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  1. #1831
    I am the α and the ω xRedStaRx's Avatar
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    Originally Posted by thebeginning88 View Post
    New guy, somewhere between stage 2 and 3 of a receding hairline.

    Don't have the time to read through all the research notes of the first few pages...any chance of getting some solid cliffs?

    Main questions:

    I have access to some good dermatologists - should I talk to them to get prescriptions for anything?

    Are all of these substances over the counter, or are they difficult to find?
    Finasteride from derm, or self medicate from online shipping. Ketoconazole (Nizoral) shampoo 2-3x/week with a conditioner.

    Topicals include minoxidil and RU.
    PhD in Hairloss bro-science
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  2. #1832
    Registered User thebeginning88's Avatar
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    Originally Posted by xRedStaRx View Post
    Finasteride from derm, or self medicate from online shipping. Ketoconazole (Nizoral) shampoo 2-3x/week with a conditioner.

    Topicals include minoxidil and RU.
    What does RU stand for? I've heard good things about Minoxidil.


    Do any of these interact? For example: If I can get the Finasteride, should I still aim to get the Nizoral AND the Minoxidil? Or just one pill and one topical usually?
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  3. #1833
    I am the α and the ω xRedStaRx's Avatar
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    Originally Posted by thebeginning88 View Post
    What does RU stand for? I've heard good things about Minoxidil.


    Do any of these interact? For example: If I can get the Finasteride, should I still aim to get the Nizoral AND the Minoxidil? Or just one pill and one topical usually?
    They all work with different mechanisms.

    Finasteride is an enzyme inhibitor that reduces DHT quantity at the follicle tissue level. Minoxidil is a growth stimulant that up-regulates growth factors and stimulates hair follicles to grow longer and faster. RU58841 is the strongest topical anti-androgen we can safely use so far, it binds to androgen receptors inside the follicle, effectively nullifying DHT's effects.
    PhD in Hairloss bro-science
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  4. #1834
    Registered User AlainnNeart's Avatar
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    20 year old here. Noticed my hair receding about 5 months ago, it stopped, thankfully. I feel that it may have been the mature hairline recede. But I noticed a bunch of hair in the shower and the front of my hair was now thinning, but not receding. Also the back of my head was thinning to my surprise. Hoped on Rogaine / Minoxidil 5% foam about 5 days ago. No one would be able to tell I'm thinning a bit, I have a TON of hair still and I really don't want to go bald. Going to buy some Nizoral and use that 3 days a week. Does the shedding phase last 2 weeks for rogaine?

    Do I have a chance at maintaining or even thickening my hair for awhile?

    For example:



    My hair is a bit thicker than the guy in this video (before clips)
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  5. #1835
    Registered User 4thdimension's Avatar
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    Just noticed today that my hair has thinned pretty fast fml. Feel like there's a big difference in hair thickness between now and 1-2 weeks ago, does this suggest that there might be something other than genetics causing it?

    It isn't very noticeable yet though, only notice that it's thinner when I run my fingers through my hair, previously I couldn't really see much scalp, but now I can. It's also looks a bit thinner on the left side than right side. Thinking of waiting a few weeks/months and see if it gets any worse before starting treatment. Hopefully it will stop at this, but we'll see.
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  6. #1836
    Registered User jumpman18's Avatar
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    Originally Posted by xRedStaRx View Post
    They all work with different mechanisms.

    Finasteride is an enzyme inhibitor that reduces DHT quantity at the follicle tissue level. Minoxidil is a growth stimulant that up-regulates growth factors and stimulates hair follicles to grow longer and faster. RU58841 is the strongest topical anti-androgen we can safely use so far, it binds to androgen receptors inside the follicle, effectively nullifying DHT's effects.
    This may seem like a dumb question, but what's the point of using Fin if you can just use RU58841. RU compLetely nullifys DHT effects like you said so what's the point of even needing to reduce the quantity of DHT with Fin??
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  7. #1837
    I am the α and the ω xRedStaRx's Avatar
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    Originally Posted by jumpman18 View Post
    This may seem like a dumb question, but what's the point of using Fin if you can just use RU58841. RU compLetely nullifys DHT effects like you said so what's the point of even needing to reduce the quantity of DHT with Fin??
    1- You are assuming that the RU is completely absorbed locally to all follicles
    2- You should use it twice per day

    Number one is not realistic, or at least bleak. Number two is a hassle for most people.
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  8. #1838
    Physicist in Training Fire8085's Avatar
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    Did some bloodwork.

