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  1. #1
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    Opiorphin: a natural painkiller in YOUR spit

    This could explain why animals lick their wounds beyond what is necessary to clean them. This drug is apparently several times stronger than morphine.

    This article also mentions that the chemical may not be addictive or cause withdrawal symptoms like opiates (morphine, codeine, etc.) do. If it's feasible to extract this drug from human saliva in amounts that are great enough to be used recreationally, we may see a movement by the government to make possession of the drug illegal. This would present an ethical paradox, though, because the drug is created naturally by the human body.

    However, that hasn't stopped the government before. Possession of diethyltryptamine (DMT), a powerful hallucinogenic which occurs naturally in many plants as well as in the pineal gland of the human brain, is also illegal. The drug is non-addictive and has no withdrawal symptoms, is not abused by a significant number of people, and is produced naturally in the human brain, yet it is banned by the government.

    I think that these types of chemicals raise many interesting questions about the nature of drug prohibition. What properties do chemicals have that make them dangerous to society? Should drugs which already occur naturally in the body be prohibited as well? Why should the government regulate what substances we put into our own bodies Furthermore, why are obviously harmful and dangerous drugs like alcohol and tobacco legal when other drugs which have almost no negative effects are illegal?

    Regardless, this is a great discovery and if the drug has few side effects, it could greatly improve modern medicine. I hope you guys enjoy the article.

    Saliva from humans has yielded a natural painkiller up to six times more powerful than morphine, researchers say.

    The substance, dubbed opiorphin, may spawn a new generation of natural painkillers that relieve pain as well as morphine but without the addictive and psychological side effects of the traditional drug.

    When the researchers injected a pain-inducing chemical into rats’ paws, 1 milligram of opiorphin per kilogram of body weight achieved the same painkilling effect as 3 milligrams of morphine.

    The substance was so successful at blocking pain that, in a test involving a platform of upended pins, the rats needed six times as much morphine as opiorphin to render them oblivious to the pain of standing on the needle points.
    Anti-depressive angle

    “Its pain-suppressive effect is like that of morphine,” says Catherine Rougeot at the Pasteur Institute in Paris, France, who led the research. “But we have to test its side effects as it is not a pure painkiller,” she says. “It may also be an anti-depressive molecule.”

    Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins.

    Opiorphin is such a simple molecule that it should be possible to synthesise it and produce large quantities without having to isolate it from saliva, Rougeot explains. Alternatively, it might be possible to find drugs which trigger patients’ bodies to produce more of the molecule themselves.

    Journal reference: Proceedings of the National Academy of Sciences (vol 103, p 17979)
    http://www.newscientist.com/article....ine-news_rss20
    Last edited by Fidelis; 11-15-2006 at 03:02 PM.
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  2. #2
    Registered User DigitalMuscle's Avatar
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    Originally Posted by Fidelis
    This could explain why animals lick their wounds beyond what is necessary to clean them. This drug is apparently several times stronger than morphine.

    This article also mentions that the chemical may not be addictive or cause withdrawal symptoms like opiates (morphine, codeine, etc.) do. If it's feasible to extract this drug from human saliva in amounts that are great enough to be used recreationally, we may see a movement by the government to make possession of the drug illegal. This would present an ethical paradox, though, because the drug is created naturally by the human body.

    However, that hasn't stopped the government before. Possession of diethyltryptamine (DMT), a powerful hallucinogenic which occurs naturally in many plants as well as in the pineal gland of the human brain, is also illegal. The drug is non-addictive and has no withdrawal symptoms, is not abused by a significant number of people, and is produced naturally in the human brain, yet it is banned by the government.

    Regardless, this is a great discovery and if the drug has few side effects, it could greatly improve modern medicine. I hope you guys enjoy the article.


    http://www.newscientist.com/article....ine-news_rss20
    Further proof of G-ds existence!
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  3. #3
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    Originally Posted by DigitalMuscle
    Further proof of G-ds existence!
    Of course, anything is proof of God's existence from your perspective.

    From now on, if those of you reading this would oblige me, please contribute something more than "Haha proof of God" or "Hey great this proves evolution". I want a discussion, not an opinion poll about your view on science and religion.
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    I'm sure people would find a way to abuse this just like every other pain-killer known to man.

