Hot-Rox and Thyroid Problem

[Boxer757]

I know hot-rox is a really popular product and i decided to try it alittle over a month ago. I would have posted this earlier but i'm very busy with classes. Anyways i'll try to keep this short. I went home last weekend and got a pretty routine checkup as being a freshman in college you have to worry about catching all kinds of nasty diseases with communal living and whatnot. They ran blood work and when my results came back by TSH levels were low, this was odd because i'm a healthy guy and everything else was tip-top. So i went in for an ultra sound and they found nothing wrong. Then it hit me i had read something about gugglesterone (sp?) messing with people's thyroids. I remembered this ingredient being listed in hot-rox but whenever i saw it back then i didn't really think twice about it. Well i'm no doctor so i'm not gunna try to BS this but i'll tell you what i know and i'm sure someone more educated on the matter can give their opinion... My T3 and T4 levels were pretty high but not in a red zone, my TSH was abnormally low however. TSH is basically the hormone produced by your brain that is sent to your thyroid to tell it to make T3 and T4. If you've got too much T3 or T4... TSH gets low, too much T3 or T4 and TSH gets higher. So my doctor and i both believe that the gugglesterone found in hot-rox was causing me to produce excess T3/T4 and therefore my TSH levels were lowering (i have since stopped taking this product and still have 1 1/3 bottles left... wasted my money i love doing that). There should be no longterm side effects but there very well could have been if i had taken this product for too much longer. To try and make a somewhat decent analogy I could have shut down my thyroid on this stuff like i could shut down my testicles on steroids... then i would have to rely on synthroid (a synthetic version of the chemicals your thyroid produces) for the rest of my life and possibly down the line have surgery.
I just felt that i should let you guys know about this. I'm sure many people are on hot-rox and supplements like it with no problems whatsoever. But i would just urge you to get some blood work done if you're considering taking this or any new supplement for that matter to be sure it isn't having any adverse effects on you're health.
I am getting some follow up bloodwork on the 21st of this month so when those results are in i will let you know if it's better/worse/the same and that should help point towards wether or not it was indeed the hot-rox that caused the problem.

[BringnIt]

No. Hot Rox is a thyroid product. Your "shutdown," so to speak, is temporary.

[Androgenic]

My guess is it is the "A7E" compound, which I know nothing about. And most likely it is temporary. Gugglesterones have mixed reviews (raising LDL cholesterol, lowering free testosterone, increasing progesterone is some studies). When you take compounds that impart hormonal effects, endogenous hormones will decrease in your body as there is less of a "need" for them this is part of the miracle of homeostasis, often though it is what we as bodybuilders are working against. Typically, when the exogenous hormone is discontinued, endogenous production will increase...again this is homeostasis. TSH is thyroid stimulating hormone and it causes the release of T3 and T4. Permanent thyrodi damage resulting in hypothyroidism may be seen with some of these thyroid-altering agents, who knows? You bring up some valid points. Another test that can be done beside TSH, T3, T4 (free), is the thyrotropin-releasing hormone (TRH) challenge test which starts the cascade prior to TSH.

The problem with proprietary compounds and little research backing them is a real role of the dice and leap of faith with a body that you only get one of.

Biotest would never get my money.
__________________________________________________ _______________
To quote Biotest's brainwashing propaganda read below:

The horsepower that fuels HOT-ROX is comprised of two novel compounds and their synergists. The big daddy, which is also the real magic behind our formula, is called A7-E™.

A7-E was designed by Bill Roberts and is best described as a thyroid supercharger. It's completely new to the industry; it has a patent filed on it; and it's so powerful on its own as a fat-loss agent that there's no contest when compared to anything else that's currently on the market.

A7-E launches us right smack dab in the middle of a new fat-loss era!

A7-E™ - Rev Up and Potentiate Thyroid Activities

The most challenging task was finding a way to boost T3 levels without suppressing TSH. From the scientific literature, there are two groups of compounds that when taken together in relatively high dosages, would do the trick nicely: 3,17-dihydroxy-delta-5-etiocholane-7-one (A7-D) supported by guggulsterones.

