Eurycoma longifolia led to 16.4% higher test levels, and 32.3% lower cortisol?

[RMA08]

Again,With Longjack do need something for estrogen control?If you do what do you recommend?

[NO HYPE]

With Longjack do need something for estrogen control?

With non-excessive dosages and a frequent washout periods, I doubt it. Maybe someone else with more knowledge could give you a better answer.



EXCERPTS FROM:
Clinics (Sao Paulo). 2010 Jan;65(1):93-8.
The effect of eurycoma longifolia jack on spermatogenesis in estrogen-treated rats.
Wahab NA, Mokhtar NM, Halim WN, Das S.

"To the best of our knowledge, there are no studies that have focused on the action of EL in estrogen-exposed subjects. For decades, estrogens have been considered to be female hormones. However, various research studies have proposed an essential role for estrogens in the male reproductive tract. Both in males and females, androgens are converted into estrogens by aromatization in androgen target tissues and in circulation. Estrogen can act by binding with its receptor, which is located in Leydig cells, germ cells and spermatozoa."

"In the present study, EL may have inhibited the apoptosis that would have resulted from the estrogen exposure. The increase in spermatogenic cells and the percentage of motile sperms in the EL-treated group, as well as the EL combined with estradiol-treated group, demonstrated the protective actions of EL. If this is the case, then in situations where there is an excess of estrogen or deficiency in testosterone, EL may be able to act as a remedy for the condition."

[NO HYPE]

Long distance endurance events are characterized by a decrease in test and increase in cortisol, while testosterone increases in response to resistance training. Would eurycoma longifolia still increase test/lower cortisol for weight lifters?

I'm thinking in the hours of post-resistance exercise.... yes.



Dietary Supplements affect the anabolic hormones after weight‐training exercise. (Chandler, Byrne et al. 1994)

Examined the effect of carbohydrate and/or protein supplements on the hormonal state of the body after weight training exercise. Subjects consumed either a control (water), protein, carbohydrate, or carbohydrate‐protein drink immediately and 2 hours after a resistance training workout. Blood samples were drawn before and immediately after exercise and during 8 hours of recovery. Exercise induced elevations in lactate, glucose, testosterone, and growth hormone in all groups. The carbohydrate and carbohydrate‐protein stimulated higher insulin concentrations that protein alone and the control. Carbohydrate‐protein led to an increase in growth hormone 6 hours post exercise which was greater than protein and control. Supplements had no effect on insulin‐like growth factor‐I but caused a significant decline in testosterone. Testosterone levels fell below resting levels 30 minutes postexercise during all supplement treatments compared to the control. The decline in testosterone was not associated with a decline in luteinizing hormone, suggesting an increased clearance of testosterone after supplementation. The results suggest that nutritive supplements after weight‐training exercise can produce a hormonal environment during recovery that may be favorable to muscle growth by stimulating insulin and growth hormone elevations.



Effect of Post‐Exercise Supplement Consumption on Adaptations to Resistance Training. (Rankin, Goldman et al. 2004)

They compared body composition and muscle function response to resistance training using either a carbohydrate supplement or milk following each training session. Muscle strength, body composition, fasted, resting concentrations of serum total and free testosterone, cortisol, IGF‐I and resting energy expenditure were measure before and after training. Milk increased body weight and fat free mass more than the carbohydrate supplement. Resting total and free testosterone concentrations decreased from baseline values in all subjects. There were no significant changes in fasting IGF‐I, cortisol, and resting energy expenditure for either group.

does a non-supraphysiological test increase do anything significant outside of a PCT context?

Following testosterone decrements during the hours of post-resistance exercise? I'd tend to think so. Your thoughts?



