Is there anything bad that can occur from taking too many BCAA's or will they just simple flush out when they are not used.
|
-
02-28-2006, 07:29 PM #1
-
02-28-2006, 07:34 PM #2
-
02-28-2006, 08:00 PM #3
-
02-28-2006, 10:51 PM #4
-
-
02-28-2006, 11:16 PM #5
- Join Date: Jan 2005
- Location: Phoenix, Arizona, United States
- Age: 39
- Posts: 2,412
- Rep Power: 556
i thought i remember reading somewhere that creating a huge imbalance of BCAA's in comparison to other amino acids can cause depression. i think someone posted that on AM. however, i have never noticed this or seen others report this problem. i would consider BCAA's one of the safer supplements for sure.
-
02-28-2006, 11:38 PM #6
-
02-28-2006, 11:41 PM #7
- Join Date: Mar 2004
- Location: New York, United States
- Age: 44
- Posts: 28,068
- Rep Power: 57862
Only if you have Maple Syrup Urine disease. No, I 'm not screwing around and it is a real disease
"Maple syrup urine disease (MSUD) is an aminoacidopathy secondary to an enzyme defect in the catabolic pathway of the branched-chain amino acids leucine, isoleucine, and valine. Accumulation of these 3 amino acids and their corresponding keto acids leads to encephalopathy and progressive neurodegeneration in the infant who is not treated for MSUD. Early diagnosis and dietary intervention prevent complications and may allow for normal intellectual development. "
http://www.emedicine.com/ped/topic1368.htm"I just use my muscles as a conversation piece, like someone walking a cheetah down 42nd Street." - Arnold Schwarzenegger
Heretic....
-
03-01-2006, 12:06 AM #8Originally Posted by bodybuilder45
In the case of lowered dopamine this could lead to increased Prolactin release (which would lower testosterone among other things)
Its just something to keep in mind when taking this stuff. If you are exercising heavily enough this won't happen and you may even get a little energy boost from correcting the deficiency.
Still I never liked the idea of BCAAs for bulking too much. Mainly because BCAA build up is more likely in this scenario.
-
-
03-01-2006, 12:23 AM #9
-
03-01-2006, 05:56 AM #10
-
03-02-2006, 05:35 PM #11
- Join Date: Mar 2004
- Location: New York, United States
- Age: 44
- Posts: 28,068
- Rep Power: 57862
J. Nutr. 135:1531S-1538S, June 2005
Brain Amino Acid Requirements and Toxicity: The Example of Leucine
Glutamic acid is an important excitatory neurotransmitter of the brain. Two key goals of brain amino acid handling are to maintain a very low intrasynaptic concentration of glutamic acid and also to provide the system with precursors from which to synthesize glutamate. The intrasynaptic glutamate level must be kept low to maximize the signal-to-noise ratio upon the release of glutamate from nerve terminals and to minimize the risk of excitotoxicity consequent to excessive glutamatergic stimulation of susceptible neurons. The brain must also provide neurons with a constant supply of glutamate, which both neurons and glia robustly oxidize. The branched-chain amino acids (BCAAs), particularly leucine, play an important role in this regard. Leucine enters the brain from the blood more rapidly than any other amino acid. Astrocytes, which are in close approximation to brain capillaries, probably are the initial site of metabolism of leucine. A mitochondrial branched-chain aminotransferase is very active in these cells. Indeed, from 30 to 50% of all -amino groups of brain glutamate and glutamine are derived from leucine alone. Astrocytes release the cognate ketoacid [-ketoisocaproate (KIC)] to neurons, which have a cytosolic branched-chain aminotransferase that reaminates the KIC to leucine, in the process consuming glutamate and providing a mechanism for the "buffering" of glutamate if concentrations become excessive. In maple syrup urine disease, or a congenital deficiency of branched-chain ketoacid dehydrogenase, the brain concentration of KIC and other branched-chain ketoacids can increase 10- to 20-fold. This leads to a depletion of glutamate and a consequent reduction in the concentration of brain glutamine, aspartate, alanine, and other amino acids. The result is a compromise of energy metabolism because of a failure of the malate–aspartate shuttle and a diminished rate of protein synthesis."I just use my muscles as a conversation piece, like someone walking a cheetah down 42nd Street." - Arnold Schwarzenegger
Heretic....
-
04-16-2006, 01:06 PM #12
Sorry to bump an old thread but this was the most recent relating to this issue.... I just have a question/issue if anyone can answer this... I know there isnt alot of strong research or evidence about this phenomenon but...
If mega dosing bcaas can theoretically lead to imbalanaces in aa ratios responsible for mood function (ie decreased tryptophan), then could supplementing with whey (which contains tryptophan) counter this?
Or does it need to be in free form?
Im just concerned since I am seeking anti depressant therapy at the moment.
Thanx"Knowing is not enough; we must apply. Willing is not enough; we must do."
- Bruce Lee
"My studying mimics my training. Brief, intense and infrequent.."
- Big Red
-
-
04-16-2006, 01:13 PM #13
- Join Date: Mar 2004
- Location: New York, United States
- Age: 44
- Posts: 28,068
- Rep Power: 57862
Originally Posted by Buff_Daddy"I just use my muscles as a conversation piece, like someone walking a cheetah down 42nd Street." - Arnold Schwarzenegger
Heretic....
-
03-01-2013, 06:19 PM #14
-
03-01-2013, 06:54 PM #15
-
03-01-2013, 07:14 PM #16
-
-
03-02-2014, 09:19 AM #17
Bookmarks