Once converted into the active species, A7-D has been shown to increase T3 in humans by as much as 30% without suppressing TSH! Additionally, and to a much greater degree, A7-D increases thermogenic malic enzyme. Remember, malic enzyme is the compound responsible for producing oxaloacetate, which fuels the TCA cycle.

Guggulsterones, on the other hand, increase the peripheral conversion of T4 into T3, making it the ideal complement to A7-D. Increasing the peripheral conversion of T3 is very important because the thyroid only produces 20% of the body's T3. Most of the remaining 80% is derived from T4 through a conversion process that occurs in various target tissues, like skeletal muscle, for example.

On the surface, A7-D and guggulsterones appear to be great choices for the HOT-ROX formula. Unfortunately, however, both have inherent problems which needed fixing if we were to achieve the desired magnitude of effect. In other words, we wanted to improve the wow factor by a bunch.

In essence, the bioavailability of A7-D isn't high enough and the active life is far too short. So to improve both bioavailability and length of active life, Bill engineered A7-D into a carbonate ester, called 3,17-dihydroxy-delta-5-etiocholane-7-one diethylcarbonate, or A7-E.

A7-E, due to its superior rate of conversion, its longer active life, and its increased bioavailability, is the premier fat-loss compound of our time. In and of itself, it's a very powerful and effective fat-loss agent. But we didn't stop there...

We wanted a synergist for A7-E. All of our research pointed to one obvious candidate - guggulsterone - because it increases the peripheral conversion of T4 into T3, further supporting the actions of A7-E. The problem, however, is guggulsterones are not available in a pure state. They're found in a plant called Commiphora mukul, which contains only small amounts of guggulsterone Z and E.

Unfortunately, a good Commiphora mukul extract is only 2.5% active, and that alone makes using an herbal extract unfeasible. Additionally, it's very difficult to get consistent raw material, making accurate dosing literally impossible. And if these weren't big enough problems, there are other constituents in the plant material that cause rather severe allergic reactions in a significant portion of the population.

Our only solution was to produce 100% pure guggulsterones, preferably with a 2:1 ratio between Z and E. And that's just what we did. We included two parts purified guggulsterone Z to one part purified guggulsterone E in our HOT-ROX formula.

So to recap, A7-E has the incredible ability to stimulate the production of T3 and thermogenic malic enzyme; and pure guggulsterones further enhance (synergize) these activities by facilitating the peripheral conversion of T4 into T3.

[SM007]

I'm sorry for bringing up this 2 year old topic again, but I'd just like to know from Boxer757 if his thyroid has recovered/returned to normal?

I've been using a thermogenic/thyroid-stimulating containing Guggulipids (USN Phedra Cut XT), for 2 weeks, 6 capsules a day.

After 2 weeks, I developed a sore throat and stopped using it. Bloodwork reveals low T4 and the swelling has increased since. I am on a 30-day trial period of Synthroid/T4, will stop after 30-days for a month with followup bloodwork.

Has anyone had similar experiences?

[Sldge]

Originally Posted by SM007

I'm sorry for bringing up this 2 year old topic again, but I'd just like to know from Boxer757 if his thyroid has recovered/returned to normal?

I've been using a thermogenic/thyroid-stimulating containing Guggulipids (USN Phedra Cut XT), for 2 weeks, 6 capsules a day.

After 2 weeks, I developed a sore throat and stopped using it. Bloodwork reveals low T4 and the swelling has increased since. I am on a 30-day trial period of Synthroid/T4, will stop after 30-days for a month with followup bloodwork.

Has anyone had similar experiences?

Just keep in mind that T4 has an extremely long half life and can have metabolites still affecting your thyroid numbers for a month after you have stopped using. My guess is that your Dr. will test you while on the t4 to see what you levels are on the script and should he want to test without them it will be atleast a month after you have stopped using it.

[SM007]

Since I'm taking T4, will that stop my thyroid from recovering/rebound?

I have a growing goiter and I'm scared if I stop taking the synthroid, it will grow even more (although it's still growing even with synthroid).