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CognitiveNutrition
03-07-2008, 03:57 AM
Anyone interested in natural safe legal supplements that boost your endocannabinoid system?

CognitiveNutrition
03-07-2008, 04:31 AM
The endocannabinoid system (ECS) tightly regulates the probability of neurotransmitter release in a host of neuronal tissues like the hippocampus, amygdala, basal ganglia, and cerebellum[1][2][3]. Data from immunologists, developmental biologists, and embryologists show that the ECS is also intimately involved in crosstalk between lymphocytes and synchronizing the timing between uterine receptivity and embryo implantation[4][5]. In the central nervous system, however, the ECS is involved in a specific type of retrograde signaling in which endogenous cannabinoids (endocannabinoids) are released from the post-synaptic neuron and bind to nearby cannabinoid receptor 1 (CB1) -expressing presynapses; this binding elicits a sharp, but temporary, suppression of presynaptic neurotransmitter release. In this way, the post-synaptic neuron can regulate its own excitability by adjusting synaptic inputs via endocannabinoids that act as retrograde messengers. The endocannabinoid system is thought to be important in long-term potentiation and memory[6][7], motor learning[8], and synaptic plasticity[9].

^ Fortin DA, Levine ES (2007). "Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons". Cereb. Cortex 17 (1): 163?74. doi:10.1093/cercor/bhj133. PMID 16467564. 
^ Good CH (2007). "Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells". J. Neurosci. 27 (1): 1?3. PMID 17205618. 
^ Hashimotodani Y, Ohno-Shosaku T, Kano M (2007). "Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus". J. Neurosci. 27 (5): 1211?9. doi:10.1523/JNEUROSCI.4159-06.2007. PMID 17267577. 
^ Paria BC, Song H, Wang X, et al (2001). "Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation". J. Biol. Chem. 276 (23): 20523?8. doi:10.1074/jbc.M100679200. PMID 11279117. 
^ Paria BC, Wang H, Dey SK (2002). "Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation". Chem. Phys. Lipids 121 (1-2): 201?10. PMID 12505701. 
^ Arenos JD, Musty RE, Bucci DJ (2006). "Blockade of cannabinoid CB1 receptors alters contextual learning and memory". Eur. J. Pharmacol. 539 (3): 177?83. doi:10.1016/j.ejphar.2006.04.017. PMID 16716290. 
^ van Beugen BJ, Nagaraja RY, Hansel C (2006). "Climbing fiber-evoked endocannabinoid signaling heterosynaptically suppresses presynaptic cerebellar long-term potentiation". J. Neurosci. 26 (32): 8289?94. doi:10.1523/JNEUROSCI.0805-06.2006. PMID 16899723. 
^ Kishimoto Y, Kano M (2006). "Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning". J. Neurosci. 26 (34): 8829?37. doi:10.1523/JNEUROSCI.1236-06.2006. PMID 16928872. 
^ Brenowitz SD, Regehr WG (2005). "Associative short-term synaptic plasticity mediated by endocannabinoids". Neuron 45 (3): 419?31. doi:10.1016/j.neuron.2004.12.045. PMID 15694328. 

Patrick Arnold
03-07-2008, 05:09 AM
Anyone interested in natural safe legal supplements that boost your endocannabinoid system?

i think if it gives a discernable euphoria or something like appetite stimulation then people would care

i don't think people will care if its something you do not feel

p.s. if it works too well then you risk prosecution under the controlled substance analog act

CognitiveNutrition
03-07-2008, 05:10 AM
i think if it gives a discernable euphoria or something like appetite stimulation then people would care

i don't think people will care if its something you do not feel

p.s. if it works too well then you risk prosecution under the controlled substance analog act

I agree.

Haha that too.

BuckeyeMuscle
03-07-2008, 05:12 AM
I think PA hit the nail on the head....But if it does cause some euphoria then I'd be interested :D

Since I'm dieting, its nice to be able to take something before I go out to the bars with all my friends since all I can drink there is water :(

Bliss Shots (Kanna) seem to be my best option right now, and they are pretty decent....just very expensive.

CognitiveNutrition
03-07-2008, 05:15 AM
I think PA hit the nail on the head....But if it does cause some euphoria then I'd be interested :D

Since I'm dieting, its nice to be able to take something before I go out to the bars with all my friends since all I can drink there is water :(

Bliss Shots (Kanna) seem to be my best option right now, and they are pretty decent....just very expensive.

Some people use phenibut for this purpose.

BuckeyeMuscle
03-07-2008, 05:18 AM
Some people use phenibut for this purpose.

