Purus Labs D-Pol

[mikaveli06]

Any thoughts on this. Its a Nitrate/DAA product....sounds like a great PCT product, or standalone testbooster...I like daa, i like nitrates, but does this make sense to combine them?? Will it be any different than using daa and creatine nitrate? In for some scientific responses. I may be wrong, but from reading some other boards, the idea was to bind the 2, but to get around the Thermolife Patent, they will just be combined if that makes sense. A little suprised there is no vit c or NAC to help with the nitrates, as this seems common to most nitrate products.

(D-POL will consist of 3120mg DAA and 350mg sodium nitrate along with
4000IU cholecalciferol and a host of B-VIT supporting co-factors)

[mikaveli06]

What is the general consensus on Purus Labs as a whole, I know they had a decent following during ph\ds days, but most of there products don't really interest me, mostly copious amts of caffeine and 1,3, but this d-pol sounds interesting at least.

[sloop]

Im holding out for the nitrate bonded raspberry ketones.

[xR1pp3Rx]

whats this with raspberry ketones down gradeing the andrgen receptor tho? i was using LGs topical with ketones before my cycle but then stopped prior to it so as to not downgrade the receptors. it seemd to be working good for lowering BF though.

[Madevilz]

Is there any writeup about DAA Nitrate?...
I really see no point in bonding nitrate to DAA.

[mikaveli06]

Is there any writeup about DAA Nitrate?...
I really see no point in bonding nitrate to DAA.

thats what im asking, i was curious cause i like both ingredients, but not sure the advantages of combining them

[swollPH91]

LG reps? I'm curious as well how LG feels binding DAA and nitrates is beneficial to test boosting

[rhadam]

LG reps? I'm curious as well how LG feels binding DAA and nitrates is beneficial to test boosting

Outside of increasing endurance... i don't see how nitrate binding would increase T.

This isn't my field of study, so i could be way off.

[em-dubya]

Is there any writeup about DAA Nitrate?...
I really see no point in bonding nitrate to DAA.

I'm not sure if its actually "bonded" to the DAA or not.
I do like both the ingred so it may be good taken pre wo. What was the price on this?

[SwolenONE]

I'm not sure if its actually "bonded" to the DAA or not.
I do like both the ingred so it may be good taken pre wo. What was the price on this?

It should be quite affordable, Purus products typically are priced well.

[jdudeck1]

I know somewhere that it is 19.99 and they are running a coupon not sure how much off though...

[SgtGreen]

Here's the write up on it.

Athletes and exercise enthusiasts are constantly looking for methods to enhance exercise performance and to gain lean body mass. Of course, improving overall health in the process of physique development is also welcome. Although many dietary supplements are marketed for purposes of improving performance, muscle mass, and health, few such supplements are actually supported by peer reviewed scientific evidence for effect in relation to the specific outcomes of interest. This is particularly true when considering the often paltry dosages of each ingredient included within the finished product. To address the need for a dietary supplement specifically designed to enhance exercise performance, to support gains in lean body mass (via increased circulating testosterone), and to improve overall health, PURUS LABS® has formulated a new product to address these areas of interest.

Introducing PURUS LABS® d-pol™
Overview and Rationale for use
d-pol™ is a new product designed by PURUS LABS®, which adheres to the established guidelines of PURUS LABS® in terms of including only those ingredients that have been used in human subjects via oral ingestion, and reported to promote favorable outcomes in relation to the target areas of interest (e.g., enhanced exercise performance, increased circulating testosterone—potentially leading to increased lean body mass, enhanced overall health). d-pol™ contains a unique blend of ingredients, each carefully selected for their potential impact on physical performance and human health—included at the precise dosage necessary to promote the desired effect (as supported by peer reviewed scientific evidence obtained from studies using human subjects). The text below outlines the ingredients used within d-pol™, while providing a brief summary of the rationale for use.

