Myostatin Deficiency?

[5M1L3Y]

i heard somewhere that that kid with abs and pics took steroids

i mean even if he lack the gene .. how can you develope such a body when you are not anywhere near pubrity .. you can gain musclle strenght but dunno about that much size ..

well maybe..

You're right, Richard Sandrak, the "Strongest Boy in the World", they say his father gave him roids, he hasn't got no myostatin deficiency. It's obvious he was given roids, he's like 5'5".

I remember watching the documentary in 2004/5.

[TestProctor]

FYI Folks: I know I'm new here but recently did some poking around on the actual medical stuff surrounding this genetic condition...

1. Individuals that have it demonstrate increased natural mass, and stronger individual cells. I don't really understand the science enough to repeat it coherently, but basically they have an increasing density of muscle cells that are individually stronger than normal... not necessarily larger individual cells.

Basically they're naturally covered in slightly large and rather cut, bodyfat percentages being rather low, muscle but would have to bulk it up like anyone else to get huge.

2. They likely don't want to get too huge. The only semi-reliable statement I could find online from someone who claimed to have it noted that because the muscles don't break down normally they can get exceptionally dense and cause frequent muscle tearing. This guy noted that he, his father, and his grandfather all tended to get debilitating muscle pain occasionally. He also thought that the inherited high blood pressure among the men in his family was related. I imagine that intentionally pushing for more bulk could make either of those worse.

3. So far the two kids who have been confirmed as having this condition (one in the U.S. in the last year or so and one in Germany five years ago) are ok as far as health goes (one had some health problems early on from being born premature and the like but is ok now), and since they started programs looking into the condition they've found at least one hundred adults in the U.S. with either the half (one of two necessary genes has the mutation) or whole (both of the necessary genes have the mutation) willing to be part of a study. Apparently, by the way, if you only have one of the two genes mutated you get a bit of a boost but not nearly as much.

And one of the original concerns is that the low bodyfat in babies would hurt brain development, but they both seem ok... likely because the parents kept them well-fed. There were also worries about the heart, as it is a different type of muscle (non-skeletal), but while it didn't get the benefits of the condition it still seems ok for now.

4. Studies done on mice with this condition seem to reveal (I say seem because there was an initial study that showed it happens but not why) that mice that have the myostatin deficiency have slightly more brittle tendons and knee joints. So that could be a concern.

5. Similar studies also found that those with the condition heal bone fractures faster, and the healed area becomes far harder than it was before. This tracks with the man who claimed to have the condition online, who claimed (I believe well before these studies came out and around when we first learned this condition could exist in humans) that his grandfather was known not only as a strong-man but for pulling stunts involving "unbreakable bones."

6. There is no real myostatin blocker that will duplicate the benefits of the condition available out there; the closest one got to being developed was a research group saying they were going to start testing a promising one and then backing out when it turned out to be a dead end. The only things currently out there are scams, and it's unclear whether the stuff would even work the way people might want it to.

So when someone tells you there's a picture of someone who has this condition, don't take them at their word.

I don't have all the links, but if you want to poke around yourself do a search for myostatin deficiency or myostatin-related muscle hypotrophy. The wikipedia entries and scientific journal summaries should be helpful.

[Icicle]

You're right, Richard Sandrak, the "Strongest Boy in the World", they say his father gave him roids, he hasn't got no myostatin deficiency. It's obvious he was given roids, he's like 5'5".

I remember watching the documentary in 2004/5.

do roids stunt growth?

[Cease2xist]

do roids stunt growth?

Strong bump!
But yes when used early in life it causes growth plates to prematurely fuse.

[KRILLEN91]

You're right, Richard Sandrak, the "Strongest Boy in the World", they say his father gave him roids, he hasn't got no myostatin deficiency. It's obvious he was given roids, he's like 5'5".

I remember watching the documentary in 2004/5.

he's like 5'9 130lbs or something i saw his myspace ages ago and in a couple of workout vids

[drewwwww17]

You're right, Richard Sandrak, the "Strongest Boy in the World", they say his father gave him roids, he hasn't got no myostatin deficiency. It's obvious he was given roids, he's like 5'5".

I remember watching the documentary in 2004/5.

every one that is 5,5 has took roids then?

[UnDiSpUtEd90]

yeah, I am not too sure about the effects of this mutation on smooth muscle tissue in the heart... if it does make that grow too then yeah there's gonna be some issues.

lol at you thinking the heart is made of smooth muscle. its definitely cardiac muscle. so much for your kinesiology degree.

