You all really need to check this out

[Majestak]

http://www.cbc.ca/story/science/nati...les040623.html

^ above: a little boy was born with a genetic mutation, where the only side effect is extreme muscle. Saw this in the Discover magazine. apparently, scientists are looking for ways to block this myostatin gene in the form of a supplement. of course, it would probably only be available to people with muscular dystrophy.

http://www.ultimate-exercise.com/ima...lgian_blue.jpg

http://www.cincinnatichildrens.org/N...FE6E/0/cow.jpg

^ these are cows that have the same disorder. No joke.

Would you take a supplement to block myostatin if the only side effect was stupid muscle and strength gains?

Where do i sign up?

[Emperiorjack]

I wish there was newer pictures of that boy. I want to see how big he is now.

[chlaxman]

There are some research supplements out now that claim to inhibit the myostatin protein. I'm not talking about the crappy Myostatin blockers that came out a while ago, either. If you search some other boards people are taking this stuff and some people claim it works well.

However, I doubt I would ever take them, due to personal objections.

[Big Natural]

Mighty mice
Through genetic engineering, Johns Hopkins scientists have crafted what might be called a biotech version of Mighty Mouse.

"The mice are fairly spectacular," says Se-Jin Lee, assistant professor of molecular biology and genetics. "They are normal in every respect, except their muscles are two to three times larger than normal." "They look like Schwarzenegger mice."

http://dox.media2.org/barista/archives/mighty1.jpg

[Big Natural]

Googlgin some more brought up some nice pics too, those mice look like lil ronnies!

here:

http://www.musclemissions.org/myostatin.jpg

[pu12en12g]

Flex Wheeler:

http://www.musclephotos.com/myogene.html

Doctors discover a toddler muscle man

By Linda A. Johnson, Associated Press
June 23, 2004

Somewhere in Germany is a baby Superman, born in Berlin with bulging arm and leg muscles. Not yet 5, he can hold seven-pound weights with arms extended, something many adults cannot do. He has muscles twice the size of other kids his age and half their body fat.

DNA testing showed why: The boy has a genetic mutation that boosts muscle growth.

The discovery, reported in Thursday's New England Journal of Medicine, represents the first documented human case of such a mutation.

Many scientists believe the find could eventually lead to drugs for treating people with muscular dystrophy and other muscle-destroying conditions. And athletes would almost surely want to get their hands on such a drug and use it like steroids to bulk up.

The boy's mutant DNA segment was found to block production of a protein called myostatin that limits muscle growth. The news comes seven years after researchers at Johns Hopkins University in Baltimore created buff "mighty mice" by "turning off" the gene that directs cells to produce myostatin.

"Now we can say that myostatin acts the same way in humans as in animals," said the boy's physician, Dr. Markus Schuelke, a professor in the child neurology department at Charite/University Medical Center Berlin. "We can apply that knowledge to humans, including trial therapies for muscular dystrophy."

Given the huge potential market for such drugs, researchers at universities and pharmaceutical companies already are trying to find a way to limit the amount and activity of myostatin in the body. Wyeth has just begun human tests of a genetically engineered antibody designed to neutralize myostatin.

Dr. Lou Kunkel, director of the genomics program at Boston Children's Hospital and professor of pediatrics and genetics at Harvard Medical School, said success is possible within several years.

"Just decreasing this protein by 20, 30, 50 percent can have a profound effect on muscle bulk," said Kunkel, who is among the doctors participating in the Wyeth research.

Muscular dystrophy is the world's most common genetic disease. There is no cure and the most common form, Duchenne's, usually kills before adulthood. The few treatments being tried to slow its progression have serious side effects.

Muscle wasting also is common in the elderly and patients with diseases such as cancer and AIDS.

"If you could find a way to block myostatin activity, you might slow the wasting process," said Dr. Se-Jin Lee, the Johns Hopkins professor whose team created the "mighty mice."

Lee said he believes a myostatin blocker also could suppress fat accumulation and thus thwart the development of diabetes. Lee and Johns Hopkins would receive royalties for any myostatin-blocking drug made by Wyeth.

Dr. Eric Hoffman, director of Children's National Medical Center's Research Center for Genetic Medicine, said he believes a muscular dystrophy cure will be found, but he is unsure whether it will be a myostatin-blocking drug, another treatment or a combination, because about a dozen genes have some effect on muscles.

He said a mystotatin-blocking drug could help other groups of people, including astronauts and others who lose muscle mass during long stints in zero gravity or when immobilized by illness or a broken limb.

Researchers would not disclose the German boy's identity but said he was born to a somewhat muscular mother, a 24-year-old former professional sprinter. Her brother and three other close male relatives all were unusually strong, with one of them a construction worker able to unload heavy curbstones by hand.

In the mother, one copy of the gene is mutated and the other is normal; the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people.

The boy is healthy now, but doctors worry he could eventually suffer heart or other health problems.

In the past few years, scientists have seen great potential in myostatin-blocking strategies.

Internet marketers have been hawking "myostatin-blocking" supplements to bodybuilders, though doctors say the products are useless and perhaps dangerous.

Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them far more muscle and less fat than other steer.

"Other members of the child's family are reportedly stronger than average, but only the mother was available for DNA testing. His mother had been a professional athlete prior to becoming pregnant.

The researchers tested for possible causes for the over-developed muscles in the boy, such as an excess of testosterone or insulin-like growth factor and found no abnormal levels.

