I have been doing some research on forskolin and have noticed that this ingredient is in a few natural test boosters, my question is does forskolin have any scientific backing that it actually helps to raise testosterone levels? I have seen a few people on this board including PA I believe mention that forskolin was shown to raise test. levels.. Any insight?
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07-10-2008, 09:58 AM #1
Forskolin raising testosterone levels??
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07-10-2008, 10:44 AM #2
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07-10-2008, 10:57 AM #3
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07-10-2008, 10:59 AM #4
http://www.nature.com/oby/journal/v1...y2005162a.html
Funded by Sabinsa (patent on Forslean)
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07-10-2008, 08:39 PM #5
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07-10-2008, 09:35 PM #6
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I just posted something similar, I read an article that states gain up to 8 lbs in 12 weeks and lose some body fat, might be worth a shot, BB.com sells it for 9.99 a bottle for a month's supply, can't hurt to try it for the price.
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07-11-2008, 09:26 PM #7
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07-12-2008, 04:14 AM #8
T-BOL write-up:
Forskolin is a labdane diterpene that is produced by the Indian Coleus plant (Plectranthus barbatus). Forskolin has a favorable effect on enhancing serum testosterone levels through it's potential influence on cAMP. Because LH exerts its effects on Leydig cells of the testicles (stimulating production of testosterone) through cAMP, an increase in testosterone levels using this compound is exhibited as well (43,44) In fact Forskolin is commonly used in studies to stimulate testosterone production from Leydig cells (45,46). Apart from this Forskolin exhibits a beneficial effect on reducing fat levels while increasing lean muscle mass. As a matter of fact, in a human study the Forskolin treated group increased mean free testosterone levels by up to 40% (49)
[43] Valenti, S, Guido, R, Giusti, M, Giordano, G. (1995) In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3',5'-monophosphate production Endocrinology 136,5357-5362
[44] Valenti, S, Fazzuoli, L, Giordano, G, Giusti, M. (2001) Changes in binding of iodomelatonin to membranes of Leydig cells and steroidogenesis after prolonged in vitro exposure to melatonin Int J Androl. 24,80-86
[45] Serotonin secretion from rat Leydig cells.Tinajero JC, Fabbri A, Ciocca DR, Dufau ML.Section on Molecular Endocrinology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892.
[46] Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats. Keeney DS, Mason JI. Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9051.
[49] Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Michael P. Godard, Brad A. Johnson and Scott R. Richmond. Obesity Research (2005) 13, 1335–1343; doi: 10.1038/oby.2005.162Last edited by NO HYPE; 07-12-2008 at 08:15 AM.
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Wherever progression lacks.... regress can be found in abundance.
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07-12-2008, 07:43 AM #9
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07-12-2008, 07:48 AM #10
Check your PM's.
http://www.thermolife.com/store/Scri...p?idproduct=18~
Wherever progression lacks.... regress can be found in abundance.
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07-12-2008, 09:19 AM #11
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09-13-2008, 04:04 PM #12
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01-05-2011, 03:52 PM #13
Yes!!!
i would say it does to a certain extent. I personally tried it from Nature's herbs and idk how great it was for building muscle but I can tell u that a little wind would get me all riled up. Sorry to be so descriptive but just to touch it to use the bathroom will get me crazy lol its so cheap its worth a try. Heard from friends that the effect was very similar, even if its just for that libido boost it will definately help. Just be sure to control urself lol it might be impossibe tho
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01-06-2011, 01:12 AM #14
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03-15-2011, 05:34 AM #15
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03-16-2011, 09:09 AM #16
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03-16-2011, 09:28 AM #17
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03-16-2011, 09:40 AM #18
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03-16-2011, 01:17 PM #19
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Not exactly. Forskolin incubation is relevant in certain cancer cell lines in which point mutations in the motif sequence impact whether or not it contains an effective cAMP response element. Cancer research showing forskolin's impact on the aromatase gene is not relevant in healthy adults.
