The real Superdrol Write-Up

[Big Cat]

Since for the last few months one hasn’t been able to view a single page in this forum without finding at least two threads asking about superdrol, I figured it would probably be an asset to have some correct information about this compound available.

The REAL superdrol Write-Up

The confusion surrounding superdrol is the result of an ill-conceived name, given to this substance, probably for marketing purposes. Which ever idiot came up with the name or first starting suggesting that superdrol has anything in common with oxymetholone (Anadrol) has thoroughly demonstrated that he/she lacks any and all insight in biochemistry. Other than the fact that both are 5alpha-reduced anabolic androgenic steroids, they have very little if anything in common.

Superdrol is a compound that was known for some time prior to it being known as such. I for one came in contact with the drug following the debate surrounding IP’s equally ill-named product called ‘oral Masteron’, which ended up being nothing more than mestanolone (17alpha-methyl-DHT). Mestanolone is actually oral DHT (if for arguments sake we suggest that the addition of 17alpha-methyl group indicates the compound as being the oral of the parent steroid, which is not strictly true). I commented that to be oral masteron it would have to be 2alpha-methyl-mestanolone, or more aptly 17alpha-methyl-drostanolone (drostanolone being Masteron). That is what we called the product back then, 17alpha-methyl-drostanolone. That was only a few years ago. But it seems somehow inconceivable that this compound hadn’t been investigated decades before. So it probably has an even longer history.

From this you can also already deduce that ‘superdrol’ is in actuality a cross between drostanolone and mestanolone, since it has the 2alpha-methyl group of drostanolone and the 17alpha-methyl-group of mestanolone. Oxymetholone is an entirely different compound, which differs from superdrol by substitution of the 2-methyl group with a 2-hydroxymethylene group. A methyl group is completely inert, since it is apolar. It confers no special biochemical properties upon the group, it is merely steric bulk. Which is exactly its purpose. It provides steric hindrance for 3alpha- and 3beta-hydroxysteroid dehydrogenase enzymes, so that in contrast to mestanolone, the product is not deactivated in muscle tissue so fast. Mestanolone is nearly inactive as an anabolic substance, because it is rapidly deactivated to 3-hydroxy metabolites. Because the 2-methyl group reduces binding of the enzymes that catalyze this, it reduces the rate of deactivation and superdrol, in contrast to mestanolone, has some anabolic activity.

Oxymetholone on the other hand has a hydroxylated carbon attached to the 2nd carbon, a polar group that is chemically reactive. That carbon is also double-bonded tot the steran nucleus, which further increases reactivity of the oxygen atom. By what mechanisms is not exactly clear yet, but this gives oxymetholone some rather unique properties, likely due to interaction with other structures that most AAS do not, or barely interact with. To illustrate I uploaded the following drawing. It shows superdrol as the cross of mestanolone and drostanolone, and underneath mestanolone is oxymetholone, since oxymetholone is also a derivative of mestanolone.

http://users.pandora.be/Bigcat/superdrol.JPG

Anabolic activity : Because of the added 17alpha-methyl group, superdrol is less succeptible to metabolic deactivation. It cannot form 17-keto-steroids, and the likelihood of 16-hydroxylations is considerably reduced as well, due to this addition. This means it probably stays active longer than does drostanolone and is excreted at a lower rate. Unfortunately, the 2-methyl-group already reduces binding to the androgen receptor (1) and the 17alpha-methyl group further reduces it (1). This seems to even out the odds for superdrol, giving it roughly the same amount of anabolic activity as drostanolone. That means superdrol is by no means a serious muscle builder, except perhaps to those smaller in stature or as of yet unexperienced with other anabolic androgenic steroids. This puts its anabolic activity in the neighbourhood of other non-aromatizing, weak oral androgens, such as Anavar (oxandrolone), Winstrol (Stanozolol) and Halotestin (Fluoxymesterone).

Androgenic activity : Comparing it to these other weak, oral, non-aromatizing androgens, the androgenic activity is considerably less than for halotestin, but considerably higher than for winstrol and anavar. The reason being that despite increased activity in muscle compared to mestanolone, deactivation is still stronger in muscle (the 2-methyl group reduces but does not eliminate reduction of the 3-keto function (2)). And contrary to popular belief, a non-deactivated DHT does still not have the same level of activity in muscle as it does in androgenic target tissues. Androgenic side-effects rarely occur in healthy young men, but if you have reason to fear such effects, than superdrol is probably the poorer choice when compared to anavar or winstrol. A lot of athletes however seem to suggest that using stronger androgens seems to increase muscle density when body-fat is low. And while this is a rather subjective trait, this does seem to hold true for superdrol as well. In which case it would then probably be a better choice than the other mentioned oral steroids.

Estrogenic/Progestagenic activity : Like most 5-alpha-reduced steroids, this product has no estrogenic activity. Neither mestanolone nor drostanolone are capable of aromatization either. Whoever is producing this stuff now seems to want to convey that it is a major plus that this does not have estrogenic effects like oxymetholone, but first off, remember that this steroid has NOTHING in common with oxymetholone and secondly, the perceived estrogenic effects of oxymetholone have never been established as being estrogenic, because despite massive bloating, the prevalence of estrogenic side-effects with oxymetholone remains low when used with other AAS to non-existent when used alone. Whether or not this drug still has anti-estrogenic activity like drostanolone is questionable. I certainly wouldn’t count on it.

