Hyperemia Advantage - Kns Supplements

[Milos Sarcev]

Here is MILOS (KNS) HYPEREMIA ADVANTAGE in short:

Average male has 5 liters of blood (females have about 4)...At rest that blood is distributed throughout the body and follows certain path - normally supplying the body with physiological order of importance (what is needed the most is being on higher list of physiological priorities)...and simply organs and other tissues take preference over the skeletal muscle AT REST...

So, when body is NOT physical (when we are resting) about 12-18% of total blood goes to our muscles and the rest is distributed ELSEWHERE (as I said - according to physiological importance at that moment)...
Also, note that this 5 liters of blood are circulating quite slowly...

Well, when we start being more physically active...we start "moving" and using our "motors" ( read: MUSCLES) - our hearts start pumping a bit faster and as a result - blood start circulating that much faster and somewhat different...No longer certain organs, systems or tissues prevail in "need for blood" internal physiological war body is having on a daily bases...

Now body faces extreme shock - WEIGHT RESISTANCE TRAINING and should I say: INTENSE KIND of weight training only BODYBUILDING could create...and as a result OUR MUSCLES start winning the war and getting high on the list of "physiological importance for blood" list...

More and more blood follow the path to OUR MUSCLES!! Each muscle contraction, every rep, every set and every exercise increases the need for blood...Higher the intensity - higher the blood flow...
NEW #1 - PHYSIOLOGICAL IMPORTANCE winer is certainly SKELETAL MUSCLE AT WORK and soon we have MAJOR BLOOD FLOW into the area of our body which is engaged the most = OUR MUSCLES!!!

Well, as science has discovered: HYPEREMIA (INCREASED BLOOD FLOW TO THE PART OF THE BODY...in this instance OUR MUSCLES) reaches incredible 80% blood flow to the muscle with up to 20 times faster circulation!!!

PLEASE PEOPLE - FOCUS ON THIS!!!




If you want to deliver something to your muscles WHEN DO YOU THINK IS THE BEST TIME?




Before training when only 15 % of the blood is in the muscle?
After the training when blood is leaving your muscles...or MAYBE (Huh)

DURING THE TRAINING - when up to 80% of the BLOOD is...where...Huh

Oh - IN EXACT MUSCLE YOU ARE TRYING TO BUILD and doing all your heavy lifting for...day after day, week after week...month after month...should i even say - year after year...or for some even decade after decade - with MEDIOCRE results at best!

So, don't you think that IF YOU UNDERSTAND WHAT YOU COULD POSSIBLY ACCOMPLISH when you have 80% of your blood in exact muscles you are trying to build and YOU ACT UPON IT - you would possibly IMPROVE like never before (or like all the athletes I am preparing who keep shocking the world with FAST IMPROVEMENTS)?

If you PREPARE your blood correctly (sound diet plan in general + 30 minutes BEFORE training knowing WHICH NUTRIENTS TO TAKE that will in synergy with YOUR WORKOUT DRINK insure that YOUR BLOOD IS ANABOLIC/ANTI-CATABOLIC BOMB - filled with maximal amount of anabolic and anti-catabolic nutrients as well as TIMELY RELEASED anabolic and anti-catabolic hormones...What do you think WILL HAPPEN?

Especially IF YOU TRAIN in this GIANT SETS FASHION where you fly from one exercise to the next, changing numerous training variables, performing mixture of lifts, using various grips, angles, tempo...repetition protocols, speeds...etc?

Well, you guessed it - YOU GET MR. OLYMPIA IN A MAKING...

I will only say this once: DON'T SEND EMPTY BLOOD TO YOUR MUSCLES AT WORK...YOU ARE WASTING YOUR TIME!!!

Would you want to send FED-EX, Airmail envelope to someone as the best and fastest way of 'sending' the envelope?

Well, PLEASE - do not send EMPTY ENVELOPE - you are paying HIGH PRICE for: NOTHING!!!

Make sure you stuff the envelope...and at the same time understand that IF YOU ARE SENDING EMPTY BLOOD to the muscle (your best friend who is anxiously awaiting to OPEN your gift envelope) - you are doing the same thing!

