Health Benefits of BCAAs

[RedRusty]

I'm obviously a 12 year old boy today because "mental masturbation" has me giggling at my desk.

[Squid24]

Don't care what ya wrote or what others may say about them...

I like all the flavors and will keep on buying them..

[ILPump]

who got canned?

He left supp industry to work at Walgreens. Ring any bells?

[dougefresh93]

I'm obviously a 12 year old boy today because "mental masturbation" has me giggling at my desk.

proof of boyhood or piss off

[compan]

He left supp industry to work at Walgreens. Ring any bells?

No, it doesn't. Are you trying to call out Vaughn? Because I can't tell what kind of pussyfooting you're doing right now. Did this person leave? Or did they get canned like you said before?

[VaughnTrue]

No, it doesn't. Are you trying to call out Vaughn? Because I can't tell what kind of pussyfooting you're doing right now. Did this person leave? Or did they get canned like you said before?

He's referring to me although I'm not sure why.

I had a pretty damn good gig going with HTP, and chose to leave because I just don't see the supp industry being what I'd like to be involved in within a few years. A few companies will go strong for the foreseeable future, but in all reality it's just not "fun" any more.


Working for Walgreens would definitely suck if that's what I left for, but thankfully I didn't.

[adikam11]

That was Good though!

[JayLS1-327]

Imagine if you rubbed it on your penis before a moo sleepover

Calling in sick tomorrow and going to G*N*C.

[Synapsin]

I miss these threads.

do you or i get to take part in this little pissing contest someone is having?

[TheFugitive]

do you or i get to take part in this little pissing contest someone is having?

It's a free world, the more the merrier

[TheFugitive]

This is interesting...

In laboratory experiments, middle-aged male healthy mice were given drinking water laced with three specific amino acids.

The animals lived significantly longer than other mice fed a normal diet.

Their lifespan range had a midpoint of 869 days compared with 774 days for untreated mice, a difference of 12 per cent.

Longer survival was accompanied by biological changes which boosted the energy supply to cells and reduced oxidative damage caused by destructive molecules called free radicals.

The treated mice had more stamina and improved muscle co-ordination.

"This is the first demonstration that an amino acid mixture can increase survival in mice," said study leader Dr Enzo Nisoli, from the University of Milan in Italy.

Last year scientists showed that the same amino acids, leucine, isoleucine and valine, could extend the lifespan of single-celled yeast.

The new findings, reported in the journal Cell Metabolism, raise the possibility of amino acid supplements benefiting humans.

The scientists pointed out that the mice studied were aged but otherwise healthy.

They believe taking the amino acids might be especially helpful for the elderly or ill, particularly people with heart failure, chronic lung disease, or other conditions characterised by flagging energy levels.

Dr Nisoli said a large patient trial was needed to provide evidence convincing enough for doctors. However, there was little financial incentive for companies to conduct such studies on dietary supplements.

Leucine, isoleucine and valine, known as branched-chain amino acids (BCAAs), account for a fraction of the 20 amino acids from which proteins are made, but appear to have special anti-ageing properties.

Mice given the three amino acids produced larger numbers of mitochondria – the rod-like "powerhouses" in cells that generate energy – in their heart and skeletal muscle.

They also showed increased activity of SIRT1, a well-known longevity gene, and developed better defenses against free radicals.

BCAA nutritional supplements are readily available in health food stores and online.

Amino acid supplements were likely to be more effective than consuming proteins containing the same amino acids, according to the researchers.

Unlike protein, they did not have to be digested, and could enter the bloodstream immediately.

"They come with no energy cost," said Dr Nisoli.

In their paper the scientists wrote: "We have provided evidence that an original BCAA mixture increases average life span in male mice.

"This was likely the consequence of increased mitochondrial biogenesis and reduced oxidative stress in cardiac and skeletal muscles.

Our study offers a rationale for deeply exploring the role of amino acids in prevention and control of age-related disorders in humans."

[eatyourspinach]

citations, not even once

[TheFugitive]

citations, not even once

Of mice and men

[ILPump]

Are we actually comparing mice to men now?


By Matilde Parente, MD

Can a Power Booster Also Be a Longevity Booster?
For years, fitness enthusiasts have used branched chain amino acids to boost muscle strength and performance.1-3

New research shows why longevity enthusiasts may also incorporate them into their nutritional regimen.

A study recently published in the respected clinical journal Cell Metabolism4 reveals that branched chain amino acids (BCAAs) have the power to increase life span in part by inducing mitochondrial biogenesis—the spontaneous generation of new mitochondria.

In this article, the results of this study are detailed. BCAAs may complement the life span effects of both pyrroloquinoline quinone (PQQ) and resveratrol.5-7


Specifically, BCAAs may trigger cellular mechanisms that enhance mitochondrial number and function while also upregulating expression of the pro-longevity gene that resveratrol targets: sirtuin-1!1,6,7

The Building Blocks of Life and Longevity
As the foundation of life and the engines that drive cellular metabolism, amino acids are the building blocks for all proteins.

The Building Blocks of Life and Longevity
The three essential branched chain amino acids are leucine, isoleucine, and valine. In concert with other simple amino acids, BCAAs comprise the functional proteins that form the structural basis of human physiology, from skeletal and cardiac musculature to the vast universe of life-sustaining enzymes. In humans, whose total muscle mass accounts for about 40% of body weight, BCAAs make up nearly a fifth of all muscle proteins.1

In the landmark Cell Metabolism study, a team of scientists went beyond BCAAs’ metabolic effects to explore their potential to boost life span.4 This effort was based on prior studies indicating that the BCAAs leucine, isoleucine, and valine prolonged life in the yeast species Saccharomyces cerevisiae.8

Lead researcher Giuseppe D’Antona and his team fed male mice a diet that included BCAA-enriched drinking water.4 Mice ingesting BCAAs experienced a 12% increase in median life span from 774 days for untreated controls to 869 days in the treatment group. Because there was no significant difference in food intake, body weight, and body fat content between the treated and untreated animals, the authors concluded that the increased life span seen in the BCAA-enriched cohort was not a function of decreased body fat but rather the BCAAs themselves.

