I want to take a Prohormone for 4 weeks to get bigger WIll this hurt my heart?

[Fster4baseball]

I just started thinking about my Health more and beginning to think that Baseball isn't everything in life. I was thinking about taking Prohormones instead of taking steroids. I have already taken Superdrol and Had a very good run with it and I took all the necessary precautions, took milkthistle and hawthorneberry. I want to run another for about 4 weeks. Will this hurt me in the longrun if i take all necessary precautions?
I know these oral supplements are hard on your liver and stuff and I actually don't drink at all either so Would these affect my heart.? like enlarge it or something (which isn't always good)

Please let me know from an unbiased viewpoint. Thankyou!!!

[Xc]

Do you have any heart conditions?

SD is a steroid. Pro Hormones convert to steroids in the body (usualy controlled by an enzyme).

[jules_d1]

you realise that its probably safer to inject steroids rather than taking these oral PH's?

[getbustered]

Someone have a link to the discussion about DMT (Phera and clones) and heart enlargement?

That's the only one that I have heard of any real issues with, and I would have to do some more reading to remember if it had actually happened, or if studies had just shown it was possible. Something about rats hearts enlarging if I remember correctly.

Never heard of any heart issues with Superdrol, outside of the normal risks and side effects common to oral methylated steroids.

[Interlocutor]

Originally Posted by getbustered

Someone have a link to the discussion about DMT (Phera and clones) and heart enlargement?
That's the only one that I have heard of any real issues with, and I would have to do some more reading to remember if it had actually happened, or if studies had just shown it was possible. Something about rats hearts enlarging if I remember correctly.
Never heard of any heart issues with Superdrol, outside of the normal risks and side effects common to oral methylated steroids.

Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping.

Diel P, Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Sch?nzer W, Thevis M, Vollmer G, Zierau O.

Center for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports University Cologne, 50927 Cologne, Germany. diel@dshs-koeln.de

Desoxymethyltestosterone (DMT), also known as Madol, is a steroid recently identified to be misused as a doping agent. Since, the knowledge of functions of this substance is rather limited, it was our aim to characterise the pharmacological profile of DMT and to identify potential adverse side effects. DMT was synthesised, its purity was confirmed and its biological activity was tested. The potency of Madol (DMT) to transactivate androgen receptor (AR) dependent reporter gene expression was two times lower as compared to dihydrotestosterone (DHT). Receptor binding tests demonstrate that DMT binds with high selectivity to the AR, binding to the progesterone receptor (PR) was low. In vivo experiments in orchiectomised rats demonstrated that treatment with DMT resulted only in a stimulation of the weight of the levator ani muscle; the prostate and seminal vesicle weights remained unaffected. Like testosterone, administration of DMT resulted in a stimulation of IGF-1 and myostatin mRNA expression in the gastrocnemius muscle. In the prostate proliferation was stimulated by TP (testosteronepropionate), but remained unaffected by DMT. Remarkably, treatment with DMT, in contrast to TP, resulted in a significant increase of the heart weight. In the liver, DMT slightly stimulates the expression of the tyrosine aminotransferase gene (TAT). Our results demonstrate that DMT is a potent AR agonist with an anabolic activity. Besides the levator ani weight, DMT also modulates the gene expression in the musculus gastrocnemius. The observed stimulation of TAT expression in the liver and the significant increase of the heart weight after DMT treatment can be taken as an indication for side effects. Summarizing these data it is obvious that DMT is a powerful anabolic steroid with selective androgen receptor modulators (SARM) like properties and some indications for toxic side effects.

see also:

http://www.ncbi.nlm.nih.gov/pubmed/8...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/7...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

THE INTERLOCUTOR

[getbustered]

Originally Posted by Interlocutor

see also:

http://www.ncbi.nlm.nih.gov/pubmed/8...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/7...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

THE INTERLOCUTOR

Thanks you, sir.

[Sissy Squat Scott]

ORIGINAL ARTICLE

Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis

Antonello D?Andrea1, Pio Caso2, Gemma Salerno1, Raffaella Scarafile1, Giuseppe De Corato3, Claudia Mita1, Giovanni Di Salvo1, Sergio Severino2, Sergio Cuomo1, Biagio Liccardo4, Nicolino Esposito4, Raffaele Calabr?1
1 Chair of Cardiology, Second University of Naples, Naples, Italy
2 Department of Cardiology, Monaldi Hospital, Naples, Italy
3 Department of Human Anatomy, Federico II University, Naples, Italy
4 Department of Cardiology, Evangelic Foundation, Naples, Italy

Correspondence to:
Correspondence to:
Dr A D?Andrea
Via G Martucci 35, 80121 Naples, Italy; antonellodandrea@libero.it

Accepted 9 October 2006









http://bjsm.bmj.com/cgi/content/full/41/3/149