d-aspartic acid
Elevating circulating testosterone has been, is now, and will likely continue to be the objective of many hard training athletes. It is well known that testosterone is associated with gains in both muscle size and strength, in addition to having positive effects on several other vital components of human health. One dietary ingredient reported to produce measureable gains in circulating testosterone is d-aspartic acid (DAA). d-aspartic acid has been reported in multiple animal and in vitro studies to be involved in testosterone synthesis, in species ranging from boar (Lamanna et al., 2007a) to lizard (Raucci et al., 2005). It also stimulates the production of other hormones such as prolactin, leutinizing hormone (LH), and growth hormone. Finally, DAA acts as a neurotransmitter/neuromodulator (D'Aniello, 2007)—an effect noted in several studies using animal models and in vitro experiments.

Considering the sound evidence for a role of DAA in testosterone synthesis, a human study was recently performed to assess the effectiveness of oral DAA supplementation with regards to testosterone elevation (Topo et al., 2009). Subjects included 43 men (27-37 yrs), 20 who received a placebo and 23 who received a DAA supplement (3.12 grams of DAA combined with B-vitamins—the same dosage of DAA provided within d-pol™). The supplement was delivered orally for 12 days. Following the 12 days of treatment with the supplement, 20 of the 23 subjects (87%) had significantly higher circulating LH levels, with an average increase of 33%. With regards to circulating testosterone, 20 of the 23 subjects (87%) had significantly higher values at day 12 compared to pretreatment, with an average increase of 42%.
For both LH and testosterone, the changes were time dependent—a greater increase was observed on day 12 compared to day 6 of treatment. Therefore, it is possible that continued treatment with the supplement may have resulted in a further increase in these variables. Although measurements of muscle size and strength were not included in this study, it is possible that the increase in circulating testosterone may be associated with a measureable increase in these variables. Further work is needed to confirm these effects.

While the above findings are interesting and may prove beneficial to those seeking a natural method of increasing circulating testosterone, it should be noted that DAA has been reported to increase aromatase activity, as measured using boar testes (Lamanna et al., 2007b). At the present time it is unknown what amount of DAA would need to be orally ingested by humans in order to promote this effect. No adverse outcomes were noted in the Topo et al. (2009) investigation. Regardless, as with other testosterone stimulating agents, a cyclic schedule of supplementation of d-pol™ is recommended. If adhering to this recommendation, and when considering the inclusion of vitamin D within d-pol™, it may be wise to cycle “off” during periods of optimal sunlight exposure (when natural vitamin D synthesis would be highest—see text below for additional information pertaining to this).

B-vitamins
B-vitamins constitute an entire group of water soluble vitamins, with multiple known
biochemical effects within the body—as evidenced by the thousands of scientific reports
documenting such effects. B-vitamins have known effects in relation to increasing the rate of
metabolism, enhancing immune function, and promoting cell growth and division. Of greatest
importance in relation to the use of these vitamins within d-pol™, the B-vitamins have been used
in combination with DAA for purposes of elevating circulating testosterone: B9 (folic acid),
B6 (pyridoxine), and B12 (cyanocobalamin). Because dietary folic acid is not well metabolized to
the active form by some individuals due to a genetic defect within the folate pathway, the
naturally occurring form of this vitamin (folate) is included within d-pol™.

Nitrate
Nitrate is an inorganic anion abundant in vegetables (e.g., beets, spinach) and converted within the body to nitrite in the entero-salivary circulation (Duncan et al., 1995). The study of nitrate, nitrite, and bioactive nitrogen oxides including nitric oxide, is of great interest to investigators, due to the multiple biological roles of the nitrate-nitrite-nitric oxide pathway (Lundberg et al., 2009).

