COVID-19 Riskiest for those with Neanderthal Ancestry

[ElrondHubbard]

From Nature.com

A recent genetic association study identified a gene cluster on chromosome 3 as a risk locus for respiratory failure upon SARS-CoV-2 infection. A new study comprising 3,199 hospitalized COVID-19 patients and controls finds that this is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neanderthals and is carried by ~50% of people in South Asia and ~16% of people in Europe today.

If this study holds up, it will be a major advance in determining who is susceptible to coronavirus and who is not. It might help with targeting treatment strategies. It also helps explain why Africa has comparatively few infections compared to Europe and Asia, since Africa has very little Neanderthal genetic material.

It doesn't give a lot of relief to African Americans, unfortunately, because they often have a significant admixture of European ancestry, and may as a result carry Neanderthal genes.

[LWW]

From Nature.com

It doesn't give a lot of relief to African Americans

First, this virus sees no color.......

Second, your quote was already determined and pinpointed to a race by CDC’s own African American speaker and every white guilt American........

Until, there was protest, Biker and Trump rallies without masks, became white mans burden.

Gotta love this $hit.

[ElrondHubbard]

First, this virus sees no color.......

Second, your quote was already determined and pinpointed to a race by CDC’s own African American speaker and every white guilt American........

Until, there was protest, Biker and Trump rallies without masks, became white mans burden.

Gotta love this $hit.

I see nouns, verbs, and adjectives. But there seems to be no relationship between them.

[Plateauplower]

From Nature.com



If this study holds up, it will be a major advance in determining who is susceptible to coronavirus and who is not. It might help with targeting treatment strategies. It also helps explain why Africa has comparatively few infections compared to Europe and Asia, since Africa has very little Neanderthal genetic material.

It doesn't give a lot of relief to African Americans, unfortunately, because they often have a significant admixture of European ancestry, and may as a result carry Neanderthal genes.

Whitey strikes again, must be that European ancestry rather than the obesity, hypertension, diabetes and other comorbidities that are very prevalent in AA populations (here) versus the many people in Africa with barely enough to eat and low obesity rates. I’d also hazard a guess that Africa “has few infections” because many areas lack the medical capacity to test and diagnose on the same scale as more developed regions. Also many rural areas while clustered are not nearly as prone to communicable disease spread due to geography and ease of travel. If you have have trouble accessing potable water, having a cough, or sore throat isn’t likely going to result in a trip to the doctor for a free Covid test.

[ElrondHubbard]

Whitey strikes again, must be that European ancestry rather than the obesity, hypertension, diabetes and other comorbidities that are very prevalent in AA populations (here) versus the many people in Africa with barely enough to eat and low obesity rates. I’d also hazard a guess that Africa “has few infections” because many areas lack the medical capacity to test and diagnose on the same scale as more developed regions. Also many rural areas while clustered are not nearly as prone to communicable disease spread due to geography and ease of travel. If you have have trouble accessing potable water, having a cough, or sore throat isn’t likely going to result in a trip to the doctor for a free Covid test.

Or, maybe the research really does show something, like the genetic risk factor shows in the data even WITH the other comorbidity factors.

And Africa is not just a bunch of mud huts. There are large cities that have similar medical capacities to those elsewhere in the world. But the good news is, that your speculation is testable. If the difference *truly* is only related to diabetes, obesity, and hypertension, then a simple genetic test will show it.

And of course obesity, hypertension, diabetes and other comorbities are also quite prevalent in populations with European descent, yet 16% of those possess the Neanderthal version of the gene cluster under study. Apparently, the study shows that those 16% show a higher risk due to the presence of that particular ancestry. Or are you arguing that the 16% carrying the Neanderthal gene are the ones with the comorbidities? I haven't seen any data indicating that.

[LWW]

I see nouns, verbs, and adjectives. But there seems to be no relationship between them.

BH, this is why Trump acts like an uncontrollable 3 year old, he has to debate against a moron exactly like this guy above.

I feel so bad for the guy, he did a hell of a job last night for biting his tongue and not calling him a fuking idiot on national tv.

[ChazWood]

Or, maybe the research really does show something, like the genetic risk factor shows in the data even WITH the other comorbidity factors.

