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  1. #1
    Registered User tevez's Avatar
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    Effects of benzodiazepines...

    How would these drugs, flunitrazepam, lorazepam etc. affect muscle building? Since they have muscle relaxant effects, shouldnt it aid the muscle building process?
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  2. #2
    Registered User tevez's Avatar
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    any1?
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  3. #3
    Welcome To ROFL House kskwerl's Avatar
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    Why are you taking those Benzo's to begin with? Just curious.
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  4. #4
    Welcome To ROFL House kskwerl's Avatar
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    Originally Posted by strong~arms View Post
    No effects at all either good or bad.
    How do you know this? Don't take that the wrong way I just would like to know.
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  5. #5
    Keep Calm & Lift Heavy Giant_Killer's Avatar
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    Thumbs down

    I have taken Clonazepam (gen. Klonopin) routinely for anxiety disorder for about 2 years. I am convinced it has absolutely no effect on muscle building. It just makes me tired and less apt to work out, LOL.
    There is no need to be upset.
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  6. #6
    Registered User bonestick's Avatar
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    Originally Posted by tevez View Post
    How would these drugs, flunitrazepam, lorazepam etc. affect muscle building? Since they have muscle relaxant effects, shouldnt it aid the muscle building process?
    I don't know who told you the "muscle relaxant effect". They primarily act on your brain and enhance GABA binding to GABA-a receptor. GABA-a receptor will then prevents neurons from firing during hyperpolarisation. Therefore, their effects are mostly nerve-related.

    As for muscle building, you have to push your muscles to the limit before they can grow. Those drugs will make you drowsy and relaxed (if you want to called it). Since you can't be mentally focused because of sleepy feeling, you can't build muscle as fast.
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    Keep Calm & Lift Heavy Giant_Killer's Avatar
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    Originally Posted by bonestick View Post
    As for muscle building, you have to push your muscles to the limit before they can grow. Those drugs will make you drowsy and relaxed (if you want to called it). Since you can't be mentally focused because of sleepy feeling, you can't build muscle as fast.
    Believe it.
    There is no need to be upset.
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  8. #8
    Actual Pharmacist Bane's Avatar
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    Originally Posted by tevez View Post
    How would these drugs, flunitrazepam, lorazepam etc. affect muscle building? Since they have muscle relaxant effects, shouldnt it aid the muscle building process?
    They sure make you feel calmer and less motivated and lower muscle tone. They have neglible impact on GH,leptin,or insulin, compete with TSH for thyroid output, but they do seem to have a positive impact on androgen levels.
    There have been cases of muscle wasting due to benzodiazepin treatment where other cases.
    All in all i'd say it's a very individual specific thing
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  9. #9
    Actual Pharmacist Bane's Avatar
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    Originally Posted by bonestick View Post
    I don't know who told you the "muscle relaxant effect". They primarily act on your brain and enhance GABA binding to GABA-a receptor. GABA-a receptor will then prevents neurons from firing during hyperpolarisation. Therefore, their effects are mostly nerve-related.
    They do reduce muscle tone, causing muscle relaxation with a mechanism independent of their CNS action, which is currently suspected to be due to reduction of spinal reflexes
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  10. #10
    Registered User tevez's Avatar
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    Thanks guys, but im not talking about taking it pre workout or anything. i usually take it 3/4 hours before bed, i feel no drowsiness or anything like that the next day, actually the opposite, i have a great sleep and feel energised the next morning, thats y i was wondering. i take it for recreational use btw...
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  11. #11
    game over DRP7's Avatar
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    Originally Posted by tevez View Post
    How would these drugs, flunitrazepam, lorazepam etc. affect muscle building? Since they have muscle relaxant effects, shouldnt it aid the muscle building process?
    benzodiazapines impair psychomotor performance in a dose-dependent manner. under the influecne of benzodiazepines you will hardly reach maximal msucle contraction force, because of central sedation + peripheral relaxation + impaired psychomotor coordination.
    the latter aspect may it even make dangerous to lift heavy weights after taking benzodiazepines because you would have a largely increased risk to hurt yourself (e.g. barbells falling off your hands etc.).

