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  1. #1
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    Nitrosigine™ - Another great reason to get PUMPED with Superpump 3.0!!





    Another great reason to try Superpump 3.0!
    http://www.bodybuilding.com/store/ga...erpump-30.html

    http://www.fasebj.org/content/28/1_S...LB418.abstract

    [b]A clinical evaluation to determine the safety, pharmacokinetics and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. (LB418)[b]
    Douglas Kalman1, Samantha Feldman1, Adam Samson1 and Diane Krieger1


    1Nutrition & Endocrinology Miami Research Associates Miami FL United States
    Abstract

    The purpose of this study was to characterize the PK/PD of Nitrosigine™, an inositol-stabilized arginine silicate dietary supplement. Ten healthy males, 26.7 ± 5.4 years, took Nitrosigine™ qd for 14 days and attended test visits on Days 1 and 14. Fasting blood and saliva collections were performed pre-dose and at 0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours post-dose for plasma arginine, serum silicon and salivary nitric oxide + nitrite (NO). After Day 1 dose, arginine levels increased (p<0.01) at 0.5, 1, 1.5, 2, 3 and 5 hours and silicon levels increased (p<0.05) at 1 and 1.5 hours. Day 1 PK parameters for arginine were: CMax 27.25±4.86 µg/ml and tMax 1.05±0.50 and for silicon: CMax 2.77±0.74 µg/ml and tMax 2.15±1.75. After Day 14 dose, arginine levels increased (p<0.05) at 0.5, 1, and 1.5 hours, and silicon levels increased (p<0.01) at 1, 1.5, 2, and 3 hours. After 14 days of use, baseline arginine trended towards being higher than baseline Day 1 (p=0.0645), and 4-hour post-dose plasma arginine was significantly higher (p=0.0488). Although not a significant difference, NO increased in four subjects and stayed the same in six subjects at 0.5 hours after the first dose (p=0.125). After 14 days of use, baseline NO levels increased in six subjects and stayed the same in four subjects (p=0.031). No safety concerns were raised by this study.

    Clinically proven to raise NO levels and most importantly no safety concerns were noted in the study.

    More on INOSITOL ARGININE SILICATE
    (AS NITROSIGINE®)


    Real innovation these days is hard to come by but fortunately Gaspari R&D was able to get their hands on this revolutionary form of clinically studied patented arginine called inositol arginine silicate (aka Nitrosigine). By itself, arginine has a poor bioavailability when taken orally due to enzymes called arginases which break it down. By attaching inositol and silicon to the molecule, it's able to avoid a high degree of degradation and increase blood vessel relaxation 5x greater than arginine hcl and increase blood flow almost 2x greater in animal models.*
    A little known fact to most athletes is that the mineral silicon serves an important role in your cardiovascular system as a host of other benefits throughout the body. Silicon has been shown to be a critical component to arterial wall strength and integrity.
    In the case of Nitrosigine, the silicon component helps increase blood levels greatly which may support increased blood flow observed when taking pre-training.*
    Additionally, human trials have looked at the effects of Nitrosigine on proteomics. The study found that Nitrosigine positively affected certain proteins that are associated with cardiovascular health, including vasodilation.* This powerful ingredients helps drive the “pump” in SuperPump to levels never seen before and in ways which were once thought not possible.*
    Last edited by Zachattack43; 05-08-2014 at 10:47 AM.
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  2. #2
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    This stuff is really good loved my samples gonna post reviews on all three flavors today im a watermelon guy so gotta say watermelon was my favorite thanks again Zach review link will be in both threads by end of day
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  3. #3
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    Originally Posted by erictovar80 View Post
    This stuff is really good loved my samples gonna post reviews on all three flavors today im a watermelon guy so gotta say watermelon was my favorite thanks again Zach review link will be in both threads by end of day
    No problem. Glad to hear you liked it!
    I always love a great watermelon hence why I am hooked on our Watermelon Carnipure.
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    yea SuperPump 3.0 was better than I expected lol here is my forum review
    http://forum.bodybuilding.com/showth...hp?t=161788263
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  5. #5
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    Originally Posted by TimeToMakeGains View Post
    yea SuperPump 3.0 was better than I expected lol here is my forum review
    http://forum.bodybuilding.com/showth...hp?t=161788263
    Thank you and I am right with you. It is a nice surprise.
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  6. #6
    Krank it up! krankphreak's Avatar
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    This stuff is amazing, I mean it! Helped me hit a PR on the bench with my 3 free samples. Review will be posted tonight Thanks Gaspari this stuff is going into my wishlist.
    My Reviews:
    https://reviews.bodybuilding.com/supplement-reviews/krankphreak

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  7. #7
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    Yea i got some samples of this stuff and it was awesome! Really recommend it!
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  8. #8
    I train with MAX, do you? AlecGaspari's Avatar
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    lovin all this feedback!


    Superpump has risen!
    Senior Gaspari Board Rep/Brand Ambassador
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    "Above post reflects my personal opinion and has not been evaluated by the FDA, nor is intended to diagnose, treat, prevent or cure any disease."
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  9. #9
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    Originally Posted by AlecGaspari View Post
    lovin all this feedback!


    Superpump has risen!
    Exactly!!!
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  10. #10
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    Won't lie, the Nitrosigine along with the full doses of creatine + BA and good amount of leucine and excellent amount of agmatine, were what sold me on the product. Will crack open my tub next week to give it a go
    Completed Logs & Reviews:
    Clear Muscle Log: http://forum.bodybuilding.com/showthread.php?t=161906833&p=1244983053#post1244983053

    "Now that you've got a basic degree of strength you can now proceed with success onto a bodybuilding type program - which I am not experienced in providing. You've exceeded what I focus on, and that is beginner strength gains." - Mark Rippetoe
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  11. #11
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    Bump
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  12. #12
    Registered User kissdadookie's Avatar
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    The pumps are good with this product. Just used it for the first time this morning.

    Make it taste like Mango Orange GlycoFuse Gaspari!
    Completed Logs & Reviews:
    Clear Muscle Log: http://forum.bodybuilding.com/showthread.php?t=161906833&p=1244983053#post1244983053

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  13. #13
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    Originally Posted by kissdadookie View Post
    The pumps are good with this product. Just used it for the first time this morning.

    Make it taste like Mango Orange GlycoFuse Gaspari!
    That would be nice, but it is easier to flavor a carb
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  14. #14
    Going a step further! starseller's Avatar
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    I had SuperPump 250 back in the days, that was my first preworkout actually. the pump was so insane i couldnt even lift haha my muscles were wayy to much pumped, couldnt flex!!

    How is SP 3.0?
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  15. #15
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    Originally Posted by starseller View Post
    I had SuperPump 250 back in the days, that was my first preworkout actually. the pump was so insane i couldnt even lift haha my muscles were wayy to much pumped, couldnt flex!!

    How is SP 3.0?
    It was one of the my first also, i stuck with it tho i loved the blue raspberry flavor even tho max redid it, it wasnt same even color was different. Have yet to try sp3.0 someday tho
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  16. #16
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    Originally Posted by starseller View Post
    I had SuperPump 250 back in the days, that was my first preworkout actually. the pump was so insane i couldnt even lift haha my muscles were wayy to much pumped, couldnt flex!!

    How is SP 3.0?
    The reviews are showing the PUMP is back in the SuperPump thanks to Nitrosigine.

    Check out the links to various reviews here:
    http://forum.bodybuilding.com/showth...1497283&page=5
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