NY "Lipitor" Pat on Suicide Watch: Statins & LDL Cholesterol Research shows...

[JUSA]

... they don't do chit. Cliffs: You'd have to treat 600 people to show one instance of positive benefit. Meanwhile, low cholesterol is dangerous as high cholesterol.



Link to study: https://pubmed.ncbi.nlm.nih.gov/33293274/

Results: Among 108 243 individuals aged 20-100, 11 376 (10.5%) died during the study, at a median age of 81. The association between levels of LDL-C and the risk of all cause mortality was U shaped, with low and high levels associated with an increased risk of all cause mortality. Compared with individuals with concentrations of LDL-C of 3.4-3.9 mmol/L (132-154 mg/dL; 61st-80th centiles), the multivariable adjusted hazard ratio for all cause mortality was 1.25 (95% confidence interval 1.15 to 1.36) for individuals with LDL-C concentrations of less than 1.8 mmol/L (<70 mg/dL; 1st-5th centiles) and 1.15 (1.05 to 1.27) for LDL-C concentrations of more than 4.8 mmol/L (>189 mg/dL; 96th-100th centiles). The concentration of LDL-C associated with the lowest risk of all cause mortality was 3.6 mmol/L (140 mg/dL) in the overall population and in individuals not receiving lipid lowering treatment, compared with 2.3 mmol/L (89 mg/dL) in individuals receiving lipid lowering treatment. Similar results were seen in men and women, across age groups, and for cancer and other mortality, but not for cardiovascular mortality. Any increase in LDL-C levels was associated with an increased risk of myocardial infarction.

Conclusions: In the general population, low and high levels of LDL-C were associated with an increased risk of all cause mortality, and the lowest risk of all cause mortality was found at an LDL-C concentration of 3.6 mmol/L (140 mg/dL).

[Dave22reborn]

Don't eat eggs for breakfast, eat cheerios instead, trust the science!!!

[Cleveland33]

Don't eat eggs for breakfast, eat cheerios instead, trust the science!!!

Cheerios is the one cereal i like - I actually bring a box to strongman comps to snack on between events for carbs

[Dave22reborn]

Cheerios is the one cereal i like - I actually bring a box to strongman comps to snack on between events for carbs

It's a snack, not breakfast though.

Same with pop tarts and muffins, those are a desert, but their not breakfast food.

[MarkyMark215]

I am 12 and what is all of this

[Fishman15]

Carnivore diet and never felt better checking in...

[BigDickBlack]

NYPat, after you are done butt-slamming your tranny dad, please respond..

[rampagefc77]

While at times pharma companies oversteps, statins aren’t one of them. On every level, we have seen benefit. Familial hypercholesterolemia leads to increase CV mortality. Lowering ldlc improves CV mortality risk. There is no limit— further reduction in ldlc continues to lower cv events and mortality.

I’m not on a statin- I have a horrible family history but my lipids are great. But I would gladly take one without question.

A study looking at all cause mortality and statin use based on dose is meant to prove what? Those on high dose statins are taking them because they have an incredibly high CV risk, and likely many other comorbidites, so it makes sense that their risk would be higher. Has nothing to do with the med.

[ParsleyTea]

I didn't watch the video, but from what I read I agree. Statins are not likely to be of much help with preventing heart attacks, or prevent cancer. I know a neighbor who strongly believes statins help prevent cancer due to talks with his doctor. Personally I believe in a majority of circumstances I doubt statins do much good, and with the side effects many report cause some people harm. I know one former army general who had to retire early due to serious side effects experienced from taking a statin.

Statins are the number one drug seller of all time though. They have made an enormous amount of money for drug firms, doctors, hospitals. So long as that remains the case I imagine statins remaining the main drug used for heart disease prevention by hospitals. Once that changes I can imagine many doctors coming out and saying, we knew that, statins don't do much good.

There are many other theories on the cause of heart disease, such as stress, high blood sugar levels, blood clots, not drinking enough water, etc. These other theories though tend to not receive a whole lot of attention from the medical field.

