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  1. #91
    Registered User Cayman20's Avatar
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    Originally Posted by AMeyer9 View Post
    Been 5+ ****ing years and you still haven't figured out what people are trying to tell you. Not one single person here will say BCAA's aren't essential/useful in numerous bodily functions.

    What you still cannot grasp is that BCAAs... are in your food. This is beyond embarrassing at this point. How have you been here for 13 years and still just utterly clueless?

    If you do something for 13 years and still can't figure it out, might be time to find something new. Maybe you and your sock account ilpump can take up improv acting or knitting. Or really anything that doesn't involve science
    The question is whether the food you're eating has enough BCAAs.
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  2. #92
    Я русский TheFugitive's Avatar
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    Originally Posted by AMeyer9 View Post
    Been 5+ ****ing years and you still haven't figured out what people are trying to tell you. Not one single person here will say BCAA's aren't essential/useful in numerous bodily functions.

    What you still cannot grasp is that BCAAs... are in your food. This is beyond embarrassing at this point. How have you been here for 13 years and still just utterly clueless?

    If you do something for 13 years and still can't figure it out, might be time to find something new. Maybe you and your sock account ilpump can take up improv acting or knitting. Or really anything that doesn't involve science
    Bioavailability is important from the point of view that you want to get the nutrition into your system during the time it needs it most, and you don’t want gastric upset of any sort. It’s been discussed that complete proteins simply do not deliver the amino acids quickly or completely enough as free form amino acids. Many athletes experience gastric distress when trying to ingest complete proteins during exercise. The value of free-form amino acids is that they don’t require digestion. Having them available in a drink is not only more palatable, but also more practical. A recent study shows that ingestion of a protein hydrolysate (a pre-digested protein), as opposed to its fully intact protein, accelerates not only protein digestion and absorption for the gut but also augments postprandial amino acid availability and increase incorporation of dietary amino acids into skeletal muscle. This study confirms that complete proteins simply do not break down into their amino acids fully and at the rate of hydrolyzed protein or free form amino acids. The body can not manufacture its own BCAA’s so this must be supplied through diet and supplementation.

    The best way to deliver amino acids is to administer them in a powdered form for oral use. Unbound or free form amino acids can access the general circulation within 15 minutes.
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  3. #93
    Fkin' Wizard ChrisLS8's Avatar
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    Been gone for a bit but still see Fug is still low-key pimping products in " educational threads" is BPI still putting not BCAAs in their BCAAs?
    Thanks for your input, you frauding fat slampig-Sirfapsalot '20

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  4. #94
    Fkin' Wizard ChrisLS8's Avatar
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    Originally Posted by TheFugitive View Post
    Bioavailability is important from the point of view that you want to get the nutrition into your system during the time it needs it most, and you don’t want gastric upset of any sort. It’s been discussed that complete proteins simply do not deliver the amino acids quickly or completely enough as free form amino acids. Many athletes experience gastric distress when trying to ingest complete proteins during exercise. The value of free-form amino acids is that they don’t require digestion. Having them available in a drink is not only more palatable, but also more practical. A recent study shows that ingestion of a protein hydrolysate (a pre-digested protein), as opposed to its fully intact protein, accelerates not only protein digestion and absorption for the gut but also augments postprandial amino acid availability and increase incorporation of dietary amino acids into skeletal muscle. This study confirms that complete proteins simply do not break down into their amino acids fully and at the rate of hydrolyzed protein or free form amino acids. The body can not manufacture its own BCAA’s so this must be supplied through diet and supplementation.

    The best way to deliver amino acids is to administer them in a powdered form for oral use. Unbound or free form amino acids can access the general circulation within 15 minutes.
    And anabrolic window
    Thanks for your input, you frauding fat slampig-Sirfapsalot '20

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  5. #95
    We know lol Farley1324's Avatar
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    Originally Posted by AMeyer9 View Post
    Been 5+ ****ing years and you still haven't figured out what people are trying to tell you.
    He figured it out. He just lies.
    Exodus 22:2
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  6. #96
    Common sense/moderation. gbullock32's Avatar
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    Originally Posted by Farley1324 View Post
    He figured it out. He just lies.
    Pimpin' aint easy.
    Short cuts to success are often paved with lies.
    1/13/16: Massive hernia.
    5/10/16: Finally back to lifting, light but improving.

