Ibuprofen-does it hurt your gains or anything like that???

**Jonblaze639** · 11-16-2002, 12:12 AM

I'm still getting over a cold, so i decided to take some ibuprofen tonight, to help w/ my cold.

My thigh which was sore as hell feels fine now. My question is can you pop a few iboprofen for a few days after a super hard workout/injection or anything like that to help w/ the pain, or would it mess w/ your gains.

I mean i know the obvious "you'll build an immunity to it, and if you get sick the pills won't have the same effect" but i'm willing to risk that...just would like to know if it has any negative effects on bodybuilding.

**RippedUp** · 11-16-2002, 05:15 AM

I believe there was a study done a while ago that showed NSAID limited protein synthetisis in lifters.

**Lonny** · 11-16-2002, 07:08 AM

Originally posted by RippedUp
I believe there was a study done a while ago that showed NSAID limited protein synthetisis in lifters.

Bump on this.

I remember reading this somewhere too.

**Icex999** · 11-16-2002, 07:25 AM

Originally posted by RippedUp
I believe there was a study done a while ago that showed NSAID limited protein synthetisis in lifters.

ditto...

**juiceman** · 11-16-2002, 07:51 AM

in Muscular Development, they had an article saying to never take it during or after a workout, as it almost stops protein synthesis. So i would imagine it would at least lower it alot when not working out too.

**ralph4u2c** · 11-16-2002, 07:55 AM

ya i read the same thing in MM that any NSAIDS will slow down protein synthesis as well. try to eat alot more, take more vitamin C, and choose your times wisely if you still want to take ibuprofen

**dodgeee-O** · 11-16-2002, 10:01 AM

Originally posted by RippedUp
I believe there was a study done a while ago that showed NSAID limited protein synthetisis in lifters.

Learn something new everyday....... Thanks for the info!

**Jonblaze639** · 11-16-2002, 10:15 AM

does this go for everything or just ibuprofin?

such as tylenol/advil, etc?

**ralph4u2c** · 11-16-2002, 10:18 AM

i know ibuprofen for a fact, and anti-inflamitories. i would just be on the safe side and take like a tylenol in the morning and work out at night. take loads of vitamine c bro.

**Marine2472002** · 11-16-2002, 10:27 AM

Originally posted by Jonblaze639
does this go for everything or just ibuprofin?

such as tylenol/advil, etc?

The study was done on ibuprophen and acetaminophen , and basically what the study was, was that when 5 or 10 athletes took either the maximin dailt intake of either ibuprophen or acetaminophen, and performed 10 sets of heavy leg extentions, their post-workout protein synthesis (muscle building) did not increase, and the control group (group not taking anything), their post workout protein synthesis increased 73% or somthing like that.

That was in Muscle Media in the beginning of this year or end of last year, I cant find my issue of it. But that was the article that interested me the most.

Ever since then I have taken OTC pain killers/anti-inflamatory drugs maybe like 3 times total in the past year.

LG.

**slipper** · 11-16-2002, 10:40 AM

great post, i had no clue. my coworker recommended advil for my back injury, good thing i didnt have any.

**StevenBallin247** · 11-16-2002, 11:36 AM

say if you take advil for a day or something cause i turned my ankle... how long does the effect of lowered/stopped protein synthesis last? Like a day or so?

**Marine2472002** · 11-16-2002, 11:54 AM

Originally posted by StevenBallin247
say if you take advil for a day or something cause i turned my ankle... how long does the effect of lowered/stopped protein synthesis last? Like a day or so?

it doesnt effect proteins synthesis all that long...only as long as the drug is in your system....

so if you take the crap for, say, 1 day.....it might slow protein synthesis for about 1.5-2 days.

LG.

**Dr Of Golf** · 11-16-2002, 12:53 PM

Originally posted by Jonblaze639
I'm still getting over a cold, so i decided to take some ibuprofen tonight, to help w/ my cold.

My thigh which was sore as hell feels fine now. My question is can you pop a few iboprofen for a few days after a super hard workout/injection or anything like that to help w/ the pain, or would it mess w/ your gains.

I mean i know the obvious "you'll build an immunity to it, and if you get sick the pills won't have the same effect" but i'm willing to risk that...just would like to know if it has any negative effects on bodybuilding.

See if you can get your Doctor to give you something stronger than Ibuprofen (like Darvon or ********). Narcs will help with the pain, and you won't have to worry (hell, you won't care) about protein synthesis.

**Jason Scott** · 11-16-2002, 01:30 PM

This info

"Sports Research Update" reiterates the fact that painkillers like Advil (ibuprofen) and Tylenol (acetaminophen) both raise prostaglandin levels and interfere with synthesis of skeletal muscle protein. It's starting to be old news, but worth repeating since so many people pop these like breath mints every day."

Can be found on and expanded upon in the Muscle & Fitness � March 2002.

