Aromasin instead of arimidex!

[SupremeDan]

IS aromasin a better antiaromatise the arimidex??? because i was gonna run arimidex at 0.5mg ed on my upcoming sust/winny lean cycle in two months and when i went to the pharmcy to buy a box (28 pills of 1mg) the dude from the pharmacy said that they had aromasin in stock too ( 30 pills a box of 25mg) and the price is relativelly cheaper then the arimidex............

i would then buy 1 box and run half a tab (12.5mg) a day................but i would like to know the insight of you guys on this one.......wich one is more efective...aromasin or arimidex??

[TheGreekGod]

Originally Posted by SupremeDan

IS aromasin a better antiaromatise the arimidex??? because i was gonna run arimidex at 0.5mg ed on my upcoming sust/winny lean cycle in two months and when i went to the pharmcy to buy a box (28 pills of 1mg) the dude from the pharmacy said that they had aromasin in stock too ( 30 pills a box of 25mg) and the price is relativelly cheaper then the arimidex............

i would then buy 1 box and run half a tab (12.5mg) a day................but i would like to know the insight of you guys on this one.......wich one is more efective...aromasin or arimidex??

aromasin should be better. I've never ran it but I'm pretty sure you need to take 25mg for it to be effective.

[SupremeDan]

Originally Posted by Big Drake

aromasin should be better. I've never ran it but I'm pretty sure you need to take 25mg for it to be effective.

why?

[TheGreekGod]

J Clin Endocrinol Metab. 2003 Dec;88(12):5951-6. Related Articles, Links


Erratum in:
J Clin Endocrinol Metab. 2004 Feb;89(2):732.

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males.

Mauras N, Lima J, Patel D, Rini A, di Salle E, Kwok A, Lippe B.

Nemours Children's Clinic and Research Programs, Jacksonville, Florida 32207, USA. nmuras@nemours.org

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14-26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P <or= 0.002); 50 mg, 32% (P <or= 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P <or= 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 +/- 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 14671195 [PubMed - indexed for MEDLINE]

[TheGreekGod]

For some reason it won't let me paste the whole article.

Here's a link. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

[NoQuarter]

aromasin is an aromatase inactivator not an inhibitor keep that in mind.

[TheGreekGod]

Originally Posted by NoQuarter

aromasin is an aromatase inactivator not an inhibitor keep that in mind.

Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor.

[NoQuarter]

Originally Posted by Big Drake

Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor.

the irreversible part means just what i said

[SupremeDan]

Originally Posted by Big Drake

J Clin Endocrinol Metab. 2003 Dec;88(12):5951-6. Related Articles, Links


Erratum in:
J Clin Endocrinol Metab. 2004 Feb;89(2):732.

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males.

Mauras N, Lima J, Patel D, Rini A, di Salle E, Kwok A, Lippe B.

Nemours Children's Clinic and Research Programs, Jacksonville, Florida 32207, USA. nmuras@nemours.org

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14-26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P <or= 0.002); 50 mg, 32% (P <or= 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P <or= 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 +/- 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 14671195 [PubMed - indexed for MEDLINE]

but they talk about 25mg and 50mg dose...not a 12.5mg...so I don´t see how you can say that 12.5mg would not have the desired effects....i was using the searrch buton and found this thread http://forum.bodybuilding.com/showth...light=aromasin

he is taking half a tab (12.5mg) and having great results.............and isn´t aromasin supposed to be stronger then letro and arimidex??? because people allways take half tabs of arimidex and letro and have great results...why should a more potent anti aromatize not work at a half tab???

[SupremeDan]

what about if i take 25mg EOD??

[MurphMan]

Originally Posted by SupremeDan

but they talk about 25mg and 50mg dose...not a 12.5mg...so I don´t see how you can say that 12.5mg would not have the desired effects....i was using the searrch buton and found this thread http://forum.bodybuilding.com/showth...light=aromasin

he is taking half a tab (12.5mg) and having great results.............and isn´t aromasin supposed to be stronger then letro and arimidex??? because people allways take half tabs of arimidex and letro and have great results...why should a more potent anti aromatize not work at a half tab???

