NO2 or NOT ??? ($$$)

[Witboy]

Hey guys!

I just kinda fell upon a couple of posts on NO2. So i stopped by my local GNC to take a look. EGHAD ! they sell it in Canada for 135$Cad (approx 85$ US) i know most poeple say it sucks and it doesn't do anything. But i've read these posts and it seems that everyone that says it doesn't do anything actually hasn't tried it! And the people who have tried it all reported great results. Is the only thing that's bothering you about it the price?

Because even if it's expensive, i believe that if you are a real hardcore trainer (like me) you will pay the 80$ at least once to judge for yourself before jumping to conclusions. What do you think.

Should i try it? or is there some orrible feedback that i'm missing??!! Or overlooking

[labrad]

Overpriced

[Witboy]

ok but forgetting the price, does it deliver what it claims?

[brooklynheight]

per ast


Nitric Oxide Supplements- Big Claims - Zero Science: NO 2 ways about it.

by Paul Cribb, B.H.Sci HMS
AST Director of Research

Supplements that reportedly increase nitric oxide levels within the body are currently being marketed as powerful muscle builders. The marketers of these supplements claim they increase nitric oxide levels within muscle tissue and a dramatic increase in muscle size, strength is experienced. Other claims also include an increase in fast-twitch muscle fiber strength, endurance, power output, and load capacity from taking these supplements. These reported benefits are quite specific, so I decided to scan the literature for the scientific evidence that supports these claims.

Nitric Oxide – what is it?

Nitric oxide is a colorless, free radical gas commonly found in tissues of all mammals (it’s also prepared commercially by passing air through an electric arc). Biologically, nitric oxide has been shown to be an important neuro-messenger in a number of vertebrate signal transduction processes. Nitric oxide is used in medical treatment; for example, nitroglycerin ameliorates the pain of angina by supplying nitric oxide to the blood vessels that supply the heart. The popular drug Viagra controls erection by regulating nitric oxide in the penile cartilage chamber.

The Research and the Claims

I don’t know where the marketers obtained their literature on nitric oxide. It looks like they are using the same journals as the companies selling Myostatin inhibitors – Alice in Wonderland. Although nitric oxide acts as a cell-to-cell communicator for certain metabolic functions, muscle growth is not one of them. After a review of the available literature I cannot find any research that remotely indicates increasing nitric oxide levels plays a part in increasing protein synthesis, contractile strength or any other biochemical pathway that may lead to increases in muscle mass.

For a company to claim their supplement increases “fast-twitch” muscle strength, the promoters must have instigated or funded some kind of research that involved biopsy procedures and histochemical analyses to extract, assesses and identify these particular muscle fibers from animals or humans, before and after supplementation. However, I could find no documentation (either on their web sites or via a literature scan) that details these findings, only the marketing claims. As far as I’m aware, there is zero scientific evidence supporting the notion that nitric oxide supplements increase “fast-twitch” muscle strength.

There also appears to be no evidence whatsoever that shows increasing nitric oxide levels enhances endurance, power output, and load capacity.

Arginine alpha-ketogluterate is the “active” ingredient reported by one company that sells this type of supplement. It is claimed that this compound increases and maintains a constantly high level of nitric oxide in muscle. Nitric oxide is synthesized within the body using the amino acid arginine, the energy cyclic substrate NADPH, and oxygen. Nitric oxide diffuses freely across membranes but it is a transient signaling molecule. Nitric oxide is by nature, a highly reactive gas that has an extremely short life – less than a few seconds. While there is a lot of research on the effects of nitric oxide, there is no research that shows supplementation with arginine alpha-ketogluterate increases or sustains nitric oxide levels in any human or animal organs.

Can you imagine, a supplement that “creates dramatic increases in muscle size, strength, endurance, power output, and load capacity”, but not a single study to support these claims. Nothing new here. Unfortunately, this is typical sports nutrition marketing bull****. It's sad, misleading, and shows you just what these companies think of the intelligence level of their target market.

When new products burst onto the market, you the consumer can cut through the advertising hype quite easily. Simply ask the supplement company making the claims to "show you the research". A reference is a start, but the actual research study is particularly what your after. You want to see the study, the protocol, the outcome and the University at which the study was conducted. In the present case, you want to see a study showing were this supplement actually increased nitric oxide above a control group, and you want to see the data that demonstrates an increase in lean muscle mass, significantly more than the group without elevated nitric oxide levels.

The fact is, there is no science supporting any of the claims made for so-called nitric oxide supplements. There is no science showing they have any effect on nitric oxide levels and certainly no science showing in effects on muscle growth or increased performance.

Ask yourself why there is no research to support these companies’ wild claims. The simple answer is that research is expensive, make believe products are not. Research provides evidence, fraudulent supplement marketing only delivers hype. It’s far more financially rewarding to sell hype than to produce effective supplements backed by science.

One promoter of a nitric oxide supplement claims to have “brought creatine supplementation to the market” and that their supplement is “the perfected version of creatine”. I’m not sure which market is being referred to but creatine has been used as a supplement for over 40 years. And in NO way are nitric oxide supplements a “perfected version of creatine”. They are nothing like creatine. While creatine is backed by a wealth of research, nitric oxide supplements do not have a shred of scientific evidence that justifies their effectiveness as a bodybuilding supplements.

Bottom line, money spent on these products is money flushed down the toilet.



Read the Real Science
1. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992 6(12):3051-64.

2. Mayer B; Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1997 22(12):477-81.

3. Janabi N; Chabrier S; Tardieu M. Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways. J Immunol 1996 1;157(5):2129-35.