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  7. #97
    Chromadex Verified faipdeooiad's Avatar
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    Our Prime minister’s in hospital. Spoke to a nurse I know at the hospital, they’ve got him on a Best BCAA drip. Snow cone I think.
    Strong & Unstable
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  8. #98
    Я русский TheFugitive's Avatar
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    Originally Posted by faipdeooiad View Post
    Our Prime minister’s in hospital. Spoke to a nurse I know at the hospital, they’ve got him on a Best BCAA drip. Snow cone I think.
    Give him our BEST
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  9. #99
    Я русский TheFugitive's Avatar
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    Originally Posted by Farley1324 View Post
    He figured it out. He just lies.
    Digestion rates don't lie. One's instant the other isn't
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  10. #100
    Я русский TheFugitive's Avatar
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    A little more info, and as always not a must just an option...

    An important variable is the ability of the body to synthesize non-essential amino acids when they are metabolized or depleted during exercise. In particular, glutamine, which is used during prolonged exercise or stress may need to be replenished if reduced by over-training or severe stress of any sort. Even though it is the most abundant amino acid in the body it is difficult to keep up with demand under severe stress. When plasma amino acid concentrations are depleted, which is the case in hard training athletes, the immune system also becomes suppressed making the athlete more susceptible to sickness. Although glutamine has been shown to increase after short term high intensity exercise, long term exercise is related to a decrease in glutamine. This decrease has been associated with the development of illness following long term exercise (marathon and longer) and with overtraining syndrome. The athlete feels fatigue, has sleep disturbances and difficulty performing, much less functioning. Heart rate responses are not consistent with effort and the resting heart rate is elevated. Development of respiratory illnesses is common. Supplementation with branched chain amino acids helps to prevent this decrease and the consequences of overtraining.

    Branched chain amino acids include Leucine, Isoleucine and Valine. These are simply amino acids that have a branched structure. Studies have shown that the use of an effective dose of BCAA’s while endurance training helps to increase levels of lean muscle mass and prevent overtraining syndrome. Some key symptoms of overtraining may be affected by an alteration in the ratio of amino acids. The amino acid tryptophan, the precursor for serotonin, may be elevated in the overtraining syndrome resulting in an imbalance with branched chain amino acids (BCAA’s). This may result in a feeling of fatigue and depression. This physiological alteration is known as central fatigue. Supplementation with BCAA’s prevents this increase in serotonin and central fatigue.

    The content and balance of amino acids, and the ratio of essential to non-essential, helps determine the value of protein quality. However, the ability to use these amino acids requires that they be digestible, absorbable and bioavailable. That means the amino acids must be delivered to the tissues when needed.
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  11. #101
    Registered User AMeyer9's Avatar
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    Originally Posted by Cayman20 View Post
    The question is whether the food you're eating has enough BCAAs.
    As I'm not vegan, quite a bit. 5th sock account confirmed?
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  12. #102
    Registered User AMeyer9's Avatar
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    Originally Posted by TheFugitive View Post
    A little more info, and as always not a must just an option...

    An important variable is the ability of the body to synthesize non-essential amino acids when they are metabolized or depleted during exercise. In particular, glutamine, which is used during prolonged exercise or stress may need to be replenished if reduced by over-training or severe stress of any sort. Even though it is the most abundant amino acid in the body it is difficult to keep up with demand under severe stress. When plasma amino acid concentrations are depleted, which is the case in hard training athletes, the immune system also becomes suppressed making the athlete more susceptible to sickness. Although glutamine has been shown to increase after short term high intensity exercise, long term exercise is related to a decrease in glutamine. This decrease has been associated with the development of illness following long term exercise (marathon and longer) and with overtraining syndrome. The athlete feels fatigue, has sleep disturbances and difficulty performing, much less functioning. Heart rate responses are not consistent with effort and the resting heart rate is elevated. Development of respiratory illnesses is common. Supplementation with branched chain amino acids helps to prevent this decrease and the consequences of overtraining.

