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View Full Version : Mystery illness causes man's muscles to grow



nice1guv
06-19-2012, 10:32 PM
Take a look at this guy, he apparently has an illness that causes his muscles to grow without lifting weights.

http://news.ninemsn.com.au/national/8486587/painful-condition-makes-aussie-look-like-bodybuilder

Oceanside
06-19-2012, 11:10 PM
they need to cut off his nuts !

GuyJin
06-19-2012, 11:15 PM
The lack of myostatin gene is strong with this one. Seems like the gene turns itself on and off whenever it wants to. Weirdest thing I've ever read.

2nd_chance
06-19-2012, 11:40 PM
Mostly what I see is a big fat a$$

http://images.ninemsn.com.au/resizer.aspx?url=http://news.ninemsn.com.au/img/2012/national/2006_Jando_sp.jpg&width=310

nice1guv
06-19-2012, 11:49 PM
Mostly what I see is a big fat a$$

http://images.ninemsn.com.au/resizer.aspx?url=http://news.ninemsn.com.au/img/2012/national/2006_Jando_sp.jpg&width=310

My thoughts exactly, but he claims to have had 25inch calves and 15 operations to remove muscle that keeps growing.

I think a cut is in order.

capnsavem
06-19-2012, 11:56 PM
Mostly what I see is a big fat a$$

http://images.ninemsn.com.au/resizer.aspx?url=http://news.ninemsn.com.au/img/2012/national/2006_Jando_sp.jpg&width=310

look closely at his arms and shoulders though. he has some mass for a guy that doesn't work out.

IronCharles
06-20-2012, 12:02 AM
The lack of myostatin gene is strong with this one. Seems like the gene turns itself on and off whenever it wants to. Weirdest thing I've ever read.This is my guess as well, especially since he has heart problems, and myostatin plays a key role in heart function. That's why, even if they can block myostatin now, it's unsafe for humans because of the cardiological implications.

pvsampson
06-20-2012, 12:13 AM
This is my guess as well, especially since he has heart problems, and myostatin plays a key role in heart function. That's why, even if they can block myostatin now, it's unsafe for humans because of the cardiological implications.

OK,srs question.As creatine has been shown to be effective in reducing myostatin levels,does this therefore increase ones chance of heart damage or possible failure if using creatine?

EDIT:Found what I was looking for,to an extent.

GuyJin
06-20-2012, 01:53 AM
OK,srs question.As creatine has been shown to be effective in reducing myostatin levels,does this therefore increase ones chance of heart damage or possible failure if using creatine?

EDIT:Found what I was looking for,to an extent.

---

Don't know what sources you looked at, but from what I read, creatine helps improve cardiac function to an extent even on those patients who've suffered heart damage. I'll try to look for a couple of sources later on when time permits.

pvsampson
06-20-2012, 02:22 AM
---

Don't know what sources you looked at, but from what I read, creatine helps improve cardiac function to an extent even on those patients who've suffered heart damage. I'll try to look for a couple of sources later on when time permits.

Yeah,pretty much what I found as well.It seems the reduction of myostatin is not significant enough to cause any damage to heart tissue

IronCharles
06-20-2012, 02:38 AM
http://repository.upenn.edu/dissertations/AAI3345907/


Myostatin overexpression leads to decreased and myostatin inhibition to increased cardiac growth both in vitro and in vivo due to modulation of Akt and NFAT3 pathways. This is the first clinical evidence that myostatin activation is increased in HF, where myostatin may negatively regulate cardiac hypertrophy and may mediate regression of cellular hypertrophy after mechanical unloading with LVAD support. In vitro and in this mouse model, myostatin negatively regulates cardiac growth



Note that it says "myostatin inhibition (leads) to increased cardiac growth". Does that mean enlarged heart? Or normal growth?

pvsampson
06-20-2012, 03:43 AM
If the heart in vitro is growing normally,I would read that to say an enlarged heart.

I was curious as to the effects on cardiac function whilst using a supplement that inhibits myostatin in adults.It seems there are no serious,if any,effects of creatine reduced myostatin levels on the heart known,at this point.

Very interesting though.If an inhibitor was developed and released,it would definitely be cause for debate as to whether it would be made available,or allowed,to be used for enhancing sports performance

GuyJin
06-20-2012, 05:44 AM
http://repository.upenn.edu/dissertations/AAI3345907/





Note that it says "myostatin inhibition (leads) to increased cardiac growth". Does that mean enlarged heart? Or normal growth?

--

The study you quoted (and thank you) talks about a mouse model and in vitro growth which is not the same as in vivo growth. This is not to say the same thing might not happen or it might--I have not seen any human models yet for obvious ethical reasons. There has been very little follow-up on the two young boys who were born with either the suppression of or deletion of the myostatin gene. So far they seem to be healthy but who knows what will happen down the road?

crupiea
06-20-2012, 09:14 AM
I think I suffer from this too.

Its called burritoitis.

Karl_Hungus
06-20-2012, 09:23 AM
My guess is there is more to it than just myostatin deficiency -- It causes him debilitating pain to where he has trouble walking. Animals with this deficiency do not seem to be physically disabled in the way this guy claims to be.

ArchAngel'73
06-20-2012, 09:54 AM
Very interesting though.If an inhibitor was developed and released,it would definitely be cause for debate as to whether it would be made available,or allowed,to be used for enhancing sports performance

There are inhibitors out there.
They were developed and released about the same time we saw a 287 lb. 3% bodyfat Mr. Olympia.;)
Imo, there is no debate. Its a performance enhancing substance and should be treated as such, banned from athletic competition.
But un-tested bodybuilders gonna be bodybuilders and take everything under the sun to get an edge.

MontyMagpie
06-22-2012, 06:02 PM
My thoughts exactly, but he claims to have had 25inch calves and 15 operations to remove muscle that keeps growing.

I think a cut is in order.

At one point, Mr Jando's calf muscle was so swollen it measured 55cm around.

55cm =21.6". My OH calves are 52cm, She has strong calves for 5ft2.

Phattso
06-22-2012, 06:49 PM
Looks more like bloating than muscles.

Vytis
06-23-2012, 04:58 AM
I think they're confusing extreme water/fluid retention in his muscles with actual muscle tissue....I was expecting to see a pic of some huge, ripped guy....not the case.

pharmamarketer
06-23-2012, 05:50 AM
Yeh. If he has to live with this it would at least be nice to look like big/jacked motha fuker.

On a serious note, I feel bad for this guy. It must be hell having to live with that



Mostly what I see is a big fat a$$

http://images.ninemsn.com.au/resizer.aspx?url=http://news.ninemsn.com.au/img/2012/national/2006_Jando_sp.jpg&width=310