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  1. #1
    up the dosage eatyourspinach's Avatar
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    Quercetin increase muscle mass?

    Effects of enzymatically modified isoquercitrin in supplementary protein powder on athlete body composition: a randomized, placebo-controlled, double-blind trial

    Background
    Enzymatically modified isoquercitrin (EMIQ), a water-soluble quercetin, has been shown to intensify muscle hypertrophy in mice. We investigated the effect of EMIQ in supplementary protein powder on athlete body composition.

    Methods
    Forty Japanese males who played American football (age: 19.8 ± 1.4 years; body height: 174.1 ± 6.0 cm; body mass: 75.5 ± 10.7 kg) were assigned to a randomized, placebo-controlled, double-blind trial of parallel group. Participants received either EMIQ in whey protein (EW, n = 19) or contrast whey protein (W, n = 20) 6 days per week over 4 months. Body composition was assessed using dual-energy X-ray absorptiometry. Markers of oxidative stress, derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), were assessed using a free radical analytical system. Data were analyzed using a univariate and repeated measures general model statistics.

    Results
    After 4 months, changes in lower limb fat-free mass and muscle mass were significantly greater in the EW group than in the W group (mean change ±95% CI; W: 324.1 ± 284.3, EW: 950.3 ± 473.2, p = 0.031, W: 255.7 ± 288.6, EW: 930.9 ± 471.5, p = 0.021, respectively). Moreover, the EW group exhibited a significantly higher BAP/d-ROMs ratio, antioxidation index, than the W group after 4 months (mean change ± SD; W: 8.8 ± 1.1, EW: 10.3 ± 2.8; p = 0.028). No significant differences in body mass, lean body mass, fat mass, or lower limb fat mass were observed between the groups.

    Conclusion
    Ingestion of EMIQ in supplementary protein powder for 4 months exerts antioxidant effects and increases muscle mass among American football players.

    https://jissn.biomedcentral.com/arti...19-0303-x#Abs1
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  2. #2
    Rustlin' and hustlin' poison's Avatar
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    What was the dose?
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  3. #3
    up the dosage eatyourspinach's Avatar
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    Originally Posted by poison View Post
    What was the dose?
    42 mg which is kind of odd
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    Originally Posted by eatyourspinach View Post
    42 mg which is kind of odd
    No way. Odd dose, and it's actually readily available and cheap. Hmm.
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    Han shot first! TolerantLactose's Avatar
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    Originally Posted by eatyourspinach View Post
    42 mg which is kind of odd
    It came down to the concentration of EMIQ in the whey they had available to them.

    EMIQ in the supplements was analyzed using a previously described high-performance liquid chromatography method [26] that revealed that the whey protein powder contained 0.0 mg of EMIQ and whey protein powder with EMIQ contained 42 mg of EMIQ. All supplements were prepared by Morinaga & Co. Ltd. (Tokyo, Japan).
    Also note:

    Enzymatically modified isoquercitrin (EMIQ), enzymatically modified rutin, and α-glycosyl isoquercitrin are glucosyl derivatives of quercetin. EMIQ is manufactured from rutin through enzymatic modification. The enzymatic treatment increases the water solubility of EMIQ; the bioavailability of EMIQ is approximately 17 times that of quercetin
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  6. #6
    up the dosage eatyourspinach's Avatar
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    Originally Posted by TolerantLactose View Post
    It came down to the concentration of EMIQ in the whey they had available to them.



    Also note:
    Yeah, its just that commercially available supplements have 50 mg, 42 just seemed kind of arbitrary
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