    Branched chain amino acids include Leucine, Isoleucine and Valine. These are simply amino acids that have a branched structure. Studies have shown that the use of an effective dose of BCAA’s while endurance training helps to increase levels of lean muscle mass and prevent overtraining syndrome. Some key symptoms of overtraining may be affected by an alteration in the ratio of amino acids. The amino acid tryptophan, the precursor for serotonin, may be elevated in the overtraining syndrome resulting in an imbalance with branched chain amino acids (BCAA’s). This may result in a feeling of fatigue and depression. This physiological alteration is known as central fatigue. Supplementation with BCAA’s prevents this increase in serotonin and central fatigue.

    The content and balance of amino acids, and the ratio of essential to non-essential, helps determine the value of protein quality. However, the ability to use these amino acids requires that they be digestible, absorbable and bioavailable. That means the amino acids must be delivered to the tissues when needed.
    What part of BCAAs are in your food have you had such trouble grasping all these years? Are you mentally challenged? Are you a troll? No one can possibly be this dull. Even Jason Genova understands BCAAs are in food.
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  13. #103
    up the dosage eatyourspinach's Avatar
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    Maybe just 3 more copypastas starting with "BCAA's are leucine, isoleucine and valine..." and people will finally understand
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  14. #104
    Я русский TheFugitive's Avatar
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    Originally Posted by AMeyer9 View Post
    What part of BCAAs are in your food have you had such trouble grasping all these years? Are you mentally challenged? Are you a troll? No one can possibly be this dull. Even Jason Genova understands BCAAs are in food.
    Here's a fancy picture to help you understand the difference

    And just incase you continue to struggle. Free-form amino acids (BCAAs) don’t require digestion

    Last edited by TheFugitive; 04-06-2020 at 08:11 PM.
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  15. #105
    Я русский TheFugitive's Avatar
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    And just incase you start to second guess yourself...

    Complete proteins simply do not deliver the amino acids quickly or completely enough as free form amino acids. The value of free-form amino acids is that they don’t require digestion. Having them available in a drink is not only more palatable, but also more practical. A recent study shows that ingestion of a protein hydrolysate (a pre-digested protein), as opposed to its fully intact protein, accelerates not only protein digestion and absorption for the gut but also augments postprandial amino acid availability and increase incorporation of dietary amino acids into skeletal muscle. This study confirms that complete proteins simply do not break down into their amino acids fully and at the rate of hydrolyzed protein or free form amino acids.

    Last edited by TheFugitive; 04-06-2020 at 10:28 PM.
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  16. #106
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    Originally Posted by faipdeooiad View Post
    Our Prime minister’s in hospital. Spoke to a nurse I know at the hospital, they’ve got him on a Best BCAA drip. Snow cone I think.
    Well, this didn’t work. He’s ended up in intensive care. Must’ve been the wrong flavour?
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  17. #107
    Я русский TheFugitive's Avatar
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    Originally Posted by faipdeooiad View Post
    Well, this didn’t work. He’s ended up in intensive care. Must’ve been the wrong flavour?
    I thought you were kidding until I seen the news, hope he gets better soon. Is the UK using Hydroxychloroquine?
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  18. #108
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    Originally Posted by TheFugitive View Post
    I thought you were kidding until I seen the news, hope he gets better soon. Is the UK using Hydroxychloroquine?
    I hope not until it’s been properly proven to work
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    BCAA and Immune Function

    People noticed the effects of BCAA on the immune system 10 yr ago because immune cells oxidize BCAA as fuel sources and incorporate BCAA as the precursors for the synthesis of new immune cells, effector molecules, and protective molecules [9]. Lack of BCAA in the diet impairs many aspects of immune function and increases susceptibility to pathogens. A recent study showed that a daily 12 g BCAA oral supplementation improved phagocytic function of neutrophils and NK activity of lymphocytes in cirrhotic patients [96]. After a BCAA enriched solution was infused into patients with rectal cancer, their immune status was improved with increased CD4+, CD4+/CD8+ and IL-2R [97]. Similarly, 12 g/d of BCAA (6 g/d L-Leu, 2 g/d L-Iso and 4 g/d L-Val) supplementation blunted the neutrophil response to intense cycling training, which might benefit immune function during a prolonged cycling season [98]. In animal husbandry, supplementing BCAA (0.1% L-Leu, 0.34% L-Val, and 0.19% L-Ile) in a 17% crude protein diet was shown to improve intestinal immune defense functions with an increase of intestinal immunoglobulins (IgA and sIgA) in weaned piglets [99]. In contrast, some studies also reported that BCAA mixture supplementation (600 mg/kg body weight/day, consist of 46% leucine, 28% valine, and 23% isoleucine) could not ameliorate the impaired function of macrophages induced by strenuous exercise in rats [100].