And Africa is not just a bunch of mud huts. There are large cities that have similar medical capacities to those elsewhere in the world. But the good news is, that your speculation is testable. If the difference *truly* is only related to diabetes, obesity, and hypertension, then a simple genetic test will show it.

And of course obesity, hypertension, diabetes and other comorbities are also quite prevalent in populations with European descent, yet 16% of those possess the Neanderthal version of the gene cluster under study. Apparently, the study shows that those 16% show a higher risk due to the presence of that particular ancestry. Or are you arguing that the 16% carrying the Neanderthal gene are the ones with the comorbidities? I haven't seen any data indicating that.

I'm totally getting into this conversation, but before I roll up my sleeves and dive in, I got one important question:

Do you pronounce data "Dah-tah" or "Day-tah.

Please hurry with you answer so I can get in here before LWW potato'z up the place with his potatolaunching cannon!!!!!1

EDIT: Dammmmit! too late!

[deadwoodgregg]

IN!!!!!

on a neanderthal thread.

Interesting to see which of the ov35 relics have commented so far

So, what are we discussing?



oh.........covid


I'm OUT!!!


Mask up for virus discussion gentlemen.


I'm headed over to the "dat ass" thread to study some pichers.

[ChazWood]

I'm headed over to the "dat ass" thread to study some pichers.

cool, cool.

That reminds me; there are 2 types of dudes up in this bitch.

The first dude: Dude#1; goes into the "dat ass" thread; scrolls through the azzes, and once he's reloaded his brain with azz, splits the thread.

Now the second dude: Dude#2; goes in, scrolls down, clicks "reply" and then types some dumb $hit about the azzes, posts that $hit and splits feeling like he's contributes something to the thread, when all he's done is break the flow of azzes and then you gotta start all over with the azz brain loading. Dude is probably not even looking at the azzes!!!1

OK, that was my last post for the night. I'm baked and don't wanna make a bigger fool of myself, but first you gotta promise me something DWG... - that you'll never change and be a Dude#2.

Peace Out my Iron Brothers and Sisters!

[Cass40]

I'm also extremely baked rite now and wanna contribute ruining elronds thread cos that's what real friends do!

[Mark1T]

I was gonna go ape sh*t crazy in this thread until I realized it was " neanderthal" and not "netherlands" OP was talking about.

Trivia: Neanderthals invented baseball bats way back.

[Mark1T]

trivia: they don't play baseball in Holland.

Oh, but they do. Not exactly world-renowned, but they do.

https://www.baseball-reference.com/b..._baseball_team

[Plateauplower]

Or, maybe the research really does show something, like the genetic risk factor shows in the data even WITH the other comorbidity factors.

And Africa is not just a bunch of mud huts. There are large cities that have similar medical capacities to those elsewhere in the world. But the good news is, that your speculation is testable. If the difference *truly* is only related to diabetes, obesity, and hypertension, then a simple genetic test will show it.

And of course obesity, hypertension, diabetes and other comorbities are also quite prevalent in populations with European descent, yet 16% of those possess the Neanderthal version of the gene cluster under study. Apparently, the study shows that those 16% show a higher risk due to the presence of that particular ancestry. Or are you arguing that the 16% carrying the Neanderthal gene are the ones with the comorbidities? I haven't seen any data indicating that.

There very well could be and likely is a genetic correlation in the risk factors as a group themselves. That said, I'm not convinced that the science is there to reliably determine what gene sequences within humans are responsible for it now, let alone in pre-human DNA. There is also the impact that epigenetic potential would have in expressing a trait from the sequence. So I doubt they have enough comparable data from pre-history.

Sure Africa has metropolitan cities just like anywhere else, and those places you would expect to see spread just like here, or anywhere else with high population density. That said, it seems like a reason their numbers are low, is because they are doing very few tests.

https://www.worldometers.info/coronavirus/

Look at the test rates in many countries, compared to countries with big Covid numbers (tests per million population should explain it to you).

Obesity and health risks associated with it are obviously a big problem in the US, all demographics. African Americans here, do have an exceedingly high rate here. That is simply not the case in other some other countries, but again other demographics don’t have that problem in those countries either.

[ChazWood]

I'm also extremely baked rite now and wanna contribute ruining elronds thread cos that's what real friends do!

There you are!!!