February 1998 - Volume 12 (1), 57-63
The Journal of Strength & Conditioning Research
A Brief Review: Testosterone and Resistance Exercise in Men

Role in Muscular Development
Testosterone is a potent stimulator of muscle protein synthesis (8,9,30). As previously stated, a hormone receptor complex must be present for the action of testosterone to occur. These complexes may occur in the cytosol and then translocate to the nucleus (65,69), or they may occur directly in the nucleus itself (84,88). Reguardless of the location, activation of the receptor-hormone complex will increase mRNA and DNA synthesis. This increase in action will lead to increased protein accreation via increased intramuscular amino acid uptake (3).

Testosterone also possesses anticatibolic properties within skeletal muscle. Inhibition of muscle glycogen breakdown (5,33) and displacement of glucocorticoid via attachment to it's receptor (66) are two powerful mechanisms of skeletal muscle protein retention. Cortisol's signal is typically related to the loss of glycogen stores in the muscle and the need for glucose. Oftentimes, cortisol increases may be related to other stress factors beyond carbohydrate metabolism and may affect protein breakdown (19,59,95). The response of testosterone to offset this effect on protein metabolism can be vital for maintaining muscle size and function.

[RMA08]

Thanks alot NO HYPE.One more question what's better for free test Longjack or Divanil based product?

[GeneGnomeX]

I'd say ask Floyd Landis, first Tour champion stripped of his title for doping:

http://www.signonsandiego.com/news/2...ng-cyclist-ai/

All the same, I am sure test:cortisol is not nearly as important in endurance as they are in bb'ing and strength related sports.

Yeah but again supraphysiological vs small increase from a supplement...

I'm thinking in the hours of post-resistance exercise.... yes.



Dietary Supplements affect the anabolic hormones after weight‐training exercise. (Chandler, Byrne et al. 1994)

Examined the effect of carbohydrate and/or protein supplements on the hormonal state of the body after weight training exercise. Subjects consumed either a control (water), protein, carbohydrate, or carbohydrate‐protein drink immediately and 2 hours after a resistance training workout. Blood samples were drawn before and immediately after exercise and during 8 hours of recovery. Exercise induced elevations in lactate, glucose, testosterone, and growth hormone in all groups. The carbohydrate and carbohydrate‐protein stimulated higher insulin concentrations that protein alone and the control. Carbohydrate‐protein led to an increase in growth hormone 6 hours post exercise which was greater than protein and control. Supplements had no effect on insulin‐like growth factor‐I but caused a significant decline in testosterone. Testosterone levels fell below resting levels 30 minutes postexercise during all supplement treatments compared to the control. The decline in testosterone was not associated with a decline in luteinizing hormone, suggesting an increased clearance of testosterone after supplementation. The results suggest that nutritive supplements after weight‐training exercise can produce a hormonal environment during recovery that may be favorable to muscle growth by stimulating insulin and growth hormone elevations.

Effect of Post‐Exercise Supplement Consumption on Adaptations to Resistance Training. (Rankin, Goldman et al. 2004)

They compared body composition and muscle function response to resistance training using either a carbohydrate supplement or milk following each training session. Muscle strength, body composition, fasted, resting concentrations of serum total and free testosterone, cortisol, IGF‐I and resting energy expenditure were measure before and after training. Milk increased body weight and fat free mass more than the carbohydrate supplement. Resting total and free testosterone concentrations decreased from baseline values in all subjects. There were no significant changes in fasting IGF‐I, cortisol, and resting energy expenditure for either group.

Again, what does this have to do with longjack? Many factors beside testosterone at play here...

Following testosterone decrements during the hours of post-resistance exercise? I'd tend to think so. Your thoughts?



February 1998 - Volume 12 (1), 57-63
The Journal of Strength & Conditioning Research
A Brief Review: Testosterone and Resistance Exercise in Men

Role in Muscular Development
Testosterone is a potent stimulator of muscle protein synthesis (8,9,30). As previously stated, a hormone receptor complex must be present for the action of testosterone to occur. These complexes may occur in the cytosol and then translocate to the nucleus (65,69), or they may occur directly in the nucleus itself (84,88). Reguardless of the location, activation of the receptor-hormone complex will increase mRNA and DNA synthesis. This increase in action will lead to increased protein accreation via increased intramuscular amino acid uptake (3).

