Designer Supplements Introduces: LEAN XTREME 2.0

[uhockey]

The pdf form will be on the website soon, but for now, here is the exclusive for all:

Lean Xtreme - New & Improved
By Designer Supplements

From the very beginnings of Designer Supplements, Lean Xtreme has been a hugely successful product for improving body composition through cortisol modulation and thyroid enhancement. While the stellar product has become a staple in the regime of many dieters and lean bulkers, even the best things in life stand for improvement. With that in mind, Designer Supplements has reformulated Lean Xtreme? and built upon the enduring 7-OH base that so many love, in order to formulate the next generation in non-stimulating fat burning products. While the original was undoubtedly effective, the new and improved Lean Xtreme targets multiple pathways to assist fat loss while also maintaining adequate testosterone levels and optimizing immune function in order to promote the ideal fat burning, muscle sparring environment.


Cortisol and Glucocorticoids

Cortisol is the body's chief stress hormone, released constantly by the adrenals to deal with day to day stressors and released in excess during demanding situations of mental and physical strain. Whether it be work or finances, romance or illness, life is full of stress for even the most carefree individual and physical training is an additional stressor that may lead to bodily breakdown in an already overstressed environment. Although catabolic by nature, it is through a complex interplay that cortisol is also one of the signals required for any growth process and proper immune function. With this in mind, cortisol obviously cannot be eliminated completely (total lack of cortisol is actually called Addison?s disease and is deadly,) but it can and should be controlled.

Cortisol is synthesized through two major pathways, one from the direct conversion of progesterone in the adrenal glands, the other from inter-conversion with another adrenal hormone called cortisone which takes place in peripheral tissues such as muscle, the liver and blood. For all intents and purposes, cortisone is an inert hormone, however it can be converted to cortisol in the liver by an enzyme known as 11beta-hydroxysteroid dehydrogenase 1 (11betaHSD1). As noted, these pathways are critical for life and are part of the growth cascade from training, however excesses of cortisol can have very detrimental effects.

Though always present in controlled quantities, extra cortisol is released when your body needs to take immediate action, such as the old 'fight or flight' concept. Amongst its many functions, cortisol instructs the liver to release catabolic enzymes that breakdown fatty acids from fat stores and sugar from muscle cells in order to provide quick energy for the organs that need it. Similarly, mental stress can also lead to excess cortisol release, however unlike the fight or flight scenario which elevates cortisol for as long as it is required, the elevation of cortisol tends to be chronic. This is damaging to the body for a multitude of reasons.

The Damaging Side of Cortisol

Cortisol alters the way your body stores fat, essentially increasing levels of what is known as visceral adipose tissue (VAT), or in layman's terms the solid belly fat that overweight men with tend to have. VAT is stored beneath the abdominal wall rather than on top, where the more jiggly fat called subcutaneous adipose tissue (SAT) tends to reside. Due to its location and receptor status, VAT is very difficult to lose when cortisol levels remain excessive and the issue is further compounded by cortisol?s effect on the thyroid gland.

As most people know, thyroid output is directly correlated with metabolic rate, governing both muscle building (via protein synthesis) and also fat burning. High stress levels from increased cortisol levels can exhaust the adrenals and adversely effect the pituitary, thereby decreasing the release of thyroid stimulating hormone (TSH) and negatively impacting the release of thyroid hormones T3 and T4. In addition, when dieting the peripheral conversion to T3, the most active thyroid hormone, is blunted as the body detects a lower energy intake and attempts to conserve energy. Putting this together, dieting increases cortisol which further decreases thyroid output during a period when output is already blunted, thus resulting in a slower metabolism, which makes dieting even harder and less effective.

If the story above wasn't damning enough, excessive cortisol comes along with other unique caveats including a pronounced impact on appetite, leaving you constantly hungry (as if dieting doesn't do that already). Additionally, bone density can be affected by excessive cortisol levels which upregulate osteoclastic bone re-absorption and may eventually lead to a condition known as osteopenia or osteoporosis. High cortisol can suppress the immune system, leaving you open to disease and infection (once again, a problem for many when hypocaloric.) Last but not least, high cortisol can negatively affect cognitive performance such as memory and quick thinking.