[dabbmw2002]

151 LDL and 61 HDL mogger checking in.

[tripod29]

I hole-hardedly agree, but allow me to play doubles advocate here for a moment. For all intensive purposes I think you are wrong. In an age where false morals are a diamond dozen, true virtues are a blessing in the skies. We often put our false morality on a petal stool like a bunch of pre-Madonnas, but you all seem to be taking something very valuable for granite. So I ask of you to mustard up all the strength you can because it is a doggy dog world out there. Although there is some merit to what you are saying it seems like you have a huge ship on your shoulder. In your argument you seem to throw everything in but the kids Nsync, and even though you are having a feel day with this I am here to bring you back into reality. I have a sick sense when it comes to these types of things. It is almost spooky, because I cannot turn a blonde eye to these glaring flaws in your rhetoric. I have zero taller ants when it comes to people spouting out hate in the name of moral righteousness. You just need to remember what comes around is all around, and when supply and command fails you will be the first to go. Make my words, when you get down to brass stacks it doesn't take rocket appliances to get two birds stoned at once. It's clear who makes the pants in this relationship, and sometimes you just have to swallow your prize and accept the facts. You might have to come to this conclusion through denial and error but I swear on my mother's mating name that when you put the petal to the medal you will pass with flying carpets like it’s a peach of cake.

[JUSA]

While at times pharma companies oversteps, statins aren’t one of them. On every level, we have seen benefit. Familial hypercholesterolemia leads to increase CV mortality. Lowering ldlc improves CV mortality risk. There is no limit— further reduction in ldlc continues to lower cv events and mortality.

I’m not on a statin- I have a horrible family history but my lipids are great. But I would gladly take one without question.

A study looking at all cause mortality and statin use based on dose is meant to prove what? Those on high dose statins are taking them because they have an incredibly high CV risk, and likely many other comorbidites, so it makes sense that their risk would be higher. Has nothing to do with the med.

I'd like to see the study where statins improve someone's (without a history of heart disease) chances.

And, since you stated people on statins have an incredibly high CV risk -- you need to show me where high cholesterol (which is why many get put on them) is directly linked to CV. Because this study directly refutes that, showing no difference in risk bw high and low.

There are many other theories on the cause of heart disease, such as stress, high blood sugar levels, blood clots, not drinking enough water, etc. These other theories though tend to not receive a whole lot of attention from the medical field.

You left out inflammation, a major reason. People blame cholesterol, because when your arteries get inflamed and damaged, the body uses is almost like spackle to repair harm. Eventually it builds up.

However, what if someone is not eating inflammatory garbage seed oils, processed chit and alcohol? For that person, cholesterol isn't likely to to build up, because there is no damage to begin with. Meanwhile, taking statins, you get a very slight reduction in CV (only in people who've already had it) with the trade off that you take all the side effects and your body shuts down production of cholesterol -- which is actually something we all need to function and be healthy.

Meanwhile, whatever dietary/lifestyle reasons your cholesterol was high and you had inflammation to begin with -- still there and still causing problems. Genetics plays a big role in your cholesterol levels, sure, but them being high on their own is not necessarily anything bad. Women with high cholesterol -- they live longer than their lower cholesterol counterparts.

[JUSA]

https://theconversation.com/benefits...w-study-175557

In our study, published in Jama Internal Medicine, we found that the absolute risk reduction from taking statins was modest compared with the relative risk reduction. The relative risk reduction for those taking statins compared with those who did not was 9% for deaths, 29% for heart attacks and 14% for strokes. Yet the absolute risk reduction of dying, having a heart attack or stroke was 0.8%, 1.3% and 0.4% respectively.

This explains the widely touted study that showed people after having a heart attack, those that could tolerate statins and stayed on them were "50% less likely to have a second heart attack". Just look at the absolute numbers to see that's 50% of a small number.

And, while that initial study to promote statins was with over 100,000 people, I do have to wonder: What caused those who could not tolerate statins? Was it a factor that would also contribute towards having a second heart attack? Did anyone look into this and rule it out?

Good read overall.

NYPat, after you are done butt-slamming your tranny dad, please respond..

Nah, he's out. Pat can't exist in any thread with adults actually talking about anything and using actual data to back up arguments. He can scream and cry, hypocritically call people morons, but the reality is he's far too stupid to engage. He needs to be told what to think in every aspect of his life.