For "stuffing" your muscle envelope go to:

www.koloseum.com


For special (30%) discount - type this code: SMNR

[Elliptical Envy]

Hmmmmmmmm.......didn't see this one coming.

[GeneGnomeX]

You've got to be kidding me. I'll play along for fun

Originally Posted by Milos Sarcev

If you PREPARE your blood correctly (sound diet plan in general + 30 minutes BEFORE training knowing WHICH NUTRIENTS TO TAKE that will in synergy with YOUR WORKOUT DRINK insure that YOUR BLOOD IS ANABOLIC/ANTI-CATABOLIC BOMB - filled with maximal amount of anabolic and anti-catabolic nutrients as well as TIMELY RELEASED anabolic and anti-catabolic hormones...What do you think WILL HAPPEN?

It is DESIRABLE to lower blood glucose. You WANT to BREAK DOWN muscle proteins (catabolic), this INITIATES hormones such as GH, glucagon, nor/epinephrine. These and the oxidative products form exercise provoke beneficial adaptations, including muscle growth.


Image made by trans_isomer

[Milos Sarcev]

Originally Posted by fitnecise

You've got to be kidding me. I'll play along for fun



It is DESIRABLE to lower blood glucose. You WANT to BREAK DOWN muscle proteins (catabolic), this INITIATES hormones such as GH, glucagon, nor/epinephrine. These and the oxidative products form exercise provoke beneficial adaptations, including muscle growth.


Image made by trans_isomer

OH NO...
While indeed counter-regulatory above mentioned hormones to INSULIN - there is a WAY where both GH and Insulin could be released and be PHYSIOLOGICALLY functional - delivering numerous benefits to trained athlete SIMULTANEOUSLY - DURING THE TRAINING!

It is NOT desirable to lower blood glucose ALL THE TIME...While keeping it in check throughout a day - there is a period in a day when ELEVATED BLOOD GLUCOSE DOES WONDERS to the trained athlete...

Stand back, observe...think about it...and than make your conclusions...

[GeneGnomeX]

Originally Posted by Milos Sarcev

OH NO...
While indeed counter-regulatory above mentioned hormones to INSULIN - there is a WAY where both GH and Insulin could be released and be PHYSIOLOGICALLY functional - delivering numerous benefits to trained athlete SIMULTANEOUSLY - DURING THE TRAINING!

How? Glucose uptake is increased during exercise independent of insulin. Blood insulin falls because it isn't necessary. Without insulin, catecholamine release will be enhanced and glycogen breakdown and glucose uptake will increase. Insulin will blunt the catecholamine release and decrease performance.

Also, for insulin to have a significant effect on enhancing protein synthesis, it takes a large dose of simple carbohydrates.

You also suggest a pre-workout supplement. I'm not sure what kind of product you are talking about, but taking something that stimulates insulin significantly immediately pre workout, and adding something during - you greatly increase risk of going hypoglycemic. Should be whole foods pre or meals distanced from the workout.

Originally Posted by Milos Sarcev

there is a period in a day when ELEVATED BLOOD GLUCOSE DOES WONDERS to the trained athlete...

For performance yes, acutely at least. But elevated glucose during exercise does not require insulin to be used.

[GeneGnomeX]

Also, blood flow does not always increase depending on how you train. In fact, restricting blood flow/oxygen to the muscle seems to result in an equal increase in muscle mass (even with less work) or even more in some research. This again suggests that the rebound is more desirable. Work the muscle, break it down, rebound adaptations. Can peri nutrition cancel or augment this? I lean toward not using supplements during your workout. It seems that decreasing lactate accumulation/acidity and limiting fatigue only makes you work harder and longer for the same mass increase as someone who doesn't take anything and does considerably less work!

Eur J Appl Physiol. 2002 Feb;86(4):308-14.

Effects of resistance exercise combined with vascular occlusion on muscle function in athletes.

Takarada Y, Sato Y, Ishii N.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba Tokyo, Japan.

