Hey guys I was at my local supp store and they had this on sale so I picked some up. I have seen peopla on here saying that it is a good anti-estrogen. Is this true and what is the main reason for supping with it? Did I waste my money or can I benefit from supping with it? Thanks
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Thread: Grape Seed Extract
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05-13-2007, 03:21 PM #1
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Grape Seed Extract
Go Bruins!
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05-13-2007, 03:32 PM #2
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05-13-2007, 05:53 PM #3
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05-13-2007, 06:00 PM #4
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05-13-2007, 06:34 PM #5
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05-14-2007, 01:58 AM #6
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05-14-2007, 03:31 AM #7
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05-14-2007, 03:37 AM #8
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05-14-2007, 06:03 AM #9
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05-14-2007, 06:26 AM #10
I suggest taking it with resveratrol - this excellent NOW product contains grape seed extract, resveratrol and green tea extract at a very reasonable price;
NOW Natural ResveratrolIf you want a picture of the future, imagine a boot stamping on a human face - forever.
$ BMBC $
-Misc Scotch Crew-
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05-14-2007, 02:22 PM #11
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05-14-2007, 04:32 PM #12
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05-14-2007, 04:58 PM #13
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05-15-2007, 04:56 PM #14
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05-16-2007, 01:29 AM #15
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An article I found with the uncited load-maintenance dose recommendation as well as GSE's other benefits including the AE effects ... Grape Expectations (Suppression of Estrogen Biosynthesis by Procyanidin Dimers in Red Wine and Grape Seeds) .
Besides the "bro-science" reason, the dosing recommendation origin was probably born in part from research done by Bagchi with higher amounts and the maintenance weight-dose recommendation he's given.It is the mark of an educated mind to be able to entertain a thought without accepting it.
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05-16-2007, 02:40 PM #16
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05-16-2007, 03:07 PM #17
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05-17-2007, 04:48 AM #18
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05-17-2007, 02:08 PM #19
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05-23-2007, 03:07 PM #20
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Since I have the research on hand (having put it into my latest product, CyoGenX), here's some cool stuff on GrapeSeedExtract (Procyanidin), from various human, in situ, in vitro, and in vivo studies:
• Inhibits the Aromatase Enzyme (prevents testosterone from converting to estrogen at the genetic level, preventing both transcription and expression of Aromatase) [1-4]
• Acts similarly to Letrozole (a prescription Aromatase Inhibitor), and can destroy breast tumor tissue (gynecomastia) [1]
• Has anabolic properties (Inhibits the Glucocorticoid Receptor, thus allowing more muscle to be built)[4]
• Has Anti-Hypertensive properties [5]
• Improves Cognitive Function [5]
• Lowers LDL Cholesterol [6]
• Is a strong Anti-Oxidant (stronger than vitamin C or E) [6]
. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.
2. Suppression of Estrogen biosynthesis by procyanidin dimmers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.
3. Suppression of aromatase (estrogen synthetase) by red wine phytochemicals. Breast Cancer Res. Treat., 67: 133-146, 2001
4. Modulation of aromatase gene expression by grape seed extract. Ikuko Kijima, et al. City of Hope, Durante, CA.
5. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R771-5.
6. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr. 2006 Jul;84(1):252-62.Am J Clin Nutr. 2006 Jul;84(1):252-62.
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05-23-2007, 03:46 PM #21
I always see GSE used as an antioxidant in NO products, and just assumed it was only used for cleaning up free radicals. So are you saying that all of us using NO products that contain GSE are also taking anti-estrogens?
I am sort of worried about this actually. Is there any chance that once I cycle off of my current NO supplement (Animal Pump) that contain GSE, I could get a rebound and get Gyno?
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05-23-2007, 04:13 PM #22
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As do I...
I put Resveratrol and GSE into an anti-estrogen product with another AI (Stinging Nettle)...
My advice is to figure out how much of each you want, and find the best product for the money. I didn't do the math, but hopefully the GSE/Res/SN product I put out with PF is priced competitively with others, and has what people are looking for, dosage-wise.
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10-22-2008, 09:17 AM #23
Found this too...
http://www.ncbi.nlm.nih.gov/pubmed/16740737
Any newer info on GSE as an AI? Would it be safe to take daily & not cycle it if used as an AI?
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10-22-2008, 12:51 PM #24
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10-22-2008, 04:36 PM #25
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10-22-2008, 04:52 PM #26
In terms of antioxidants and bodybuilding, while baseline ROS generation is of physiological benefit to muscle growth, the higher the level of ROS, the greater the dysruption of myogenic fusion and/or regeneration [1]. This suggests that ROS attenuation [via nutritional supplementation] aquires the ability to benefit and/or speed the recovery process.
[1] Zaccagnini et al. (2007) J. Biol. Chem., Vol. 282, Issue 43, 31453-31459~
Wherever progression lacks.... regress can be found in abundance.
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10-22-2008, 04:54 PM #27
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10-22-2008, 05:00 PM #28
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10-22-2008, 05:02 PM #29
I have taken this stuff for a long time, just because it's such a powerful antioxidant that's extremely good for your overall health, especially your heart and blood vessels.
I learned a while back that it helps stimulate collagen synthesis.
Now I learn that it has anti-estrogenic properties? This **** keeps gettin better and better.
I use nutra planet's grape seed extract powder.
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10-22-2008, 05:02 PM #30
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