Further characterization of the molecular mechanism, including the binding protein for CLS and S1 motifs, may clarify the specific mechanism of CYP19 gene expression in adrenal tumors.
http://joe.endocrinology-journals.or.../180/1/125.pdf
FSK denotes forskolin, in normal osteoblasts (bone cells):
The results of RT-PCR also suggest that promoter II, which responds to FSK, was not activated even in the presence of FSK in SV-HFO.
http://www.eje.org/cgi/content/full/152/4/619Driven Sports
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03-16-2011, 04:02 PM #20
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03-16-2011, 04:29 PM #21
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03-16-2011, 06:45 PM #22
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Re-read my post then read the full texts you're referencing (and post them here). I mean, due to the effects of cytokines and glucocorticoids on aromatase expression, you could argue that strength training "significantly" up-regulates aromatase... lol. It's really just splitting hairs and has no physiological relevance. We're usually dealing with obscene db-cAMP concentrations non-ceteris paribus.
Driven Sports
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03-16-2011, 07:43 PM #23
Abstract
We have previously demonstrated that the aromatase activity in human endometrial stromal cells is stimulated by progestin and enhanced by oestrogen. In this study, we have investigated the effect of forskolin (Fk), an agent that stimulates the hormone-sensitive adenylate cyclase in mammalian cells, on the intracellular cAMP content and aromatase activity in endometrial stromal cells in primary culture. Stromal cells were isolated from proliferative and secretory endometria and were individually cultured in nutrient medium or medium supplemented with medroxyprogesterone acetate (MPA), oestradiol (E2) and Fk, separately or in combination. The intracellular cAMP content of stromal cells was increased after incubation with Fk. Stromal cells treated with Fk alone or FK and MPA for 1-3 days sustained the elevated intracellular cAMP content but 90% of this nucleotide was released to the medium. Aromatase activity was either not affected or was increased up to 5-fold over the control by Fk alone. Forskolin exerted a synergistic effect upon aromatase activity in the presence of progestin or progestin and oestradiol. Sequential incubation of the stromal cells with MPA and then Fk indicated that the additional increase in aromatase activity caused by Fk occurred after 24 h of incubation. These results demonstrate that intracellular cAMP exerts a stimulatory effect on aromatase activity in progestin-conditioned stromal cells. We also investigated whether the endometrial aromatase activity changes in vivo during the reproductive cycle by measuring the activities in endometrial specimens obtained from women during their reproductive age.
I don't see this relevant. Stimulatory effect... I need to find full text.I can do amazing things for your body composition. PM for more info.
Disclaimer: posting while erect.
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03-16-2011, 07:50 PM #24
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03-16-2011, 07:53 PM #25
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03-16-2011, 07:58 PM #26
A factor that significantly increases aromatase activity in osteoblasts, as did the combination of Dex and FSK in this study, would be beneficial, especially for the treatment of osteopenia and osteoporosis. Estrogen-replacement therapy (ERT) has been used to treat osteopenia and osteoporosis in postmenopausal women. However, ERT has various risks – for example uterine body cancer, thrombosis, and breast cancer –because ERT increases estrogen levels throughout the entire body. On the other hand, a drug that increases the expression of aromatase only in osteoblasts would increase the estrogen concentration only in bone tissue and would thus most likely not affect other tissues. The present study should form the basis for the development of such a tissue-specific ERT.
I can do amazing things for your body composition. PM for more info.
Disclaimer: posting while erect.
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03-16-2011, 08:00 PM #27
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The variables are so extensive when you deal a ubiquitous second messenger, e.g.
In contrast, the presence of 8-Br-cAMP for 2 days significantly decreased basal estradiol-17β output, as well as conversion of androstenedione to estradiol-17β; the conversion of androstenedione to estrone was not affected. 8-Br-cAMP attenuated the conversion of testosterone to both estradiol-17β and estrone
Does this mean anything? No, but why not use it to put together an argument? Amirite? :mentallymasturbates:Driven Sports
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03-16-2011, 08:02 PM #28
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03-17-2011, 08:26 AM #29
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03-18-2011, 03:45 AM #30
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