Sister, if we ever hung out, we would crack each other up so bad with laughter, the energy would make Chuck Norris suddenly find himself browsing the Gap.com for a top that goes with mustard yellow Capri pants.

OK, drag racing is on. I out.

[LWW]

Here is something interesting for Elround to put together, but the man has already admitted his bias.

I pasted this from Lurch's Google-

About
Neanderthals are an extinct species or subspecies of archaic humans who lived in Eurasia until about 40,000 years ago. They probably went extinct due to competition with or extermination by immigrating European early modern humans or due to great climatic change, disease, or a combination of these factors.

El, read these two things - 40,000 years ago and climatic change.

Keep drinking the cool-aide.

[Icepops81]

From Nature.com



If this study holds up, it will be a major advance in determining who is susceptible to coronavirus and who is not. It might help with targeting treatment strategies. It also helps explain why Africa has comparatively few infections compared to Europe and Asia, since Africa has very little Neanderthal genetic material.

It doesn't give a lot of relief to African Americans, unfortunately, because they often have a significant admixture of European ancestry, and may as a result carry Neanderthal genes.

How dare you sir. Racist a hole jerk. I went to high school with an African American so this hits close to home. I hope you can understand. Call you later

[Cass40]

There you are!!!

Sister, if we ever hung out, we would crack each other up so bad with laughter, the energy would make Chuck Norris suddenly find himself browsing the Gap.com for a top that goes with mustard yellow Capri pants.

OK, drag racing is on. I out.

I think you're so tall I wouldn't be able to hear what ya saying...and then there's the Canadian accent and everything..

But...I just got here and u already out..story of my life...

[ElrondHubbard]

Trivia: Neanderthals invented baseball bats way back.

This is literally true, and I have data and graphs to prove it.


I just don't feel like posting them right now.

[ElrondHubbard]

Here is something interesting for Elround to put together, but the man has already admitted his bias.

I pasted this from Lurch's Google-

About
Neanderthals are an extinct species or subspecies of archaic humans who lived in Eurasia until about 40,000 years ago. They probably went extinct due to competition with or extermination by immigrating European early modern humans or due to great climatic change, disease, or a combination of these factors.

El, read these two things - 40,000 years ago and climatic change.

Keep drinking the cool-aide.

Stefan Milo is a pretty good guy.



Although contrary to his implication, Neanderthals at least at Gibralter also ate abundant fish and small prey as well.

[Plateauplower]

How dare you sir. Racist a hole jerk. I went to high school with an African American so this hits close to home. I hope you can understand. Call you later

I know people always gotta inject their prejudice. He probably doesn’t even know that when the alien overlords were making us to mine gold for their spaceships, they didn’t do it all at once. They tweaked the design a little on later models and made them more Covid resistant and able to run faster etc (more gold for them right?).

[Mark1T]

This is literally true, and I have data and graphs to prove it.


I just don't feel like posting them right now.

By the time you find your charts, I will find my old Neanderthal videos playing prehistoric baseball. The uniforms weren't great and the Mammoth skin baseballs were a little fuzzy, kind of like Cassie's feet, but they could play.

[Cass40]

By the time you find your charts, I will find my old Neanderthal videos playing prehistoric baseball. The uniforms weren't great and the Mammoth skin baseballs were a little fuzzy, kind of like Cassie's feet, but they could play.

They keep me warm

I don't actually have feet, I have jet skis.

[Plateauplower]

They keep me warm

I don't actually have feet, I have jet skis.

I have flippers.

[ElrondHubbard]

By the time you find your charts, I will find my old Neanderthal videos playing prehistoric baseball. The uniforms weren't great and the Mammoth skin baseballs were a little fuzzy, kind of like Cassie's feet, but they could play.

I think in that case the hammertoe pitch would have been illegal, but it was ok to use an athletes foot.

[ElrondHubbard]

They keep me warm

I don't actually have feet, I have jet skis.

A girlfriend back in the '90s had a pair of Jet Skis (and feet, too!).

That was a difficult breakup. I hated knowing that the relationship was sinking, and we were drifting apart.

We broke up out on the lake one day, and all I could say in response was "Dam!"

[Cass40]

A girlfriend back in the '90s had a pair of Jet Skis (and feet, too!).

That was a difficult breakup. I hated knowing that the relationship was sinking, and we were drifting apart.

