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  1. #1
    Слава Україні! eatyourspinach's Avatar
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    Does piperine negate caffeine's stimuation?

    *Stimulation

    Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice

    https://mdpi-res.com/d_attachment/nu...ion=1653967600

    Abstract: Sleep is one of the most essential factors required to maintain good health. However, the global prevalence of insomnia is increasing, and caffeine intake is a major trigger. The objective of this study was to investigate the inhibitory effect of black pepper, Piper nigrum extract (PE), on caffeine-induced sleep disruption and excitation in mice. Caffeine significantly decreased sleep duration in the pentobarbital-induced sleep test. It also resulted in a significant increase in sleep onset and a decrease in non-rapid eye movement sleep. Moreover, in an open-field test, caffeine-treated mice exhibited a significantly increased time in the center zone and total distance traveled. However, the co-administration of caffeine and PE did not result in similar arousal activities. Thus, our results suggest that PE can be used as a potential therapeutic agent to treat sleep problems and excitatory status associated with caffeine intake

    "Piperine, a major alkaloid isolated from black pepper,increases pentobarbitone sleeping time and has been identified as a positive allosteric modulator of γ-aminobutyric acid type A (GABAA) benzodiazepine receptor in in vitro cell models "

    "We investigated whether PE could attenuate sleep disturbance induced by caffeine. In this study, caffeine (50 mg/kg) significantly (p <0.05) inhibited pentobarbital-induced sleep in ICR mice. Co-administration of PE at 100, 250, or 500 mg/kg with caffeine significantly (p <0.01) increased sleep duration compared to treatment with caffeine alone. Thus, PE can attenuate the wake-enhancing effects of caffeine"
    Last edited by eatyourspinach; 07-08-2022 at 03:09 AM.
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    Carbonation Rules TheFugitive's Avatar
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    Registered User air2fakie's Avatar
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    Those mice should stop drinking coffee hours before bedtime.
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