    In recent years, there has been growing interest in the role of isoleucine, leucine and valine in immune function (Table 1). Notably, concentrations of isoleucine have a strong correlation with the excretion of β-defensin. 25 or 50 μg/mL isoleucine increases the mRNA and protein expressions of β-defensin 1, 2 and 3 in IPEC-J2 cells [101]. Also, treating patients with 250 μg of intratracheal L-isoleucine every 48 h is considered as a novel immunotherapy in tuberculosis as it induced a significant increase of β-defensins 3 and 4 associated with decreased bacillary loads and tissue damage [102]. This inducing function of isoleucine might be associated with the G-Protein Coupled Receptor and ERK signaling pathways [103]. Additionally, proximally 2% dietary isoleucine could enhance intestinal immunity in juvenile Jian carp and innate immunity in olive flounder [104, 105]. Similar functions in regulation of the immune response and antioxidant status in the head kidney were also observed in fish fed about 1.3% isoleucine [106]. In contrast to isoleucine, leucine regulates the immune system mainly through the mTOR signaling pathway. mTOR plays a vital role in the regulation of the innate and adaptive immune responses and also several immune functions like promoting differentiation, activation, and function in T cells, B cells and antigen-presenting cells [107, 108]. For instance, a reasonable dose of leucine (40 mg/mL) provides enhanced protective immunity against mucosal infection with herpes simplex virus type 1 [109]. Leucine deficiency could impair the immune status, up-regulate pro-inflammatory cytokines and down-regulate anti-inflammatory cytokines of grass carp (Ctenopharyngodon idella) by the NF-κB and TOR signaling pathways which was reversed by optimum leucine supplementation [94]. Recently, an in vitro experiment found that an increased extracellular concentration of BCAA, especially valine (800 nmol/mL), could improve the dendritic cell function in cirrhotic patients [110]. In addition, valine deficiency (less than 1.45%) decreased growth and intestinal immune status in young grass carp (Ctenopharyngodon idella) by increasing pro-inflammatory cytokines (IL-8 and TNF-α) and decreasing anti-inflammatory cytokines (IL-10 and TGF-β1) which might be caused by changes in the NF-κB and mTOR signaling pathways [111]. However, some studies found there was little effect of valine (increase from 0.64% to 0.87%) on innate or adaptive immunity for broilers [112]. Although still unclear, all these studies are evidence that BCAA may function in improving health and preventing infectious diseases in animals and humans by regulating the immune system.

    Nakamura I. Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids. World J Gastroenterol. 2014;20:7298.

    Zhang W, Feng F, Wang WZ, Li MB, Ji G, Guan C. The effects of BCAA-enriched amino acid solution on immune function and protein metabolism in postoperative patients with rectal cancer. Parenteral & Enteral Nutrition. 2007;2:009.

    Kephart WC, Wachs TD, Mac Thompson R, Mobley CB, Fox CD, McDonald JR, et al. Ten weeks of branched-chain amino acid supplementation improves select performance and immunological variables in trained cyclists. Amino Acids. 2016;48:779–89.

    Ren M, Zhang S, Zeng X, Liu H, Qiao S. Branched-chain amino acids are beneficial to maintain growth performance and intestinal immune-related function in weaned piglets fed protein restricted diet. Asian-Australas J Anim Sci. 2015;28:1742.

    Xiao W, Chen P, Liu X, Zhao L. The impaired function of macrophages induced by strenuous exercise could not be ameliorated by BCAA supplementation. Nutrients. 2015;7:8645–56.

    Mao X, Qi S, Yu B, He J, Yu J, Chen D. Zn2+ and l-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells. Mol Biol Rep. 2013;40:1547–52.

    Rivas-Santiago C, Rivas-Santiago B, León D, Castañeda-Delgado J, Hernández PR. Induction of β-efensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis. Clin Exp Immunol. 2011;164:80–9.

    Youkou K, Toshifumi A, Yuhei I, Takahiro I, Hiroki T, Atsuo M, et al. Isoleucine, an essential amino acid, induces the expression of human β defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia. Food Nutr Sci. 2012. doi:10.4236/fns.2012.34077.

