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  1. #31
    Registered User OT2000's Avatar
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  2. #32
    Registered User OT2000's Avatar
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  3. #33
    Registered User gailh's Avatar
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    this is a very interesting subject. sounds like more governmental overkill, our tax dollars hard at work.
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  4. #34
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    Here's a study on how CBD works. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423229/

    Cannabinoids have antioxidant, neuroprotective, proapoptotic and anti-tumour properties (Klein et al., 1998; Galve-Roperh et al., 2000; McKallip et al., 2002; Cabral and Staab, 2005; van der Stelt and Di Marzo, 2005; Klein and Cabral, 2006; Massi et al., 2006; Kozela et al., 2010; Rieder et al., 2010). Several cannabinoids were effective in treating pain, glaucoma, wasting, nausea and vomiting as well as AIDS, and spasticity in multiple sclerosis (Pertwee, 2002; Guzman, 2003; Di Marzo and De Petrocellis, 2006; Kogan and Mechoulam, 2007). Various cannabinoids also have immunomodulatory and anti-inflammatory effects which are probably mediated via their activity on various types of immune cells (such as B cells, T cells, macrophages, NK cells, dendritic cells) and microglia (Klein et al., 1998; 2000; Croxford and Yamamura, 2005; Kozela et al., 2010; Rieder et al., 2010). These cannabinoids exert their immunosuppressive activity by induction of apoptosis, inhibition of cell proliferation, down-regulation of cytokines and chemokine production and release, and induction of regulatory T cells (Croxford and Yamamura, 2005; Klein and Cabral, 2006; Kozela et al., 2010; Rieder et al., 2010). Moreover, both THC and CBD have anti-inflammatory activities, even though CBD does not seem to be active on either CB1 or CB2 receptors, suggesting a CB1/CB2 receptor-independent mechanism and the involvement of other cell targets (Kozela et al., 2010; O'Sullivan and Kendall, 2010).

    We show here, that CBD, and less so THC, repressed the expression of an important subset of pro-inflammatory genes, especially the chemokine ligands, CCL2, CCL7, CXCL14, CCL6, CCL9 and the chemokine receptor CX3CR1. These effects are in agreement with reports showing that cannabinoids can modulate the functional activities of immune cells and exert immunosuppressive effects mainly by inhibition of cytokine and chemokine production, induction of apoptosis and inhibition of cell proliferation (Klein and Cabral, 2006; Kozela et al., 2010; Rieder et al., 2010).

    As mentioned above, the CBD-induced pathways include genes involved in Nrf2-mediated oxidative stress. Nrf2 is a redox-sensitive transcription factor that plays a central role in cellular defence against oxidative stress- and cytotoxic electrophile-induced insults through transcriptional activation of an array of genes, including phase II detoxifying enzymes, antioxidants and transporters. Nrf2 binds to the antioxidant response element/electrophile response element (ARE/EpRE), located in the promoter region of genes encoding phase II detoxifying or antioxidant enzymes and related stress-response proteins (Kobayashi and Yamamoto, 2006). These include among others, haem oxygenase-1 (Hmox1), GSH S-transferase (GST), GSH peroxidase, NAD(P)H:quinone oxidoreductase (Nqo1) and glutamate-cysteine ligase (Gcl), which play key roles in cellular defense by enhancing the removal of cytotoxic electrophiles and ROS, and by maintaining GSH homeostasis.

    We found that CBD increases ROS formation in BV-2 cells. This result is in agreement with our gene array analysis, where we found up-regulation of the expression of Herpud1, Gclm, Gstm6, Hmox, Nqo1 and Gstm1 by CBD. These are key enzymes which are involved in cellular defence by increasing the removal of cytotoxic electrophiles and ROS, leading to GSH homeostasis. These results are in agreement with previous reports showing the ability of CBD to induce ROS production as well as enhancing apoptosis via an oxidative stress-dependent mechanism (Massi et al., 2006; Wu et al., 2008; Lee et al., 2008a). In our previous work, we reported that THC (0.11.0 M) is able to enhance cellular damage from oxidative stress in C6 glioma cells, when incubated in the presence of the synthetic cell permeable quinone Qcb (2-phenyl-4-[butylamino]-naphtholquinoline-7,12-dione), a reagent that generates ROS. No effect of THC on release of LDH was observed in the absence of this ROS generator, demonstrating that THC by itself is a weak generator of ROS.

