AI Sports Nutrition: Glycobol. powerful insulin mimetic

[JohnSmeton]

potent insulin mimetic, along with so many other benefits like potent anti-oxidant benefits. One capsules contains 250 mgs na-r-ala!

buy it here http://www.bodybuilding.com/store/ai/glycobol.html


Glycobol works, not like typical muscle gainers, but primarily by its ability to mimic and boost insulin.* On its own, insulin is a powerful growth peptide, but it also plays a critical role in the action of androgens. Just like insulin, androgens are another fundamental class of endocrine hormones. Studies suggest that androgens fail to sustain a positive muscle nitrogen balance in the absence of insulin, emphasizing the critical role of insulin as a potential limiting factor to the anabolic capacity of androgens. Therefore, Glycobol may be used to optimize and exaggerate gains by its essential synergistic contribution.*

Insulin also interacts synergistically with GH, IGF and thyroid hormones to compound growth effects, even when these endocrine co-factors are only present at average physiological levels. Therefore, Glycobol can be used to support impressive natural muscle gains and body recomposition as an effective stand-alone agent too.*

Glycobol:

Promotes muscle mass, strength and endurance.*
Encourages fat loss.*
Improves recovery time by rapid glycogen resynthesis.*
Provides lasting "pump", hardness and vascularity.*
Drives amino acid and creatine uptake into muscle.*
Promotes muscle protein synthesis and reduces breakdown.*
Optimizes nutrient utilization.*
You asked for something Innovative, now you've got it!

Glycobol Blend:

Sodium R-Lipoate (Na-r-ALA)
ALA is naturally produced in the body as a mitochondrial enzyme cofactor. It is important to aerobic metabolism. ALA has been suggested to increase cellular uptake of glucose to cell membranes by recruiting the glucose transporter GLUT4.* ALA improves skeletal muscle glucose transport, resulting in desirable blood glucose disposal and increased muscle glycogen concentrations.* (1) Studies also suggest that in muscle, ALA is a potent anti-oxidant which protects cells from oxidative stress-induced insulin resistance.* (2) The ALA used in this formula is chemically stabilized and of high quality.* It's one of the most active isomers and one of the highest efficiency salts commercially available.* ALA is an invaluable addition that offers a multitude of benefits plus countless extras for any serious athlete.*

Bottom Line: Best way to describe this effect is that it almost adds a filter to the muscle fibers; Taking in what it needs to prepare for growth.*

Trigonella Seed isolate (standardized to 10% 4-hydroxyisoleucine)
Fenugreek has been successfully applied for thousands of years to support health.* Modern research suggests that it supports endurance and lowers blood lactate concentrations dramatically.* Use of fenugreek seed may also help decrease fat accumulation.* These results suggest that this improvement in endurance and reduction in body fat is caused by an increase in the utilization of fatty acids as an energy source.* (3) Fenugreek supplements high in 4-HIL have also been suggested to increase post-exercise glycogen resynthesis in athletes, which promotes rapid recovery and helps reduce training fatigue.* (4) The visible results of this glycogenic effect are big, pumped muscles that look extremely full and vascular.*

Bottom Line: Helps you use fatty acids as an energy source, rather than store them as Fat!*

Phellodendron extract (standardized to 90% berberine)
Phellodendron is one of the highly valued traditional Chinese herbs. It is reported that some subjects show improved strength in response to Phellodendron isolates.* Laboratory studies suggest that one of these alkaloidal isolates called berberine may accomplish these benefits by promoting insulin production.* (5) Improved health and increased physical performance encourages greater strength and muscle gains in the gym.*

Bottom Line: Increased performance encourages greater strength and muscle gains.*

Cinnamon Bark 20:1 extract (standardized for 16% flavonoids)
Cinnamon is a common spice used all over the world, but it's not commonly known that the spice has significant health supportive value.* Cinnamon contains the element chromium, which is needed for proper glucose metabolism, and also compounds called flavonoids. Flavonoids are potent anti-oxidants. The specific flavonoids found in cinnamon bark suggest to stimulate glucose uptake and glycogen synthesis similar to insulin.* These flavonoids may activate receptors by direct insulin mimicking action, or indirect insulin potentiation, or both.* (7) If you train consistently and have a healthy diet, your big muscular improvements from this powerful little cinnamon extract might surprise you.*

Bottom Line: Insulin is very anabolic, so the insulin boosting action of cinnamon extract can encourage bigger, stronger muscles.*

Bis(Maltolato)Oxovanadium (BMOV)
BMOV is an organic form of the mineral vanadium. Although elemental vanadium and inorganic salts of vanadium show significant biological potential, it has a poor health supportive index due to low gastrointestinal absorbance.* BMOV is recognized as safer, more absorbable, and able to deliver a health supportive effect up to 50% greater than the inorganic forms.* (9) Vanadium is one of the rare microelements that can promote a profound boost in endurance and strongly support anabolism.* BMOV can promote muscle hardness.* The form of vanadium used in this formula is one of the very best you can find, if not the best.*

*Bottom Line: Promote Muscle hardness and vascularity!*

References

(1) The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.; Konrad D, Somwar R, Sweeney G, Yaworsky K, Hayashi M, Ramlal T, Klip A.; Diabetes. 2001 Jun;50(6):1464-71.

(2) Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.; Maddux BA, See W, Lawrence JC Jr, Goldfine AL, Goldfine ID, Evans JL.; Diabetes. 2001 Feb;50(2):404-10.

(3) Effects of Fenugreek Seeds (Trigonella foenum greaecum) Extract on Endurance Capacity in Mice.; Mayumi Ikeuchi, et al; Journal of Nutritional Science and Vitaminology; Vol. 52 (2006), No.4 pp.287-292.

(4) The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise.; Ruby BC, Gaskill SE, Slivka D, Harger SG.; Amino Acids. 2005 Feb;28(1):71-6.

(5) Therapeutic effect of berberine on 60 patients with non-insulin dependent diabetes mellitus and experimental research; Ni Yanxia, et al.; Chinese Journal of Integrated Traditional and Western Medicine 1995; 1(2); 91-95.

(6) Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins; Kong Weijia, et al.; Nature Medicine 2004; 10(12): 1344-1351.

(7) Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity.; Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ.; J Agric Food Chem. 2004 Jan 14;52(1):65-70.

(8) Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes.; Cao H, Polansky MM, Anderson RA.; Arch Biochem Biophys. 2007 Mar 15;459(2):214-22. Epub 2007 Jan 25.

(9) Trace elements in nutrition.; Dreosti IE.; Med J Aust., 1980 August 9;2(3):117-23.