    In sum, benzodiazepines have no place in weightlifting / bodybuilding.
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  12. #12
    game over DRP7's Avatar
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    Originally Posted by tevez View Post
    Thanks guys, but im not talking about taking it pre workout or anything. i usually take it 3/4 hours before bed, i feel no drowsiness or anything like that the next day, actually the opposite, i have a great sleep and feel energised the next morning, thats y i was wondering. i take it for recreational use btw...
    benzodiazepines have a GREAT abuse potential. you need to only take them a few times and a tolerance wills tart building up. the brain loves benzodiazepines, it can't get enouh of them. inc ases of severe insomnia or high levels of anxiety they can be taken for a very limited time. they MUST NOT be taken long-term wise. if you take them regularly you will have a very hard time to come off of them.

    there are much better options for better sleep than to take benzodiazepines.
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  13. #13
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    Originally Posted by Dr.P View Post
    benzodiazepines have a GREAT abuse potential. you need to only take them a few times and a tolerance wills tart building up. the brain loves benzodiazepines, it can't get enouh of them. inc ases of severe insomnia or high levels of anxiety they can be taken for a very limited time. they MUST NOT be taken long-term wise. if you take them regularly you will have a very hard time to come off of them.

    there are much better options for better sleep than to take benzodiazepines.
    Nothing like the benzo induced seizures. Off all the drugs to abuse we see these drugs abused most of the time. Our UDS's pop for, in order of popularity, 1. Marijuana 2. Cocaine, mostly crack, our pt. pop mostly cannot afford the powder. 3. Benzos.

    As far as sleep goes have you tried Benadryl or Lunesta? I am partial to Benadryl.
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  14. #14
    Mother Natures Son.. meanmo's Avatar
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    Originally Posted by tevez View Post
    Thanks guys, but im not talking about taking it pre workout or anything. i usually take it 3/4 hours before bed, i feel no drowsiness or anything like that the next day, actually the opposite, i have a great sleep and feel energised the next morning, thats y i was wondering. i take it for recreational use btw...
    Be careful with Benzo's, people development some pretty nasty addictions to that class of drug and many of the effects really rebound on sudden discontinuation. Im a long time insomniac and used them for awhile with some success under supervision, nothing worth the addiction though. If you use them for sleep you may want to consider asking your doctor to try one of the new classes of sleep drugs or even the old tricyclic trazadone which does not cause any dependence. If you use them for recreation then your on your own. I would really advise against it.. few things are as pathetic as a guy hooked on downers..
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  15. #15
    Registered User Mike83's Avatar
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    They are quite addicting and if you plan on using them, don't use them day after day. You will have a rebound effect very fast if you use them daily then discontinue suddenly, which will be a very nasty feeling to deal with.

    I personally use them usually once a week instead of alcohol. Also the shorter acting benzos (xanax) will cause a rebound effect much faster than a longer acting Valium.

    I think they have some use in the bodybuilding world, as an alternative to alcohol. They are much safer on your body than consuming a nights worth of alcohol. Just my few thoughts on this.
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  16. #16
    Registered User tevez's Avatar
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    I dont drink alcohol, never have, so i use benzo's maybe once or twice a week to chillout, i understand the potential for abuse of these drugs but i feel i can control it. Thanks again for the info, Dr. P, Bane etc...
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  17. #17
    Actual Pharmacist Bane's Avatar
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    Originally Posted by icetrauma View Post

    As far as sleep goes
    GABA
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    Registered User Stef76's Avatar
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    Hey, i'm new on the forum here.
    I was looking for the same answer to this question. You may call me stupid, but when they say that GHB has positive effects for GH release, and since i read a lot about the benefits of taking GHB. Why wouldn't benzo's are? Since they work almost the same in your brain, it are relaxend products, just GHB is short acting, and much stronger then many other benzo's like lorazepam, bromazepam, etc. I had experiences with both, and i find GHB more addictive, cause of the rush you get. Not saying that benzo's aren't too, but these are more controlable to take.

    As i said, i don't know it, but i think if GHB is good when you do bodybuilding, why wouldn't benzo's are. You get a good night sleep, you're mucles are relaxed which is good for recuperation. Oke, it's clear that you don't take a benzo before a workout!!!! that's plain stupid. But for overnight, i think it definitly won't harm a thing.

    This is just my thoughts, correct me if i'm wrong, preferable on scientific facts!!!
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  19. #19
    Actual Pharmacist Bane's Avatar
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    Originally Posted by Stef76 View Post
    Hey, i'm new on the forum here.
    I was looking for the same answer to this question. You may call me stupid, but when they say that GHB has positive effects for GH release, and since i read a lot about the benefits of taking GHB. Why wouldn't benzo's are? Since they work almost the same in your brain, it are relaxend products, just GHB is short acting, and much stronger then many other benzo's like lorazepam, bromazepam, etc. I had experiences with both, and i find GHB more addictive, cause of the rush you get. Not saying that benzo's aren't too, but these are more controlable to take.