Introducing the New & Improved Lean Xtreme

The brand new Lean Xtreme is designed to combat all of the issues outlined above, while also enhancing fat loss efforts and lean muscle preservation. The formula comprises of the tried and true as well as the new and advanced. First, 7-OH? for cortisol control and thyroid enhancement. Next, we have added 5-AT, another cortisol controller that works by influencing cytokines responsible for inflammation and cortisol signalling. Additionally, Forslean is added to improve body composition and signal optimal testosterone levels, and green tea extract is included for the myriad of benefits it confers and further immune enhancement.

7-OH (7-hydroxy-dehydroepiandrosterone)

7-hydroxy-dehydroepiandrosterone, better known to many simply as 7-OH, was the sole component of the highly successful original Lean Xtreme. 7-OH is comprised of both the 7-alpha and 7-beta hydroxyl metabolites of DHEA (dehydroepiandrosterone) in a specific ratio for maximal efficacy. While DHEA itself serves as a precursor to androgens and estrogens in the body, neither of the two isomers of 7-OH can convert to androgens or estrogens but appear instead to convert between each other and another DHEA metabolite called 7-keto-DHEA (5). 7-keto and the two isomers use the enzyme 11betaHSD1 to interconvert, which fortuitously is the same enzyme that converts the relatively inactive cortisone to the very active and potentially catabolic cortisol. Through this enzyme, 7-OH provides competitive inhibition of cortisol synthesis, thereby reducing the overall concentrations of cortisol.

Because of this anti-glucocorticoid activity, 7-OH has positive effect on the immune system (6) and is also thought to have considerable neuroprotective properties due to glucocorticoid regulation in the brain (7). In fact, 7beta-hydroxy steroids are currently being evaluated as novel endogenous neuroprotective aids (8). As an additional benefit, there also appears to be a very definite link between 7-OH and the thyroid hormone T3 (9), further enhancing the positive body composition effects exerted by 7-OH.

5-AT (5-androstene-3 beta, 7 beta, 17 beta-triol)

5-AT, the first new ingredient in Lean Xtreme, is another interesting compound. Like 7-OH, it is a metabolite of DHEA, but unlike 7-OH which works to control cortisol via the 11-beta-HSD-1 enzyme, the full means by which 5-AT exerts anti-glucocorticoid activity is not fully understood. While its mechanistics still require full elucidation, 5-AT appears to be a very potent inhibitor of glucocorticoids (1-3) and their adverse effects through modulation of the cytokine and interleukin systems.

While a multitude of mechanisms are at play, glucocorticoids exert some of their negative effects by stimulating interleukin-4 (IL-4) and suppressing interleukin-2 (IL-2) amongst others. When this cytokine imbalance is maintained in a chronic fashion, secondary to excess glucocorticoids, the milieu is created for ultimate deterioration of the immune system and inefficient repair processes to the damages of mental and physical stressors. 5-AT has been demonstrated in studies to significantly stimulate the production of both IL-2 which assists in T-cell function and interleukin-3 (IL-3) which is essential to the development of all cells of the immune system, including T-cells, B-cells, and macro****es (4). In addition, 5-AT not only stimulates production, but also appears to assist white blood cell activity (measured by lymphocytes) significantly above its original level (2) in the presence of potential pathogens and mitogens. The previous point is very important in that too much promotion of the immune response could be problematic, but much like the 7-OH effect on cortisol, the 5-AT? effect on cytokines appears to promote balance instead of elimination.

Using both 5-AT and 7-OH in the new Lean Xtreme helps control cortisol via two distinct mechanisms while additionally ensuring a healthy balance of inflammatory cytokines for proper immune function.