LOL, it doesn't matter whether it's a half tab or a whole tab......wtf, who cares about that? It's all about the ammount of the drug IN the tab. Obviously Adex is much more potent if you only need 1/2mg per day and you need possibly up to 25mg per day of exemestane. But there are other reasons that people choose exemestane over adex. One is that exemestane is a steroidal AI, unlike Adex. Steroidal AI's have been shown to actually increase bone density and improve lipids, whereas non-steroidal AI's do the opposite.

[SupremeDan]

Originally Posted by MurphMan

LOL, it doesn't matter whether it's a half tab or a whole tab......wtf, who cares about that? It's all about the ammount of the drug IN the tab. Obviously Adex is much more potent if you only need 1/2mg per day and you need possibly up to 25mg per day of exemestane. But there are other reasons that people choose exemestane over adex. One is that exemestane is a steroidal AI, unlike Adex. Steroidal AI's have been shown to actually increase bone density and improve lipids, whereas non-steroidal AI's do the opposite.

so you would recomend aromasin over adex????? 25mg eod would do the job??? cause i can only aford to buy one box.........and sinse the cycle is 8 weeks i would either take 12.5mg ed or 25mg eod ( 30 tabs)

[MurphMan]

Originally Posted by SupremeDan

so you would recomend aromasin over adex????? 25mg eod would do the job??? cause i can only aford to buy one box.........and sinse the cycle is 8 weeks i would either take 12.5mg ed or 25mg eod ( 30 tabs)

I would use the Aromasin, @ 12.5mg ED, that should be enough to keep the water down.

[SupremeDan]

Originally Posted by MurphMan

I would use the Aromasin, @ 12.5mg ED, that should be enough to keep the water down.

yeah i think it will do the job........ i will be only using 500mg of sust a week.....so i tjink this will do the job...........

any big diference if i take 12.5mg ed or 25mg eod??? because cutting the tab in half is a pain in the ass....if it don´t make much a difference i would rather do it 25mg eod...but if it does then i will take half a tab...no problem at all........

[MurphMan]

Originally Posted by SupremeDan

yeah i think it will do the job........ i will be only using 500mg of sust a week.....so i tjink this will do the job...........

any big diference if i take 12.5mg ed or 25mg eod??? because cutting the tab in half is a pain in the ass....if it don´t make much a difference i would rather do it 25mg eod...but if it does then i will take half a tab...no problem at all........

I don't know what the half life is.........but I'd bet 25 EOD will be fine.

[Vail]

Originally Posted by Big Drake

Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor.

Does this mean that someone(such as myself) who cant run certain compounds because they always aromitize too heavly might be able to run some aromasin alone for a while maybe at say 25mg ED for a couple weeks/month or so and alleviate this problem completely?

[saiyanjin]

Aromasin and Arimidex do almost the EXACT same thing. whichever is cheaper go for it, i goto ag-guys.com they have all liquids and the best ****! usually overdosed, i get all my PCT/Clen/T3 their!!!! PROPS TO AG-GUYS!

[WTFRUDOING]

Originally Posted by saiyanjin

Aromasin and Arimidex do almost the EXACT same thing. whichever is cheaper go for it, i goto ag-guys.com they have all liquids and the best ****! usually overdosed, i get all my PCT/Clen/T3 their!!!! PROPS TO AG-GUYS!

Wrong

Aromasin is easier on the lipids than dex. Dex raises test levels more. Aromasin is more potent (though not mg for mg). The list goes on.. Research before posting. They both lower estogen, that is were the similarities end bro.

[WTFRUDOING]

Originally Posted by SupremeDan

and isn´t aromasin supposed to be stronger then letro and arimidex

No. (as far as lowering estrogen goes) Letro is the strongest, then aromasin, then dex.

Each have their pros and cons.

This is for, well if the shoes fits......judging by this thread, there needs to be some serious research preformed by 90% of the people in this thread. Seriously. Get a search engine.

[MurphMan]

Originally Posted by WTFRUDOING

This is for, well if the shoes fits......judging by this thread, there needs to be some serious research preformed by 90% of the people in this thread. Seriously. Get a search engine.