We broke up out on the lake one day, and all I could say in response was "Dam!"

Very punny.

[OldFartTom]

...If this study holds up, it will be a major advance in determining who is susceptible to coronavirus and who is not. It might help with targeting treatment strategies. It also helps explain why Africa has comparatively few infections compared to Europe and Asia, since Africa has very little Neanderthal genetic material.

It doesn't give a lot of relief to African Americans, unfortunately, because they often have a significant admixture of European ancestry, and may as a result carry Neanderthal genes.

Don't gettit sorry. Struggling to get my head round this
As a population, AA will have less Neanderthal genetic heritage than Americans whose ancestors originated in Europe so on that basis AA would be expected to have less susceptibility to Covid than average American (population as a whole) and be more closely comparable to people in West and Central Africa (although higher than Africa due to more mixing). That's not the case.

In terms of being a large/largest factor for determining risk? meh...!

(interesting though)

Edit, still struggling with the overall world significance as if the average Neanderthal and the average Cro-Magnon went to a powerlifting meet I would put my money on the Neanderthal. I don't see how anyone in their right mind can question this anyway. What is this "Nature" magazine, sounds like some weird subscription thing for nudists? Unless they have articles on training etc I'd ignore low quality tabloid stuff like that and see what Dr Jim Stoppani has to say on the matter

[NorwichGrad]

Good thing we Filipinos look like stoned Mexicans. Maybe rona will get confuzed and skip me.

Orale vato!!

[ElrondHubbard]

Don't gettit sorry. Struggling to get my head round this
As a population, AA will have less Neanderthal genetic heritage than Americans whose ancestors originated in Europe so on that basis AA would be expected to have less susceptibility to Covid than average American (population as a whole) and be more closely comparable to people in West and Central Africa (although higher than Africa due to more mixing). That's not the case.

In terms of being a large/largest factor for determining risk? meh...!

(interesting though)

Edit, still struggling with the overall world significance as if the average Neanderthal and the average Cro-Magnon went to a powerlifting meet I would put my money on the Neanderthal. I don't see how anyone in their right mind can question this anyway. What is this "Nature" magazine, sounds like some weird subscription thing for nudists? Unless they have articles on training etc I'd ignore low quality tabloid stuff like that and see what Dr Jim Stoppani has to say on the matter

"Nature" is a legitimate and respected peer reviewed scientific publication. It's been around a long time and has been the vehicle for communicating a lot of important discoveries over the years. The paper's co-author, Svante Pääbo, is a researcher with the Max Planck Institute for Evolutionary Anthropology, and has been studying the genetics of Neanderthals and Denisovans ever since it became possible to do so.

As far as the current study goes, it's still unedited and in review, so with respect to African Americans I'm applying my own logic and not speaking for the authors. I can't say that it's the largest factor for determining risk, but it's presented as a major factor for the "respiratory failure" effect of the disease. That doesn't mean that carriers of these genes are more susceptible or less susceptible to contracting the disease, but they do appear to be more likely to develop the serious respiratory consequences. I'm sure that the other factors still exist as influences.

The Publisher (not the authors) considered the work significant enough that they made it available in full, without a paywall, as a pre-release prior to its publication date, so that speaks against it being one of the typical "publish or perish" papers that are often put out by these journals.

Here's a quote from the paper itself:

"Recently, a new dataset was released from the COVID-19 Host Genetics Initiative where the region on chromosome 3 is the only region significantly associated with severe COVID-19 at the genome-wide level (Fig. 1a). The risk variant in this region confers an odds ratio for requiring hospitalization of 1.6 (95% confidence interval (CI): 1.42-1.79, Extended Data Figure 1)"

So it's not so much a factor in contracting COVID, it's something that significantly raises your odds of requiring hospitalization if you do have it.

Unfortunately, the "Access Denied" bug means I'm going to have to neglect the rest of my response.

[ElrondHubbard]

Good thing we Filipinos look like stoned Mexicans. Maybe rona will get confuzed and skip me.

Orale vato!!

It might.You Filipinos ARE confusing. There's a lot of south Asian ancestry there, though, so the chances are decent that you carry the Neanderthal allele in that location. Less than 100%, but possibly more than a European would. I wouldn't just assume immunity just yet.