Cortisol Blockers (Lean Xtreme) and Anxiety/Depression

[kochbros2012]

The direction of the reaction depends on NADPH/NADP+, and you're correct that reduction predominates, chiefly due to H6PDH providing NADPH in vivo. Regarding oral bioavailability, I feel like an idiot because I can't find a freakin text and the quote I provided was indeed SubQ, not PO as I had thought when I first read it.

ur not an idiot

[PinchTheBear]

ur not an idiot

If that's true I'm going to need to rewrite my memoirs

[Nailbomb9]

If that's true I'm going to need to rewrite my memoirs

Damn Pinch, you have more than enough clout on here to make a SMALL error. Don't sweat it man, I always look for your opinions and such on products I might want to buy...

[madbenchman]

ur not an idiot

Wow that's some serious verbiage. Props to pinch. Another thing to know about cortisol blockers is that really its about stress reduction. So having a better job that keeps you happy or taking a cortisol blocker that helps you to adapt to stress can help too.

[kochbros2012]

Wow that's some serious verbiage. Props to pinch. Another thing to know about cortisol blockers is that really its about stress reduction. So having a better job that keeps you happy or taking a cortisol blocker that helps you to adapt to stress can help too.

stress reduction is numero uno

and you dont wanna block cortisol per se. You may wanna influence its metabolism though, and 11b-HSD1 reductase inhibition can do that. Or influence certain aspects of its activity by modulating transcription factors or post translational phenomena, and some compounds can acheive that as well

[NO HYPE]

You may wanna influence its metabolism though, and 11b-HSD1 reductase inhibition can do that. Or influence certain aspects of its activity at the translational level, and some compounds can acheive that as well

I like 11-KT as well.

[realdude2u]

Chk this predatornutrition.com/en/content/does-phosphatidylserine

[EatTrainClean]

Hmm, thanks^ I had to Google it, but their source study is interesting.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503954/

Interestingly, I was looking this up earlier, for the potential memory benefits. Excuse my ignorance, but has Lean Extreme been around and popular for a while now?

Why was the 7-OH removed? I know a fair amount of organic chem and such, but am learning some good stuff via this thread.

[jonneysmooth]

In the past I have used cissus to lower cortisol levels which is very effective. Makes me feel great at first but then I would develop side effects after a few weeks. Like acne and anxiety. So I believe you are right with it increasing other hormones.

Recently I heard about Ashwagandha which is advertised as an anti anxiety and calming herbal supplement. It works by aiding the body to cope with stress which results in lower cortisol levels. I've been on it for about a month now and still feel amazing. No acne and the slight anxiety that I have on the regular is gone. No other side effects I can notice either I'm about to start a thread on it