creatine/creatinine= toxic..

[chada618]

*I've read the great things about creatine. However, I've come across this article which shows that creatine turns into a toxin in the body called creatinine. Does anybody have any insight as to why people take creatine if its proven to turn into a toxin once absorbed in the body?*



Downsides of Creatine:

The main problem with all existing creatine supplementation is the ability to successfully deliver a concentrated amount of creatine to the system.

Research proves prior creatine arts actually convert to creatinine once ingested - a poison and toxic by product. Over the years there have been a number of advertisements for the purity of creatine. Numerous companies have claimed their creatine product to contains less creatinine than the next. However, all of these claims were only partially factual - each creatine supplement might contain less creatinine while in a dry form, but once ingested or mixed with fluids, it again converts into creatinine.

Over the years, athletes had to load creatine and maintain a high level intake in order to notice its effects. Along with this consumption also came all the complaints and side effects creatine has increasingly become noticed for. Listed below are a few of the more common health issues :

- Headaches
- Stomach cramps
- Dehydration
- Indemia
- Bloating
- Cotton Mouth
- Excess water retention
- Lack of energy
- Liver problems
- Kidney problems
- Creatinine poisoning
- Impaired renal function

What are these side effects caused from?

They are caused by the body?s defense to a toxic compound called creatinine. Creatinine is synthesized in the liver, pancreas and kidneys. The body?s internal defense mechanism to save itself from this ingested poison is to try and dilute the toxin with water. Creatinine is very toxic and can become extremely dangerous.

[chada618]

bump

[Docta J]

*I've read the great things about creatine. However, I've come across this article which shows that creatine turns into a toxin in the body called creatinine. Does anybody have any insight as to why people take creatine if its proven to turn into a toxin once absorbed in the body?*



Downsides of Creatine:

The main problem with all existing creatine supplementation is the ability to successfully deliver a concentrated amount of creatine to the system.

Research proves prior creatine arts actually convert to creatinine once ingested - a poison and toxic by product. Over the years there have been a number of advertisements for the purity of creatine. Numerous companies have claimed their creatine product to contains less creatinine than the next. However, all of these claims were only partially factual - each creatine supplement might contain less creatinine while in a dry form, but once ingested or mixed with fluids, it again converts into creatinine.

Over the years, athletes had to load creatine and maintain a high level intake in order to notice its effects. Along with this consumption also came all the complaints and side effects creatine has increasingly become noticed for. Listed below are a few of the more common health issues :

- Headaches
- Stomach cramps
- Dehydration
- Indemia
- Bloating
- Cotton Mouth
- Excess water retention
- Lack of energy
- Liver problems
- Kidney problems
- Creatinine poisoning
- Impaired renal function

What are these side effects caused from?

They are caused by the body?s defense to a toxic compound called creatinine. Creatinine is synthesized in the liver, pancreas and kidneys. The body?s internal defense mechanism to save itself from this ingested poison is to try and dilute the toxin with water. Creatinine is very toxic and can become extremely dangerous.

Creatine does not turn into creatinine once its absorbed by the body, however it can turn into creatinine if it stays in a liquid for long enough. And most of those downsides like cramps, headaches, etc. come from not taking in enough water while using creatine. I recommended that you take in at LEAST 1 gallon of water per day while on creatine. Also, loading is not necessary at all, but creatinine is a useless toxic compound but taking creatine wont really trigger large amounts of creatinine in your body anyway. Check out This Creatine FAQ Thread for more info!

[tweaked17]

cite your ****ing sources:

http://209.85.165.104/search?q=cache...ient=firefox-a

KRE-ALKALYN?

10 Times More Effective Than Creatine?

The main problem with ALL existing creatine supplements is their ability to deliver a concentrated amount of creatine to the system. Our patent pending research proves that these prior creatine arts actually have the human body ingesting creatinine (a poison and toxic by-product of creatine). Over the years we have read and seen all types of advertisements regarding the purity of creatine. Everyone has claimed that their creatine product contains less creatinine than the next. This was only partially factual, or at least until the bottle was opened.

Over the years, the athletes have had to load creatine and maintain a high level intake in order to feel something. http://www.bodybuilding.com/fun/tallon8.htm Now, if you are currently using creatine, you might want to sit down for this. The following are some of the more common side effects, complaints and ailments you may or may not be aware of: Edema, Bloating, Dehydration, Headaches, Liver problems, Kidney problems (damaged kidneys are irreversible), and Impaired Renal Function.

What are these side effects caused from?

