[QUOTE=fishnbrah;1657396543]How could I possibly know if you were joking[/QUOTE]
That's easy; you just have to ignore what he actually said. :)
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[QUOTE=fishnbrah;1657396543]How could I possibly know if you were joking[/QUOTE]
That's easy; you just have to ignore what he actually said. :)
[QUOTE=fishnbrah;1657396543]How could I possibly know if you were joking[/QUOTE]
Most of us joke a lot around here. To recognize a joke, I guess the first step would be to take the stick out of your ass and lighten up a little..
Don't as Supra for any help though, his stick is worked all the way up inside him and completely disappeared
[QUOTE=mtpockets;1657397643]Most of us joke a lot around here. To recognize a joke, I guess the first step would be to take the stick out of your ass and lighten up a little..
Don't as Supra for any help though, his stick is worked all the way up inside him and completely disappeared[/QUOTE]
There is no stick. :)
[QUOTE=fishnbrah;1657396543]How could I possibly know if you were joking[/QUOTE]Honest to God? You can read and discern truth from bull****.
Hey vaxxed people, ever worry this might happen?
[url]https://ulozto.net/file/gDC4a1A852i4/img-4447-mov#!ZJAyZmR2AGD4ZGEwMzV3MGWuLGZ0AGEcZwIBpSM2oRInZmWuBD==[/url]
[QUOTE=supramax;1657385623]What a choice; focus on a genocide and possibly the beginnings of a nuclear war or focus on a bunch of disgruntled truckers. :)[/QUOTE]
Right because the rest of the world stops & we should ignore any other countries & their acts of aggression towards their own people. And make no mistake here, forcing businesses to close for no damn reason is an act of aggression,
[img]https://i.imgur.com/xnNIV4t.jpg[/img]
Bump for COVID hype being over. Feeling blessed I didn't fall for another govt scam.
Nice to see this thread bumped. What Ya'll know about faking Covid tests to get out of stuff for work? LoL I heard Coca-Cola does the trick.
[QUOTE=_zman;1657971953]Bump for COVID hype being over. Feeling blessed I didn't fall for another govt scam.[/QUOTE]
What do you mean?
Pfizer and BioNTech are expected to seek US authorization this week for a second Covid vaccine booster for people 65 and older.
Deltacron comming at a theater near you. BAAAAH BAAAAHHHH.
[QUOTE=_zman;1657971953]Bump for COVID hype being over. Feeling blessed I didn't fall for another govt scam.[/QUOTE]
Yeah you are right, China needs to quit playing with their crisis actors because no one is buying it at this point. :)
[url]www.dailymail.co.uk/news/article-10619301/Morgues-overflow-bodies-Hong-Kong-deadly-Covid-wave-hits.html[/url]
[QUOTE=Corbi;1657412813]Right because the rest of the world stops & we should ignore any other countries & their acts of aggression towards their own people. And make no mistake here, forcing businesses to close for no damn reason is an act of aggression,[/QUOTE]Forgive the tardy response. I agree 100%. What happened in Ottawa for instance, would have lasted half a day when Trudeaus father was Prime Minister. These slobs would have been pulled from their trucks and thrown in jail and their trucks impounded.
Sad how you see the anti freedom people in here fighting to be locked down.
[QUOTE=_zman;1657971953]Bump for COVID hype being over. Feeling blessed I didn't fall for another govt scam.[/QUOTE]
It's not over, it's just taking a break and forcing focus on Ukraine. Get ready for a new "Super Delta" and a "vaccine" that is a patch on the skin, already in testing.
[QUOTE=Paul Kreul;1658063153]It's not over, it's just taking a break and forcing focus on Ukraine. Get ready for a new "Super Delta" and a "vaccine" that is a patch on the skin, already in testing.[/QUOTE]
I think a nuclear war will kill the virus.
It ain’t over yet
[Quote]
Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron
March 16, 2022
DOI: 10.1056/NEJMc2202542
In this open-label, nonrandomized clinical study, we assessed the immunogenicity and safety of a fourth dose of either BNT162b2 (Pfizer–BioNTech) or mRNA-1273 (Moderna) administered 4 months after the third dose in a series of three BNT162b2 doses (ClinicalTrials.gov numbers, NCT05231005. opens in new tab and NCT05230953. opens in new tab; the protocol is available with the full text of this letter at NEJM.org). Of the 1050 eligible health care workers enrolled in the Sheba HCW COVID-19 Cohort,1,2 154 received the fourth dose of BNT162b2 and, 1 week later, 120 received mRNA-1273. For each participant, two age-matched controls were selected from the remaining eligible participants (Fig. S1 in the Supplementary Appendix, available at NEJM.org).