Yeah, I didn't get too much from phenibut. I used up to 2.5 grams and didn't feel anything. I'm thinking about buying some more to try using it with Bliss Shots. But when I have the Bliss Shots I drink a whole one (2 servings), and its already pretty strong.

CognitiveNutrition
03-07-2008, 05:23 AM
Yeah, I didn't get too much from phenibut. I used up to 2.5 grams and didn't feel anything. I'm thinking about buying some more to try using it with Bliss Shots. But when I have the Bliss Shots I drink a whole one (2 servings), and its already pretty strong.

Interesting. Maybe some lsd or lsa next time?

sobelik
03-07-2008, 05:38 AM
Interesting. Maybe some lsd or lsa next time?
Hahaha you have to be careful with getting LSA from morning glory, get the organic non coated seeds...or else trouble is going to happen

CognitiveNutrition
03-07-2008, 05:40 AM
Hahaha you have to be careful with getting LSA from morning glory, get the organic non coated seeds...or else trouble is going to happen

Good advice but I would rather use Hawaiian baby woodrose instead.

MrOneEyedBoh
03-07-2008, 05:41 AM
how many do you have to eat? hawaiian

CognitiveNutrition
03-07-2008, 05:41 AM
how many do you have to eat? hawaiian

4-6.

MrOneEyedBoh
03-07-2008, 05:43 AM
eating is the best right? bc i know you can extract with like 151 alchol

CognitiveNutrition
03-07-2008, 05:46 AM
eating is the best right? bc i know you can extract with like 151 alchol

Eating is recommended but nausea can be common especially in higher doses.

pittbleauxs
03-07-2008, 05:53 AM
Yeah, I didn't get too much from phenibut. I used up to 2.5 grams and didn't feel anything. I'm thinking about buying some more to try using it with Bliss Shots. But when I have the Bliss Shots I drink a whole one (2 servings), and its already pretty strong.

What kind (brand) of Phenibut did you use?

IBE Labs
03-07-2008, 12:45 PM
endocannabinoid are nothing but fatty acids and as nothing to do with THC in terms of analog but only in pharmacology so how can you get prosecuted? endocannabinoid only bind to the cannabinoid receptors thats it





i think if it gives a discernable euphoria or something like appetite stimulation then people would care

i don't think people will care if its something you do not feel

p.s. if it works too well then you risk prosecution under the controlled substance analog act

Patrick Arnold
03-07-2008, 01:51 PM
endocannabinoid are nothing but fatty acids and as nothing to do with THC in terms of analog but only in pharmacology so how can you get prosecuted? endocannabinoid only bind to the cannabinoid receptors thats it


what is the exact wording of the analog act? does it require chemical similarity?


and what constitutes chemical similarity? that is such an arbitrary term

these controlled substances laws are messed up


and are you saying that THC does more than bind to cannabinoid receptors? i don't follow your last statement

CognitiveNutrition
03-07-2008, 01:56 PM
what is the exact wording of the analog act? does it require chemical similarity?


and what constitutes chemical similarity? that is such an arbitrary term

these controlled substances laws are messed up


and are you saying that THC does more than bind to cannabinoid receptors? i don't follow your last statement

The laws are very vague and up to how they view it not us sadly.

quigs
03-07-2008, 08:03 PM
I think PA hit the nail on the head....But if it does cause some euphoria then I'd be interested :D

Since I'm dieting, its nice to be able to take something before I go out to the bars with all my friends since all I can drink there is water :(

Bliss Shots (Kanna) seem to be my best option right now, and they are pretty decent....just very expensive.


Bliss shots would be okay if they didn't throw in a s-load of yohimbine. I'm a fan of kanna, but when combined with that much yohimbine it made me feel like i was gonna crawl out of my skin.

Give kratom a shot, its much better than kanna/bliss shots.

anth28
03-07-2008, 08:28 PM
If it will take me to higher points of philosophical awareness and prevent me from smelling like ganja, then I would be interested :D

bongd
03-07-2008, 08:31 PM
Good advice but I would rather use Hawaiian baby woodrose instead.

I still have a bunch of HBWR seeds. What a trip (in the literal sense) :o :(

Ohh, and Steve. Empty your PM box!

EMartNJ
03-07-2008, 08:35 PM
do you even have to ask if people would be interested in this?

in any case my answer is yes. i hope when i come back from boot camp i can try out the synesthesia/endocannabinoid stack ;)

NO HYPE
03-07-2008, 08:53 PM
Any correlation between enhanced endocannabinoid functions and the proposed synesthetic response of the other product? Just curious.