[uhockey]

Green Tea Extract

Herbal green tea has been used in Eastern traditional medicine for centuries due to its incredible health promoting effects but only recently has it gained favor in the western world. Green tea is comprised of several catechins, most significantly epigallocatechin gallate (EGCG), as well as a small amount caffeine and a number of vitamins and minerals. A full explanation into green tea is well beyond the scope of this write-up, however a basic understanding of some of the effects will be explained.

Lean Xtreme™ contains a high potency green tea extract (GTE) for a plethora of reasons. First and foremost, GTE has the ability to increase metabolic rate, thereby promoting lipolysis (breakdown of fat for fuel) by promoting the release of two neurotransmitters called epinephrine and norepinephrine (10). These two transmitters possess the ability to stimulate the activity of hormone sensitive lipase (HSL), an enzyme required to release fatty acids into the bloodstream from their stored state. Further down the biochemical pathway, the effects of HSL are promoted by a second messenger called cyclical adenosine monophosphate (cAMP) which is broken down by an enzyme called Phosphodiesterase. It is at this step that the caffeine in green tea functions as it acts an inhibitor of Phosphodiesterase, thereby elevating cAMP and prolonging the life of HSL. As if this information didn’t sell GTE on its own, further down the chain EGCG inhibits an enzyme called catechol-O-methyltransferase (COMT) (10, 11), that is partially responsible for the breakdown of epinephrine and norepinephrine. Avoiding the science for a moment, the ultimate effect of this cascade is enhanced fat burning for longer periods. An additional benefit of catechins in the presence of caffeine is a synergistic effect including the concept of ‘futile cycling’ (12, 18.) Futile cycling occurs when HSL releases fatty acids and not all of them are oxidized for energy. These fatty acids are then re-esterified with glycerol to form triglycerides and stored. This procedure requires energy and so is wasteful process.

Addition benefits for body composition from green tea include fat gain reduction (and possibly prevention) by inhibiting the enzyme fatty acid Synthase (FAS) (13-15), appetite inhibition (16), and improved glucose disposal (17). Lastly, green tea appears to elevate levels of dopamine in the brain (19). During dieting, dopamine is of particular importance because it is generally theorized to be the body’s means of communication between the brain and the anti-starvation hormone Leptin. Unfortunately, when you diet, dopamine also happens to decrease quite significantly (20). Incidentally, by prolonging the life of cAMP, caffeine also has the effect of maintaining dopamine signalling, so once again the catechins and caffeine work in synergy. For anyone paranoid about the caffeine content of green tea extract, the amount present in high quality GTE is low and only mildly stimulating for even the most sensitive of users.

Forskolin

Much like green tea, forskolin (extracted from the herb Coleus forskohlii) has been used extensively in the Far East for centuries in traditional medicine. Its effects on body composition are really second to none, including fat loss, thyroid enhancement and testosterone enhancement.

The effects of forskolin on fat loss begin with its ability to activate adenylate cyclase (21). Typically, adenylate cyclase is activated by one of the hormone mentioned earlier – norepinephrine or epinephrine – when they attach to the adrenergic receptors on the surface of the fat cell. This activates cAMP which in turn activates HSL. Forskolin mimics these hormones in this sense, only it does not attach to the adrenergic receptor like the hormones, but in fact bypasses them by going straight through the cell membrane. So with forskolin, you have a “non-stimulating thermogenic” of sorts. In addition to this, forskolin appears to be able to directly inhibit the glucose transporter of fat cells, thereby preventing glucose uptake and gains in adiposity (22). Interestingly, it is also hypothesized that there may be a secondary mechanism through which this occurs that is cAMP-dependant, involving inhibition of the gene for the glucose transporter (23). These effects alone make the combination of forskolin and green tea exciting, but there is more.

