This could explain why animals lick their wounds beyond what is necessary to clean them. This drug is apparently several times stronger than morphine.
This article also mentions that the chemical may not be addictive or cause withdrawal symptoms like opiates (morphine, codeine, etc.) do. If it's feasible to extract this drug from human saliva in amounts that are great enough to be used recreationally, we may see a movement by the government to make possession of the drug illegal. This would present an ethical paradox, though, because the drug is created naturally by the human body.
However, that hasn't stopped the government before. Possession of diethyltryptamine (DMT), a powerful hallucinogenic which occurs naturally in many plants as well as in the pineal gland of the human brain, is also illegal. The drug is non-addictive and has no withdrawal symptoms, is not abused by a significant number of people, and is produced naturally in the human brain, yet it is banned by the government.
I think that these types of chemicals raise many interesting questions about the nature of drug prohibition. What properties do chemicals have that make them dangerous to society? Should drugs which already occur naturally in the body be prohibited as well? Why should the government regulate what substances we put into our own bodies Furthermore, why are obviously harmful and dangerous drugs like alcohol and tobacco legal when other drugs which have almost no negative effects are illegal?
Regardless, this is a great discovery and if the drug has few side effects, it could greatly improve modern medicine. I hope you guys enjoy the article.
http://www.newscientist.com/article....ine-news_rss20Saliva from humans has yielded a natural painkiller up to six times more powerful than morphine, researchers say.
The substance, dubbed opiorphin, may spawn a new generation of natural painkillers that relieve pain as well as morphine but without the addictive and psychological side effects of the traditional drug.
When the researchers injected a pain-inducing chemical into rats’ paws, 1 milligram of opiorphin per kilogram of body weight achieved the same painkilling effect as 3 milligrams of morphine.
The substance was so successful at blocking pain that, in a test involving a platform of upended pins, the rats needed six times as much morphine as opiorphin to render them oblivious to the pain of standing on the needle points.
“Its pain-suppressive effect is like that of morphine,” says Catherine Rougeot at the Pasteur Institute in Paris, France, who led the research. “But we have to test its side effects as it is not a pure painkiller,” she says. “It may also be an anti-depressive molecule.”
Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins.
Opiorphin is such a simple molecule that it should be possible to synthesise it and produce large quantities without having to isolate it from saliva, Rougeot explains. Alternatively, it might be possible to find drugs which trigger patients’ bodies to produce more of the molecule themselves.
Journal reference: Proceedings of the National Academy of Sciences (vol 103, p 17979)
11-15-2006, 03:59 PM #1
Opiorphin: a natural painkiller in YOUR spit
Last edited by Fidelis; 11-15-2006 at 04:02 PM.
11-15-2006, 04:01 PM #2
11-15-2006, 04:10 PM #3Originally Posted by DigitalMuscle
From now on, if those of you reading this would oblige me, please contribute something more than "Haha proof of God" or "Hey great this proves evolution". I want a discussion, not an opinion poll about your view on science and religion.
11-15-2006, 11:03 PM #4
11-15-2006, 11:20 PM #5
11-15-2006, 11:22 PM #6
11-16-2006, 12:09 AM #7Originally Posted by monkeylips
Yeah, I think it's a really stupid substance to outlaw. It's definitely not likely to be abused by lots of people because it's a very, very potent and short-acting hallucinogen. It's not something anyone would take for fun at a party. It's used by indigenous peoples of South and Central America for religious purposes.
Originally Posted by NicVJ
"Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins."
It seems strange, though... does it have to travel from the wound into the bloodstream and eventually to the spine?
Last edited by Fidelis; 11-16-2006 at 12:11 AM.
11-16-2006, 12:25 AM #8
11-16-2006, 12:29 AM #9
If your talking about the ayahuasca-using tribes of the Amazon then Dmt is definately not short-acting. They also used it for tribal wars in an effort to 'see' their enemies.
But you're right, Dmt cannot be abused. Most people who take it (especially in ayahuasca form) never take it again (cos the got their butts kicked).
11-16-2006, 12:59 AM #10
11-16-2006, 06:25 AM #11
11-16-2006, 07:59 AM #12Originally Posted by monkeylips
edit: I should mention that drinking it as a tea does make the duration longer, but the trip isn't as intense. I can't remember which website I read that at but that's true for any drug that's eaten and not IV'd, snorted, smoked, etc.
Originally Posted by DigitalMuscle
Last edited by Fidelis; 11-16-2006 at 08:02 AM.
11-16-2006, 08:40 AM #13
11-16-2006, 11:09 PM #14Originally Posted by Fidelis
While smoking Dmt is more intense, it is often so far-out there and short-lasting that it becomes difficult to intergrate the experience into ones existing knowledge schemas. It is also quite difficult to remember the peak of the experience.
11-16-2006, 11:12 PM #15Originally Posted by DigitalMuscleCapitol Hill Switchboard: 1-877-242-0100
"Republics are created by the virtue, public spirit, and intelligence of the citizens. They fall, when the wise are banished from the public councils, because they dare to be honest, and the profligate are rewarded, because they flatter the people, in order to betray them." --Joseph Story, Commentaries on the Constitution, 1833
11-16-2006, 11:37 PM #16Originally Posted by DigitalMuscle
Next time I'm just going to neg.
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10-30-2013, 12:34 PM #25أشهد أن لا إله إلاَّ الله و أشهد أن محمد رسول الله
Nvious source of information about Islam: religionofpeace, by a blogger named, "Daniel Greenfield" a known Pro-Zionist Israeli shill.
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