A relatively new area of investigation is now focused on the use of nitrate supplementation for purposes of improving exercise performance (Bailey et al., 2009; 2010; Lansley et al., 2010; Larsen et al., 2007; 2010; Vanhatalo et al., 2010). In general, the findings from this work indicate an increase in circulating levels of nitrite following nitrate supplementation (possibly suggesting an increase in circulating nitric oxide), in addition to a lower oxygen cost during exercise. Interestingly, these findings are observed after just a few (e.g., 4-7) days of nitrate supplementation. Such results may translate into lower perceived effort at any given submaximal workload or an increase in the actual amount of work that subjects are able to perform during a given exercise session.

While this area of research remains in its infancy, additional studies inclusive of outcome measures beyond blood nitrite and oxygen cost of exercise are needed to more fully detail the ergogenic benefits of nitrate supplementation. To date, the majority of this work has been performed in the laboratory of Professor Andrew Jones at Exeter University in the UK, using beetroot juice as the delivery vehicle for nitrate. In much of this work, subjects ingest 500mL of beetroot juice (providing approximately 350mg of dietary nitrate—the same dosage provided within d-pol™). Other work has used dietary nitrate directly (e.g., sodium nitrate), with the dosage based on subjects’ body mass.

As stated, findings from these studies indicate an increase in circulating levels of nitrite and a reduction in the oxygen cost during exercise. While most exercise studies have involved aerobic work, one recent investigation has focused on resistance exercise (Bailey et al., 2010). In this study, subjects received beetroot juice for six consecutive days and completed a series of low-intensity and high-intensity "step" exercise tests on the last 3 days of supplementation for the determination of the muscle metabolic (using (31)P-MRS) and pulmonary oxygen uptake (VO2) responses to exercise. As is typical, on days 4-6, beetroot juice resulted in a significant increase in blood nitrite. During low-intensity exercise, beetroot juice attenuated the reduction in muscle phosphocreatine concentration and the increase in VO2. During high-intensity exercise, beetroot juice reduced VO2 slow components and significantly improved exercise time to exhaustion. Moreover, the total rate of ATP turnover was estimated to be less for both low-intensity and high-intensity exercise. The authors concluded that the reduced oxygen cost of exercise following nitrate supplementation appears to be due to a reduction in the ATP cost of muscle force production. These findings are further supported by a recent investigation noting an improvement in mitochondrial efficiency with nitrate supplementation (Larsen et al., 2011), a finding that is also correlated to the reduction in oxygen cost during exercise. Collectively, these changes appear to allow exercise to be tolerated for a greater period of time—which may translate into more repetitions being performed during a given set of exercise and/or a greater load to be used during each set of exercise. For aerobic exercise bouts, the duration of exercise may be increased following supplementation. These are indeed findings of interest to any exercise enthusiast.

[SgtGreen]

Aside from a performance benefit, nitrate supplementation has been reported to lower blood pressure in humans (Kapil et al., 2010; Vanhatalo et al., 2010; Webb et al., 2008), as discussed recently (Ferreira & Behnke, 2010; Gilchrist et al., 2011). Dietary nitrate has been reported to prevent endothelial dysfunction induced by an acute ischemic insult in the human forearm and to attenuate ex vivo platelet aggregation in response to collagen and ADP (Webb et al., 2008). These effects, coupled with the vasodilatory effects of increased circulating nitrite, seem to be responsible for the blood pressure lowering effect of dietary nitrate. While this may not be of primary importance to many athletes, a reduction in blood pressure should at least be of interest to individuals, in particular those who use bodybuilding drugs known to cause elevations in both resting and stress-induced blood pressure. From a general health point of view, a slight reduction in blood pressure is correlated to a lower risk of cardiovascular disease.

In addition to the above benefits of nitrate supplementation, it has been noted that nitrate may also improve the absorption of certain nutrients. While this appears of some interest, because such findings are isolated to designs not involving oral ingestion of nitrate by human subjects, the potential for improved absorption of nutrients following nitrate ingestion it is not a major consideration for the inclusion of nitrate within d-pol™. If such effects on enhanced nutrient absorption are apparent with nitrate ingestion, this would simply be an adjunct to the well-documented performance and health benefits that are observed.

