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Thread: Dutasteride

  1. #1
    Jkeith for MOD! xGhostinGx's Avatar
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    Thumbs down Dutasteride

    Im not going to answer any questions about Dutasteride, Im only posting this because everyone is pushing this as a new anti-hairloss drug.

    Just an FYI about Dutasteride vs Finasteride. Dutasteride elminates 95% of the bodies DHT. Not good at all for so many reasons. Finasteride elminates 70% of the bodies DHT. Finasteride lowers DHT on the scalp by about 30% (where it counts). Dutasteride is better at the scalp by so little, its hardly worth mentioning. Dutasteride is a horrible compound to release on the public, like it will do any better on the hair. Deception.

    DHT is an estrogen antagonist. Removal of that high of an amount will allow estrogen to run loco. Increasing the likelyhood of gyno.
    Now I know they 'claim' low sides, but a 95% elmination of DHT is major. Them calling it superior for hair is true but deceiving. It is superior by a very small amount, certainly not worth what it does to your body. Excessive DHT is bad for the hair and prostate if you have a genetic predisposition to these things, but elminating too much DHT will have serious consequences. I think that people think that a DHT blocker on-cycle will be helpful in blocking androgenic effects.

    .5mg pills of Avodart (dutasteride) is what it comes in, and yes it is bad to remove that much DHT from your body, and it wont make a difference on hair that you will see. 95% DHT is a lot. 2.5mg once a week is the usual dosing for hair.

    * Duration of Side Effects

    The greatest concern however, is the potential duration of side effects. The long half life of dutasteride exceeds 240 hours vs. the rather short 6 to 8 hours for finasteride. There have been some cases where the DHT levels were still had only returned to 25% of their original levels nearly a YEAR after having discontinued Dutasteride. As a result, any dangers or side effects that may be seen from Avodart, whether directly related or as a hypersensitive or allergic reaction may take literally months to resolve.

    * Conversely, there is no biological model for 5AR type 1 deficiency, which Avodart creates, and there are measurable levels of 5AR-1 in the human brain. Conclusion -- the blockage of 5AR-1 may have yet unknown neurological implications.

    * Remember Fen-Fen for weight loss? Personally, I do not want my patients to be the guinea pigs.

    If you still want to take it after this, knock yourself out. I would not.

    There are NO long term studies on Dutasteride.

    Some of this was cut & paste.
    IP ban Nutrabolics for lying and now threats.
    http://forum.bodybuilding.com/showthread.php?&p=9560766#post9560766

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    Registered User KD1's Avatar
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    Actually it almost cuts scalp DHT in half compared to fin. 55% is the number I have seen compared to fin 30%.

    Also, sides for Dut are approx the same as fin. If you can tolerate fin, you can probably tolerate Dut.

    The worst thing about Dut ( and the reason I dont take it ) is that its half life is very very long. On the order of months. So if you do get sides, you are going to have them for a while. Fin gets out of your system in a few days.
    Last edited by KD1; 02-20-2006 at 01:15 PM.
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    so if the half life is so long...does this mean it is not required to take it every day? this offset some cost
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    Jkeith for MOD! xGhostinGx's Avatar
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    The study on Dutasteride for hair was abandoned. I have seen 32% Dutasteride, but my concern is :

    1. 95% removal of DHT from the body. That alone is bordering on retarded.

    2. Elminates 5ar-1. 5ar-1 is present in the brain. Removal may cause long-term damage.

    3. No long term studies.


    Knowing this, you would almost have to be a fool to take. Especially with Finasteride and all the topical anti-androgens out their being more than sufficient.
    IP ban Nutrabolics for lying and now threats.
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  5. #5
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    Originally Posted by kingpin0625
    so if the half life is so long...does this mean it is not required to take it every day? this offset some cost
    Most cost effective is 1.5mg for 5 days to bring your blood dht down to ~80%, then 0.5mg every other day. This should bring your scalp DHT down to around 50%, keeping your blood DHT around 80%.

    If you keep on 0.5mg/day it will get your blood DHT down around 95% but only bring your scalp down another 5%, not really worth it.

    Ive got a link to a chart showing this, lemme dig it up.