Figure 1.
Immunogenicity and Efficacy of a Fourth Dose of mRNA Vaccine.
After the fourth dose, both messenger RNA (mRNA) vaccines induced IgG antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (Figure 1A) and increased neutralizing antibody titers (Fig. S3); each measure was increased by a factor of 9 to 10, to titers that were slightly higher than those achieved after the third dose, with no significant difference between the two vaccines. Concurrently, antibody levels in the control group continued to wane (Table S5). Both vaccines induced an increase in live neutralization of the B.1.1.529 (omicron) variant and other viral strains by a factor of approximately 10 (Figure 1B), similar to the response after the third dose.3 We found that the fourth dose did not lead to substantial adverse events despite triggering mild systemic and local symptoms in the majority of recipients (Fig. S2 and Table S4A and S4B).
Because of the extremely high infection incidence and meticulous active surveillance with weekly SARS-CoV-2 polymerase-chain-reaction testing, we were also able to assess vaccine efficacy with a Poisson regression model (see the Supplementary Appendix). Overall, 25.0% of the participants in the control group were infected with the omicron variant, as compared with 18.3% of the participants in the BNT162b2 group and 20.7% of those in the mRNA-1273 group. Vaccine efficacy against any SARS-CoV-2 infection was 30% (95% confidence interval [CI], −9 to 55) for BNT162b2 and 11% (95% CI, −43 to 44) for mRNA-1273 (Figure 1C). Most infected health care workers reported negligible symptoms, both in the control group and the intervention groups. However, most of the infected participants were potentially infectious, with relatively high viral loads (nucleocapsid gene cycle threshold, ≤25) (Table S6). Vaccine efficacy was estimated to be higher for the prevention of symptomatic disease (43% for BNT162b2 and 31% for mRNA-1273) (Fig. S4).
Limitations of the study include its nonrandomized design and the 1-week difference between enrollment in the two intervention groups, generating potential biases. To overcome this, we assessed each intervention group separately and used a Poisson model accounting for calendar time. In addition, despite similar requests for weekly SARS-CoV-2 testing, adherence was slightly lower in the control group. We did not sequence the infecting virus and cannot be absolutely certain that all cases were caused by the omicron variant; however, during the study period, omicron accounted for 100% of the isolates that were typed. Finally, our cohort was too small to allow for accurate determination of vaccine efficacy. However, within the wide confidence intervals of our estimates, vaccine efficacy against symptomatic disease was 65% at most.
Our data provide evidence that a fourth dose of mRNA vaccine is immunogenic, safe, and somewhat efficacious (primarily against symptomatic disease). A comparison of the initial response to the fourth dose with the peak response to a third dose did not show substantial differences in humoral response or in levels of omicron-specific neutralizing antibodies. Along with previous data showing the superiority of a third dose to a second dose,4 our results suggest that maximal immunogenicity of mRNA vaccines is achieved after three doses and that antibody levels can be restored by a fourth dose. Furthermore, we observed low vaccine efficacy against infections in health care workers, as well as relatively high viral loads suggesting that those who were infected were infectious. Thus, a fourth vaccination of healthy young health care workers may have only marginal benefits. Older and vulnerable populations were not assessed.
Gili Regev-Yochay, M.D.
Tal Gonen, B.A.
Mayan Gilboa, M.D.
Sheba Medical Center Tel Hashomer, Ramat Gan, Israel
[email]gili.regev@sheba.health.gov.il[/email]
Michal Mandelboim, Ph.D.
Victoria Indenbaum, Ph.D.
Ministry of Health, Ramat Gan, Israel
Sharon Amit, M.D.
Lilac Meltzer, B.Sc.
Keren Asraf, Ph.D.
Carmit Cohen, Ph.D.
Ronen Fluss, M.Sc.
Asaf Biber, M.D.
Sheba Medical Center Tel Hashomer, Ramat Gan, Israel
Ital Nemet, Ph.D.
Limor Kliker, M.Sc.
Ministry of Health, Ramat Gan, Israel
Gili Joseph, Ph.D.
Ram Doolman, Ph.D.
Sheba Medical Center Tel Hashomer, Ramat Gan, Israel
Ella Mendelson, Ph.D.
Ministry of Health, Ramat Gan, Israel
Laurence S. Freedman, Ph.D.