Testosterone also possesses anticatibolic properties within skeletal muscle. Inhibition of muscle glycogen breakdown (5,33) and displacement of glucocorticoid via attachment to it's receptor (66) are two powerful mechanisms of skeletal muscle protein retention. Cortisol's signal is typically related to the loss of glycogen stores in the muscle and the need for glucose. Oftentimes, cortisol increases may be related to other stress factors beyond carbohydrate metabolism and may affect protein breakdown (19,59,95). The response of testosterone to offset this effect on protein metabolism can be vital for maintaining muscle size and function.

I think testosterone is one part of the anabolic milieu. IF longjack can increase testosterone, we need to know if it can potentiate the lifting induced increase, and then we need to find out if that increases muscle mass more than taking nothing.

There is certainly evidence that low testosterone results in a decreased ability to add muscle mass, and supraphysiological doses increase the ability, both which do suggest that test might be the most important factor. But I am not convinced yet that taking a supplement to slightly boost test will do anything significant, there may be a threshold response. And even if there is a dose dependent response, i'm not convinced that test boosters are worth the money.

[NO HYPE]

Again, what does this have to do with longjack? Many factors beside testosterone at play here...

In case I've missed something, let's just quickly review the aforementioned observations/commnents....



"in situations where there is an excess of estrogen or deficiency in testosterone, EL may be able to act as a remedy for the condition."

Long distance endurance events are characterized by a decrease in test and increase in cortisol, while testosterone increases in response to resistance training. Would eurycoma longifolia still increase test/lower cortisol for weight lifters?

I'm thinking in the hours of post-resistance exercise.... yes.

"Examined the effect of carbohydrate and/or protein supplements on the hormonal state of the body after weight training exercise."

"Testosterone levels fell below resting levels 30 minutes postexercise during all supplement treatments compared to the control."


If decrements in testosterone occur following resistance exercise and EL has the ability to ameliorate these decrements to some degree, then would that not enhance testosterone's ability to inhibit skeletal muscle glycogen breakdown and enhance protein retention, thereby enhancing muscle size and force production to a greater degree than without EL?

[NO HYPE]

Correcting systemic androgen levels using Eurycoma longifolia
[United States Patent Application 20070009621]

EXAMPLE 5
Eurycoma longifolia Saliva Testosterone Test
The amount of testosterone was measured using a saliva testosterone test. This test was administered to 9 Individuals, ranging from 26 to 52 years of age. Volunteers 1-5 are athletes; Volunteers 6-9 do not exercise on a regular basis. Each test subject was administered Eurycoma longifolia, two 50 mg capsules (a total of 100 mg), twice a day (morning & evening) (for a total of 200 mg per day) for 10 days.

The results are shown in the Table. For comparison, the normal range for an athlete is 800=150 ng of testosterone per dl of blood.

[pre treatment] [after treatment]
[Volunteer] [age] [ng/dl blood] [ng/dl blood] [Increase]

1. 26 860 = 30 1,650 = 50 : 91.86% increase
2. 28 580 = 30 985 = 35 : 69.83% increase
3. 35 875 = 40 1,576 = 60 : 80.11% increase
4. 24 950 = 45 2,210 = 55 : 132.63% increase
5. 29 755 = 30 1,345 = 35 : 78.15% increase
6. 48 650 = 20 875 = 30 : 34.62% increase
7. 52 450 = 25 765 = 35 : 70.00% increase
8. 50 585 = 25 875 = 35 : 49.57% increase
9. 42 350 = 30 480 = 35 : 37.14% increase

This data provides preliminary results, leaving open the possibility for more productive work to be carried out. This data, however, shows significant increases in testosterone levels, as measured by a saliva test, with the administration of Eurycoma longifolia. For all subjects, Eurycoma longifolia increases the level of testosterone an average of 71.56%. Among athletic subjects, Eurycoma longifolia increases the level of testosterone even more, an average of 90.52%.