I attached some stuff I found on a textbook so if you are interested to find out a bit more look at it, it is not very clear but its good enough.

It also says the the life of the drug is 4 hours, so I imagine as long as you take this 4 hours from meal or workouts there would be no problem.

There are two enzymes forms of Cycloclooxygenase, COX-1 and COX-2 these are both blocked by Aspirin and NSAIDs, this enzyme is what is needed for the biosynthesis of prostaglandis which is the problem. There is also a new drug that only blocks COX-2, I do not know if this one would eliminate the problem since it is not blocking both forms. Vioxx by Merk.

Jay

**jimsp** · 11-16-2002, 01:53 PM

im pretty sure that i herd that ibuprofin/anti-inflamatories thin your blood. would this affect you in any way??? I can remember wethere it was anti-inflamatories or acetaminophen that thin ur blood im pretty sure it is the anit-inflamatories.

**w_llewellyn** · 11-16-2002, 02:47 PM

Originally posted by Dr Of Golf
See if you can get your Doctor to give you something stronger than Ibuprofen (like Darvon or ********). Narcs will help with the pain, and you won't have to worry (hell, you won't care) about protein synthesis.

Percs contain acetominophen in addition to the oxycodone. Not too many of the readily dispensed Narcs come without NSAIDS of some sort. I get a script for Vicoprofen for my back, which is hydrocodone/ibuprofen. I hate to take that ****, and at times when I'm using it regularly I definitely feel it interferes. Although I must admit that I have made progress while taking them 2-3 times a day as well, but it seems notably slower than without.

BTW- The quote above is incorrect. They all lower prostaglandin levels, which is the problem.

**Gene** · 11-16-2002, 05:44 PM

Yes, pain killers such as ibuprofen suppress the synthesis of prostaglandins.

Trappe, T.A., Fluckey, J.D., White, F., Lambert, C.P., & Evans, W.J. (2001). Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen. Journal of Clinical Endocrinology and Metabolism, 86, 5067-5070

**slipper** · 11-16-2002, 05:58 PM

Originally posted by jimsp
im pretty sure that i herd that ibuprofin/anti-inflamatories thin your blood.

your refering to asprin.

**windwords7** · 11-16-2002, 06:13 PM

Whats the solution then? So we cant take standard pain reliever W/O hurting our progress. What alternatives are there for things like headaches, etc.

There are some natural anti-inflams but I don't know by which mechansim the work and if it would cause a similar problem.

What CAN we do now that we know what we CAN'T do without negative consquences.

**Jason Scott** · 11-16-2002, 09:56 PM

Originally posted by windwords7
Whats the solution then? So we cant take standard pain reliever W/O hurting our progress. What alternatives are there for things like headaches, etc.

There are some natural anti-inflams but I don't know by which mechansim the work and if it would cause a similar problem.

What CAN we do now that we know what we CAN'T do without negative consquences.

Don't know the answer to that, however I would like to bring this up.

What do you guys think about the use of an ECA (Aspirin)?. Is this hurting us as well? We do not use that for pain and maybe the dosages are minimal, however it would still act in the same manner I would think.

To JohnBlaze seeming you use that for quicker recovery, (the Ibuprofen) you can always pop em midnight if you awake. Giiven the 4 hour reaction time you should encounter no problems.

Jay

**institutional** · 11-17-2002, 10:50 AM

Originally posted by windwords7
Whats the solution then? So we cant take standard pain reliever W/O hurting our progress. What alternatives are there for things like headaches, etc.

There are some natural anti-inflams but I don't know by which mechansim the work and if it would cause a similar problem.

What CAN we do now that we know what we CAN'T do without negative consquences.

i think it all depends on what your priorities are. If you wanna feel pain relief in your lower back spasms which are bothering the hell out of you, or would u rather suck it up and deal with this miserable pain? for me its a no-brainer im going to take my 3-4 advils for instant relieve. i have a history of lower back muscle spasms and i go thru period where i pop 4-8 advils a day for a couple of weeks. and then i will be fine for maybe 6 months and then boom, the same thing (i think i would be better off just dropping my deadlifts,lol). but i have never noticed a difference when taking the advils in my phsique, my strenght levels, my recovery levels or anything for that matter. Im sure scientiffically there is a problem with ibuprofen and protien synthesis, but in a real-life matter i almost feel its a non-issue. sometimes i think we as body builders and health nuts take health matter a litte to litterally.

**slipper** · 11-18-2002, 08:55 PM

Originally posted by Jason Scott
What do you guys think about the use of an ECA (Aspirin)?

yeah what about asprin? does that harm protein synthesis also?

**Biggin** · 11-18-2002, 09:31 PM

Psh, painkillers... kidding, good info in these posts guys, thanks.

**Jason Scott** · 11-19-2002, 04:43 AM

Originally posted by slipper
yeah what about asprin? does that harm protein synthesis also?

According to the studies .. yes.

Jay

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