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  1. #1
    Registered User Caiolgn's Avatar
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    Effects of Alpha-GPC on GH levels

    Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise

    Tim Ziegenfuss email, Jamie Landis and Jennifer Hofheins

    The Center for Applied Health Science Research, Division of Sports Nutrition and Exercise Science, Fairlawn, OH 44333, USA

    Background

    Many of the positive adaptations resulting from resistance exercise training (i.e., increased muscle mass and strength, decreased fat mass) are thought to be mediated, in part, by exercise-induced increases in growth hormone (GH). One ingredient that has shown clinical promise in elevating GH is the acetylcholine precursor alpha-glycerylphosphorylcholine (A-GPC). The purpose of this study was to examine the effects of a supplement containing primarily A-GPC on serum GH levels, explosive performance, and post-exercise substrate oxidation.

    Methods

    Using a randomized, placebo-controlled, crossover design, seven men (mean ? SD age, height, weight, body fat: 30.1 ? 7.3 y, 179.2 ? 7.4 cm, 87.3 ? 11.6 kg, 18.1 ? 5.9%) with at least two years of resistance training experience ingested 600 mg A-GPC (as AlphaSize?) or a placebo 90-minutes prior to completing 6 sets ? 10 repetitions of Smith Machine squats at 70% of their pre-determined 1-repetition maximum. At 30-minutes post-exercise, resting metabolic rate (RMR) and respiratory exchange ratio (RER) were measured with indirect calorimetry to assess post-exercise caloric expenditure and carbohydrate and fat oxidation, respectively. Immediately following RMR and RER measurements, subjects performed three sets of bench press throws at 50% of their pre-determined 1-repetition maximum to assess peak force, peak power, and rate of force development. All trials were performed after an overnight fast, a 48-hour abstention from intense exercise, and during the same time of day to minimize diurnal variation. Serum samples were obtained prior to exercise and again 0, 5, 15, 30, 60, 90 and 120 minutes post-exercise. Hormone concentrations were analyzed in duplicate by Quest Diagnostics? via immunoassay. Statistical evaluation of the data was accomplished using dependent t-tests (peak force, peak power, rate of force development) and repeated measures ANOVA (GH, RMR, RER). Differences were considered "significant" at P ≤ 0.05.

    Results

    Compared to baseline (pre) values, peak GH increased 44-fold during A-GPC (from 0.19 ? 0.06 to 8.4 ? 2.1 ng/mL) vs. 2.6-fold during placebo (from 1.9 ? 0.8 to 5.0 ? 4.8 ng/mL, P < 0.03) (Figure 1). Peak bench press force was 14% greater in A-GPC (933 ? 89 N) vs. placebo (818 ? 77 N, P < 0.02). Trends toward higher peak bench press power (P < 0.13) and lower post-exercise RER (P < 0.12) were noted in the A-GPC trial.

    Conclusion

    These data indicate that a single 600 mg dose of A-GPC (as AlphaSize?), when administered 90 minutes prior to resistance exercise, increases post-exercise serum GH and peak bench press force. In contrast, A-GPC had no statistically significant effect on peak power, rate of force development, RMR, or cardiovascular hemodynamics (i.e., heart rate and blood pressure). Future work should examine how resistance exercise + A-GPC affect the GH-IGF axis and their associated family of binding proteins.
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  2. #2
    Registered User GOTSPEED's Avatar
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    44 fold!!!! that's sick right there
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    Registered User GOTSPEED's Avatar
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    ^^^^ is 44 fold a lot? how much growth hormone is produced by a few intense set of squats
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    That sounds pretty good, but Id guess on a 'fed' stomach it would be diminished.

    These guys fasted overnight (12 hours? hard to say) and then worked out without eating anything and didn't eat after their workouts for 2 hours.

    In a vacuum..it might work...but if it takes a dead empty stomach followed by a fasted workout with no proper pre / post nutrition and no meal till 2 hours later...forget it...give me food..Im not going without food 14 hours a day!!
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    Originally Posted by GOTSPEED View Post
    44 fold!!!! that's sick right there
    sorry to be the skeptic but most people do not train after an overnight fast

    lets see this experiment repeated under some actual realistic conditions
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    From what I remember working with the commercially available alpha-gpc in bulk is that it was cut with around 50% "sugar" of some kind.