Well, seeing as how this is the 20th post and you are 1 of the two people here that knows what they are talking about..........I guess I should thank you for acknowledging my knowledge!


*edit* ......oops, sorry BigDrake! Didn't see you up there!

[WTFRUDOING]

ATTENTION: We have a smartass . Perhaps 85% would be more accurate to include little drake lol.

[xb5869]

Originally Posted by saiyanjin

Aromasin and Arimidex do almost the EXACT same thing. whichever is cheaper go for it, i goto ag-guys.com they have all liquids and the best ****! usually overdosed, i get all my PCT/Clen/T3 their!!!! PROPS TO AG-GUYS!

I even hint at this source a week ago, didnt even spell it out, but just hinti at it and i get banned, this guys just flat out says it and all is cool, I dont get it.... I dont understand why I got banned for it anyway, its in a MOD'S sig.

END RANT: this has been a public service announcment, my hijack is over, thank you for listening

x

[xb5869]

^^^^^^^^^^^ out of curiosity

[SupremeDan]

Originally Posted by WTFRUDOING

No. (as far as lowering estrogen goes) Letro is the strongest, then aromasin, then dex.

Each have their pros and cons.

This is for, well if the shoes fits......judging by this thread, there needs to be some serious research preformed by 90% of the people in this thread. Seriously. Get a search engine.

well i will run nolva together and letro seems not to be the option here since nolva interacts with letro..............anyways.....i allways thought aromasin was the stronger sinse it´s the 3rd generation aromitize inhibitor or whatever.......... so let me end this thread with a simple question.......25mg eod of aromasin is more effective than 1mg of a-dex eod at lowering strongen??

i will also be running 50mg of proviron..................

[MurphMan]

Originally Posted by SupremeDan

well i will run nolva together and letro seems not to be the option here since nolva interacts with letro..............anyways.....i allways thought aromasin was the stronger sinse it´s the 3rd generation aromitize inhibitor or whatever.......... so let me end this thread with a simple question.......25mg eod of aromasin is more effective than 1mg of a-dex eod at lowering strongen??

i will also be running 50mg of proviron..................

Proviron sucks IMHO......why would you switch, if you know something works for you?

[SupremeDan]

Originally Posted by MurphMan

Proviron sucks IMHO......why would you switch, if you know something works for you?

i am not going to swich..i am just saying that i will run proviron at 50mg + nolva plus an anti -a........proviron is for the libido......

[TheGreekGod]

Originally Posted by SupremeDan

i am not going to swich..i am just saying that i will run proviron at 50mg + nolva plus an anti -a........proviron is for the libido......

Your not making sense. Test is all you need for your libido. You don't need nolva if your running letro, adex or aromasin. All your doing is adding more drugs to your system which could have sides. That and your spending too much money controlling estrogen. Estrogen can be your friend, it doesn't mean you'll get gyno.

Save the nolva for pct.

[SupremeDan]

Originally Posted by Big Drake

Your not making sense. Test is all you need for your libido. You don't need nolva if your running letro, adex or aromasin. All your doing is adding more drugs to your system which could have sides. That and your spending too much money controlling estrogen. Estrogen can be your friend, it doesn't mean you'll get gyno.

Save the nolva for pct.

i allready have a purbetial gyno and i canot take any risks..........it´s really sensible even when i am not on anthing....it´s not really noticeble because my BF is way down...but if it gets a little high...like over 12% then it starts to really show........so nolva is just to make sure any strogen that does form will not go over there.............and sinse i will be taking probably aromasin i would take nolva to have sme estrogen circulating sinse nolva mimics strogen in some tissues.......

[TheGreekGod]

Originally Posted by SupremeDan

and sinse i will be taking probably aromasin i would take nolva to have sme estrogen circulating sinse nolva mimics strogen in some tissues.......

Please explain this.

[SupremeDan]

Originally Posted by Big Drake

Please explain this.

aromasin will probably leave me with almost no strogen and this is not good for lipid profile .....nolva has being shown to mimic strogens effects on lipid....so to keep good lipid profile i would take nolva....