[QUOTE=Plateauplower;1654913323]I'm not sure how to quantify how much reduction the vaccines are having on sever cases right now though. It is relatively mild for most (more so than original) and we are still seeing record numbers of hospitalizations while having record high vaccination rates... Again this is expected when positivity rates are so high, 25% in some places, which insane when you think about it. 1 in 4 people tested are testing positive. Reductions to lost productivity are also coming from revised guidance for the 5 day quarantine, and likely helping drive herd immunity as I am sure that is putting more people in circulation who are still contagious. Someone who doesn't have paid sick leave isn't going to be honest about being symptom free to RTW.[/QUOTE]
Sucks, only having these antiquated wild type mRNA vaccines with a highly adaptable virus, doesn't it. 1 in 4 is scary given everyone seems to want to get tested. I'm mostly ignoring numbers and just watching how the incidence and mortality are tracking. At some point, we'll have herd immunity to Omicron too. That'll be nice, I hope.
I'm going to test my 10 month old outdated antibody levels at the UNC/Virginia Tech game later. Both my kids' schools, so should be entertaining, and UNC has been playing poorly enough that VT has a chance.
Kind of curious to see how many adults actually show up to watch.
Edit:
Thinking about the additional cellular immunity based on non-spike antigens, if you figure you get 90% of your benefit from the immune response to the spike protein, and then you lose 75% of that due to mutations, even if we pretend that the 10% didn't decrease at all strain to strain, you're still only left with 35% of the effect. 25 vs 35 of our original immunity level does make it 40% better, but it's still going to be a comparison of bad to piss poor at preventing clinical infections. Of course, if that safe 25% from the vaccine still prevents bad outcomes in our at risk patients, it's better than nothing.