Finally, it is important to address the potential safety concern over ingestion of dietary nitrate, which has been raised (Derave & Taes, 2009; Petróczi & Naughton, 2010), with more specific concern over ingestion of high amounts of dietary nitrite (Lundberg et al., 2011). This has been appeased in recent years by experts working specifically in this area of research (Benjamin et al., 2009; Gilchrist et al., 2010). The general consensus is that ingestion of low amounts of dietary nitrate appears safe and may be associated with improvements in parameters of health (e.g., vascular function) and physical performance.

Vitamin D
Vitamin D is a fat-soluble vitamin with multiple known functions within the body (Holick, 2004; Sutton & MacDonald, 2003; Thacher & Clarke, 2011), ranging from the maintenance of normal calcium metabolism to a modulator of cellular immunity. Vitamin D3 (cholecalciferol) can be synthesized by humans in the skin upon exposure to ultraviolet-B radiation from sunlight. Vitamin D can also be obtained from the diet. Unfortunately, vitamin D is found naturally in very few foods. According to the Linus Pauling Institute, “foods containing vitamin D include some fatty fish (mackerel, salmon, sardines), fish liver oils, and eggs from hens that have been fed vitamin D. In the U.S., milk and infant formula are fortified with vitamin D so that they contain 400 IU (10 mcg) per quart. However, other dairy products, such as cheese and yogurt, are not always fortified with vitamin D. Some cereals and breads are also fortified with vitamin D. Recently, orange juice fortified with vitamin D has been made available in the U.S.”

Based on the above, vitamin D supplementation is likely required by most individuals. This is particular true if exposure to natural sunlight is limited and/or the use of sunscreen in routine. In fact, it has been reported that the majority (87%) of adults living in the relatively sunny climate of Tennessee are deficient in vitamin D (Long et al., 2011); a finding that is well supported by numerous investigations including adults (Holick, 2007), in addition to those including children. Individuals residing in parts of the country where the amount and intensity of sunlight is less than average may be at even greater risk for deficiency. Without adequate dietary intake and/or natural synthesis of vitamin D, multiple components of physical health may be compromised—again, a well documented outcome that has fueled the continued growth of vitamin D research.
Activated vitamin D (calcitriol) has been referred to as a pluripotent pleiotropic secosteroid hormone (Cannell et al., 2009). As a steroid hormone regulating more than 1000 vitamin D-responsive human genes, vitamin D may influence athletic performance. Most of the studies supporting the role of vitamin D with regards to exercise performance involved older adults. However, as noted by Cannell and colleagues (2009) in a recent review article on the topic “physical and athletic performance is seasonal; it peaks when 25-hydroxy-vitamin D levels peak, declines as they decline, and reaches its nadir when 25-hydroxy-vitamin D levels are at their lowest.” These findings are underscored by the potential impact that vitamin D has on skeletal muscle, as described recently (Bartoszewska et al., 2010; Ceglia, 2009; Hamilton, 2010). Furthermore, a recent study (Pilz et al., 2011) in healthy men who supplemented with 3332 IU of vitamin D daily for one year, noted a significant increase in total, bioactive, and free testosterone levels. Although this finding requires confirmation through further research, it appears as though some of the noted health-related effects of vitamin D supplementation in men may be mediated through an increase in testosterone. Considering the well-described health effects of vitamin D, coupled with the potential impact of vitamin D on exercise performance, supplementation with this powerful vitamin should be considered by all individuals.

Research indicates that vitamin D toxicity is very unlikely in healthy individuals when used at amounts less than 10,000 IU/day (Vieth, 1999). However, the Food and Nutrition Board of the Institute of Medicine (IOM) and a recent Clinical Practice Guideline from the IOM in conjunction with the Endocrine Society (Holick et al., 2011) has set a conservative tolerable upper intake level of 4,000 IU/day (100 mcg/day) for all adults. This is similar to the dosage used in many clinical trials and is the dosage provided within d-pol™.