Abstract: The effects of resistance exercise combined with vascular occlusion on muscle function were investigated in highly trained athletes. Elite rugby players (n = 17) took part in an 8 week study of exercise training of the knee extensor muscles, in which low-intensity [about 50% of one repetition maximum] exercise combined with an occlusion pressure of about 200 mmHg (LIO, n = 6), low-intensity exercise without the occlusion (LI, n = 6), and no exercise training (untrained control, n = 5) were included. The exercise in the LI group was of the same intensity and amount as in the LIO group. The LIO group showed a significantly larger increase in isokinetic knee extension torque than that in the other two groups (P < 0.05) at all the velocities studied. On the other hand, no significant difference was seen between LI and the control group. In the LIO group, the cross-sectional area of knee extensors increased significantly (P < 0.01), suggesting that the increase in knee extension strength was mainly caused by muscle hypertrophy. The dynamic endurance of knee extensors estimated from the decreases in mechanical work production and peak force after 50 repeated concentric contractions was also improved after LIO, whereas no significant change was observed in the LI and control groups. The results indicated that low-intensity resistance exercise causes, in almost fully trained athletes, increases in muscle size, strength and endurance, when combined with vascular occlusion.

Good review: http://jap.physiology.org/cgi/content/full/100/5/1443

[Dr.Dave1]

Originally Posted by fitnecise

Also, blood flow does not always increase depending on how you train. In fact, restricting blood flow/oxygen to the muscle seems to result in an equal increase in muscle mass (even with less work) or even more in some research. This again suggests that the rebound is more desirable. Work the muscle, break it down, rebound adaptations. Can peri nutrition cancel or augment this? I lean toward not using supplements during your workout. It seems that decreasing lactate accumulation/acidity and limiting fatigue only makes you work harder and longer for the same mass increase as someone who doesn't take anything and does considerably less work!



Good review: http://jap.physiology.org/cgi/content/full/100/5/1443

Interesting discussion guys. I like the kaatsu reference . . . Limiting the nutrient supply and waste disposal of muscles under stress seems to be a relatively easy way to increase muscle stress/damage and force adaptation.

Another thread discussing kaatsu http://forum.bodybuilding.com/showthread.php?t=750704, quite a few studies referenced here.

[NO HYPE]

Just some food for thought, reguarding pre-workout supplementation....

One important role of dietary carbohydrate (through pyruvate) is in anaplerosis, the replenishing of Krebs cycle intermediates, (or tricarboxylic acid cycle intermediates?TCAI). The primary role of this cycle is to generate reduced forms of the enzymes NADH and FADH2, transferring high energy electrons to the mitochondrial electron transport chain for use in the resynthesis of ATP (85). Five of the intermediates of Krebs cycle are involved in additional reactions which involve amino acids and will be limited if insufficient carbohydrate is available. Oxaloacetate and a-ketoglutarate are used in the synthesis of several amino acids such as phosphoenolpyruvate. Heme synthesis uses succinyl CoA, glutamine synthesis draws upon a-ketoglutarate, and citrate is the source of acetyl-CoA in the cystol and is used for the synthesis of lipids and amino acids (59, 70). Adequate dietary carbohydrate during exercise is thus critical, because its availability is inversely related to the rate of exercise protein catabolism (86), hence adequate carbohydrate can prevent cataplerosis, the reverse of anaplerosis, which takes place in the absence of sufficient pyruvate (from carbohydrate). Gluconeogenesis can be considered cataplerotic and can result in a ?drain? of Krebs cycle intermediates (70), which may result in a decreased production of ATP, and an increased muscle protein breakdown. There may be a critical minimum intake of carbohydrate to provide a sufficient flux of pyruvate to maintain anaplerosis (87), and prevent muscle protein breakdown via gluconeogenesis.