Dror Harats, M.D.
Yitshak Kreiss, M.D
Sheba Medical Center Tel Hashomer, Ramat Gan, Israel
Yaniv Lustig, Ph.D.
Ministry of Health, Ramat Gan, Israel
Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.
This letter was published on March 16, 2022, at NEJM.org.
Deidentified data will be made available on request.
Drs. Kreiss and Lustig contributed equally to this letter.
[/Quote]
[url]https://www.nejm.org/doi/full/10.1056/NEJMc2202542[/url]
another Ivermectin discussion
[url]https://www.jpost.com/health-and-wellness/coronavirus/article-703050[/url]
[QUOTE=x-trainer ben;1659113553]another Ivermectin discussion
[url]https://www.jpost.com/health-and-wellness/coronavirus/article-703050[/url][/QUOTE]
At this point the Ivermectin bandwagon has crashed and burned.
[QUOTE=Reliance012;1659114813]At this point the Ivermectin bandwagon has crashed and burned.[/QUOTE]
Your average miscer still thinks it's the wonder cure
[img]https://i.imgur.com/XEj2e3d.png[/img]
Looking good pockets
[QUOTE=mgftp;1659135793]Looking good pockets[/QUOTE]
LMAO, Thanks my man...
Got a jab today (Pfizer)
This is on top of 1st - AZ in April 2021
2nd Pfizer in June 2021
COVID infection end of January
Any clinical benefit from getting it is probably small and close to zero, but need it to keep current vaccinations for foreign travel -- so motivation is BS paperwork.
Hopefully it's my last COVID jab ever!
[QUOTE=OldFartTom;1659474793]Got a jab today (Pfizer)
This is on top of 1st - AZ in April 2021
2nd Pfizer in June 2021
COVID infection end of January
Any clinical benefit from getting it is probably small and close to zero, but need it to keep current vaccinations for foreign travel -- so motivation is BS paperwork.
Hopefully it's my last COVID jab ever![/QUOTE]
Ya that’s a negative. If they can keep people taking them they will do that. It has nothing to do with health, and everything to do with money. Look at all these boosted politicians getting covid, then claiming it would have been worse without it. LMAO it is barely a cold at this point.
[QUOTE=OldFartTom;1659474793]Got a jab today (Pfizer)
This is on top of 1st - AZ in April 2021
2nd Pfizer in June 2021
COVID infection end of January
Any clinical benefit from getting it is probably small and close to zero, but need it to keep current vaccinations for foreign travel -- so motivation is BS paperwork.
Hopefully it's my last COVID jab ever![/QUOTE]
How bad was that infection and recovery from Jan? Was it worse than side effects from the vaccine?
I’m contemplating getting a booster. Got 1st and 2nd jab almost the same timeframe as you last year
[QUOTE=TryingBB;1659500003]How bad was that infection and recovery from Jan? Was it worse than side effects from the vaccine?
I’m contemplating getting a booster. Got 1st and 2nd jab almost the same timeframe as you last year[/QUOTE]
In rigorous study of 100% of the population (of the people living in my house called Tom) using key indicators such as how do I feel in general and am I extra *** when doing squats (The LWW diagnostic framework) I can report the study findings as follows
* 1st jab: sick as a dog for 12 hours, slightly sick for 12 hours, fine after that
* 2nd jab: slightly ill for 24 hours and missed training next morning, next session wasn't missed but a poor score on the LWW scale otherwise OK
* Covid infection: First alerted by strong and unexpected LWW-test result, next day started to felt very ill for 12 hours and then very very slightly ill for a week
* Booster yesterday: really sore left arm!! although I did a lot of top-half-of-OHP and top-half-of-dips accessory work on the morning of the booster and triceps were sore already (weird half exercises because my OHP has a bad sticking point at top) so maybe that doesn't help. Didn't go for morning jog as just wasn't feeling it, don't feel at my best today but wouldn't describe myself as ill
There... results based on 100% of the population, so methodologically absolutely sound, feel free to use it for important public policy decisions.
Great review Tom, lmao!
The local news just told us that mask mandates for universities are returning due to rising cases in the DC region. Plus that large white house gathering spread ba2 to a bunch of politicians, so there is that.
Here we go ....
On the weekend, around here....in Home Depot, the grocery store and Walmart..... heavy mask use.
Also we have lost some folks to self isolation for testing positive, some have returned...... everyone else in the building is back to masking
All voluntary.....LOL.