Cofactors for Vitamin D
For optimal vitamin D absorption, taking vitamin D with the largest meal of the day seems most appropriate (Mulligan & Licata, 2010). Beyond this, it has been suggested that certain vitamin and mineral cofactors are potentially needed for optimal vitamin D action and effect. However, it should be noted that the need for these cofactors is debatable. Moreover, most of these co-factors are present in vitamin/mineral supplements, which most individuals consume regularly. The cofactors of interest include magnesium, zinc, vitamin K2, vitamin A, and boron. With regards to boron, aside from acting as a cofactor for vitamin D, one recent report indicates a testosterone elevating effect of this mineral (Naghii et al., 2010). It is possible that this may enhance the action of DAA on circulating testosterone. However, an earlier report for boron refutes these findings (Green and Ferrando, 1994). Collectively considering the above, boron and other co-factors are not included within d-pol™.

SUMMARY
d-pol™ contains a carefully selected blend of ingredients, based on human evidence for effect in relation to multiple aspects of health and performance. While regular and strenuous exercise, as well as optimal dietary intake inclusive of frequent, macronutrient balanced and nutrient dense meals (as well as adequate water intake) should be viewed as most important in the quest for optimal health and physical functioning, use of a dietary supplement such as d-pol™ may be an adjunct to this lifestyle plan. The use of d-pol™ should be considered in a single dosage with the largest meal of the day.

As with all nutritional supplements, potential users should only use d-pol™ under the guidance of their personal physician. Moreover, because d-aspartic acid (a chief ingredient in d-pol™) has been reported to increase circulating testosterone, d-pol™ should not be used by women. Individuals considering using d-pol™ should be healthy and over the age of 21. Users of d-pol™ should review the product nutrition panel and label for information regarding the ingredients, dosing, and precautions for use. For more information on PURUS LABS® and their other performance/physique-enhancing products, please visit Purus Labs | Research Forged.

[SgtGreen]

Serving Size -3 TABLETs
Servings Per Container- 30

AMOUNT DV %

VITAMIN D3(CHOLECALCIFEROL) 4000IU 1000%
VITAMIN B6(PYRIDOXINE) 2MG 100%
VITAMIN B9(FOLATE) 400MCG 100%
VITAMIN B12(CYANOCOBALAMIN) 6MCG 100%
SODIUM 130MG 5%


LH/FREE TESTOSTERONE/ATP AMPLIFYING 3600.1MG**
VAODILATORY OXYGEN SPARING MATRIX

D-Apartic Acid (3,120mg),Nitratine(std. for 73% Nitrates),
Vitamin D3(Cholecalciferol)(4,000IU)

Other ingredients: silicified microcrystalline cellulose, stearic acid, Carbopol TM (controlled/extended release polymer) , furned silica


D-Pol usage: Take 1 serving with a mixed food meal 60 minutes prior to intese exercise, preferably with a multivitamin/multimineral, which may aid in Vitamin D absorbtion. For optimal results, use in conjunction with Muscle Marinade to aid in nutrient delivery and uptake. Avoid taking immediately prior to bedtime as your body's natural growth hormone release is at its peak. Tolerance to dosing should be assessed by all individuals prior to starting the full dosage of 3 tablets per day.

[aioros777]

Where can I buy it?

[HydroShake]

from the serving size, these sound like horse pills.

[sloop]

from the serving size, these sound like horse pills.

You don't know how right you are. They're very large.

I'm 3 days into my bottle of D-pol, and I've noticed something. I'm going to wait and see if what I'm experiencing is isolated, or other users are reporting the same...

[xR1pp3Rx]

You don't know how right you are. They're very large.