    It's been a while.
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  7. #7
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    That is the same form (AlphaSize) and dose (600mg) of Alpha-GPC that EndoAmp Max uses... I look forward to future related research, but regardless if I have always viewed A-GPC as a superior choline source for reasons far beyond the vain.
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    Originally Posted by Peter LeDrew View Post
    That is the same form (AlphaSize) and dose (600mg) of Alpha-GPC that EndoAmp Max uses... I look forward to future related research, but regardless if I have always viewed A-GPC as a superior choline source for reasons far beyond the vain.
    I need to pick up a TRS. I did not realize Eric added A-GPC to the new EndoAmp.
    "Strong people are harder to kill than weak people, and more useful in general."
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    Originally Posted by SouthernLord View Post
    I need to pick up a TRS. I did not realize Eric added A-GPC to the new EndoAmp.
    Don't worry, you're not alone. I didn't either... I'm not saying this is stronger than D-Bol, but I love those ingredients for many reasons.
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  10. #10
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    "from 0.19 ? 0.06 to 8.4 ? 2.1 ng/mL) vs. 2.6-fold during placebo (from 1.9 ? 0.8 to 5.0 ? 4.8 ng/mL)"

    It's 44x vs 2.6x because the supplemented group had much lower (.19 vs 1.9) GH before workout. Gotta read the study. If they had had the same beginning GH levels it would have been a 4.4x increase. At the same time, you have to wonder whether the supplemented group reached higher levels DUE to their beginning low levels. We know that drastically reducing protein intake skyrockets GH levels, I'm just guessing and pulling this out of my ass, but could extremely low GH levels be easier to increase?

    just sayin'.

    oh, and no one trains fasted. studies done on fasted subjects are fun and all, but they are almost NEVER applicable. which really makes them useless.
    I want to touch the butt.
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  11. #11
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    Originally Posted by Seamless View Post
    "from 0.19 ? 0.06 to 8.4 ? 2.1 ng/mL) vs. 2.6-fold during placebo (from 1.9 ? 0.8 to 5.0 ? 4.8 ng/mL)"

    It's 44x vs 2.6x because the supplemented group had much lower (.19 vs 1.9) GH before workout. Gotta read the study. If they had had the same beginning GH levels it would have been a 4.4x increase. At the same time, you have to wonder whether the supplemented group reached higher levels DUE to their beginning low levels. We know that drastically reducing protein intake skyrockets GH levels, I'm just guessing and pulling this out of my ass, but could extremely low GH levels be easier to increase?

    just sayin'.

    oh, and no one trains fasted. studies done on fasted subjects are fun and all, but they are almost NEVER applicable. which really makes them useless.

    gh levels are cyclical. they have multiple peaks and troughs throughout the day. if you catch a cohort of subjects who are mostly at their troughs at time 0 then you will see a profound increase after a period of time, even without supplementation
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  12. #12
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    Originally Posted by Patrick Arnold View Post
    gh levels are cyclical. they have multiple peaks and troughs throughout the day. if you catch a cohort of subjects who are mostly at their troughs at time 0 then you will see a profound increase after a period of time, even without supplementation
    I thought as much.
    I want to touch the butt.
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  13. #13
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    Originally Posted by spreadtheword View Post
    I'm not really noticing the increase in force from taking this crap to be honest.
    How long have you been taking it, and at what dosage?
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  14. #14
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    Originally Posted by spreadtheword View Post
    I'm not really noticing the increase in force from taking this crap to be honest.

