What is the purpose of glucuronidase inhibitors such as Calcium D-Saccharate Tetrahydrate? What role does it play in the body?
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04-01-2011, 03:39 AM #1
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04-01-2011, 06:58 PM #2
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Calcium d-saccharate tetrahydrate is a gulcuronidase donor, not inhibitor.
An inhibitor would block phase II metabolism in the liver, which seeks to make substances more water soluble via conjugation (glucuronidation/sulfation).
If a drug is determined to be heavily dependent on phase II metabolism, then blocking this step would increase the drugs half-life.twitter: @bullexinferis
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04-01-2011, 08:56 PM #3
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04-02-2011, 03:02 PM #4
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I mispoke above. It is a glucuronidation donor, and a glucuronidase inhibitor. The end result is the same: decreased half-life of substances heavily dependent on phase II metabolism in the liver. It also blocks bacterial de-conjugation in the gut, which decreases biliary-intestinal re-circulation. The result of this process increases intestinal elimination of various substances.
OTOH, substances like quercetin or kaempferol decrease glucuronidation, and therefore would prolong the half-lives of substances undergoing phase II metabolism.twitter: @bullexinferis
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04-02-2011, 03:21 PM #5
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04-02-2011, 04:58 PM #6
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One of the main ways through which the body regulates estrogen is via conjugation (phase II), and biliary excretion. Some % of that estrogen is de-conjugated (via bacterial beta-glucuronidase), and reabsorbed. Blocking this event with the previously mentioned substance does indeed lower systemic estrogen levels. The problem with this compound is that it can potentially decrease the half-lives of whatever else you are also supplementing with.
twitter: @bullexinferis
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04-02-2011, 05:04 PM #7
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04-04-2011, 01:47 PM #8
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Not quite.
http://en.wikipedia.org/wiki/Biological_half-life
The biological half-life or elimination half life of a substance is the time it takes for a substance (for example a metabolite, drug, signalling molecule, radioactive nuclide, or other substance) to lose half of its pharmacologic, physiologic, or radiologic activity... In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.Nutrition and Supp Science FAQ:
http://forum.bodybuilding.com/showthread.php?t=139153843&p=849049173&viewfull=1#post849049173
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