This has practical significance to fitness enthusiasts, athletes, and bodybuilders where 150 to 400 g of protein can be consumed per day (15-17), especially if consumed at the expense of sufficient carbohydrate. In elite athletes it has been clearly established that low glycogen availability for exercising skeletal muscles leads to fatigue more rapidly in prolonged exercise (88, 89). Other studies show the time until the onset of fatigue during high-intensity exercise in untrained individuals consuming diets deficient in carbohydrate is shortened (90-93), however similar results are not found in trained individuals (94). In high-intensity resistance training, fatigue may also be associated with carbohydrate depletion (95). While high protein diets have focused on protein and its value in building lean muscle and preventing protein breakdown, it is vitally important for athletes to understand that high protein consumption at the expense of sufficient amounts of carbohydrate can be potentially detrimental to lean muscle.

http://www.humankinetics.com/eJourna.../pdfs/5642.pdf

[GeneGnomeX]

Originally Posted by Dr.Dave1

Interesting discussion guys. I like the kaatsu reference . . . Limiting the nutrient supply and waste disposal of muscles under stress seems to be a relatively easy way to increase muscle stress/damage and force adaptation.

Another thread discussing kaatsu http://forum.bodybuilding.com/showthread.php?t=750704, quite a few studies referenced here.

Ah thanks hadn't seen that one.

[GeneGnomeX]

Originally Posted by NO HYPE

Just some food for thought, reguarding pre-workout supplementation....

related sorta


J Appl Physiol 102: 1604-1611, 2007. First published January 11, 2007; doi:10.1152/japplphysiol.01260.2006

Influence of preexercise muscle glycogen content on transcriptional activity of metabolic and myogenic genes in well-trained humans
Emmanuel G. Churchley,1 Vernon G. Coffey,1 David J. Pedersen,1 Anthony Shield,1 Kate A. Carey,2 David Cameron-Smith,2 and John A. Hawley1

1School of Medical Sciences, RMIT University, Melbourne, Australia; and 2School of Exercise and Nutrition Sciences, Deakin University, Melbourne, Australia

Submitted 6 November 2006 ; accepted in final form 8 January 2007

To determine whether preexercise muscle glycogen content influences the transcription of several early-response genes involved in the regulation of muscle growth, seven male strength-trained subjects performed one-legged cycling exercise to exhaustion to lower muscle glycogen levels (Low) in one leg compared with the leg with normal muscle glycogen (Norm) and then the following day completed a unilateral bout of resistance training (RT). Muscle biopsies from both legs were taken at rest, immediately after RT, and after 3 h of recovery. Resting glycogen content was higher in the control leg (Norm leg) than in the Low leg (435 ? 87 vs. 193 ? 29 mmol/kg dry wt; P < 0.01). RT decreased glycogen content in both legs (P < 0.05), but postexercise values remained significantly higher in the Norm than the Low leg (312 ? 129 vs. 102 ? 34 mmol/kg dry wt; P < 0.01). GLUT4 (3-fold; P < 0.01) and glycogenin mRNA abundance (2.5-fold; not significant) were elevated at rest in the Norm leg, but such differences were abolished after exercise. Preexercise mRNA abundance of atrogenes was also higher in the Norm compared with the Low leg [atrogin: ~14-fold, P < 0.01; RING (really interesting novel gene) finger: ~3-fold, P < 0.05] but decreased for atrogin in Norm following RT (P < 0.05). There were no differences in the mRNA abundance of myogenic regulatory factors and IGF-I in the Norm compared with the Low leg. Our results demonstrate that 1) low muscle glycogen content has variable effects on the basal transcription of select metabolic and myogenic genes at rest, and 2) any differences in basal transcription are completely abolished after a single bout of heavy resistance training. We conclude that commencing resistance exercise with low muscle glycogen does not enhance the activity of genes implicated in promoting hypertrophy.

[The_cannibal]

You guys have totally lost Milos on that one. I don't think he knows much about science.
He posted the same stuff in the IFBB section, and when I asked for any science that would verify his claims, he never answered. In addition to this, it seemed to have shocked a lot of guys that I DARED to ask an ex-IFBB pro to prove his claims.