    Regulated water transport is important for mitochondrial homeostasis. It is known that changes in mitochondrial volume are associated with normal physiological processes as well as with pathological conditions such as those involved in ROS formation and cell injury. Aquaporin water channels are responsible for water transport (import and export) through mitochondrial and cell membranes (see Gena et al., 2009). In this regard, we found that CBD up-regulated genes related to water, iron and zinc transport, including Aqp9 (14-fold), Slc40a1 (iron-regulated transporter; 6.5-fold) and the zinc transporters Slc39a4 and Slc30a1 (3.5-fold and 2.6-fold respectively)
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  5. #35
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    Signed, Pogue PM me for other sources.

    I'm a MMJ Refugee (moved from Texas to a legal state so I could get my card) and I use CBD oil daily and it's saved my life. Most of y'all know I've gone through countless rounds of chemo and radiation for melanoma. It's come back four times and I started having severe seizures from the brain metasteses, to the point where I had to start working from home because I couldn't drive or leave the house. 30 seizures a day, applying for disability because as much as I wanted to I could not function.

    Started using CBD oil in as many forms as my body would tolerate and my seizures stopped overnight. I'm not joking at all. I don't know if it can cure cancer, but it's given me my life back and I've been in remission now for over a year (previously the melanoma came back every 3-4 months.) My life isn't perfect but I can function and work and be okay now.

    With insurance, I've spent over 95,000 on cancer treatments in three-ish years.

    As of today, I've spent nothing on seeds (thank you DC Seed Exchange) and maybe $100 bucks testing CBD strains from a dispensary before learning to grow my own medicine. And that's why the DEA is doing this, those turbokunts.


    This is absolutely a human rights issue.
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  6. #36
    Ecclesiastes 3:1-11 dazedncnfz's Avatar
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  7. #37
    Pickthingsup putthemdown Dirk__Diggler's Avatar
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    Another pathetic attempt to help the big PHARMA companies imo!
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  8. #38
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    Bump it up
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  9. #39
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  10. #40
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  11. #41
    up the dosage eatyourspinach's Avatar
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    Surprised this hasn't been posted yet https://ministryofhemp.com/blog/new-...le-cbd-absurd/
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  12. #42
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  13. #43
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    Signed. Can't believe the FDA will even do this with how it helps kids with epilespy.. terrible.

    EDIT Is there any research to show this being beneficial towards condition likes Parkinson's? Curious.
    Last edited by cartermathis; 12-17-2016 at 08:40 PM.
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  14. #44
    Do you even lift? Motiviert's Avatar
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    Signed. I've had patients that this stuff helps :/
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  15. #45
    Do you even lift? Motiviert's Avatar
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    I was the 55th signature
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  16. #46
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  17. #47
    Tonight, we make soap. compan's Avatar
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    Yeah this one has me baffled. Has to be tied to big pharma in one way or another. CBD is the most beneficial/therapeutic compound in marijuana.

    This however does not affect those states that have legalized marijuana, correct? There doesn't need to be a second legalization process since they've seemed to categorize CBD a certain way? If so then this even worse than I thought. CBD is a great pain relief alternative out there for those affected by IBD.
    Last edited by compan; 12-17-2016 at 10:21 PM.
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  18. #48
    Platinum User seanb1979's Avatar
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    Originally Posted by compan View Post
    Yeah this one has me baffled. Has to be tied to big pharma in one way or another. CBD is the most beneficial/therapeutic compound in marijuana.