4. Esposito C; Cozzolino A; Porta R; Mariniello L; Buommino E; Morelli F; Metafora V; Metafora S. Protein SV-IV promotes nitric oxide production not associated with apoptosis in murine macro****es. Eur J Cell Biol 2002 81(4):185-96.

5. Eckmann L; Laurent F; Langford TD; Hetsko ML; Smith JR; Kagnoff MF; Gillin FD. Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia. J Immunol 2000 1;164(3):1478-87.

6. Kelly RA; Smith TW. Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol 1996 30;77(13):2C-7C.

7. Stryer L. Biochemistry 4th Ed. Freeman & Co. 1997.

[diesel4life]

NOT

[CHUCK DIESEL]

ast is going to find something negative about anything they don't sell.

They do it all the time. but they do have a point nitric oxide doesn't build muscle itself. It increases the utilization of other nutritions by cleaning out the blood vessels

[brooklynheight]

ast doesnt sell vegetables.
and they encourage eating them.lol

[Witboy]

hey
ok well you guys haven't convinced me.

Once again i have a feeling no one even read what i wrote

i didn't ask wether or not you BELIEVE It works. Obviously the claims sound outrageous.

However, i asked if anyone tried it and didn't get any effects at all. And i haven't got any answer like that.

and everyone that has seemed to have tried it got good results.

therefore i will give it a go. at least once.
And i,ll take pictures and measurements to make sure i'm not just hallucinating results

[SMACKAVELI]

I've been using NO2 and I agree that the price is way overdoing it. I love the results but I don't depend on it, I still use Creatine, Protein Bars, Whey, MRPs', Glutamine. I just consider it part of my diet now instead of a supplement, kinda like popping a vitamin. Although I've been reading up on how NO is promoting oxidents in your body. I personally have not had any of the symptons but I am using 3 grams of Vite C, 400 IU of Gamma E, 1 Gram of ALA as my Antioxidents after workouts.

As far as AST, those guys can F' off for all I care. I hate those guys. HATE. They slam every new product that comes out on the market, Nitric Oxide precursors, 1-Test, 4-HT, etc. They still think Andro is the king of Prohormones.

I'm willing to try Chuck's version of a Nitric Oxide Precursor. Price is cheaper and the bottle would last ALOT longer then NO2's.

The last NO product I've used in NOX2, and I found it better then NO2. It contains an additional ingrediant Arginine-Ketoisocaproate (A-KIC) on top of the Arginine alpha-Ketoglutarate (A-AKG). It has the same amount of pills and same strength as NO2 but cheaper in price, about 38 dollars.

Just my .02 cents...

[Zachattack43]

search online for cheap NO2. MRI used to have there own site and sold the site 180 for 80 dollars plus the book and 90 bottle free, but i tried to open the site last week and it didnt work. weird...anyways i heard the sold distributing rights to GNC.....grrrrr those ****ing sellouts!!!

[Zachattack43]

Ast is against lots of supplements like liquid creatine, ripping gel, myostatin, ecdy and methoxy. all those do not work, ripping gel slightly works, but you see my point there, so maybe just myabe AST is on to something, its too early to tell

[Witboy]

Originally posted by zachattack43
Ast is against lots of supplements like liquid creatine, ripping gel, myostatin, ecdy and methoxy. all those do not work, ripping gel slightly works, but you see my point there, so maybe just myabe AST is on to something, its too early to tell

What does that mean too early??

how about we just try the damn bottle and see if it works and if it does than it won't be too early to tell that AST is **** and not on to something

[Witboy]

Originally posted by zachattack43
Ast is against lots of supplements like liquid creatine, ripping gel, myostatin, ecdy and methoxy. all those do not work, ripping gel slightly works, but you see my point there, so maybe just myabe AST is on to something, its too early to tell

What does that mean too early??

how about we just try the damn bottle and see if it works and if it does than it won't be too early to tell that AST is **** and not on to something

[CHUCK DIESEL]

methoxy works, you just need about 1200mg day.

[SMACKAVELI]

Originally posted by zachattack43
Ast is against lots of supplements like liquid creatine, ripping gel, myostatin, ecdy and methoxy. all those do not work, ripping gel slightly works, but you see my point there, so maybe just myabe AST is on to something, its too early to tell

I don't need AST to tell me those don't work. I know they don't work. But they ripped on 1-test and that works fine, same with NO2-worked great for me. AST can go to hell.

[Zachattack43]

methoxy slightly works, but not even near whats advertised and besides its not work the money and all. i still say waste of money. true AST seems to rip up lots of products, but most dont work. NO2, ripping gel and 1-test all seem to work. what i mean its too early to tell is that AST seems to be jumping the gun in sayin this doesnt work and this doesnt work and so on. we have to give some of these products a try or listen to others experience with it before we can really judge the product and all. AST maybe a lil biased i dunno.3

[fsheva]

The funny things is, AST could write a bulls*it article to further promote all the ripping gels and NO2 and just make the product and then sit and wait for the money to come in. Instead they choose to inform the consumer about it. Do you really think AST writes biased articles because they can't produce NO2. I bet they could start making it with a click of a button and have people buy it off them and make a sh*tload of money, but for some reason they don't, so they choose to write biased articles instead of increasing their income...that makes no sense.
Yeah their 1-test opinion may be controversial, but pretty much all of the products they diss are in some way garbage or a waste of money.

[Zachattack43]

I believe NO2 works, i admit its a lil overpriced, but i look for really good deals before i buy it i.e. - just bought 3 1/2 bottles of MRI's NO2 for 95 from a friend on this forum. that **** worked big time for me and i only had 2 bottles ( 1 180 bottle and 1 90bottle)