As discussed earlier, the thyroid plays a great part in the regulation of metabolic rate, as well as the rates of protein synthesis. Thyroid output is dependant on the pituitary gland which releases a hormone called thyroid stimulating hormone (TSH) that serves to inform the thyroid to release its hormones (namely T3 and T4). Forskolin has been shown to mimic the effects of TSH, thereby promoting thyroid hormone release (24). Additionally, of the two main thyroid hormones, T4 is relatively inactive compared to T3 and as such the body converts T4 to T3 whenever required using an enzyme called Type II Deiodinase. Literature suggests Forskolin enhances the expression of this enzyme, thereby promoting the conversion of stored T4 to the highly active T3 (25). Taking into consideration the combined effects on thyroid output possessed by forskolin and 7-OH, the new Lean Xtreme clearly targets the optimization of fat burning and body composition improvement.

An additional benefit of cAMP is it’s involvement in the cascade of signals that ultimately result in testosterone production and release. By elevating cAMP with forskolin, a rise in testosterone should be noted. Forskolin also appears to stimulate Gonadatropin Releasing Hormone (GnRH) which stimulates Luteinizing Hormone (LH) and thus, Leydig cells of the testes to produce testosterone (26). During dieting, elevations in testosterone, or even maintenance of testosterone levels, are incredibly valuable for maintaining muscle mass. cAMP can also help in this regard through a non-hormonal mechanism as it can inhibit calcium-dependant enzymes that degrade muscle tissue (27). All these effects combined make forskolin an incredibly handy dietary aid.

Summary

During dieting, the human body fights to hold onto as much body fat as it can, making efforts to lose additional pounds significantly more difficult. Likewise, when bulking, many people’s bodies are more than happy to take on extra body fat stores in preparation of future diets. The new and improved Lean Xtreme™ caters for the potential issues that arise during both of these times, thereby making it an excellent tool for both dieting and lean bulking. Additionally, while a hypocaloric state may be unpleasant on the gut and the mind, its effect on the immune system and stress hormone levels are often overlooked. It is tough to imagine that efforts to be ones best may actually be creating a biochemical profile to hold back progress, but this indeed is the case. While the original Lean Xtreme was and still is fantastic, the upgrades to the formula act to further optimize the hormonal mileu for maximal benefit. At Designer Supplements there are no thoughts of holding back progress, only helping the customer achieve his or her goals. If you are giving your best in the gym, why expect your body to give you less than the best results? If you are expecting the best from your body, why expect less than the best from your supplement company? With the new Lean Xtreme Designer Supplements offers you the best option on the market for non-stimulant body composition optimization...until we decide to upgrade again.

References

1. Loria RM, Padgett DA. Mobilization of cutaneous immunity for systemic protection against infections. Ann N Y Acad Sci. 1992 Apr 15;650:363-6.

2. Padgett DA, Loria RM. In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol. J Immunol. 1994 Aug 15;153(4):1544-52.

3. Loria RM. Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology. 1997;22 Suppl 1:S103-8.

4. Loria RM, Padgett DA. Control of the immune response by DHEA and its metabolites. Rinsho Byori. 1998 Jun;46(6):505-17.

5. Robinzon B, Michael KK, Ripp SL, Winters SJ, Prough RA. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases? Arch Biochem Biophys. 2003 Apr 15;412(2):251-8.

6. Hampl R, Lapcik O, Hill M, Klak J, Kasal A, Novacek A, Sterzl I, Sterzl J, Starka L. 7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy? Physiol Res. 2000;49 Suppl 1:S107-12.

7. Morfin R, Starka L. 2001;46:79-95. Neurosteroid 7-hydroxylation products in the brain. Int Rev Neurobiol.

8. Dudas B, Hanin I, Rose M, Wulfert E. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8.

[uhockey]

9. Hampl R, Hill M, Bilek R, Starka L. Relationship of dehydroepiandrosterone and its 7-hydroxylated metabolites to thyroid parameters and sex hormone-binding globulin (SHBG) in healthy subjects. Clin Chem Lab Med. 2003 Aug;41(8):1081-6.

10. Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y. Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J Med Food. 2006 Winter;9(4):451-8.

11. Lu H, Meng X, Yang CS. Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate. Drug Metab Dispos. 2003 May;31(5):572-9.

12. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999 Dec;70(6):1040-5.