Volunteers 1-5 are athletes—data are an average of measurements at three different times

Volunteers 6-9 do not exercise on a regular basis

Other Applications

1. Activates enzymatic sequence of Androgen Steroid Biosynthesis:

(a) Break down Cholesterol to Pregnelolone, which is further converted to Progesterone and Testosterone (Reduce Cholesterol and Pregnenolone)
(b) Activates CYP17 enzymes, which enhanced the metabolism of pregnenolone and 17-OH pregnenolone to yield more dehyroepiandrosterone (DHEA).
(c) Increase dehydroepiandrosterone (DHEA)
(d) Increase Progesterone

2. Decrease Sex Hormone Binding Globulin

3. Increase Free Testosterone (FT)

4. Increase DHEA

5. Increase Progesterone level:

blocks enzyme 5 alpha-reductase, inhibits the conversion of testosterone to dihydrotestosterone (DHT),
maintain healthy level of testosterone/estradiol level and prostate health.
Helps normalize blood sugar levels
Helps use fat for energy
Prevents water accumulation (acts as mild diuretic)
Helps (normalizes) thyroid hormone function
Stimulates new bone formation (osteoporosis protection and even reversal)
Improves brain function, has antidepressant properties
Improves skin problems including acne, seborrhea, rosacea, psoriasis
Improves sleep pattern
Improves libido.

6. Increase the synthesis of Pheromone An-alpha responsible for Sexual communication and behavior

7. Increase ATP (adenosine triphosphate) basic energy unit production

8. Increase cGMP and cAMP leads to vasodilation in penile tissue

9. Increase Insulin-like Growth Factor-1 (IGF1) level/Anti-aging/human

Regulates cellular growth and development
IGF-1 stimulates muscle bulk and lean body mass
helps burn fat
promotes healthy blood sugar level
decreases LDL Cholesterol.

10. Weight Management: Increase Tyroxin level leads to increase metabolism rate, increase calories burned, improve physical development, and decrease fatigue.

11. Modulate Cortisol: Boost Immune Function during illnesses and body defense during health crisis.

12. Improved Sports Performance:

(a) Increase FT leads to improved energy as adenosine triphosphate (ATP) production increases
(b) Increase FT leads to increment in fat free mass, greater decrement in body fat, increase in muscle mass and strength
(c) Improved recovery time
(d) Increase Tyroxin level leads to increase Basal Body Metabolism Rate, increase calories burned, improve physical development, decrease fatigue and sleeps disorder, and improving overall quality of life.
(e) Increase IFG-1 level, a natural anabolic growth factor that stimulates muscle bulk and lean body mass, and helps burn fat.

13. For treatment of Andropause/symptomatic late-onset hypogonadism/****topause: Decrease Sex Hormone Binding Globulin that result in increase Free Testosterone (FT), leads to

(a) Enhancement Sexual Performance:
(i) Increase the synthesis of Pheromone An-? Responsible for Sexual communication and behavior
(ii) Increase cGMP and cAMP that causes relaxation of erectile tissue, increase vasodilation that leads to penile erection
(b) Stimulate production of red blood cell in bone marrow bone formation
(c) Regulates Cholesterol: Increase lipid metabolism leads to improvement in high-density lipoprotein(HDL Cholesterol-good cholesterol). Lower HDL are normally associated with a lower risk of heart attack.
(d) Increased carbohydrate metabolism
(e) Promote hair growth
(f) Promote immune response
(g) Promote spermatogenesis
(h) Inhibits osteoclasts that enhance bone breakdown

14. For treating type-2 diabetes: lowering the blood glucose levels

15. For treating Metabolic Syndrome X

16. For reducing estrogen-dominance in men.

[NO HYPE]

Not the full text however, there were about four human trials that related to enhanced testosterone....