[mrperson1746]

FYI Folks: I know I'm new here but recently did some poking around on the actual medical stuff surrounding this genetic condition...

1. Individuals that have it demonstrate increased natural mass, and stronger individual cells. I don't really understand the science enough to repeat it coherently, but basically they have an increasing density of muscle cells that are individually stronger than normal... not necessarily larger individual cells.

Basically they're naturally covered in slightly large and rather cut, bodyfat percentages being rather low, muscle but would have to bulk it up like anyone else to get huge.

2. They likely don't want to get too huge. The only semi-reliable statement I could find online from someone who claimed to have it noted that because the muscles don't break down normally they can get exceptionally dense and cause frequent muscle tearing. This guy noted that he, his father, and his grandfather all tended to get debilitating muscle pain occasionally. He also thought that the inherited high blood pressure among the men in his family was related. I imagine that intentionally pushing for more bulk could make either of those worse.

3. So far the two kids who have been confirmed as having this condition (one in the U.S. in the last year or so and one in Germany five years ago) are ok as far as health goes (one had some health problems early on from being born premature and the like but is ok now), and since they started programs looking into the condition they've found at least one hundred adults in the U.S. with either the half (one of two necessary genes has the mutation) or whole (both of the necessary genes have the mutation) willing to be part of a study. Apparently, by the way, if you only have one of the two genes mutated you get a bit of a boost but not nearly as much.

And one of the original concerns is that the low bodyfat in babies would hurt brain development, but they both seem ok... likely because the parents kept them well-fed. There were also worries about the heart, as it is a different type of muscle (non-skeletal), but while it didn't get the benefits of the condition it still seems ok for now.

4. Studies done on mice with this condition seem to reveal (I say seem because there was an initial study that showed it happens but not why) that mice that have the myostatin deficiency have slightly more brittle tendons and knee joints. So that could be a concern.

5. Similar studies also found that those with the condition heal bone fractures faster, and the healed area becomes far harder than it was before. This tracks with the man who claimed to have the condition online, who claimed (I believe well before these studies came out and around when we first learned this condition could exist in humans) that his grandfather was known not only as a strong-man but for pulling stunts involving "unbreakable bones."

6. There is no real myostatin blocker that will duplicate the benefits of the condition available out there; the closest one got to being developed was a research group saying they were going to start testing a promising one and then backing out when it turned out to be a dead end. The only things currently out there are scams, and it's unclear whether the stuff would even work the way people might want it to.

So when someone tells you there's a picture of someone who has this condition, don't take them at their word.

I don't have all the links, but if you want to poke around yourself do a search for myostatin deficiency or myostatin-related muscle hypotrophy. The wikipedia entries and scientific journal summaries should be helpful.

Thank God someone actually posted some legitimate information here. Everyone here is talking about their own speculation on myostatin deficiency. Having an abnormally large heart would cause death at an early age, but the myostatin deficiency in the kids only affects their structural muscles. You can't die because of having a normal sized heart with large [traps, delts, biceps, etc..], if this was the case there would be restrictions on how long people can work out for.
But once successful myostatin inhibitors are available on the market, body builders and athletes will want their hands on them. The inhibitors will be illegal to those who are already able bodied. Also, these inhibitors are being tested on many muscular eroding diseases, such as muscular dystrophy.

[batmanman]

strong nearly two year bump of my thread

[AirChair]

Strong bump!
But yes when used early in life it causes growth plates to prematurely fuse.

Not entirely true. The effects of oxandrolone on epiphyseal plate viability has been studied, and found to not effect them negatively. In fact oxandrolone has been shown to be a safe, effective means of treating constitutional growth delay.

[TheBreadWinner]

Not entirely true. The effects of oxandrolone on epiphyseal plate viability has been studied, and found to not effect them negatively. In fact oxandrolone has been shown to be a safe, effective means of treating constitutional growth delay.

It's my understanding that the estrogen to test ratio at the end of a cycle was what caused premature growth plates closer. i.e. more estro than test, which is why we take a PCT with AAS

[ArcaneKnight]

imagine one of them on gear, perfect diet and training after like 10 years

flex wheeler..

[Dgwear]

some people have all the luck haha. i think they specifically are only breeding those cows with bulls who have the mutation to produce more babys with the defect/gift

[jiggly_puff]

brb heart hypertrophy

[AsianAesthetics]

strong bump.

i dont think cardiac muscles can undergo hypertrophy after a certain age. plus, all the animals that had the mutation was already born a predetermined heart problem.