    Zhao J, Feng L, Liu Y, Jiang W, Wu P, Jiang J, et al. Effect of dietary isoleucine on the immunity, antioxidant status, tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian). Fish Shellfish Immunol. 2014;41:663–73.

    Rahimnejad S, Lee KJ. Dietary Isoleucine Influences Non-Specific Immune Response in Juvenile Olive Flounder (Paralichthys olivaceus). Turk J Fish Aquat Sci. 2014;14:853–62.
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    This is what stupid looks like.
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    Originally Posted by AMeyer9 View Post
    This is what stupid looks like.
    So, if you’re adhering to your daily protein intake goals and sticking to your workout regimen, you should be all set for optimal gains, right? Maybe. If you’re on a mission to get swole, the aptly named essential amino acids are indeed, essential. Three of the nine essential amino acids—leucine, isoleucine and valine—comprise 35 percent of our muscle protein. These three key players are branched-chain amino acids (BCAAs) and they’re especially important. BCAAs are essential amino acids that are part of muscle protein. They help to preserve muscle glycogen stores and reduce the amount of protein breakdown. When it comes to protein synthesis, leucine is arguably the most important BCAA, and it’s in whey protein. But this doesn’t mean that simply consuming more whey protein will give you the maximum BCAA benefits. In separate supplement form, BCAAs aren’t bound to other amino acids, like they are in whey protein. This means they can be digested and absorbed more quickly, which makes them available faster to impact protein synthesis

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    I have seen another site mention that GDA’s also help with immune system and a few ingredients show anti-viral activity against respiratory infections. The main ingredients are oxymatrine and berberine which both have good research for them. So these would be a better bet than BCAA.
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    Originally Posted by Archi21 View Post
    I have seen another site mention that GDA’s also help with immune system and a few ingredients show anti-viral activity against respiratory infections. The main ingredients are oxymatrine and berberine which both have good research for them. So these would be a better bet than BCAA.
    Anything that supports immunity is worth trying
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    Originally Posted by TheFugitive View Post
    Branched-Chain Amino Acids and Immunity
    https://academic.oup.com/jn/article/136/1/288S/4664141
    I already broke this down above....here. Let me snip it for you.
    Originally Posted by lucia316 View Post
    The other piece you referenced, simply discussed how the 3 amino acids are relevant in immune system and how the immune system utilizes leucine, isoleucine and valine. There is ZERO evidence that supplemental BCAAs does anything positive for the immune system or the cells that make it up. The tests and studies it did reference were a low protein diet in rats study and another rat study that limited BCAAs specifically.

    Originally Posted by TheFugitive View Post
    You can read into this however you like, the outcome is still favorable
    Yet it was out of context per your usual game. Can't respond to the actual points. Can't comprehend that statistical significance does not equal real world benefit and in this case it's made worse by the fact that the results were driven by people trying to remember over the course of a month how they felt in subjective areas. That's not science. That's a poll for the Family Feud.
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    Originally Posted by TheFugitive View Post
    I like photoshop too...
    "I'm pretty sure your wrong, but care to elaborate..."
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    Originally Posted by lucia316 View Post
    I already broke this down above....here. Let me snip it for you.





    Yet it was out of context per your usual game. Can't respond to the actual points. Can't comprehend that statistical significance does not equal real world benefit and in this case it's made worse by the fact that the results were driven by people trying to remember over the course of a month how they felt in subjective areas. That's not science. That's a poll for the Family Feud.
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    Originally Posted by TheFugitive View Post

    Confirmed
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    ITT: lack of basic comprehension. I miss Coop
    Thanks for your input, you frauding fat slampig-Sirfapsalot '20

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    Originally Posted by TheFugitive View Post
    Anything that supports immunity is worth trying
    No, it isn't. Cytokine storm.
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    I'm pretty sure your wrong, but care to elaborate...

    Disclaimer: The above post is my personal opinion and does not represent the official position of any company or entity. It does not constitute medical advice.
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    Originally Posted by powercage View Post
    No, it isn't. Cytokine storm.
    Supporting immunity healthy and "not sick" and supporting immunity while "being sick" are two different things

    Mixed reviews and studies will continue to circulate on Vitamins C - D and Zinc
    Last edited by TheFugitive; 04-09-2020 at 09:25 PM.
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