    This however does not affect those states that have legalized marijuana, correct? There doesn't need to be a second legalization process since they've seemed to categorize CBD a certain way? If so then this even worse than I thought. CBD is a great pain relief alternative out there for those affected by IBD.
    weed has been federally illegal and states are basically saying FU to that now.. i assume it will carry over to cbd
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  19. #49
    Ecclesiastes 3:1-11 dazedncnfz's Avatar
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  20. #50
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    Signed and bump...DEA is getting out of hand, its just one thing after another lately
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  21. #51
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    Originally Posted by pogue View Post
    It's baffling and I can think of no legitimate reason for the govt to want to remove it's access from the general public. I don't know if they came up with some poison control center numbers or emergency room visits to try and justify it, but again, I'm sure it pales in comparison to alcohol/tobacco and Tylenol.
    Isn't the plant as a whole banned and schedule I at the federal level? This is going to be the same as the legality of the plant in the US currently, so states may still allow it at the state level but you can't transport it across state lines since then it becomes a federal issue. This is not to defend the feds but the underlying problem here is the scheduling of the cannabis plant.
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    never tried CBD Oil personally but my sister has several medical issues that requires pain relief and she swears by the benefits. anything that can improve the quality of life im 100% behind
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    Originally Posted by dazedncnfz View Post
    Back to the front.
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    Un****ingbelievable. Don't even know what to say
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    Signed. Sad that this is even being proposed
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    Originally Posted by redraider86 View Post
    Signed, Pogue PM me for other sources.

    I'm a MMJ Refugee (moved from Texas to a legal state so I could get my card) and I use CBD oil daily and it's saved my life. Most of y'all know I've gone through countless rounds of chemo and radiation for melanoma. It's come back four times and I started having severe seizures from the brain metasteses, to the point where I had to start working from home because I couldn't drive or leave the house. 30 seizures a day, applying for disability because as much as I wanted to I could not function.

    Started using CBD oil in as many forms as my body would tolerate and my seizures stopped overnight. I'm not joking at all. I don't know if it can cure cancer, but it's given me my life back and I've been in remission now for over a year (previously the melanoma came back every 3-4 months.) My life isn't perfect but I can function and work and be okay now.

    With insurance, I've spent over 95,000 on cancer treatments in three-ish years.

    As of today, I've spent nothing on seeds (thank you DC Seed Exchange) and maybe $100 bucks testing CBD strains from a dispensary before learning to grow my own medicine. And that's why the DEA is doing this, those turbokunts.


    This is absolutely a human rights issue.
    There are tons and tons of case studies like this. This is so absurd.

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  28. #58
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    Originally Posted by pogue View Post
    It's baffling and I can think of no legitimate reason for the govt to want to remove it's access from the general public. I don't know if they came up with some poison control center numbers or emergency room visits to try and justify it, but again, I'm sure it pales in comparison to alcohol/tobacco and Tylenol.
    Agreed, it's completely crazy to want CBD Oil off the market. The government has baffled me once again.
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  29. #59
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    There is a reason all of this is Schedule 1. The US Govt. owns the patent on this. Mind you, Schedule 1 drugs are not supposed to have any kind of medical uses. The patent could technically be challenged in court since the government is contradicting itself. Schedule 1, yet they have a patent on the medical uses. It would take an idealist patent attorney working with a medical marijuana criminal defense attorney to make this happen since the man hours would equal major major $$$$

    http://www.thecannabist.co/2016/08/2...nnalife/61255/
    (U.S. Patent No. 6,630,507 was granted to the U.S. Department of Health and Human Services in 2003.)

    http://patft.uspto.gov/netacgi/nph-P...&RS=PN/6630507


    Abstract
    Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##

    Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD)
    Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
    Family ID: 26767641
    Appl. No.: 09/674,028
    Filed: February 2, 2001
    PCT Filed: April 21, 1999
    PCT No.: PCT/US99/08769
    PCT Pub. No.: WO99/53917
    PCT Pub. Date: October 28, 1999

    http://www.thecannabist.co/2016/08/2...nnalife/61255/
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