13. Zhang R, Xiao W, Wang X, Wu X, Tian W. Novel inhibitors of fatty-acid synthase from green tea (Camellia sinensis Xihu Longjing) with high activity and a new reacting site. Biotechnol Appl Biochem. 2006 Jan;43(Pt 1):1-7.

14. Tian WX, Li LC, Wu XD, Chen CC. Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. Life Sci. 2004 Mar 26;74(19):2389-99.

15. Wang X, Tian W. Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1200-6.

16. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology. 2000 Mar;141(3):980-7.

17. Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol 2004 Aug 26;4(1):18

18. , K. J., Gremaud, G., Meirim, I., Montigon, F., Krebs, Y., Fay, L. B., Gay, L. J., Schneiter, P., Schindler, C., Tappy, L. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? American Journal of Clinical Nutrition, 2004 (Vol. 79) (No. 1) 40-46

19. Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res. 1998 May;23(5):667-73

20. Ernsberger P, Koletsky RJ, Kilani A, Viswan G, Bedol D. Effects of weight cycling on urinary catecholamines: sympathoadrenal role in refeeding hypertension. J Hypertens. 1998 Dec;16(12 Pt 2):2001-5.

21. Ammon HP, M?ller AB. Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 1985 Dec;(6):473-7.

22. Joost HG, Steinfelder HJ. Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter. Mol Pharmacol. 1987 Mar;31(3):279-83.

23. Kaestner KH, Flores-Riveros JR, McLenithan JC, Janicot M, Lane MD. Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1933-7.

24. Becks GP, Buckingham DK, Wang JF, Phillips ID, Hill DJ Regulation of thyroid hormone synthesis in cultured ovine thyroid follicles Endocrinology 1992 May;130(5):2789-9

25. Hosoi Y, Murakami M, Mizuma H, Ogiwara T, Imamura M, Mori M. Expression and regulation of type II iodothyronine deiodinase in cultured human skeletal muscle cells. J Clin Endocrinol Metab 1999 Sep;84(9):3293-300

26. Cronin MJ, Evans WS, Hewlett EL, Thorner MO. LH release is facilitated by agents that alter cyclic AMP-generating system. Am J Physiol. 1984 Jan;246(1 Pt 1):E44-51.

27. Cong M, Goll DE, Antin PB. cAMP responsiveness of the bovine calpastatin gene promoter. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):186-92.

[uhockey]

FAQ, Tester thread, and bb.com availability soon.

[Mickfootie]

What would the dosing of this be Mike? Would it be as the old formula of 1-2 caps 2-3 times daily? Or would it be less? Also how long would be a safe run?

[uhockey]

You know asking me vs. asking everyone else gets different responses!

Start low and assess for tolerance. 1-2 caps, 2-3x a day......though I cannot imagine anyone needing more than 3 caps daily. And I ALWAYS recommend 30 day cycles.....though many will opt to do more and see great results, y'know?

[Mickfootie]

You know asking me vs. asking everyone else gets different responses!

Start low and assess for tolerance. 1-2 caps, 2-3x a day......though I cannot imagine anyone needing more than 3 caps daily. And I ALWAYS recommend 30 day cycles.....though many will opt to do more and see great results, y'know?

Thanks Mike, When will this be available for purchase from the likes of bb.com?

[uhockey]

It has been shipped. Just a matter of them getting it up on the site.

[Mickfootie]

It has been shipped. Just a matter of them getting it up on the site.

That is great. I don't like cutting and so this should help me continue building and keeping leaner in the process. I'm gonna give this a go when they get it in.

[Big_Tom(tk)]

It has been shipped. Just a matter of them getting it up on the site.

Awesome.. The Label looks pretty sweet too!

[uhockey]

The caps are pretty, too. I believe the color is "highlighter yellow" or "WTF Radioactive"

[Skull Crusher Chris]

The caps are pretty, too. I believe the color is "highlighter yellow" or "WTF Radioactive"

Haha, sounds awesome!

[riseboi]

Noice!!! Lookin forward to it!!!!