    Free test was high
    Total test mid range
    DHT levels were low
    Estradiol levels were low as well.

    Gonna start fin and see what happens.
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  9. #1839
    Registered User viku_vv's Avatar
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    I have tried a lot of those stuff mentioned here and also the various stuff available in the market and nothing gave me any good results. So i worked hard, saved some money and did a HT 6 months back. Now waiting for the hair to grow!
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  10. #1840
    Registered User bayareamac's Avatar
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    Originally Posted by Fire8085 View Post
    Did some bloodwork.

    Free test was high
    Total test mid range
    DHT levels were low
    Estradiol levels were low as well.

    Gonna start fin and see what happens.
    Your estradiol will go up on Fin.
    MD, MPH
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  11. #1841
    Registered User Hitch23's Avatar
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    Can rogaine fukk up your hair even more than before? Right now I've got some recession and thinning in the temples, not really noticeable to others (yet) but I've definitely noticed it the past couple years and I'm starting to get paranoid about it. Already use nizoral and I'm thinking of adding rogaine, just don't want to if there's a chance that it could make my current situation worse
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  12. #1842
    Not AfricanAmerican (srs) JayC24's Avatar
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    how much more effective would the 2% nizoral be over the 1%? I'm not a chemist but I'm assuming it isn't exactly "double" even though it looks it seeing as how it wouldn't make sense to require a script for something you could just double up on... not even sure how that would work.

    I've always used 1% nizoral on and off, probably about 2-3 times a week when I'm actually sticking to it and was wondering if it would be worth it to purchase the 2% next time I order fin.
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  13. #1843
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    Question

    Redstar and other hair loss experts.

    Questions,

    If you can grow a full thick beard and your hairline is still intact. Does that mean you aren’t sensitive to DHT induced hairloss?

    Why don’t MPB suffers lose hair in the side and back of the hair?

    Why do hair transplant receivers who get hair from the back still take fin if those hairs aren’t sensitive to DHT? Doesn’t this mean that the hair follicle DHT sensitivity theory is a myth? And there is a real why DHT causes hairloss in the scalp not the side and back
    Last edited by Skinnyfloyd; 04-11-2015 at 07:51 AM.
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  14. #1844
    Romper Crew Krunk Fu's Avatar
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    Originally Posted by xRedStaRx View Post
    They all work with different mechanisms.

    Finasteride is an enzyme inhibitor that reduces DHT quantity at the follicle tissue level. Minoxidil is a growth stimulant that up-regulates growth factors and stimulates hair follicles to grow longer and faster. RU58841 is the strongest topical anti-androgen we can safely use so far, it binds to androgen receptors inside the follicle, effectively nullifying DHT's effects.
    I'm assuming there are really no rogaine alternatives? It irritates my pussy ass sensitive skin too much.

    Also - where do you buy RU? Is it a topical?
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  15. #1845
    Registered User 8MoreReps's Avatar
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    Been using this jamaican castor oil for a few days so far and it helps with thickness of the hair and it conditions it at the same time. Hair thinning areas look a lot better and hair looks healthier. Of course to early to tell if it will actually regrow some hair.

    Miscer a few posts back recommended. Anyone else tried this?

    http://www.amazon.com/dp/B00A7ISRFA/...jamaican+black
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  16. #1846
    Registered User Glutamine1's Avatar
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    Originally Posted by xRedStaRx View Post
    They all work with different mechanisms.

    Finasteride is an enzyme inhibitor that reduces DHT quantity at the follicle tissue level. Minoxidil is a growth stimulant that up-regulates growth factors and stimulates hair follicles to grow longer and faster. RU58841 is the strongest topical anti-androgen we can safely use so far, it binds to androgen receptors inside the follicle, effectively nullifying DHT's effects.
    I know you also read articles from PubMed like myself, but can you like to any recent articles about RU. Btw, what's the current status with RU? Are they starting clinical trials on it, is the project still canned, etc etc? Hope you're doing well mang.