    Id be all over the stuff if it had a normal half life, but what if you develop gyno or ED? I dont feel like gulping Nolva for 5-8 months, and my g/f would dump me if my junk wasnt working for that long!
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    anybody else have updates to this older thread?

    The main benifit of the Dutasteride over finasterid was the LH increase and less sexual side effects...
    Last edited by E-10; 03-27-2008 at 11:47 AM.
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  7. #7
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    Originally Posted by xGhostinGx View Post
    Im not going to answer any questions about Dutasteride, Im only posting this because everyone is pushing this as a new anti-hairloss drug.

    Just an FYI about Dutasteride vs Finasteride. Dutasteride elminates 95% of the bodies DHT. Not good at all for so many reasons. Finasteride elminates 70% of the bodies DHT. Finasteride lowers DHT on the scalp by about 30% (where it counts). Dutasteride is better at the scalp by so little, its hardly worth mentioning. Dutasteride is a horrible compound to release on the public, like it will do any better on the hair. Deception.

    DHT is an estrogen antagonist. Removal of that high of an amount will allow estrogen to run loco. Increasing the likelyhood of gyno.
    Now I know they 'claim' low sides, but a 95% elmination of DHT is major. Them calling it superior for hair is true but deceiving. It is superior by a very small amount, certainly not worth what it does to your body. Excessive DHT is bad for the hair and prostate if you have a genetic predisposition to these things, but elminating too much DHT will have serious consequences. I think that people think that a DHT blocker on-cycle will be helpful in blocking androgenic effects.

    .5mg pills of Avodart (dutasteride) is what it comes in, and yes it is bad to remove that much DHT from your body, and it wont make a difference on hair that you will see. 95% DHT is a lot. 2.5mg once a week is the usual dosing for hair.

    * Duration of Side Effects

    The greatest concern however, is the potential duration of side effects. The long half life of dutasteride exceeds 240 hours vs. the rather short 6 to 8 hours for finasteride. There have been some cases where the DHT levels were still had only returned to 25% of their original levels nearly a YEAR after having discontinued Dutasteride. As a result, any dangers or side effects that may be seen from Avodart, whether directly related or as a hypersensitive or allergic reaction may take literally months to resolve.

    * Conversely, there is no biological model for 5AR type 1 deficiency, which Avodart creates, and there are measurable levels of 5AR-1 in the human brain. Conclusion -- the blockage of 5AR-1 may have yet unknown neurological implications.

    * Remember Fen-Fen for weight loss? Personally, I do not want my patients to be the guinea pigs.

    If you still want to take it after this, knock yourself out. I would not.

    There are NO long term studies on Dutasteride.

    Some of this was cut & paste.
    Dutasteride destroyed my sex drive and made my gyno a now constant problem. Everyone should avoid this like the plague.
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    Thank you very much, this thread is excellent and should be read by millions.

    Avoid Dutasteride, or at least take it sledomly, otherwise stick with finasteride.
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    Originally Posted by Sldge View Post
    Dutasteride destroyed my sex drive and made my gyno a now constant problem. Everyone should avoid this like the plague.
    even with fina my libido dropped a lot, man I don't want to imagine with duta...
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    Originally Posted by nunes View Post
    even with fina my libido dropped a lot, man I don't want to imagine with duta...
    I've had absolutely no negative sides with fin
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    Originally Posted by BiggJohn View Post
    I've had absolutely no negative sides with fin
    Maybe you took it with testoserone enhancing supplements, so you don't feel the loss of libido.
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    He was a good and smart guy. Him and Bane were probably the smartest posters back then when all the big shots had left for a while.

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    Dutasteride ruined my sex drive PERMANENTLY, resulted in penile fibrosis, and caused major neurological complications that have yet to resolve. It was stupid I know-- but now I'm permanently ****ed up. SAVE YOURSELF-- screw the hair. I would gladly give up every hair on my head if I could undo what I did to myself.
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    I hated Propecia, didnt feel right while on it.

    Treat hair loss topically if its an option. They make topical DHT inhibitors. No need in eradicating DHT from your body completely.
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    Originally Posted by Roke View Post
    Maybe you took it with testoserone enhancing supplements, so you don't feel the loss of libido.
    No, it just doesn't effect everybody the same way.
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