positive effect. So, in the end, pre work out leucine can be a very very good thing (in spite of some negative effects). It's like saying "we shouldnt drive car, because some people die in car crash".
Also, his whole article is the same. Total bull****.
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