    As i said, i don't know it, but i think if GHB is good when you do bodybuilding, why wouldn't benzo's are. You get a good night sleep, you're mucles are relaxed which is good for recuperation. Oke, it's clear that you don't take a benzo before a workout!!!! that's plain stupid. But for overnight, i think it definitly won't harm a thing.

    This is just my thoughts, correct me if i'm wrong, preferable on scientific facts!!!
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  20. #20
    Registered User Stef76's Avatar
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    Ok?j, bad comparison of me , so no benefits, thanks

    But are there disadvantages of talking benzo's, i mean besides the sedative effects, and probably bad for a maximum performance. I think not. I experience a great appetite because of them, not for junk food, but for good eating.
    I suppose there's no direct disadvantage or advantage of taking them, when not excesserating....

    Besides keeping a good diet, good workout etc.. a man may have some plesant "habits" too... not?
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    Thumbs up

    Originally Posted by Stef76 View Post
    I experience a great appetite because of them

    Brilliant logic.
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    [QUOTE=NO HYPE;105549901][url=http://jcem.endojournals.org/cgi/content/abstract/56/6/1316]Effect of the benzodiazepine derivative, diazepam, on the clonidine- stimulated human growth hormone secretion


    So Diazepam , stimulates GH production?>


    Also on this benzo topic, Im sure most benzos increase gh and reduce cortisol.

    Also, Valium (diazepam) has shown to increase testosterone according to patrick arnold.


    One thing I have noticed, different benzos stimulate appetite cravings and control differently. Xanax is notorious for increasing appetite and craving junk food. Valium, gives better control over cravings. Klonopin is a hit or miss, depends on mood, if depressed it will make you binge!
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    So if you took bromo with this it may increase gh?
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    Originally Posted by Stef76 View Post
    Hey, i'm new on the forum here.
    I was looking for the same answer to this question. You may call me stupid, but when they say that GHB has positive effects for GH release, and since i read a lot about the benefits of taking GHB. Why wouldn't benzo's are? Since they work almost the same in your brain, it are relaxend products, just GHB is short acting, and much stronger then many other benzo's like lorazepam, bromazepam, etc. I had experiences with both, and i find GHB more addictive, cause of the rush you get. Not saying that benzo's aren't too, but these are more controlable to take.

    As i said, i don't know it, but i think if GHB is good when you do bodybuilding, why wouldn't benzo's are. You get a good night sleep, you're mucles are relaxed which is good for recuperation. Oke, it's clear that you don't take a benzo before a workout!!!! that's plain stupid. But for overnight, i think it definitly won't harm a thing.


    They can be good, helpful if used properly. I used GHB (gbl twice as strong as ghb) also not as toxic as most think, must dilute it.

    Its way too strong and fast acting, Withdrawl comes so fast its insane, I used it 4 or so nights in a row and had withdrawls the next few days, and had trouble sleeping for a few more nights.
    This is just my thoughts, correct me if i'm wrong, preferable on scientific facts!!!
    They can be helpful if used properly. I used GHB (GBL twice as strong as ghb, not toxic as most think, must be diluted) Its way to strong and after 4 or so nights of use I got withdrawls and couldnt sleep for 4 or more days. Its way to fast acting. If you consider xanax fast acting gbl makes that seem like nothing.
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    bump on benzo research and discovery!
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    This is some stuff I've wondered about as well since I have some problems with anxiety and depression.
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    Originally Posted by Mike83 View Post
    bump on benzo research and discovery!

    If the benzo in question inhibits cholinergic receptors (e.g. pirenzepine).... forget about it.
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    Originally Posted by tevez View Post
    Thanks guys, but im not talking about taking it pre workout or anything. i usually take it 3/4 hours before bed, i feel no drowsiness or anything like that the next day, actually the opposite, i have a great sleep and feel energised the next morning, thats y i was wondering. i take it for recreational use btw...
    a better option would be GHB - you might have heard of it. GHB has been shown to increase hGH levels and used to be used a lot by bodybuilders. it's illegal now (it's easy to overdose on, very dangerous when combined with alcohol, and is sometimes used as a date-rape drug), but it's very easy to synthesize (you need GBL or 1,4-butanediol and sodium or potassium hydroxide). if it's pure, sensibly dosed, and you don't drink/take other drugs while on it, it's completely harmless.
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    Benzodiazepines do supress cortisol secretion and increase GH levels, but continuous use blunts GH release.

    http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus
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