Pro-hormone question

[De__eB]

From the first link:

"Pharmacokinetics
Following oral administration, milk thistle is poorly absorbed from the gastrointestinal tract with a bioavailability of approximately 23-47%. Peak plasma concentrations occur within 2-4 hours (3). Milk thistle inhibits cytochrome p450 isoenzyme 3A4 and has an elimination half-life of approximately 4 hours. 30-40% of administered dose is recoverable from the bile as both glucuronide or sulfate conjugates and 2-5% is excreted in the urine (4)."

It appears that milk thistle has a half life of 4 hours.

Peak plasma concentrations occur within 2-4 hour"

What I was getting at is that I imagine that number would be higher in the liver due to aforementioned recirculation

First-Pass Effect
"the metabolism of orally administered drugs by gastrointestinal and hepatic enzymes, resulting in a significant reduction of the amount of unmetabolized drug reaching the systemic circulation."

http://medical-dictionary.thefreedic...st-pass+effect

This first pass is where I believe the methyl bond of a methyl prohormone is broken. Still researching the relationship between the liver and small intestine in digestion/absorption, but I think do to enterohepatic recirculation, is why you get more then one pass through the liver.

The 17alpha group isn't removed...

[PinchTheBear]

What are your views on the topic at hand?

LNCaP studies are irrelevant, milk thistle is a perfectly sound and clinically proven supplement, and you're spinning your wheels dealing with physiological semantics.

[maggotspawn]

"...has an elimination half-life of approximately 4 hours."
Whatever, Just trying to figure out the best dosage time for liver care while on cycle. It has nothing to do with semantics.

Did find a good read on oral steroids here: http://forums.rxmuscle.com/showthread.php?p=319881

So thanks for that tip.