    Originally Posted by jumpman18 View Post
    This may seem like a dumb question, but what's the point of using Fin if you can just use RU58841. RU compLetely nullifys DHT effects like you said so what's the point of even needing to reduce the quantity of DHT with Fin??
    The problem with RU is the availability of it. There are several vendors in Asia which will supply you with the powder. Since you're dealing internationally there are people that have been burned by receiving poor product with low purity &/or because of the international sales - their shipment was flagged at customs. If you're one of the lucky ones who gets a good purified batch, the first thing to do is find a local chemist and have him synthesis more of it for you, so you can just get it locally now without having to worry about the problems which I mentioned above. In addition once you have the powder you need to purchase many other things to make it work, such as a small weigh scale. You basically have to mix it with several solutions and what not to make it work. There's a massive thread on the product on baldtruthtalk.com

    Originally Posted by Hitch23 View Post
    Can rogaine fukk up your hair even more than before? Right now I've got some recession and thinning in the temples, not really noticeable to others (yet) but I've definitely noticed it the past couple years and I'm starting to get paranoid about it. Already use nizoral and I'm thinking of adding rogaine, just don't want to if there's a chance that it could make my current situation worse
    Yes, all these products have an interim amount of causing shedding. This is completely normal and just a process of your body shedding those weaker follicles and growing new stronger follicles. It's basically like lifting. You tear down the microfibers of muscles and regrow stronger and thicker fibers.

    Originally Posted by JayC24 View Post
    how much more effective would the 2% nizoral be over the 1%? I'm not a chemist but I'm assuming it isn't exactly "double" even though it looks it seeing as how it wouldn't make sense to require a script for something you could just double up on... not even sure how that would work.

    I've always used 1% nizoral on and off, probably about 2-3 times a week when I'm actually sticking to it and was wondering if it would be worth it to purchase the 2% next time I order fin.
    I don't know the answer to your question, but I remember a poster saying Nizoral is bad to use in the hair because of the sulfates. I was a long time user of Nizoral and told users to get it. After finding out that it contains sulfates, I switched over to Regenepure. Has the same ingredients as Nizoral, but without the sulfates.

    Originally Posted by Skinnyfloyd View Post
    Redstar and other hair loss experts.

    Questions,

    If you can grow a full thick beard and your hairline is still intact. Does that mean you aren’t sensitive to DHT induced hairloss?

    Why don’t MPB suffers lose hair in the side and back of the hair?

    Why do hair transplant receivers who get hair from the back still take fin if those hairs aren’t sensitive to DHT? Doesn’t this mean that the hair follicle DHT sensitivity theory is a myth? And there is a real why DHT causes hairloss in the scalp not the side and back
    That first statement is a pretty bold statement. Don't think the two really have any connection to each other. Hair loss is a multifactoral condition involving the interplay between genes and social environment. The gene can turn on at anytime and you can start losing hair over a period of time. Basically like Type 2 Diabetes. Genetics plays a role and so does environmental factors in what you eat, if a person works out, etc etc.

    MPB suffers will lose hair on the side and back over time. The hairs there are just more resistant to DHT. You still have to take fin because you're not transplanting hair over your whole scalp. Most are just transplanting hairs at their temple region. Well, what about the other parts of your scalp that haven't been transplanted? Those follicles are still susceptible to miniaturization by DHT.

    Originally Posted by Krunk Fu View Post
    I'm assuming there are really no rogaine alternatives? It irritates my pussy ass sensitive skin too much.

    Also - where do you buy RU? Is it a topical?
    I have the same problem as yourself. Thinned out a part of my temple the size of a silver dollar coin. Here you go. This is the massive thread on baldtruthtalk about the RU. Has everything in there that you need to know from where to purchase, what else you need, how to mix and store, and etc.

    https://www.baldtruthtalk.com/showth...41-Usage-Guide

    As I said above, if you get a good batch. Be smart and find a local chemist to synthesize more of it for you locally. You will end up paying more, but the comfort of knowing you won't ever run out of the product is worth the price. Last thing you want is to have good results from the compound, lose your ties with the international supplier, and you'll be back to square 1 in no time.
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  17. #1847
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    Originally Posted by Glutamine1 View Post

    That first statement is a pretty bold statement. Don't think the two really have any connection to each other. Hair loss is a multifactoral condition involving the interplay between genes and social environment. The gene can turn on at anytime and you can start losing hair over a period of time. Basically like Type 2 Diabetes. Genetics plays a role and so does environmental factors in what you eat, if a person works out, etc etc.

    MPB suffers will lose hair on the side and back over time. The hairs there are just more resistant to DHT. You still have to take fin because you're not transplanting hair over your whole scalp. Most are just transplanting hairs at their temple region. Well, what about the other parts of your scalp that haven't been transplanted? Those follicles are still susceptible to miniaturization by DHT.
    It really wasn’t a bold statement but a reasonable assumption. DHT is responsible for beard growth. So if something can grow a thick beard and at the same time their hairline/hair isn’t effect; would it be reasonable to assume that they won’t experience MPB.