[Big_Tom(tk)]

[ZDub212]

It looks fantastic, I'll definitely be picking this up! Hey instead of X-Factor/ActivaTe Xtreme logs, why don't you do some X-Factor/LXT 2.0 logs? Meh, wishful thinking.

Anyway, best of luck on the release, I can't wait to give this a go.

And now we just need GXR 2.0...and the perfection will be complete. I noticed the original has been discontinued, any ETA on the new version?

ANY word at all on Sustain, or is that really just a done deal at this point?

[naturalguy]

Interesting. Formula looks great.

[uhockey]

Noice!!! Lookin forward to it!!!!

We're gonna do a tester thread, but if you want in, just ask.....the ActX log was amazing. (Essentially, you and Des get the "prize" for best logs and that is first crack at LX2.0 and the new stim.)

It looks fantastic, I'll definitely be picking this up! Hey instead of X-Factor/ActivaTe Xtreme logs, why don't you do some X-Factor/LXT 2.0 logs? Meh, wishful thinking.

Anyway, best of luck on the release, I can't wait to give this a go.

And now we just need GXR 2.0...and the perfection will be complete. I noticed the original has been discontinued, any ETA on the new version?

ANY word at all on Sustain, or is that really just a done deal at this point?

If you wish to supply the XFactor yourself and apply in the thread going up tomorrow, I'll let ya do XF/LX2.0 as a log.

GXR2 will be renamed, and will be excellent, and will be out in 2008.

Sustain is gone, for a while, stop asking.

Next on the list is the stim (done formula, tweaking doses,) a new anabolic (non PH, non PS, totally novel), and Xceed2.

Interesting. Formula looks great.

Looks? IS!

[MattyH7688]

geeze.. you guys come out with this when i am done cutting


actually i still might pick some of this up.. this looks awesome for keeping lean on a bulk

[Bolt10]

yeaa ive been waiting for this write up...and now i have somethin to read this mornin

[uhockey]

geeze.. you guys come out with this when i am done cutting

actually i still might pick some of this up.. this looks awesome for keeping lean on a bulk

I've never liked the original on a cut NEARLY as much as when recomping or bulking. Then again, I've never used PHs or done PCT, and that is when people really really dig LX.

yeaa ive been waiting for this write up...and now i have somethin to read this mornin

Enjoy. If you find errors, let me know. (?s don't count, since bb.com uses some archaic formatting system....I tried to edit them all out)

[DinoT1985]

Its about time! lol Cant wait to try this stuff.

[uhockey]

Its about time! lol Cant wait to try this stuff.

Like everyone else, tester thread goes up tomorrow. I'll talk to Matt about allowing WELL QUALIFIED foreign logs.

[j_neatherlin]

awesome budday!

[dtrain13]

Nyce!!!!!!!!!

[fates_child03]

Wow definitely awesome to see this. I'll be picking up alot of bottles of this for the winter lol. I agree with mike on the fact I much prefered LX while bulking over cutting. It basically negated worrying over too much fat gain while clean bulking with some serious calories.
Awesome to see this out!

[dvsness]

I've never liked the original on a cut NEARLY as much as when recomping or bulking. Then again, I've never used PHs or done PCT, and that is when people really really dig LX.

I know you don't like answering questions about this, but I am curious. It's my understanding that for PCT purposes, LX was the goods for cortisol and thyroid. What seems to be the consensus about this new version in that regard?

[haiz69]

Wow. Sweet Sweet formula.

[SoCool]

If you like to get a DISCOUNT on your ANABOLICS you can find this now. I just bought a bunch of 7-keto, dang it!

[Zachattack43]

Will this formula have the same or more of 7-OH?

[EMISGOD]

We're gonna do a tester thread, but if you want in, just ask.....the ActX log was amazing. (Essentially, you and Des get the "prize" for best logs and that is first crack at LX2.0 and the new stim.)

Hey hey hey...

Did someone say new stim?

I actually thought Dino's log was the best one, but Rise and Des' were also nifty...