I'm 3 days into my bottle of D-pol, and I've noticed something. I'm going to wait and see if what I'm experiencing is isolated, or other users are reporting the same...

good play.. cant wait to hear whats going on tho.

[mikaveli06]

I'm not sure if its actually "bonded" to the DAA or not.
I do like both the ingred so it may be good taken pre wo. What was the price on this?

I don't believe it is bonded. The original formula was planned to be bonded but had to be be changed due to the TL patent on nitrate and aminos and etc, so they just added daa and sodium nitrates together.....I may run this in future but as of now I have daa and creatin nitrate, so I don't see how it can be any difference, but if price is right I may give it a go on my next run of daa

[Grambo25]

I don't believe it is bonded. The original formula was planned to be bonded but had to be be changed due to the TL patent on nitrate and aminos and etc, so they just added daa and sodium nitrates together.....I may run this in future but as of now I have daa and creatin nitrate, so I don't see how it can be any difference, but if price is right I may give it a go on my next run of daa

You are correct in your original statements that it is not bonded because of the legal issues.
The bonding most likely would not help DAA absorption (the B vitamins as per the Italian study do help the DAA though) and the nitrates are more for their performance enhancing effects than to help absorption.

Price should be anywhere from $25-32 depending on the retailer. So it really is an affordable product. Obviously you are pretty set for now though!

[Grambo25]

You don't know how right you are. They're very large.

I'm 3 days into my bottle of D-pol, and I've noticed something. I'm going to wait and see if what I'm experiencing is isolated, or other users are reporting the same...

Interested to hear, feel free to PM me if you feel like it.
Really just hit the market so not tons of feedback just yet....thought there should be 10+ logs going on over different boards soon.

[Grambo25]

Outside of increasing endurance... i don't see how nitrate binding would increase T.

This isn't my field of study, so i could be way off.

You are correct. There are some studies (though not oral consumption so not really worth much) that nitrates may help with some nutrients. They weren't added for that purpose however.

[SgtGreen]

It's $18 today only.
I wish bb.com sold it.

[sloop]

Interested to hear, feel free to PM me if you feel like it.
Really just hit the market so not tons of feedback just yet....thought there should be 10+ logs going on over different boards soon.

Im having mild anxiety issues about 30 minutes after dosing (3 pills, 15 minutes before workout taken with multi-vitamin). Nothing major, just an overall "anxious" feeling, sort of like the feeling you get in your stomach before you speak to a large crowd of people, or interview for a job. It's a "queazy" feeling, if that makes any sense. It usually lasts 20-30 minutes than goes away, but it's very strange...

[Grambo25]

Im having mild anxiety issues about 30 minutes after dosing (3 pills, 15 minutes before workout taken with multi-vitamin). Nothing major, just an overall "anxious" feeling, sort of like the feeling you get in your stomach before you speak to a large crowd of people, or interview for a job. It's a "queazy" feeling, if that makes any sense. It usually lasts 20-30 minutes than goes away, but it's very strange...

Have you continued to have trouble with this? Obviously if it is causing anxiety issues you may want to discontinue use.
Have you used other DAA products at all?

I looked into this after you mentioned it and this should not be too much of a worry for the majority of people. Someone with more knowledge than me mentioned that the possibility could be there with someone sensitive to anxiety and the supplement itself.

[kilsong]

I'm on day three of this stuff and I THINK I feel a difference.

[AJP1]

The nitrates does a few things....
-Help with nutrition delivery
-Improve exercise endurance.
-Help with pumps/vascularity
-it also helps drive/shuttle the test boosting properties.

[UnflappedAcorn]

purus labs make good stuff

[theguitarman128]

I'm actually forming a stack around this. I haven't tried it yet, but 3G daa and nitrates for $20? Yes please

[Grambo25]

I'm actually forming a stack around this. I haven't tried it yet, but 3G daa and nitrates for $20? Yes please

And 4,000iu Vitamin D......Just a nice looked over extra