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  1. #1
    Registered User bosshogg3's Avatar
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    Metformin for fat loss

    Has anyone taken Metformin aka GLUCOPHAGE for fat loss and not have diabetes.I was given this with a weekly b12/hcg shot for fat loss.Thanks
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  2. #2
    Figure it out Rob Awesome's Avatar
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    The concept/ideology behind metformin & fat loss is that metformin has no lipolytic effect / nor induce thermogenesis. Metformin is a biguanide drug (sister to phenformin) that is used to battle hyperglycemia due to T2DM (Type II Diabetes). Typically an individual who is prediabetic (ie Blood Sugar levels >95-100mg/dl but <139 mg/dl) or someone who is T2DM (blood glucose >140mg/dl) is prescribed metformin.

    the idea is that metformin inhibits hepatic glucose output via gluconeogenesis which theoretically overproduces the compensation of increased serum insulin (ie - hyperinsulinemia)... which is thought to be 3x's greater than normal hepatic sugar output.

    Additionally.. although minimally.. metformin also increases AMPK which peripherally can induce Glut4 (glucose transporter 4) in the muscle to shuttle sugar into the muscles...

    the whole 'idea' and 'theory' behind metformin and weight loss is that metformin (in a recent study - Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 diabetes
    P. J. English 1, A. Ashcroft 2, M. Patterson 4, T. M. Dovey 2, J. C. G. Halford 2, J. Harrison 3, D. Eccleston 3, S. R. Bloom 4, M. A. Ghatei 4, J. P. H. Wilding 1 *
    1Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK (PJE, JPHW).
    2School of Psychology, University of Liverpool, Liverpool, UK (AA, TMD, JCGH).
    3Department of Immunology, University Hospital Aintree, Liverpool, UK (DE, JH).
    4Endocrine Unit, Imperial College School of Medicine, London, UK (MP, MAG, SRB) )

    ...that ghrelin, an orexigenic hormone that is episodic (meal to meal) stimulates appetite. Metformin has been shown to blunt the increase of ghrelin levels postprandial... or post meal. So basically ghrelin levels are suppressed for a longer period after a meal for a longer period, thus it's thought to decrease food intake due to a suppressed appetite...

    And the idea of energy balance plays a huge role in weight gain or loss. Energy In > Energy Out = Weight Gain. Energy In < Energy Out = Weight Loss... and then obviously E In = E out = Ebal or Energy Balance.

    ....stick to generic diet, exercise and eat clean.
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  3. #3
    Registered User Zach1982's Avatar
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    Metformin is usually given to type II diabetics.

    Its key functions:

    * Stop liver producing glucose
    * Enhance receptor sensitivity on cells to increase glucose uptake (remember diabetes is essentially elevated blood glucose, most often due to failure of uptake by cells).

    Unless you are actually diabetic and even then only after consultation with your doctor should you be taking this.

    As the poster above says, stick to the good ol fashion clean diet and exercise.
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  4. #4
    Figure it out Rob Awesome's Avatar
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    Red face

    Originally Posted by Zach1982 View Post
    Metformin is usually given to type II diabetics.

    Its key functions:

    * Stop liver producing glucose
    * Enhance receptor sensitivity on cells to increase glucose uptake (remember diabetes is essentially elevated blood glucose, most often due to failure of uptake by cells).

    Unless you are actually diabetic and even then only after consultation with your doctor should you be taking this.

    As the poster above says, stick to the good ol fashion clean diet and exercise.
    Sorry.. I think I used too many big words. Thanks!!!
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