[DRP7]

Originally Posted by fitnecise

Also, blood flow does not always increase depending on how you train. In fact, restricting blood flow/oxygen to the muscle seems to result in an equal increase in muscle mass (even with less work) or even more in some research. This again suggests that the rebound is more desirable. Work the muscle, break it down, rebound adaptations. Can peri nutrition cancel or augment this? I lean toward not using supplements during your workout. It seems that decreasing lactate accumulation/acidity and limiting fatigue only makes you work harder and longer for the same mass increase as someone who doesn't take anything and does considerably less work!

this is an interesting reasoning and i must admit that i askedy myself the same thing very often. i did, however not reach any useful conclusion.

if your argument is correct, then wouldn't it be absolutely counterproductive (with regards to metabolic adaptation and muscle/strength gains) to use lactate buffering substances / precursors (such as beta-alanine)?

lactate acidosis surely induces many adaptational processes, in consequence of which the muscle gets better performance.
however, it appears unlikely to me that lactacidosis is the only stimulus for adaptation. what if lactacidosis is just a bottleneck for other stimuli that may induce muscle growth?

just a few questions on which i don't have an answer as of yet.

maybe we could discuss this a bit more in depth.

[GeneGnomeX]

As I understand beta-alanine buffers the hydrogen ion and not lactate itself:

In the presence of carnosine, the
muscle can accumulate enormous amounts of lactate
without obstruction, but in the absence of carnosine lactate
causes dramatic acidification of the tissue, thus
inducing contraction. [2].

http://2.mol.bio.msu.ru/biokhimiya/c...f/bcm_0749.pdf

Though i'm not entirely convinced of carnosine as a very effective ergogen yet anyway

[GeneGnomeX]

Re-reading through this discussion I came across as kind of a know-it-all-dick (mostly annoyance of a moderator advertising in the science section) when in reality my argument may be pretty weak, but I still think there is potential for acute restriction of nutrients during exercise to enhance subsequent adaptations and wish more research would look into it.

And more discussion on peri-workout supplements definitely welcome.

[treerollins]

Gastric emptying is delayed during intense exercise.

Pre-workout fat intake blunts exercise induced GH release. Pre-workout carbohydrate intake (as mentioned above) opposes the actions of exercise induced and supplemental catecholamines in stimulating HSL activity in muscle. Both moderate and intense exercise cause muscle HSL activity to increase within one minute of exercising. GH and catecholamines/HSL are synergistic in increasing fatty acid oxidation in both acute and long term phases.

Carbohydrates provide bulk material for intermediaries such as oxaloacetate. If you're restricting carbohydrate intake at other times during the day (to increase HSL activity in adipose and muscle tissue at rest), the post-workout situation can be a great time to utilize moderate amounts of carbohydrates (15-50 grams) without significantly affecting 24 hour lipolysis. I still stand behind the consumption of specific protein hydrolysates and free form amino acids, along with moderate amounts of carbohydrates post-workout. Intra-workout supplementation beyond a 6-8 % glucose/electrolyte solution is worthless. For individuals seeking to increase fat burning, even the 6-8 % glucose solution is worthless. If you're seeking to "bulk", then pre-workout carbohydrates can help; if you're seeking maximum fat loss they can be detrimental.

I don't know if restricting buffering agents pre-workout increases the training response. I do know lactate is an important fuel during exercise, and can be used to re-synthesize muscle glycogen following a workout. Acute increases in lactate are also not required for increases in exercise induced GH release.

[DRP7]

Originally Posted by Dr.Dave1

Interesting discussion guys. I like the kaatsu reference . . . Limiting the nutrient supply and waste disposal of muscles under stress seems to be a relatively easy way to increase muscle stress/damage and force adaptation.

this is however limited only to pretty low training intensity. when you train at high intensity, blood flow restricition does not add any further benefit.

[INGENIUM]

thread moved to Company Promotion...

[SinewySam]

Originally Posted by Milos Sarcev

Here is MILOS (KNS) HYPEREMIA ADVANTAGE in short:

Average male has 5 liters of blood (females have about 4)...At rest that blood is distributed throughout the body and follows certain path - normally supplying the body with physiological order of importance (what is needed the most is being on higher list of physiological priorities)...and simply organs and other tissues take preference over the skeletal muscle AT REST...

