ATD vs Exemestane (Aromasin)

[WCC]

just wondering how these two AIs compare in terms of their effects on the body. it seems as though ATD is based off Exemestane. could you do standalone cycles of Exemestane, or run it alongside an SHBG-inhibitor?
just wondering.

[thebrakes]

usually comes down to price, availability and legal status...aromasin is extremely spendy, illegal to use, and hard to get.

stick with formestane - it has similar effects for a low price.

[WCC]

Originally Posted by thebrakes

usually comes down to price, availability and legal status...aromasin is extremely spendy, illegal to use, and hard to get.

not for me. i live in the UK (it's legal), and i know people who can get it for a reasonable price.

[sonicology]

Originally Posted by WCC

it seems as though ATD is based off Exemestane.

Yeah they're structurally similar as you can see:



However the methylene group on the 6th carbon dramatically improves exemestanes bioavailability and half life as compared to ATD; exemestane has a half life of 27 hours as compared to around 4 minutes for ATD. The literature I've seen also suggests exemestane is a slightly stronger inhibitor of aromatase, although both agents are quite potent. Also as far as I am aware exemestane has not been shown to block androgen receptors in the brain the way ATD does, so it should not lower libido in this way (although it may lower libido if E levels are driven down too low).

If price and availability aren't an issue, I'd suggest the literature supports the view that exemestane is the superior agent.

Originally Posted by WCC

could you do standalone cycles of Exemestane, or run it alongside an SHBG-inhibitor?
just wondering.

Sure why not? Exemestane has a strong affinity for SHBG so it should work in synergy with an SHBG inhibitor, also in addition to raising both free and total test it raises IGF-1 by around 20%. Certainly the bloodwork for young males looks promising:

http://jcem.endojournals.org/cgi/con...ull/88/12/5951

[WCC]

Originally Posted by sonicology

Yeah they're structurally similar as you can see:



However the methylene group on the 6th carbon dramatically improves exemestanes bioavailability and half life as compared to ATD; exemestane has a half life of 27 hours as compared to around 4 minutes for ATD. The literature I've seen also suggests exemestane is a slightly stronger inhibitor of aromatase, although both agents are quite potent. Also as far as I am aware exemestane has not been shown to block androgen receptors in the brain the way ATD does, so it should not lower libido in this way (although it may lower libido if E levels are driven down too low).

If price and availability aren't an issue, I'd suggest the literature supports the view that exemestane is the superior agent.



Sure why not? Exemestane has a strong affinity for SHBG so it should work in synergy with an SHBG inhibitor, also in addition to raising both free and total test it raises IGF-1 by around 20%. Certainly the bloodwork for young males looks promising:

http://jcem.endojournals.org/cgi/con...ull/88/12/5951

thanks - it looks like good stuff. i might consider using it in one of my next stacks, or maybe standalone.

[VegetaGD]

Originally Posted by WCC

thanks - it looks like good stuff. i might consider using it in one of my next stacks, or maybe standalone.

Yes...I'm looking at using it as a standalone at about 10mg per day. Can it be used indefinatley at a low dose?

[VegetaGD]

Originally Posted by VegetaGD

Yes...I'm looking at using it as a standalone at about 10mg per day. Can it be used indefinatley at a low dose?

Hi guys...I wanted to bump this becuase I have a specific question. I just got bloodwork back (not on any anything nor am I planning anything).

As has been the case over the past 4 bloodworks I've done, a trend has become apparent.

Low DHEA-S (275 ish)
Low Free Test (15 ish)
Higher E2 (50ish)
Higher SHBG (40ish)

The funny thing here is that from a physical perspective, I'm pretty happy. I'm 28 @ 5"10/ 200, DL 500, BP 300 +, Squat 450 +

My concern is, if I could get these numbers more in the upper end of the ranges like most on here preach, perhaps my body would be even more responsive.

I was thinking of using aromasin standalone to bring that E2 down & hopefully drag shbg down too while bumping free test. A few spoke out against it.

My question here is what can I do to bring that E2 down? Novadex XT? Any legit suggestions would be much appreciated.

[Vadim Beliaev]

aromasin is too powerful to be used standalone (i.e. when youre only dealing with natural levels of testosterone) IMO, bringing estrogen too low is just as bad as having it higher than normal.

[ssouthbeach14]

Originally Posted by Vadim Beliaev

aromasin is too powerful to be used standalone (i.e. when youre only dealing with natural levels of testosterone) IMO, bringing estrogen too low is just as bad as having it higher than normal.

very true..

[VegetaGD]

Originally Posted by Vadim Beliaev

aromasin is too powerful to be used standalone (i.e. when youre only dealing with natural levels of testosterone) IMO, bringing estrogen too low is just as bad as having it higher than normal.

I agree 100% that bringing e2 too low is bad, but are you saying that using a small dose of aromasin (10mg) every other day would spike E into the ground?

[Vadim Beliaev]

Originally Posted by VegetaGD

I agree 100% that bringing e2 too low is bad, but are you saying that using a small dose of aromasin (10mg) every other day would spike E into the ground?

its not that small of a dose, some people find that 12.5 mg every other day is just enough on a cycle which has your test levels at 5 times over the natural max.

[VegetaGD]

Originally Posted by Vadim Beliaev

its not that small of a dose, some people find that 12.5 mg every other day is just enough on a cycle which has your test levels at 5 times over the natural max.

Hmm...so do you you have a suggestion of what I might do to get my estradiol levels in the sweet spot of around 20. Novadex XT? Dietary changes? Thanks!

[TheSupremeBeing]

Originally Posted by VegetaGD

I agree 100% that bringing e2 too low is bad, but are you saying that using a small dose of aromasin (10mg) every other day would spike E into the ground?

No, a low dosage of Aromasin is extremely safe and effective.

[VegetaGD]

Originally Posted by TheSupremeBeing

No, a low dosage of Aromasin is extremely safe and effective.

Holy Moly! That's why this is tough...so many different opinions on this. Do you think E2 of 45 to 50 is high for a 28 year old? If so & if you think aromasin is OK, how many mgs would be a decent amount & at what frequency?

Should I buy the liquid aromasin? Thanks!

[rakmm1]

Originally Posted by Vadim Beliaev

aromasin is too powerful to be used standalone (i.e. when youre only dealing with natural levels of testosterone) IMO, bringing estrogen too low is just as bad as having it higher than normal.

So you're basically calling bull$hit on this article?

http://www.musculardevelopment.com/c.../view/1559/51/

[Vadim Beliaev]

sure

[rakmm1]

Originally Posted by Vadim Beliaev

sure

LOL, ok.

To be fair, this article did come out after your original post. They do make some interesting points about estrogen levels not being elminated entirely, and test levels rising to the high end of what is normally seen in young males.

[Buildinfortres]

It depends on the purpose of use, however I would prefer a very
low dose of Aromasin rather than ATD, specially if you can get
it legally and at good price.

[VegetaGD]

Originally Posted by Vadim Beliaev

sure

OK...I know we talked about this a while back, but I still really want to try Exemestane (Aromasin). Remember that I'm using no test at all & would only use Aromasin as an AI.

My thought is to try 10mg twice per week. I'm using this article as sort of a guideline.

http://jcem.endojournals.org/cgi/con...urcetype=HWCIT

I'm aware that spiking estrogen levels too low is just as bad so I'm looking for the sweet spot.