    Originally Posted by Fidelis
    However, that hasn't stopped the government before. Possession of diethyltryptamine (DMT), a powerful hallucinogenic which occurs naturally in many plants as well as in the pineal gland of the human brain, is also illegal. The drug is non-addictive and has no withdrawal symptoms, is not abused by a significant number of people, and is produced naturally in the human brain, yet it is banned by the government.
    Does this mean humans are illegal?
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    How does it act as a painkiller? I don't find cuts and wounds any less painful when I lick them.
    People should not be afraid of governments; Governments should be afraid of people.

    I don't believe in any eye for an eye; I believe in two eyes for an eye.
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    LOL

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  7. #7
    Archaeologist Fidelis's Avatar
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    Originally Posted by monkeylips
    Does this mean humans are illegal?
    I guess so.

    Yeah, I think it's a really stupid substance to outlaw. It's definitely not likely to be abused by lots of people because it's a very, very potent and short-acting hallucinogen. It's not something anyone would take for fun at a party. It's used by indigenous peoples of South and Central America for religious purposes.

    Originally Posted by NicVJ
    How does it act as a painkiller? I don't find cuts and wounds any less painful when I lick them.
    If I'm not mistaken, the article briefly describes how it works.

    edit: yeah

    "Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins."

    It seems strange, though... does it have to travel from the wound into the bloodstream and eventually to the spine?
    Last edited by Fidelis; 11-15-2006 at 11:11 PM.
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  8. #8
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    Originally Posted by Fidelis
    I guess so.

    Yeah, I think it's a really stupid substance to outlaw. It's definitely not likely to be abused by lots of people because it's a very, very potent and short-acting hallucinogen. It's not something anyone would take for fun at a party. It's used by indigenous peoples of South and Central America for religious purposes.


    If I'm not mistaken, the article briefly describes how it works.

    edit: yeah

    "Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins."

    It seems strange, though... does it have to travel from the wound into the bloodstream and eventually to the spine?

    Ya people use their pineal gland to trip balls at all those televangelist concerts. You see them shaking around and falling over. Same thing with the south american dances. Pineal gland has to be made Schedule 1. Detain every human with brain
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    If your talking about the ayahuasca-using tribes of the Amazon then Dmt is definately not short-acting. They also used it for tribal wars in an effort to 'see' their enemies.

    But you're right, Dmt cannot be abused. Most people who take it (especially in ayahuasca form) never take it again (cos the got their butts kicked).
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    Originally Posted by Fidelis
    Of course, anything is proof of God's existence from your perspective.

    From now on, if those of you reading this would oblige me, please contribute something more than "Haha proof of God" or "Hey great this proves evolution". I want a discussion, not an opinion poll about your view on science and religion.
    You are aware that you are in a religious forum correct? If you do not like it, post somewhere else!
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  12. #12
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    Originally Posted by monkeylips
    If your talking about the ayahuasca-using tribes of the Amazon then Dmt is definately not short-acting. They also used it for tribal wars in an effort to 'see' their enemies.

    But you're right, Dmt cannot be abused. Most people who take it (especially in ayahuasca form) never take it again (cos the got their butts kicked).
    It is definitely short-acting.

    http://www.erowid.org/chemicals/dmt/dmt_dose.shtml

    edit: I should mention that drinking it as a tea does make the duration longer, but the trip isn't as intense. I can't remember which website I read that at but that's true for any drug that's eaten and not IV'd, snorted, smoked, etc.

    Originally Posted by DigitalMuscle
    You are aware that you are in a religious forum correct? If you do not like it, post somewhere else!
    Yes, I am aware. However, that doesn't mean that every thread is appropriate for religious discussion. If you want to talk about how opiorphin is proof of God, go ahead; just make your own thread.
    Last edited by Fidelis; 11-16-2006 at 07:02 AM.
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    Originally Posted by Fidelis
    It is definitely short-acting.

    http://www.erowid.org/chemicals/dmt/dmt_dose.shtml


    Yes, I am aware. However, that doesn't mean that every thread is appropriate for religious discussion. If you want to talk about how opiorphin is proof of God, go ahead; just make your own thread.
    Relegious forum = relegious discussion!

