Clean your mouth -> Worse response to Nitrates -> less NO ?

[Autobody]

Recent studies surprisingly show that dietary inorganic nitrate, abundant in vegetables, can be metabolized in vivo to form nitrite and then bioactive nitric oxide. A reduction in blood pressure was recently noted in healthy volunteers after dietary supplementation with nitrate; an effect consistent with formation of vasodilatory nitric oxide. Oral bacteria have been suggested to play a role in bioactivation of nitrate by first reducing it to the more reactive anion nitrite. In a cross-over designed study in seven healthy volunteers we examined the effects of a commercially available chlorhexidine-containing antibacterial mouthwash on salivary and plasma levels of nitrite measured after an oral intake of sodium nitrate (10mg/kg dissolved in water). In the control situation the salivary and plasma levels of nitrate and nitrite increased greatly after the nitrate load. Rinsing the mouth with the antibacterial mouthwash prior to the nitrate load had no effect on nitrate accumulation in saliva or plasma but abolished its conversion to nitrite in saliva and markedly attenuated the rise in plasma nitrite. We conclude that the acute increase in plasma nitrite seen after a nitrate load is critically dependent on nitrate reduction in the oral cavity by commensal bacteria. The removal of these bacteria with an antibacterial mouthwash will very likely attenuate the NO-dependent biological effects of dietary nitrate.

18793740


dont Rinse before C-bol?

[GeneGnomeX]

Yep there are at least a couple of studies on this.

I am concerned about potentially beneficial health effects of dietary nitrate being negated by mouthwash use; I couldn't find a good answer as to how quickly the bacteria completely repopulate.

[Autobody]

Yep there are at least a couple of studies on this.

I am concerned about potentially beneficial health effects of dietary nitrate being negated by mouthwash use; I couldn't find a good answer as to how quickly the bacteria completely repopulate.

Lots of sugar while keeping the mouth closed to spur re-population. :O~

[Bane]

Intestinal flora and specific reductases in the body can also convert nitrate to nitrite.

[Peter LeDrew]

Intestinal flora and specific reductases in the body can also convert nitrate to nitrite.

Yeah, I read about this before. Goes to show how much there is to seeing benefits from NO supps... overall health goes a long way to seeing benefits from supplements and exercise.