    have you tried it with THE STRAP?
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    Originally Posted by Patrick Arnold View Post
    have you tried it with THE STRAP?
    Nice avatar, it looks like you are smoking outside of a bar in downtown Champaign.
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  16. #16
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    Originally Posted by newequation View Post
    Nice avatar, it looks like you are smoking outside of a bar in downtown Champaign.
    you live in champaign?
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  17. #17
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    Originally Posted by spreadtheword View Post
    I'm not really noticing the increase in force from taking this crap to be honest.
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  18. #18
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    Hey every one. I started drinking Monavie about 2 months ago and it has done amazing things for me. I have lost 57 pounds, no pain or soreness after 2 hour workouts. My endurance is amazing in all aspects, wink wink. Man I wish I had this product years ago. Anyone else try this stuff?
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    Originally Posted by Patrick Arnold View Post
    Hey every one. I started drinking Monavie about 2 months ago and it has done amazing things for me. I have lost 57 pounds, no pain or soreness after 2 hour workouts. My endurance is amazing in all aspects, wink wink. Man I wish I had this product years ago. Anyone else try this stuff?
    as*hole
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  20. #20
    Registered User Adjusting's Avatar
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    lol huh?
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    Originally Posted by Patrick Arnold View Post
    as*hole
    I can not tell if he is being serious or a joke?
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    Registered User Adjusting's Avatar
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    Originally Posted by Mfusick View Post
    I can not tell if he is being serious or a joke?
    I see he did this in another thread.
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    Originally Posted by Adjusting View Post
    I see he did this in another thread.
    Yeah I never heard of it. Looked it up online.

    Its a scam drink. Overpriced. Patrick is just having one of those days...

    I saw him post the same thing in a few threads.. It intrigued me for about 30 seconds then I search engined it and laughed.
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    Originally Posted by Mfusick View Post
    Yeah I never heard of it. Looked it up online.

    Its a scam drink. Overpriced. Patrick is just having one of those days...

    I saw him post the same thing in a few threads.. It intrigued me for about 30 seconds then I search engined it and laughed.
    so i guessed i failed as a MLM salesman. damn

    i gotta find something to do. the bills are piling up
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    Registered User Adjusting's Avatar
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    Originally Posted by Patrick Arnold View Post
    so i guessed i failed as a MLM salesman. damn

    i gotta find something to do. the bills are piling up
    You need to try harder. Make it more obvious that MLM is the best thing ever.

    There's got to be a dozen supplement companies who would pay for a PA formulation. Either that or you can bus tables at Denny's. Your options should be endless.
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    Originally Posted by Patrick Arnold View Post
    so i guessed i failed as a MLM salesman. damn

    i gotta find something to do. the bills are piling up
    Pat- for a little while you had me sold.

    I never heard about it. Had no clue what it was.

    FYI- becuase you were suggesting it - it did peak my interest.

    When I searched it out- I did laugh. Thanks for that.

    the point is that becuase your name was there... it had stronger rep automatically.

    You should consider doing somthing when the time comes .. and you have somthing worth doing it over... but don't wait too long... or you will lose some of the repuation you have as people forget and things change.
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  27. #27
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    Originally Posted by Patrick Arnold View Post
    so i guessed i failed as a MLM salesman. damn

    i gotta find something to do. the bills are piling up
    I did give you rep points. and laugh though...
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  28. #28
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    Originally Posted by Mfusick View Post
    Pat- for a little while you had me sold.

    I never heard about it. Had no clue what it was.

    FYI- becuase you were suggesting it - it did peak my interest.

    When I searched it out- I did laugh. Thanks for that.

    the point is that becuase your name was there... it had stronger rep automatically.

    You should consider doing somthing when the time comes .. and you have somthing worth doing it over... but don't wait too long... or you will lose some of the repuation you have as people forget and things change.

    if only i had no ethical standards. i could be rich
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  29. #29
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    f*cking great

    now i have people pm'ing me asking where they can get monavie

    i can't win
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  30. #30
    Evolutionary Muse dsade's Avatar
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    Originally Posted by Patrick Arnold View Post
    f*cking great

    now i have people pm'ing me asking where they can get monavie

    i can't win
    You should come out with Hormon-avie.

    /middle finger at fate
    "Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade

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    ---ACCELERATED gains * increased MASS = unstoppable FORCE--- Know your physics for maximum performance.
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