[QUOTE=JustTheDad;1651386913]I will try to pay better attention Miss Cass.
and
yeah, I guess we often do.
Also, don't forget that I'm only planning to wait a couple of months to see if anyone has a phase 3 vaccine study running on a more delta specific antigen. I know Curevac is working on a second vaccine and pulled their first version, but I don't know if the sequence if different, or if they simply changed the carrier or something else.
Companies may not bother to modify the S protein for a lot of reasons, one of which is that the delta variant's S protein is still very close to the original S protein. I believe the changes in the S protein are primarily in the S1 subunit of the protein where the receptor binding domain is. According to what I've read that makes it better at binding to ACE receptors. I tend to think of it as S1 grabs your cell and S2 tunnels through to inject your cell with the genome. If the area on the Delta spike protein that changed isn't a strong antigenic site, meaning it isn't one of the epitopes that anti-covid antibodies bind to, then there may not be a better mRNA code to use. In that case, using the current vaccines might be as good as it gets for a long time. Scary stuff, right? But like I said, I'm comfortable waiting a couple of months to see. If I ever get a chance to speak with a conformational or structural biologist or biochemist doing research on this, I'll ask. Maybe the answer is out there but I can't find it. The bottom line is I don't know if modifying the current mRNA to match the delta variant's spike protein would help. It might just be that the delta variant is so much better at binding to our cells that we are getting exposed to higher loads from infected people and higher Ab levels is the best we can do for now. That's why I try not to discourage anyone who is concerned from getting a booster. I wish I had better answers for you guys but I don't right now. Sorry.[/QUOTE]
It's ok. I won't blame you if I get covid and die.
[QUOTE=TryingBB;1651398553]You don’t have a clue where they were a few minutes ago. Stop judging. Maybe they don’t wanna take it off and put it on over and over again? Easier to make peace with it and keep it on sometimes.
But sure is a cringe when I see people riding in a car by themselves and have a mask on. Now that’s fkn retarted[/QUOTE]
I wear it outside and in car sorry that y'all mad.