    I beg to disagree on your second point respectfully. MPB suffers NEVER lose hair on the side and the back of the hair. If you look at Norwood scale; you will see side and back hair is NOT affected by MPB.
    So this goes back to my original point. Those who utilize hair transplants where they take donor hair from the back, still have to use FIN to prevent hair loss again. If this is the case, than the theory about each hair follicles being sensitive to DHT is debunk.
    So there is a reason why DHT causes hair loss in the sclap/galea not anywhere else.
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  18. #1848
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    My hair has been thinning since i was 17 and it's only recently started to thin on the crown which is really noticeable when my hair is wet (not too much when it's dry). I really want to try Finasteride but have read about the sexual side effects and that's what i'm most afraid of. Have also read about people that continued experiencing the side effects even after they stopped using it.

    I'm not sure if it's worth trying
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  19. #1849
    Registered User Imaneya's Avatar
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    still no cure?

    cool. will check back in a few months.
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  20. #1850
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    Red face

    Where can I buy finasteride online ?
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    tl;dr
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    Setipiprant news made headlines across all the hair loss forums and you guys are still talking about finasteride? LOL
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    I should buy a boat Tzaddiq's Avatar
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    Originally Posted by hellouser View Post
    Setipiprant news made headlines across all the hair loss forums and you guys are still talking about finasteride? LOL

    Who the hell keeps up with hair loss forums? Explain Setipiprant pls.
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    Registered User hellouser's Avatar
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    Originally Posted by Tzaddiq View Post
    Who the hell keeps up with hair loss forums?
    Anyone who gives a damn about treatments better than ones from 20 years ago.

    Explain Setipiprant pls.
    I already explained it here:
    http://forum.bodybuilding.com/showth...post1338866771

    You guys need to read more.
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    I should buy a boat Tzaddiq's Avatar
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    Originally Posted by hellouser View Post
    Anyone who gives a damn about treatments better than ones from 20 years ago.



    I already explained it here:
    http://forum.bodybuilding.com/showth...post1338866771

    You guys need to read more.
    Oh yeah I semi-remember that post.

    So if it's jumping to phase 2 clinical trials, we're looking at about a year for that and phase 3, then it's available in a few years?
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    Originally Posted by hellouser View Post
    Setipiprant news made headlines across all the hair loss forums and you guys are still talking about finasteride? LOL
    inb4 it makes your dink fall off.

    Also, your post is fuking useless because you don't mention where to get this chit.
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    Been on fin/minox for 4 months now.
    Looks to be working a little as i shed pretty badly, then things started filling out
    I definitely have more hair on this certain area that was nearly fully slick before.

    Minox gave me all this weird hair growth in places I never had, like
    the sides of my eyebrows.

    Had watery semen from fin early on, but its less watery now,
    Still not where it used to be though, but my gf likes it like that haha
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  28. #1858
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    Originally Posted by Pimpus View Post
    inb4 it makes your dink fall off.

    Also, your post is fuking useless because you don't mention where to get this chit.
    Why do you fail to read? I already stated how to get it, but nobody gave a sh*t. I'll be getting my batch in a few months, so have fun masturbating over finasteride... that is, if that poison hasn't screwed you sexually already.

    ps. PGD2 inhibition does NOT affect you sexually (again, READ).
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  29. #1859
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    Originally Posted by Imaneya View Post
    still no cure? cool. will check back in a few months.
    Make that a few decades. The hair loss industry is a joke. Much like the weight loss industry, 99% of the sh!t out there doesn't work. At least if you have a weight issue, you can follow a strict diet and exercise regime and fix your problem.. but baldness? There's nothing you can really do. No amount of exercise or eating right will bring your hair back. You have a couple drugs that toy with your hormones and god knows what else and about a billion other lotions and potions that don't do sh!t but make your wallet lighter.

    I've been lurking hair loss forums for years now and I can safely say that it's just a repeated cycle over and over. I don't think I need to explain it, but if you still don't understand what I mean, have a look at my signature. Hair loss won't ever be cured because 1) no one gives a sh!t about men's health and 2) where's the profit in a cure? Haven't you heard that the 'best' customer is a returning customer? I've already accepted that this is my life and it will never be close to the same quality as it was before when I had hair, but lurking the forums everyday and waiting for a cure is a dead end. As much as I hate to join the 'just shave it' crew, it's the next best option if one of the few drugs that we have aren't working out for ya.
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    Originally Posted by hellouser View Post
    I'll be getting my batch in a few months.
    Still tied up in customs? Hope the stuff doesn't expire.
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