Asian J Androl 2009; 11 (5 Suppl): 25-95
Nutrients and Botanicals for optimizing Men's Health.
Examining the evidence for Erycoma longfolia Jack, the Malaysian Ginseng in men's health
Mohd Ismail Tambi - Damai Service Hospital, Biotropics Berhad, Malaysia

[Guardian]

I have used it and can feel it work for sure, I just wish there was more on the market and the price would go down. Right now sci fit is only company that sells it on here.

I wish all these fancy test boosters would cut the extra crap and just make a a good lonjack formula, made with some iccarin.

[NO HYPE]

There is an obvious EL-induced mechanism of action that may or may not be initiated during resistance exercise. I have a feeling [with appropriate dosing protocols] that this compound would elicit beneficial effects even in resistance-trained individuals however, this will remain to be seen.

Br J Sports Med 2003;37:464–470
S. Hamzah, A. Yusof. Department of Exercise Physiology, Sports Centre,
THE ERGOGENIC EFFECTS OF EURYCOMA LONGIFOLIA JACK: A PILOT STUDY

Eurycoma longifolia Jack (ELJ), which contains quassinoids such as eurycomalacton, eurycomanon, and eurycomanol, has been reported to have aphrodisiac properties and to increase testosterone levels in men.1 Previous studies have established that the testosterone supplementation increases fat free mass, muscle strength, and muscle mass, which are important for physical function and athletic performance. 2,3 Thus, the objective of this study was to investigate the effect of the increase in testosterone levels, obtained by administration of ELJ, on body composition and muscle strength and size in man. Fourteen healthy men performed an intense strength training programme with initial load of 60% RM (2 sets of 10 repetitions with 1 minute rest between, for 10 stations) on alternate days for five weeks. Simultaneously, seven men were randomly selected to consume 100 mg/day ELJ water soluble extract, and seven men received placebo. The intensity of the exercise was increased by 10% RM/week. Body composition, arm circumference, one repetition maximum (1 RM), and surface electromyography (sEMG) activity were measured and recorded one day before and after the five weeks of supplementation and intervention. The lean body mass of the treatment group showed a significant increment, from 52.26 (7.18) kg to 54.39 (7.43) kg (p = 0.012), but no significant changes in fat free mass were observed in the placebo group. Percentage body fat was significantly decreased in the treatment and placebo group, from 31.30 (5.48)% to 28.44 (6.43)% (p = 0.01) and from 22.83 (2.43)% to 21.33 (2.35)% (p = 0.001) respectively. The 1RM test showed a significant increase from 73.71 (16.63) to 78.71 (17.0) kg (p = 0.006) in the treatment group and from 77.29 (8.9) to 79.43 (8.8) kg (p = 0.011) in the placebo group. The increase in strength in the treatment group was larger than in the placebo group (6.78% and 2.77% respectively). The mean frequency of sEMG on the biceps in the treatment and placebo groups decreased significantly, from 121.77 (40.0) to 90.47 (64.6) µV (p = 0.012) and from 127.95 (30.9) to 98.8 (50.1) µV (p = 0.036) respectively. The treatment produced 2.92% greater reduction in electrical activity of the muscle measured at the end of the experiment compared with placebo. The mean arm circumference of the treatment group increased significantly by 1.8 cm after the supplementation, from 30.87 (1.88) to 32.67 (1.96) cm (p = 0.011), but there was no significant increase in the placebo group. The results suggest that water soluble extract of Eurycoma longifolia Jack increased fat free mass, reduced body fat, and increased muscle strength and size, and thus may have an ergogenic effect. Further investigations are warranted. http://www.ncbi.nlm.nih.gov/pmc/arti...v037p00464.pdf

1. Ismail MTM. Proceedings paper: Asian Congress of Sexology. 2002.

2. Bhasin S, Storer TW, Berman N, et al. The effects of supraphysiologic doses of testosterone on muscle size and strength in men. N Engl J Med 1996;335:1–7.

3. Brodsky IG, Balagopal P, Nair KS. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men: a Clinical Research Center Study. J Clin Endocrinol Metab
1996;81:3469–75.