Because the baby's increased muscle was similar to that found in mice and in cattle lacking the gene that produces myostatin, the researchers checked the mother's and child's genetic profile. They discovered the mother had a mutation in one copy of the myostatin gene and that both copies of the baby's myostatin gene were defective. Humans inherit one copy of each gene from each parent."

http://www.dailycamera.com/bdc/natio...984793,00.html

http://www.wric.com/Global/story.asp?S=1964711

http://www.forbes.com/lifestyle/heal...out519696.html

http://www.newscientist.com/news/news.jsp?id=ns99996065

Related:

http://www.thinkmuscle.com/articles/volk/myostatin.htm

http://articles.findarticles.com/p/a...22/ai_84255235

Photo:

http://abcnews.go.com/wire/Living/ap20040623_2062.html

Myostatin "Mighty Mice":

http://www.mesomorphosis.com/images/...tatin-mice.jpg

"Mighty Mice" and "Mighty Cattle":

http://www.ultimate-exercise.com/muscp.html

^^^

[Big Natural]

I cannot wait to start using this ****! A natural way to gain muscle.

can you imagine how buff that baby is gonna be? Potential to become the worlds strongest powerlifter or biggest bodybuilder without the roids or other crap!

http://www.ergogenics.org/myostatin2.html

Here is a dutch article (I can read) that talks about a company that is developing the protein and has some testresults too:

No side effects.

Yes none at all .

How cool is that? Everyone can become buff when this is legal and on the market.

[Big Natural]

Update,

I read that Wyeth is going to produce the first ever real working drug that will give you the muscleincreases. They have the patents and thus they are the only company that can legally produce the Myostatin blocker. They are currently testing it:

http://www.wyeth.com/news/Pressed_an...5_14_20_25.asp

This means it will probably take another 3 years for the drug to hit the market. Maybe longer.

[TurboGuy]

I cannot wait to start using this ****! A natural way to gain muscle.

can you imagine how buff that baby is gonna be? Potential to become the worlds strongest powerlifter or biggest bodybuilder without the roids or other crap!

http://www.ergogenics.org/myostatin2.html

Here is a dutch article (I can read) that talks about a company that is developing the protein and has some testresults too:

No side effects.

Yes none at all .

How cool is that? Everyone can become buff when this is legal and on the market.

Don't believe everything you hear. In particular, "no side effects". There are heart development concerns with that baby boy, among other things. And this "drug", myo-029 is certainly uncharted territory, so to make claims of "no side effects" is ludicrous IMO. This research and "avenue" is fairly new and certainly uncharted. Only time will tell, which there has not been enough time at this point.

[Big Natural]

Don't believe everything you hear. In particular, "no side effects". There are heart development concerns with that baby boy, among other things, and only time will tell, which there has not been enough time at this point.

Yep that is true, I am awaiting the phaseII and phase III research results to see what kind of effects it has. Only after it has been proven okay the drug and health administration will give the green light for producing it.

[Majestak]

no doubt. probably not a good idea to jump into a new thing like this w/o knowing its effects. i'm sure we'll be hearing about it in the near future, though.

[Big Natural]

no doubt. probably not a good idea to jump into a new thing like this w/o knowing its effects. i'm sure we'll be hearing about it in the near future, though.

Yea, it also states that the drug has permanent effects. This means you will stay superbig and there might be no way to reverse it. Being big a couple of years in your life is nice but after a while I can imagine you want to be 'normal' again. Being musclebound isn't that nice...

[Emperiorjack]

Yea, it also states that the drug has permanent effects. This means you will stay superbig and there might be no way to reverse it. Being big a couple of years in your life is nice but after a while I can imagine you want to be 'normal' again. Being musclebound isn't that nice...

No way that sucks.

[pepingtom]

If everyone takes this and gets big, then eventually being big won't be a big deal anymore.

[dexterium]

Thats something I fear in life... what if the undeserving McDonalds fatties can all of a sudden take a pill and be fit like us. That would suck.

[niCe99]

Thats something I fear in life... what if the undeserving McDonalds fatties can all of a sudden take a pill and be fit like us. That would suck.

bad thing is they wont be "fit"

shure they can be big but they wont be physically active.

[pu12en12g]

bad thing is they wont be "fit"

shure they can be big but they wont be physically active.

Agreed.

There is more to fitness than size.

[TurboGuy]

If everyone takes this and gets big, then eventually being big won't be a big deal anymore.

big will be out and skinny will be in. . . and I will have a headstart on everyone..

[dexterium]

Agreed.

There is more to fitness than size.

Well, I was talking more specifically about the light weight type with a six pack. I don't think it would be fair to have Joe Blow go and down 5 big macs, head er to pizza hut for a pizza and then to dairy queen for a blizzard and then lay there in his disgust and then all of a sudden just take a pill and still be able to retain his 6 pack. You know.

[Big Natural]

Well, I was talking more specifically about the light weight type with a six pack. I don't think it would be fair to have Joe Blow go and down 5 big macs, head er to pizza hut for a pizza and then to dairy queen for a blizzard and then lay there in his disgust and then all of a sudden just take a pill and still be able to retain his 6 pack. You know.

Wouldn't that be great?

On another note, a sixpack is obtained by having low bf%, not having much muscle. So you will become fat AND strong, a bit like this:

http://www.81x.com/Authors/bigwillevo/lp3.jpg

And if you don't workout and become muscular you will probably run into cardiovascular problems, people who do Mcdonalds and become big will only die sooner .

[NJLife]

there goes sports records