Liver-toxicity : The hepatoxicity of this compound is rather high. That may have been one of the reasons no one has marketed or researched such a compound for pharmaceutical use before. In all instances I observed personally (which were admittedly only 4 instances of use of 40 mg/day for 6 weeks), liver values were elevated above acceptable levels, and considerably elevated above the values seen for the same duration of time with equal (dbol) or higher (Anavar, Anadrol, Winstrol) doses of other commonly (ab)used oral steroids. Use should therefore definitely be restricted to 30-40 mg/day for 6 weeks. If higher doses are used, or compound is used for a longer period of time, liver values should be checked at regular intervals.

Stacking and use : It should be quite obvious that the use of this compound (at least to the experienced steroid user) will be limited to cutting purposes. For the same amount of money there are simply far more suitable compounds for gaining muscle mass. As with most oral steroids (with notable exception of Halotestin) I would advise against using it alone, in conjunction with other oral steroids, or in the last week of a cycle. This because most 17alpha-alkylated androgens are known to increase glucocorticoid receptor density (3) and result in increased loss of muscle mass post-cycle. An added reason for not using it with other oral steroids is the increased risk for hepatoxic side-effects.

References

(1) Ojasoo T, Raynaud JP.Unique steroid congeners for receptor studies.Cancer Res. 1978 Nov;38(11 Pt 2):4186-98

(2) de Boer D, de Jong EG, Maes RA, van Rossum JM.The methyl-5 alpha-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites.J Steroid Biochem Mol Biol. 1992 May;42(3-4):411-9.

(3) Fernandez L, Boada LD, Luzardo OP, Zumbado M, Lopez A, Diaz-Chico BN, Chirino R.[3H]dexamethasone binding activity in liver microsomes is modulated differently by 17 alpha-alkylated androgens and testosterone in vivo.Pharmacol Toxicol. 1995 Oct;77(4):264-9.

[wiseguy1111]

Nice work.

[2pounds]

bump for no more SD questions,,

[vipastyle]

great post!

[Kroms_laugh]

"And another one" /Biggie's Voice/

Awesome post!

[bdiesel]

Originally Posted by 2pounds

bump for no more SD questions,,

but what am i supposed to do about my sd gyno?!

[Intellectural]

Fabulous research, I must admit, I bought into the hype and have a bottle sitting here. I don't think I'll be using it now due to the freaky rapid liver problems that seem to be popping up. I wish someone would have put that together a long time ago, I'm exhausted by the endless SD threads!

[jjjxmmmxbbb]

nice post

[6ft8monster]

ttt

[Big Cat]

Originally Posted by Intellectural

Fabulous research, I must admit, I bought into the hype and have a bottle sitting here. I don't think I'll be using it now due to the freaky rapid liver problems that seem to be popping up. I wish someone would have put that together a long time ago, I'm exhausted by the endless SD threads!

I think its a very useable compound at 30-40 mg for 4-5 weeks in a cutting cycle, or for hardening up in contest prep. If you have it, I'm sure a little creativity will offer you a use for it I, for example, have found many uses for fluoxymesterone, despite its low direct anabolism and high hepatoxicity. Its just a question of knowing the compound and finding the right use for it.

It just means that if you bought SD to gain mad weight you'll probably be dissapointed

[_Bladen_]

I used SD to jumpstart my TestE cycle, worked REALLY well Killed my liver though... cry!


Reps for a kick ass post

[joey_tgstk]

God bless you Big Cat, it should be sticky.

-Joey

[Vail]

Originally Posted by joey_tgstk

God bless you Big Cat, it should be sticky.

-Joey

^^^^^ agreed. Thanks Big Cat

[BigHulkHogan]

I was just under the impression that SD was a decent idea for someone looking to pack on some weight(not tons) because they cannot find any real steroid suppliers or cannot trust their suppliers.

[Habeed]

"For the price, there are other more effective substances". Please elaborate further on this. It doesn't do to tell us newbies who have our appetites whetted by the (compared to natural) dramatic effects of superdrol that far better substances are available with telling us what they are.

[Alcatraz1662]

True, please sticky this!

[dirty hands]

Originally Posted by Big Cat

I would advise against using it alone, in conjunction with other oral steroids, or in the last week of a cycle. This because most 17alpha-alkylated androgens are known to increase glucocorticoid receptor density (3) and result in increased loss of muscle mass post-cycle.[/i]

this is new to me. all ive ever heard was to run orals or short esters all the way up until pct. so you would stop using any 17-aa steroids the last week before you start your pct? if you could please shed some more light on this for me i'd greatly appreciate it.

[allforspeed]

bump, that answers alot of questions, by the way legal gear just stopped making it because they are scared of the FDA and i'm sure its shelf life is limited, not sure if thats bad or good, but that was their response to my email i sent them

thanks for the write up bro, answers alot of questions

[The Booger]

Big Cat I have a question for you.