They are caused by the body's defense to a toxic compound called creatinine. Creatinine is synthesized in the liver, pancreas and kidneys. Our body's internal defense mechanism to save itself from this ingested poison is to try and dilute the toxin with water. This is where a lot of the excess water retention and bloating comes from during creatine use. Creatinine is very toxic and extremely dangerous! Don't assume what you consume is safe.

similar enough for me to be suspicious.

[tweaked17]

After 3 minutes in the most popular forms, the following math is derived:

* Creatine mixed with water???????50% conversion
* Creatine mixed with fruit juice?????. 100% "
* Creatine with Dextrose mixes?????. 100% "
* Creatine in an Effervescent formula??... 100% "
* -------------------------------------------------------------------
* 350% divided by 4 = 87.5% average

Oh, really? Gee, I don't know of many reactions that go to 100% completion in 3 minutes.. would this website bother stating where they got this information? Of course not.

WTF how is that average derived?? That's.. just retarded...


http://www.bodybuilding.com/fun/tallon8.htm

"Solutions were heated at day 0 to accelerate breakdown" pfft...

Days... it's measured in days. Why? Because the solution reaches an equilibrium... unless you change the amounts of reactants or products, heat, or pH, the composition of the solution isn't going to change much. Even in orange juice, it wouldn't make a big deal unless you left it in solution for a long time. It's on its way to your stomach anyway...

Dextrose? it degrades 100% in dextrose solution? Ok.

[naga4999]

I was taken creatine and also limejuices & green tea and it affect me badly.my muscles are not able to workouts
how to get recover from this?

[cdnecam]

Hey I just thought I'd throw my hat in the ring here. Just a background first, I am currently a paramedic with a passion for pathophysiology and exercise science. Im definately no doc, phd, or masters - but i think my background integrates medicine and sport science well. I am responding to this because I am studying renal failure and medication dosage adjustments in patients with acute and chronic renal issues. Most of this is fact and supported by data, but I will tell you if something has more speculation or if I am making more of an assertion or assumption.

Now, let's start with creatine, because it is the precurser to creatinine. As you can expect in a forum like this, it is required for energy utilization. We know that energy is released by the conversion of ATP to ADP (adenosine TRI-phosphate to adenosine DI-phosphate). From an exercise standpoint, we have a few energy systems in place utilizing this method for varying lengths of exercise. There's (1) aerobic respiration using oxygen stored in myoglobin in your muscles, (2) the phosphagen system, (3) the anaerobic metabolism (glycogen-lactic acid system), and lastly (1a) aerobic respiration supported by cardiopulmonary function. When you ingest creatine, it filters from your GI tract, into the blood stream, and next to you're liver to get a phosphate group attached to it. Recalling the energy systems mentioned above, creatine phosphate (CP) donates that new attached phosphate group to an ADP to make the ATP - and boom you've got your energy! The phosphagen system provides nearly all the energy used for short bursts of intense activity. Perhaps surprisingly, at the outset of an intense exercise, the amount of ATP in the muscle fibers changes very little, but the amount of CP drops rapidly.

Now for creatinine. When your body makes CP in the liver from creatine, the byproduct is creatinine. The kidneys filter out creatinine. In emergency medicine, we utilize the concentration of creatinine in the blood to evaluate kidney function. If creatinine levels are elevated, it can indicate a problem - either there's too much to be filtered or your filtration system (kidneys) is impaired or damaged. In reviewing numerous pubmed articles and other scholarly articles, it is unclear the mechanism of toxicity. So why do articles say it's toxic? It's likely because that an increased level of creatinine in the body correlate with bad stuff - and yes, there is data to show this. This data however is typically more relevent to your average emergency department patient - and so confounds how dangerous it is for healthy young exercisers. Now I could write pages and pages on that bad stuff, but it wouldn't be very relevant to your question. So here are a few relavent notes.

a) Your creatinine levels CAN be too low. Could be muscle loss, such like that from muscular dystrophy. Could be other things.
b) toxicity is relative. Too much of anything can kill you, even water. It is very difficult to know a safe threshold. This is difficult because people can survive at different levels, and we just don't know everything about creatinine. Just because the range of creatinine is 0.7 to 2.2 and you're sitting at 2.3 does not necessarily mean all hell is breaking loose in your body.


(edit) It won't let me post links. Go to Science Direct website and search creatinine
Anatomy and Physiology: the Unity of Form and Function 6th ed, Kenneth S Saladin (2012)
Robbins and Cotran Pathological Basis of Disease, 9th ed. Kumar, Abbas, Aster (2015)

[WolfRose7]

^^

1. This is ****ing 11 years old.
2. Creatines benefit for performance is fully substantiated, more so than any other (legal) substance aside from caffeine probably