So, when body is NOT physical (when we are resting) about 12-18% of total blood goes to our muscles and the rest is distributed ELSEWHERE (as I said - according to physiological importance at that moment)...
Also, note that this 5 liters of blood are circulating quite slowly...

Well, when we start being more physically active...we start "moving" and using our "motors" ( read: MUSCLES) - our hearts start pumping a bit faster and as a result - blood start circulating that much faster and somewhat different...No longer certain organs, systems or tissues prevail in "need for blood" internal physiological war body is having on a daily bases...

Now body faces extreme shock - WEIGHT RESISTANCE TRAINING and should I say: INTENSE KIND of weight training only BODYBUILDING could create...and as a result OUR MUSCLES start winning the war and getting high on the list of "physiological importance for blood" list...

More and more blood follow the path to OUR MUSCLES!! Each muscle contraction, every rep, every set and every exercise increases the need for blood...Higher the intensity - higher the blood flow...
NEW #1 - PHYSIOLOGICAL IMPORTANCE winer is certainly SKELETAL MUSCLE AT WORK and soon we have MAJOR BLOOD FLOW into the area of our body which is engaged the most = OUR MUSCLES!!!

Well, as science has discovered: HYPEREMIA (INCREASED BLOOD FLOW TO THE PART OF THE BODY...in this instance OUR MUSCLES) reaches incredible 80% blood flow to the muscle with up to 20 times faster circulation!!!

PLEASE PEOPLE - FOCUS ON THIS!!!




If you want to deliver something to your muscles WHEN DO YOU THINK IS THE BEST TIME?




Before training when only 15 % of the blood is in the muscle?
After the training when blood is leaving your muscles...or MAYBE (Huh)

DURING THE TRAINING - when up to 80% of the BLOOD is...where...Huh

Oh - IN EXACT MUSCLE YOU ARE TRYING TO BUILD and doing all your heavy lifting for...day after day, week after week...month after month...should i even say - year after year...or for some even decade after decade - with MEDIOCRE results at best!

So, don't you think that IF YOU UNDERSTAND WHAT YOU COULD POSSIBLY ACCOMPLISH when you have 80% of your blood in exact muscles you are trying to build and YOU ACT UPON IT - you would possibly IMPROVE like never before (or like all the athletes I am preparing who keep shocking the world with FAST IMPROVEMENTS)?

If you PREPARE your blood correctly (sound diet plan in general + 30 minutes BEFORE training knowing WHICH NUTRIENTS TO TAKE that will in synergy with YOUR WORKOUT DRINK insure that YOUR BLOOD IS ANABOLIC/ANTI-CATABOLIC BOMB - filled with maximal amount of anabolic and anti-catabolic nutrients as well as TIMELY RELEASED anabolic and anti-catabolic hormones...What do you think WILL HAPPEN?

Especially IF YOU TRAIN in this GIANT SETS FASHION where you fly from one exercise to the next, changing numerous training variables, performing mixture of lifts, using various grips, angles, tempo...repetition protocols, speeds...etc?

Well, you guessed it - YOU GET MR. OLYMPIA IN A MAKING...

I will only say this once: DON'T SEND EMPTY BLOOD TO YOUR MUSCLES AT WORK...YOU ARE WASTING YOUR TIME!!!

Would you want to send FED-EX, Airmail envelope to someone as the best and fastest way of 'sending' the envelope?

Well, PLEASE - do not send EMPTY ENVELOPE - you are paying HIGH PRICE for: NOTHING!!!

Make sure you stuff the envelope...and at the same time understand that IF YOU ARE SENDING EMPTY BLOOD to the muscle (your best friend who is anxiously awaiting to OPEN your gift envelope) - you are doing the same thing!

For "stuffing" your muscle envelope go to:

www.koloseum.com


For special (30%) discount - type this code: SMNR

While exercise is the time that the most blood is in your muscle, thats not the time your muscles repair and grow...

So why be obsessive compulsive about taking protein or aminos during your workout? Oh yeah, so you can consume "koloseum" products.

Being an accomplished bodybuilder does not make your science theory automatically correct