What's your view on using SD combined with Test? Should make for a pretty effective cycle I'd think (maybe wrong here, just trying to learn). Stand alone it has produced some great gains for people.

I've only seen one cycle done this way.

I still really don't see a big issue with running this at 20mg for two weeks. It's shown good gains in that amount of time. Although I have a bottle here, using it won't happen until I'm 100% sure of what I want to do.

[StanChampion]

Originally Posted by Big Cat

I think its a very useable compound at 30-40 mg for 4-5 weeks in a cutting cycle, or for hardening up in contest prep. If you have it, I'm sure a little creativity will offer you a use for it I, for example, have found many uses for fluoxymesterone, despite its low direct anabolism and high hepatoxicity. Its just a question of knowing the compound and finding the right use for it.

It just means that if you bought SD to gain mad weight you'll probably be dissapointed

better keep track of your lipid profile if taking 30-40 mg for that long.

Also, just about every log I ahve seen on SD has shown large weight gain.

I gained about 14-15# in a 6 week cycle @ 20mg/day. This was on a calorie reduced diet as well, with cardio 3x/week.

[ratmonkey]

Originally Posted by BigHulkHogan

I was just under the impression that SD was a decent idea for someone looking to pack on some weight(not tons) because they cannot find any real steroid suppliers or cannot trust their suppliers.

umm....*looks around*...are you that clueless?

[sikboy]

What would you say is better for hardness, in a test cycle, 50 mg of proviron ed, .5 mg of adex ed, or 40-50 mg of SD ed?

[Big Cat]

Originally Posted by dirty hands

this is new to me. all ive ever heard was to run orals or short esters all the way up until pct. so you would stop using any 17-aa steroids the last week before you start your pct? if you could please shed some more light on this for me i'd greatly appreciate it.

As explained in the post, most 17AA's have a slight tendency to upregulate the glucocorticoid receptor. This could be the result of some Glucocorticoid activity caused by the 17AA, that would explain why it happens to alarger degree with steroids known to have GR activity, like danazol, and probably stanozolol, and the opposite happens with the only 17AA known to be a potent anti-glucocorticoid, fluoxymesterone. This also explains why oral only cycles don't result in gains you can keep and muscle is lost rapidly afterwards. The increased glucocorticoid activity impairs recovery afterwards as well.

[Krzna]

I hope u can come up with something for pheraplex ... am working on one and would love to see something from you.
On that note...most of what i and many otherz here have learnt is from you.

[Big Cat]

Originally Posted by allforspeed

bump, that answers alot of questions, by the way legal gear just stopped making it because they are scared of the FDA and i'm sure its shelf life is limited, not sure if thats bad or good, but that was their response to my email i sent them

thanks for the write up bro, answers alot of questions

Steroids keep rather well. Just store in a dry and dark place. The only thing that could spoil is the actual tablet. They should have stopped making this a long time ago by the way. But its a fairly useful compound as a cutting drug, I'm sure in time we'll see it on some lists as well.

[Big Cat]

Originally Posted by StanChampion

better keep track of your lipid profile if taking 30-40 mg for that long.

Also, just about every log I ahve seen on SD has shown large weight gain.

I gained about 14-15# in a 6 week cycle @ 20mg/day. This was on a calorie reduced diet as well, with cardio 3x/week.

The majority of this stuff was sold to people not used to using steroids, and don't have access to better steroids. Logically the gains will be bigger in that perspective. Lipid profiles showed no large abnormalities at those doses and for those periods. The usual drop in HDL, but no nominal differences in total cholesterol.

[Big Cat]

Originally Posted by The Booger

Big Cat I have a question for you.

What's your view on using SD combined with Test? Should make for a pretty effective cycle I'd think (maybe wrong here, just trying to learn). Stand alone it has produced some great gains for people.

I've only seen one cycle done this way.

I still really don't see a big issue with running this at 20mg for two weeks. It's shown good gains in that amount of time. Although I have a bottle here, using it won't happen until I'm 100% sure of what I want to do.

I'm afraid the test may obscure anything you may see from the SD. With a good diet, use prop, and finish with some diuretics, the final result of such a cutting cycle might be good though. But i'd be more inclined to recommend stacking it with a hefty dose of boldenone. 600-800 mg a week. That dose keeps your test levels in normal range as well, so you don't have to stack testosterone with it. 10-12 weeks, and add 30 mg of SD the last 5 weeks.

[Big Cat]

Originally Posted by Krzna

I hope u can come up with something for pheraplex ... am working on one and would love to see something from you.
On that note...most of what i and many otherz here have learnt is from you.

Not familiar with pheraplex, what is the active ingredient ?

[Krzna]

Originally Posted by Big Cat

Not familiar with pheraplex, what is the active ingredient ?

2-ene - 10mg
(17a-Methyl-etioallocholan-2-ene-17b-ol)

[Big Cat]

Originally Posted by Krzna

2-ene - 10mg
(17a-Methyl-etioallocholan-2-ene-17b-ol)

That's DMT (Madol) I'll see if I can do a write-up on that soon, I just profiled it for my book.