    Do you fail to see the connection between opiorphin in your spit and the world being created by design?
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    Originally Posted by Fidelis
    edit: I should mention that drinking it as a tea does make the duration longer, but the trip isn't as intense. I can't remember which website I read that at but that's true for any drug that's eaten and not IV'd, snorted, smoked, etc.
    The tribes in the Amazon either used the tea (ayahuasca) or snorted it. Neither is as strong as smoking it which only came about recently. Drinking the tea also requires another drug (a MAOI) to stop Dmt being digested which changes the effect of the drug and lasts almost 10 hrs. This tea is the traditional way of taking Dmt and produces a more profound, long-lasting spiritual effect for the user.

    While smoking Dmt is more intense, it is often so far-out there and short-lasting that it becomes difficult to intergrate the experience into ones existing knowledge schemas. It is also quite difficult to remember the peak of the experience.
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    Originally Posted by DigitalMuscle
    Further proof of G-ds existence!
    Remember the story in John 9 when Jesus healed the blind man by spitting in the dirt then rubbing it in the mans eyes?
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    Originally Posted by DigitalMuscle
    Relegious forum = relegious discussion!

    Do you fail to see the connection between opiorphin in your spit and the world being created by design?
    Please get out and stay out of this thread. I've stated more than once that this particular thread is not for a religious discussion. This is like going into a thread in Workout Programs that's about 5x5 and then talking about an entirely different program, then saying "Well it's a workout program forum!"

    Next time I'm just going to neg.
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    are there any articles on how to use it, or in emergency cases would it work without extracting it from saliva?
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    Originally Posted by James717 View Post
    are there any articles on how to use it, or in emergency cases would it work without extracting it from saliva?
    I'm sure those who have responded to this thread are still monitoring it five years later. Strong bump.
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    This is why I spit on the homeless
    My prescription for anxiety RELIEF
    http://forum.bodybuilding.com/showthread.php?t=156287103&pagenumber=

    Lift moderately, not too much or else you'll fear your own strength
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  20. #20
    I Am therefore I Am Spuddy's Avatar
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    Originally Posted by stezus View Post
    This is why I spit on the homeless
    Yeah I always like to rub a little spit in their wounds
    Be.
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  21. #21
    Ἐν ἀρχῇ ἦν ὁ Λόγος lasher's Avatar
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    Originally Posted by Spuddy View Post
    Yeah I always like to rub a little spit in their wounds
    You need to put some spit on that nose bro.
    "Dionysus has undone us. Too late I see it."

    "A liar is someone who willfully misplaces his ontological predicates."

    "Error has no rights." - Pope Leo XIII

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    *52 Books In 52 Weeks Crew*
    RIP 530

    #JustIbnKutubThings
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  22. #22
    Barbarian Spartan5364's Avatar
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    what a bump...
    how do people come across these necro threads?
    *cold approach girls and they think I'm a beggar crew*

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  23. #23
    Gainz Hunter Posthardcore's Avatar
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    BUMP OF FUKKING PEACE LMAO

    Originally Posted by Spartan5364 View Post
    what a bump...
    how do people come across these necro threads?
    they probably either use the search or click on a ''related thread''
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  24. #24
    I Am therefore I Am Spuddy's Avatar
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    Originally Posted by lasher View Post
    You need to put some spit on that nose bro.
    On it.. If I don't have any concentrated natural spit opiates available, can I put other synthesized opiates in my nose instead?
    Be.
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  25. #25
    Neosapien illriginalized's Avatar
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    INB4 big pharma companies pay FDA and FDA bans human saliva lulz

    Originally Posted by monkeylips View Post
    But you're right, Dmt cannot be abused. Most people who take it (especially in ayahuasca form) never take it again (cos the got their butts kicked).
    lulz dat purge effect from dat der ayahuasca.
    أشهد أن لا إله إلاَّ الله و أشهد أن محمد رسول الله
    I do not hate Jews. What I specifically dislike is racial/ethnic supremacy and extremism that inevitably contradicts a root belief system. An example is Jewish (ethnic) supremacy aka Zionists. This is not exclusive to Jews nor their religion, there is in fact Arab zionists, Muslim zionists, Christian zionists, American zionists, Democrat zionists, and even atheist zionists.
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    Fanculo la democrazia! Morte al liberalismo!
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  26. #26
    Banned JoshSP1985's Avatar
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    The OP is interesting something must have fell through with the studies as I haven't heard anything about it.

    Better than morphine pain killer is a pretty big headline.
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