Does NAC / N-Acetyl L-Cysteine affect bodybuilders negatively?

[Sources]

I am looking into taking this supplement but came across this:

http://www.life-enhancement.com/maga...ts-of-exercise

"Discussion of these effects included the explanation by the authors that “[a]dequate removal of cellular debris by neutrophils or macro****es may be critical for complete recovery of injured muscle, whereas molecules released by these cells (cytokines, prostaglandins, and chemokines) may regulate muscle repair and growth. [] NAC treatment resulted in a 30% drop in neutrophil count and macro****e infiltration 48 h after exercise. Whereas not statistically significant, it is of physiological interest. [] The NAC-enhanced GSH [glutathione] availability may have induced redox perturbations, downregulating pathways mediating immune cell mobilization. This may result in incomplete clearing of debris, which may be a prerequisite for full recovery of muscle performance.” Thus, the authors propose that their results point to amelioration of oxidative damage by an antioxidant (NAC) and enhanced muscle performance shortly after aseptic muscle damage, but that NAC may paradoxically delay long-term recovery by interfering with intracellular redox signaling pathways."

Any thoughts?

[eatyourspinach]

Excessive supplementation of any anti oxidant can have this effect, timing is relevant as the subjects received NAC immediately after exercise. You'd like to give it some time for the inflammatory response to exercise to subside.

[rhadam]

I am looking into taking this supplement but came across this:

http://www.life-enhancement.com/maga...ts-of-exercise

"Discussion of these effects included the explanation by the authors that “[a]dequate removal of cellular debris by neutrophils or macro****es may be critical for complete recovery of injured muscle, whereas molecules released by these cells (cytokines, prostaglandins, and chemokines) may regulate muscle repair and growth. [] NAC treatment resulted in a 30% drop in neutrophil count and macro****e infiltration 48 h after exercise. Whereas not statistically significant, it is of physiological interest. [] The NAC-enhanced GSH [glutathione] availability may have induced redox perturbations, downregulating pathways mediating immune cell mobilization. This may result in incomplete clearing of debris, which may be a prerequisite for full recovery of muscle performance.” Thus, the authors propose that their results point to amelioration of oxidative damage by an antioxidant (NAC) and enhanced muscle performance shortly after aseptic muscle damage, but that NAC may paradoxically delay long-term recovery by interfering with intracellular redox signaling pathways."

Any thoughts?

Do you even understand anything in that abstract?

[Sources]

Excessive supplementation of any anti oxidant can have this effect, timing is relevant as the subjects received NAC immediately after exercise. You'd like to give it some time for the inflammatory response to exercise to subside.

And how long would that be? Actually, would it be okay to just take NAC in the morning while working out in the evening?

Do you even understand anything in that abstract?

I'd like to think so, however, instead of replying like a dick, maybe you can shed your amazing insight?

[Sources]

any other insight on this topic?

[eatyourspinach]

There are lots of studies showing it's benefits for exercise and health, just take it a few hours away from your workouts i.e. morning and night

[powercage]

There are lots of studies showing it's benefits for exercise and health, just take it a few hours away from your workouts i.e. morning and night

this

[XCriticalBenchX]

Don't overthink things OP.. that is what you are doing..

Mike