It was further discovered that mice enjoying increased longevity had high levels of SIRT1,4 a mammalian form of sirtuins, a subset of genes conclusively linked to increased longevity across a range of species.6,7,9

BCAA-treated mice also exhibited upregulation of genetic defense systems that blunt the detrimental effects of specific reactive oxygen species (ROS)4 associated with cellular and ****tic (body) aging in many organisms, including mammals.

BCAA-fed groups further experienced a dose-dependent response of new mitochondrial formation4 or mitochondrial biogenesis, as measured through specific markers of cellular energetic output in heart muscle cells.

Unique, Systemic Benefits
Exercise was shown to further enhance the mitochondrial function induced by BCAAs.4 Trained, BCAA-fed mice exhibited greater amounts of mitochondria in heart and skeletal muscle when those tissues were examined by electron microscopy. The BCAAs treatment groups also showed greater endurance scores on treadmill tests and better performance in tests of motor coordination, seen to an even greater degree in exercise-trained animals.1

Dr. D’Antona’s study included a second group of mice that carry a specific mutation. These mutant mice lack a key enzyme involved in blood vessel relaxation and regulation called endothelial nitric oxide synthase or eNOS.4 Without eNOS, mice die earlier and develop cardiovascular disease and other age-related pathologies similar to humans suffering from metabolic syndrome.10 Mice lacking the eNOS enzyme did not experience the same benefits of longer life span, improved ability to form new mitochondria, increased expression of SIRT1, or enhanced defense against ROS in response to BCAAs treatment.4

This led the researchers to conclude that healthy eNOS activity also plays a key role in BCAAs’ pro-longevity action, mitochondrial biogenesis, and reduced oxidative stress.4

Unique, Systemic Benefits
Once ingested, dietary BCAAs are transported and metabolized by a group of specific enzymes. What makes BCAAs unique among amino acids is that they are not broken down in the liver. Instead, they enter the bloodstream and are directly absorbed into the skeletal muscle.11 There they enter the cellular powerhouses known as mitochondria, the source of over 90% of all energetic output in the human body.1

Exercise was shown to further enhance the mitochondrial function induced by BCAAs.
BCAAs exert a profound influence over metabolic processes central to protein synthesis. Leucine also appears to play a particularly key role in protein formation and the regulation of protein metabolism.12 Human studies that have examined these exceptional actions in the bloodstream and skeletal muscle point to a role for BCAAs in muscle recovery from fatigue or intensive physical activity such as strength training.1,2 A 2010 review published in the Journal of the International Society of Sports Nutrition cited the power of BCAAs to bolster muscle protein building and delay the onset of fatigue as key benefits for exercising individuals.3 The paper also noted the possible effectiveness of BCAAs as performance enhancers.

In addition to their newly confirmed pro-longevity and mitochondria-generating effects, BCAAs show promise in fighting multiple killer diseases of aging.

WHAT YOU NEED TO KNOW: BRANCHED CHAIN AMINO ACIDS AND CALORIE RESTRICTION
Branched Chain Amino Acids and Calorie Restriction
The three branched chain amino acids leucine, isoleucine, and valine are essential nutrients that cannot be made by the body and must be consumed in the diet.
BCAAs are not metabolized by the liver, but instead enter the bloodstream, where they are directly taken up by muscle and used for muscle energy, repair, or building.
Studies in mice and lower life forms show that BCAAs can extend longevity and may share pathways with mTOR. A recent mouse study also showed that BCAAs may provide fuel or signaling ability to enhance the proliferation of new mitochondria, a finding that holds promise for healthier aging.
Administration of BCAAs also appears to bolster cellular defense mechanisms against harmful oxidizing molecules.
BCAAs also show promise in supporting insulin sensitivity, maintaining muscle mass with aging, and supporting healthy nervous system function.
Human trials reveal favorable effects of essential amino acid ingestion, including BCAAs, on insulin sensitivity and blood glucose control, as demonstrated in a study of 34 elderly diabetic subjects over a test period of more than a year. A BCAA-rich amino acid mixture improved numerous parameters of blood sugar metabolism, including hemoglobin A1c, in this group of older adults with poorly controlled diabetes.13

Branched Chain Amino Acids and Calorie Restriction
BCAA-enriched amino acid mixtures have also shown promise for improving the muscle-wasting condition known as sarcopenia in elderly human subjects, who gained muscle mass during treatment.14 This finding holds important implications for BCAAs’ use in other conditions characterized by debilitation and muscle loss.

Since BCAAs are involved in the formation and maintenance of glutamate and the neurotransmitter gamma-aminobutyric acid (GABA) in brain tissue, researchers believe they may play a role in supporting healthy nervous system function. Studies in animal models have shown promise that oral BCAA administration can improve the devastating consequences of traumatic brain injury by improving cognitive performance

[grubman]

[lucia316]

And /thread

[x-trainer ben]

"mice"

at least use pigs, come on!

[TheFugitive]

And /thread

You live for BCAA threads

[AMeyer9]

Lol, still BCAA threads in 2019

[stan47islav]

Lol, still BCAA threads in 2019

Some people just won't let them die...

[TheFugitive]

Thanks for stopping by x2 ^^

[compan]

Have we figured out yet if these magical BCAAs are contained in any foods we eat already?

[TCWoody]

Have we figured out yet if these magical BCAAs are contained in any foods we eat already?

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